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NanoSafetyCluster - Compendium 2012 2 Compendium of Projects in the European NanoSafety Cluster
ENNSATOX ENgineered Nanoparticle Impact on Aquatic Environments: Structure, Activity and Toxicology NanoSafetyCluster - Compendium 2012 Contract Agreement: NMP4-SL-2009-229244 Website: http://www.ennatox.eu Scientific Coordinator: Professor Andrew Nelson, Centre for Molecular Nanoscience (CMNS), School of Chemistry, University of Leeds, UK Project Manager: Dr Karen Steenson, Faculty of Engineering, University of Leeds, UK No. Beneficiary name Short name Country 1 2 3 4 5 6 7 Contents University of Leeds (Coordinator) UNIVLEEDS UK Wageningen University WU Netherlands University of Antwerp UA Belgium Stazione Zoologica Anton Dohrn SZN Italy Lleida University UdL Spain Marine Biological Association of UK MBA UK Society of Environmental Toxicology And Chemistry (SETAC) – Europe SETAC Belgium 1 Summary ....................................................................................... 3 2 Background – The ENNSATOX Project ........................................ 4 2.1 Introduction, Scientific / Industry Needs & Problem Addressed.................................................................................. 4 2.2 Scope & Objectives ................................................................... 5 1 Summary Project Duration: 1 July 2009 – 30 June 2012 Project Funding: €3,655,316 Total Budget; €2,816,500 EC Contribution The use of engineered nanoparticles (NP) in cosmetics, pharmaceuticals, sensors and many other commercial applications has been growing exponentially over the past decade. EU and Member States' research into the environmental impact of these materials, particularly in aquatic systems, is at an early stage. There is a large uncertainty into the environmental risk posed by these new materials. ENNSATOX addresses this deficit through a comprehensive investigation relating the structure and functionality of well characterised engineered nanoparticles to their biological activity in environmental aquatic systems. ENNSATOX takes account of the impact of nanoparticles on environmental systems from the initial discharge to the uptake by organisms. Accordingly an integrated approach will assess the 2.3 Technical Approach, Work Description & Achievements To- Date ........................................................................................... 6 2.4 Conclusion To-Date & Plans for the Future ............................. 10 3 Directory ...................................................................................... 12 4 Copyright ..................................................................................... 13 activity of the particles in a series of biological models of increasing complexity. Parallel environmental studies will take place on the behaviour of the nanoparticles in natural waters and how they modify the particles' chemical reactivity, physical form and biological activity. A comprehensive theoretical model will be developed describing the environmental system as a series of biological compartments where particles transport between a) compartments by advection-diffusion and b) between phases by a transfer function. Following optimisation of the transfer functions a generic predictive model will be derived for the environmental impact of each class of nanoparticle in aqueous systems. The project will include the use of unique biological membrane models not only to understand better the interaction of nanoparticles with cell membranes from an organism health point of view but also to develop suitable nanoparticle screening procedures which can substitute for the more lengthy in vivo tests. ENNSATOX will generate: 1) Exploitable IP of screening devices and simulation software; 2) Set of standard protocols; 3) Global dissemination of Compendium of Projects in the European NanoSafety Cluster 3
Page 1: Compendium of Projects in the Europ
Page 5 and 6: EDITED BY Michael Riediker, PD Dr.s
Page 7 and 8: CONTENTS NanoSafetyCluster - Compen
Page 9 and 10: Project Acronym ENNSATOX ENPRA EURO
Page 11: Foreword NanoSafetyCluster - Compen
Page 15 and 16: The biological membrane and its dep
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Page 19 and 20: Figure 10. Schematic representation
Page 21 and 22: WP5: • Permeability of NPs in hyd
Page 23 and 24: NanoSafetyCluster - Compendium 2012
Page 25 and 26: ENPRA RISK ASSESSMENT OF ENGINEERED
Page 27 and 28: vitro findings with in vivo models;
Page 29 and 30: protocols with real biological samp
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Page 37 and 38: EURO-NanoTox European Center for Na
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Page 41 and 42: The core functions of the Center, h
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Page 45 and 46: HINAMOX Health Impact of Engineered
Page 47 and 48: High Resolution Electron Microscopy
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Page 57 and 58: InLiveTox Intestinal, Liver and End
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INSTANT Innovative Sensor for the f
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complementary research which will l
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7 Copyright NanoSafetyCluster - Com
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ITS-NANO Intelligent testing strate
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approach to conveying the appropria
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in the discussion. The integration
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MARINA MANAGING RISKS of NANOMATERI
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for risk analysis, these tools need
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environmental ENM toxicity, but tox
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propose it as a Method Validation F
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and SiO2-NM200 and NM203, and a SiO
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ModNanoTox Modelling nanoparticle t
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3) To model environmental exposure
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Nanodetector European Network on th
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measurement interval. Measurements
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5 Directory Table 1 Directory of pe
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NANODEVICE Novel Concepts, Methods,
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ENP in order to be sure of their sa
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4.3 Exploring the association betwe
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NanoSafetyCluster - Compendium 2012
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NanoFATE Nanoparticle Fate Assessme
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or proteins associated with particu
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sludge. Information on rates of slu
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The exposures to be conducted will
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NanoFATE progression beyond the “
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Timing, hosts and locations of (grouped) events of NanoImpactNet

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