Timing, hosts and locations of (grouped) events of NanoImpactNet

NanoReTox
The Reactivity and Toxicity of
Engineered Nanoparticles: Risks to
the Environment and Human Health
NanoSafetyCluster - Compendium 2012
Contract Agreement: NMP4-SL-2008-214478 Website: http://www.nanoretox.eu
Coordinator: Dr Eugenia Valsami-Jones, Natural History Museum, London, UK*
No. Beneficiary name Short name Country
1 Natural History Museum NHM United Kingdom
2 Imperial College of Science, Technology and Medicine IMPERIAL United Kingdom
3 Roskilde Universitetscenter RU Denmark
4 Université de Nice Sophia Antipolis UNS France
5 Université Catholique de l’Ouest UCO France
6 Universidad del Pais Vasco/Euskal Herriko Unibertsitatea UPV-EHU Spain
7 Commission of the European Communities – Directorate General Joint Research Centre JRC Belgium
8 Universita di Pisa UNIPI Italy
9 Ahava – Dead Sea Laboratories Ltd DSL Israel
10 King’s College London KCL United Kingdom
11 United States Geological Survey USGS USA
12 Intrinsiq Materials Ltd IML United Kingdom
* Now at: University of Birmingham, Birmingham, UK
Contents
1 Summary .................................................................................... 167
2 Background .............................................................................. 168
3 What is NanoReTox .................................................................. 168
3.1 The three principles of NanoReTox ...................................... 169
4 Organisation of NanoReTox .................................................... 169
4.1 WP 1: Synthesis and characterisation ................................... 169
4.2 WP 2: Abiotic reactivity .......................................................... 170
4.3 WP 3: In vivo exposure, aquatic organisms .......................... 170
4.4 WP 4: In vitro exposure, aquatic species primary cells.......... 171
4.5 WP 5: Cellular/molecular mechanisms of action; human ....... 171
4.6 WP 6: Cellular/molecular mechanisms of action; human ...... 171
Project Duration: 1 December 2008 – 30 November 2012
Project Funding: 3.2 Mio. EUR
1 Summary
NanoReTox aims to investigate the potential risks of engineered
nanomaterials to the environment and human health by
comprehensively addressing five key questions:
[1] How does the environment affect the physicochemical
properties and the bioreactivity of nanoparticles?
4.7 WP 7: Interpretative comparison and interlinkage of
reactivity, bioavailability and health effects ......................... 172
4.8 WP 8: Risk model and communication .................................. 172
4.9 WP 9: Project management ................................................... 172
5 NanoReTox Results ................................................................... 173
5.1 Results from WP1 and WP2 .................................................... 173
5.2 Results from WP3 and WP4 ................................................... 173
5.3 Results from WP5 and WP6 ................................................... 173
5.4 WP7 and WP8 ......................................................................... 174
6 Directory .................................................................................... 174
7 Copyright ................................................................................... 179
[2] How does this impact on their ability to interact with and/or
penetrate organisms and cells and will bioavailability result in
toxicity?
[3] Is there a pattern of cellular reactivity and/or toxicity related to
physicochemical properties?
[4] What combination of conditions are most likely to pose a risk to
human health and the environment?
[5] How can this information be incorporated in a risk assessment
model?
A team of experts from across the EU and the US are working
together to address these questions in depth. A description of
each group involved can be found at www.nanoretox.eu.
Compendium of Projects in the European NanoSafety Cluster 167