NanoSafetyCluster - Compendium 2012 identity. The capacity to quantitatively track the particles over long periods <strong>of</strong> time allows us to determine their biological fate, opening the way for significant advances in our underst<strong>and</strong>ing <strong>of</strong> the transport pathways used by nanoparticles to access the brain, using advanced quantitative dosimetrics, selected <strong>and</strong> controlled exposure scenarios, long-lifetime radiolabelled nanoparticles, <strong>and</strong> biophysical approaches such as fluorescently labelling certain proteins involved in the transport pathways <strong>and</strong> determining co-localization <strong>of</strong> the proteins <strong>and</strong> nanoparticles. • deliver the basis for an inventory <strong>of</strong> nanoparticles based on potential for exposure, categorising nanoparticles on the basis <strong>of</strong> physicochemical, structural <strong>and</strong> toxicological properties: As above, the capacity to categorise nanoparticles based on their biological identity will <strong>of</strong>fer key advances in our predictive skills, <strong>and</strong> enable us to connect high throughput screening data to a screening predictive phenomenological models. • establish relations between experimental (based on available data) <strong>and</strong> computational properties: 6 References 1. Cedervall, T., Lynch, I., Lindman, S., Nilsson, H., Thulin, E., Linse, S., Dawson K.A. PNAS 2007, 104, 2050-2055. 2. Cedervall, T., Lynch, I., Foy, M., Berggård, T., Donnelly, S.C., Cagney, G., Linse, S., Dawson, K.A. . Angew. Chem. Int. Ed. 2007, 46, 5754 -5756. 3. Lundqvist, M., Stigler, J., Cedervall, T., Elia, G., Lynch, I., Dawson, K.A. PNAS 2008, 105, 14265-14270. 7 Directory Table 1 Directory <strong>of</strong> people involved in the NanoTransKinetics project as beneficiaries*. Data from several successful EU FP6 <strong>and</strong> FP7 projects is being used as the basis for the project (the minimum set <strong>of</strong> experimental data is already under our control via the NanoInteract, NeuroNano <strong>and</strong> BioNanoInteract projects which were coordinated by P1, <strong>and</strong> additional data will be acquired, assessed <strong>and</strong> implemented via WP5, the NanoSafety cluster <strong>and</strong> the twinned US projects). As the modelling approaches described are phenomenological initially, they rely directly on the experimental data, in order to reproduce the phenomena, such as protein corona formation, nanoparticles uptake <strong>and</strong> subcellular transport <strong>and</strong> localisation) <strong>and</strong> we see a key outcome <strong>of</strong> the project as being a set <strong>of</strong> modelling tools that can be linked directly to High Content Analysis assays, such as lysosomal load, in order to correlate impacts with sub-cellular localisation <strong>and</strong> bioaccumulation potential, for example. We believe that the approach outlined here is the only realistic possibility for underst<strong>and</strong>ing <strong>and</strong> predicting the implications <strong>of</strong> nanoparticles for living systems, as it is based on underst<strong>and</strong>ing the mechanisms <strong>of</strong> interaction <strong>of</strong> nanoparticles with cells. 4. Walczyk, D., Baldelli-Bombelli, F., Campbell, A., Lynch, I., Dawson, K.A. J. Am. Chem. Soc. 2010, 132, 5761-5768. 5. Salvati, A.; dos Santos, T.; Varela, J.; Pinto, P.; Lynch, I.; Dawson, K.A., NanoMedicine, 2011, in press. 6. Shapero, K., Fenaroli, F., Lynch, I., Cottell, D.C., Salvati, A., Dawson, K.A. Time <strong>and</strong> space resolved uptake study <strong>of</strong> silica nanoparticles by human cells. Mol Biosyst. 2010 Sep 29. [Epub ahead <strong>of</strong> print] 7. Watson, P. J., A.T., Stephens, D.J. Adv. Drug Del. Rev. 2005, 57, 43- 61. First Name Last Name Affiliation Address e-mail Vicki Colvin Rice University Houston TX 77005-1827 USA Kenneth Dawson National University <strong>of</strong> Irel<strong>and</strong>, Dublin / University College Dublin Belfield IE-4 Dublin Irel<strong>and</strong> Giancarlo Franzese University <strong>of</strong> Barcelona Av. Diagonal 647 Barcelona 08028 Spain Iseult Lynch National University <strong>of</strong> Irel<strong>and</strong>, Dublin / University College Dublin Aine Moore National University <strong>of</strong> Irel<strong>and</strong>, Dublin / University College Dublin Belfield IE-4 Dublin Irel<strong>and</strong> Belfield IE-4 Dublin Irel<strong>and</strong> Joachim Rädler Ludwig-Maximilians University Geschwister-Scholl- Platz 1 Munich 80539 Germany colvin@rice.edu kenneth.a.dawson@cbni.ucd.ie gfranzese@ub.edu iseult.lynch@cbni.ucd.ie aine.moore@cbni.ucd.ie joachim.raedler@lmu.de 202 Compendium <strong>of</strong> Projects in the European NanoSafety Cluster
