Timing, hosts and locations of (grouped) events of NanoImpactNet

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NanoSafetyCluster - Compendium 2012 A list of deliverables arising out of these activities can be summarised as: • Fundamental insight into nanoparticle interactions and transport in the aquatic environment and in living cells and organisms. • Relation between structure and functionality and activity of nanoparticles and modified nanoparticles at all levels of biological organisation. • Integrated model to assess and predict the fate and risks of nanoparticles in the environment. • Protocols for screening nanoparticle activity to be accredited for statutory use. The following has been achieved in the second year of the project: • Synthesis of constant particle size >10 nm ZnO particles. • Comprehensive characterisation of biomembrane activity of SiO2 and ZnO particles of wide range of particle size. • Chemical characterisation and modelling of solubility of ZnO particles. • Cross calibration of results throughout the Consortium. • Chronic toxicity and bioavailability of indicator organisms to nanoparticles. • Development of theoretical models simulating interaction of NP with phospholipid membranes, the transport and fate of nanoparticles in environmental aqueous systems and the uptake of nanoparticles by unicellular organisms. • Interaction of ZnO with ion channel proteins. 2.4 Conclusion To-Date & Plans for the Future Initial conclusions from the first half of the work programme associated with relevant work package are outlined below: WP1: • Water solubility of ZnO nanoparticles of varying size and functionality has been determined. • Work has sourced and synthesised stable dispersions of ZnO nanoparticles, and provided a set of well characterised single class of ZnO nanoparticles to the Consortium. • Characterisation of NPs after exposure to biological media and characterisation of NPs internalized by cells and organisms. WP1/WP2: • Full comprehensive relationship between the structure and functionality of SiO 2 and ZnO particles and their biomembrane activity and their in vitro and in vivo biological activity established. WP2: • Toxicity screens consolidated and inter-calibrated. • Mechanisms of SiO 2 and ZnO particle interaction with biomembrane model determined using electrochemical methods of impedance. WP3: • Detailed assessment and comprehensive feedback of in vitro test results to WPs 2 and 4. • EMs of NPs in cells and tissues. • On-line in vitro assays for NP toxicity developed. WP4: • NP effects on Ciona intestinalis growth determined, correlation with specific/non specific response. • Structure Activity (SA) relationships established with WPs 2 and 3. WP5: • Determination of the surface charge density and zetapotential of the NP dispersions in the presence of other ions and organic substances fulvic and humic acid present in the aqueous environment. • Analysis of the heterogeneity of metal ion binding by silica NPs, and comparison with heterogeneities observed in the metal ion binding by macroscopic silica surfaces. • Verification of the lability of Pb 2+ /SiO 2 nanoparticulate complexes by Eigen type reconstruction of the kinetic steps involved in the surface complex formation Surface characterisation of ZnO NPs. WP6: • Advection/diffusion of NPs in aquatic environment studied. • Results from WPs 2 and 5 integrated into model. WP7: • Intercalibrative testing of ZnO on MBA indicator organisms. The scientific work plan for the last part of the project includes: WP1: • Extensive characterisation of sourced samples of TiO 2 and distribution round Consortium. Correlation of surface chemical with physical characterisation. WP1/WP2: • Full comprehensive relationship between the structure and functionality of SiO 2, ZnO and TiO 2 particles and their biomembrane activity and their in vitro and in vivo biological activity to be established. WP2: • Comprehensive studies on TiO 2 biomembrane activity. WP3: • In vitro studies of TiO 2 biological activity. WP4: • TiO 2 effects on Ciona intestinalis growth determined, correlation with specific/non specific response. • Structure Activity (SA) relationships established with WPs 2 and 3. 10 Compendium of Projects in the European NanoSafety Cluster
WP5: • Permeability of NPs in hydrogels/model cell walls. Physiochemical conditions on permeability rate established. • Form, permeation of SiO 2 and TiO 2 determined. Rigorous kinetic analysis of permeation. WP6: • Advection/diffusion of NPs in aquatic environment consolidated. • Results from WPs 2 and 5 integrated into model. • Integrated model developed as protocol. NanoSafetyCluster - Compendium 2012 WP7: • Organisation of procedures for inter-laboratory toxicity trials for nanomaterials using standard and novel testing procedures. Compendium of Projects in the European NanoSafety Cluster 11
Page 1: Compendium of Projects in the Europ
Page 5 and 6: EDITED BY Michael Riediker, PD Dr.s
Page 7 and 8: CONTENTS NanoSafetyCluster - Compen
Page 9 and 10: Project Acronym ENNSATOX ENPRA EURO
Page 11 and 12: Foreword NanoSafetyCluster - Compen
Page 13 and 14: ENNSATOX ENgineered Nanoparticle Im
Page 15 and 16: The biological membrane and its dep
Page 17 and 18: distinguishes between the interacti
Page 19: Figure 10. Schematic representation
Page 23 and 24: NanoSafetyCluster - Compendium 2012
Page 25 and 26: ENPRA RISK ASSESSMENT OF ENGINEERED
Page 27 and 28: vitro findings with in vivo models;
Page 29 and 30: protocols with real biological samp
Page 31 and 32: and it was organised in the frame o
Page 33 and 34: First Name Last Name Affiliation Ad
Page 37 and 38: EURO-NanoTox European Center for Na
Page 39 and 40: silver nanoparticles, iron nanopart
Page 41 and 42: The core functions of the Center, h
Page 43 and 44: 8 Directory Table 1 Directory of pe
Page 45 and 46: HINAMOX Health Impact of Engineered
Page 47 and 48: High Resolution Electron Microscopy
Page 49 and 50: integrated risk assessment. Integra
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Page 57 and 58: InLiveTox Intestinal, Liver and End
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Page 69 and 70: ITS-NANO Intelligent testing strate
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approach to conveying the appropria
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in the discussion. The integration
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MARINA MANAGING RISKS of NANOMATERI
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for risk analysis, these tools need
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environmental ENM toxicity, but tox
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propose it as a Method Validation F
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and SiO2-NM200 and NM203, and a SiO
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ModNanoTox Modelling nanoparticle t
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3) To model environmental exposure
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Nanodetector European Network on th
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measurement interval. Measurements
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5 Directory Table 1 Directory of pe
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NANODEVICE Novel Concepts, Methods,
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ENP in order to be sure of their sa
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4.3 Exploring the association betwe
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NanoSafetyCluster - Compendium 2012
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NanoFATE Nanoparticle Fate Assessme
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or proteins associated with particu
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sludge. Information on rates of slu
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The exposures to be conducted will
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NanoFATE progression beyond the “
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Timing, hosts and locations of (grouped) events of NanoImpactNet

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