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Timing, hosts and locations of (grouped) events of NanoImpactNet

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NanoSafetyCluster - Compendium 2012<br />

20 DANMARKS TEKNISKE UNIVERSITET DTU Denmark<br />

21 BASF SE BASF Germany<br />

22 FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER<br />

ANGEWANDTEN FORSCHUNG E.V<br />

23 BERGBAU BERUFSGENOSSENSCHAFT IGF-<br />

BGRCI<br />

Fraunh<strong>of</strong>er Germany<br />

24 INSTITUTE OF OCCUPATIONAL MEDICINE IOM UK<br />

25 EUROPEAN VIRTUAL INSTITUTE FOR INTEGRATED RISK<br />

MANAGEMENT<br />

Germany<br />

EU-VRi Germany<br />

26 LUNDS UNIVERSITET LU Sweden<br />

Content<br />

1 Introduction ................................................................................ 86<br />

2 Project summary ........................................................................ 86<br />

3 Scientific <strong>and</strong> technological objectives <strong>of</strong> the NANODEVICE<br />

project ......................................................................................... 86<br />

4 Summary preliminary results ..................................................... 87<br />

1 Introduction<br />

The motive <strong>of</strong> the NANODEVICE project is based on the lack <strong>of</strong><br />

knowledge <strong>of</strong> the health effects <strong>of</strong> the widely used engineered<br />

nanoparticles (ENP) <strong>and</strong> on the shortage <strong>of</strong> field-worthy, costeffective<br />

ways - especially in real time - for reliable assessment<br />

<strong>of</strong> exposure levels to ENP in workplace air.<br />

2 Project summary<br />

Due to their unique properties, engineered nanoparticles (ENP)<br />

are now used for a myriad <strong>of</strong> novel applications with great<br />

economic <strong>and</strong> technological importance. However, some <strong>of</strong><br />

these properties, especially their surface reactivity, have raised<br />

health concerns, which have prompted scientists, regulators,<br />

<strong>and</strong> industry to seek consensus protocols for the safe<br />

production <strong>and</strong> us <strong>of</strong> the different forms <strong>of</strong> ENP.<br />

There is currently a shortage <strong>of</strong> field-worthy, cost-effective ways<br />

- especially in real time - for reliable assessment <strong>of</strong> exposure<br />

levels to ENP in workplace air. In addition to the problems with<br />

the size distribution, a major uncertainty in the safety<br />

assessment <strong>of</strong> airborne ENP arises from the lack <strong>of</strong> knowledge<br />

<strong>of</strong> their physical <strong>and</strong> chemical properties, <strong>and</strong> the levels <strong>of</strong><br />

exposure. A special challenge <strong>of</strong> ENP monitoring is to separate<br />

ubiquitous background nanoparticles from different sources<br />

from the ENP.<br />

Here the main project goal is to develop innovative concepts<br />

<strong>and</strong> reliable methods for characterizing ENP in workplace air<br />

5 Conclusions ................................................................................ 90<br />

6 Directory..................................................................................... 90<br />

7 Copyright ..................................................................................... 91<br />

with novel, portable <strong>and</strong> easy-to-use devices suitable for<br />

workplaces.<br />

Additional research objectives are:<br />

1) identification <strong>of</strong> relevant physico-chemical properties <strong>and</strong><br />

metrics <strong>of</strong> airborne ENP, establishment <strong>of</strong> reference materials<br />

2) exploring the association between physico-chemical <strong>and</strong><br />

toxicological properties <strong>of</strong> ENP<br />

3) analyzing industrial processes as a source <strong>of</strong> ENP in workplace<br />

air<br />

4) developing methods for calibration <strong>and</strong> testing <strong>of</strong> the novel<br />

devices in real <strong>and</strong> simulated exposure situations<br />

5) dissemination <strong>of</strong> the research results to promote the safe use<br />

<strong>of</strong> ENP through guidance, st<strong>and</strong>ards <strong>and</strong> education,<br />

implementing <strong>of</strong> safety objectives in ENP production <strong>and</strong><br />

h<strong>and</strong>ling, <strong>and</strong> promotion <strong>of</strong> safety related collaborations<br />

through an international nanosafety forum.<br />

3 Scientific <strong>and</strong> technological objectives <strong>of</strong><br />

the NANODEVICE project<br />

Engineered nanoparticles (ENP), defined as having at least one<br />

dimension ≤100 nm, have attracted a great deal <strong>of</strong> interest<br />

during recent years, due to their many technologically<br />

interesting properties. The unique properties <strong>of</strong> ENP <strong>and</strong> their<br />

applications have given birth to immense technological <strong>and</strong><br />

economic expectations for industries using ENP. However, some<br />

<strong>of</strong> these properties have given rise to concern that they may be<br />

harmful to humans. This has prompted scientists, regulators,<br />

<strong>and</strong> the industrial representatives to investigate the features <strong>of</strong><br />

86 Compendium <strong>of</strong> Projects in the European NanoSafety Cluster

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