8 Copyright NanoSafetyCluster - Compendium 2012 Disclaimer: Most parts <strong>of</strong> this document were published before under the creatives commons attribution license 3.0. © 2012, University College Dublin, Irel<strong>and</strong> on behalf <strong>of</strong> the NanoTranskinetics consortium. NanoTranskinetics is a Research Project under the European Commission's 7th Framework Programme. This is an Open Access document distributed under the terms <strong>of</strong> the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, <strong>and</strong> reproduction in any medium, provided the original work is properly cited. Anyone is free: • to Share — to copy, distribute <strong>and</strong> transmit the work • to Remix — to adapt the work • to make commercial use <strong>of</strong> the work; Under the following conditions: Attribution. • NanoTranskinetics <strong>and</strong> the European Commission's 7th Framework Programme must be given credit, but not in any way that suggests that they endorse you or your use <strong>of</strong> the work; • For any reuse or distribution, you must make clear to others the license terms <strong>of</strong> this work. The best way to do this is with a link to this web page: http://creativecommons.org/licenses/by/3.0. Statutory fair use <strong>and</strong> other rights are in no way affected by the above. Compendium <strong>of</strong> Projects in the European NanoSafety Cluster 203
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Compendium of Projects in the Europ
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EDITED BY Michael Riediker, PD Dr.s
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CONTENTS NanoSafetyCluster - Compen
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Project Acronym ENNSATOX ENPRA EURO
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Foreword NanoSafetyCluster - Compen
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ENNSATOX ENgineered Nanoparticle Im
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The biological membrane and its dep
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distinguishes between the interacti
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Figure 10. Schematic representation
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WP5: • Permeability of NPs in hyd
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ENPRA RISK ASSESSMENT OF ENGINEERED
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vitro findings with in vivo models;
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protocols with real biological samp
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and it was organised in the frame o
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First Name Last Name Affiliation Ad
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First Name Last Name Affiliation Ad
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EURO-NanoTox European Center for Na
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silver nanoparticles, iron nanopart
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The core functions of the Center, h
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8 Directory Table 1 Directory of pe
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HINAMOX Health Impact of Engineered
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High Resolution Electron Microscopy
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integrated risk assessment. Integra
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powders: What is the difference in
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First Name Last Name Affiliation Ad
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First Name Last Name Affiliation Ad
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InLiveTox Intestinal, Liver and End
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- to develop and validate a novel m
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environments, IEEE Industrial Elect
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INSTANT Innovative Sensor for the f
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complementary research which will l
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7 Copyright NanoSafetyCluster - Com
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ITS-NANO Intelligent testing strate
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approach to conveying the appropria
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in the discussion. The integration
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MARINA MANAGING RISKS of NANOMATERI
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for risk analysis, these tools need
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environmental ENM toxicity, but tox
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propose it as a Method Validation F
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and SiO2-NM200 and NM203, and a SiO
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ModNanoTox Modelling nanoparticle t
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3) To model environmental exposure
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Nanodetector European Network on th
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measurement interval. Measurements
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5 Directory Table 1 Directory of pe
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NANODEVICE Novel Concepts, Methods,
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ENP in order to be sure of their sa
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4.3 Exploring the association betwe
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NanoFATE Nanoparticle Fate Assessme
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or proteins associated with particu
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sludge. Information on rates of slu
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The exposures to be conducted will
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NanoFATE progression beyond the “
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