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Timing, hosts and locations of (grouped) events of NanoImpactNet

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4.3 Exploring the association between physico-chemical <strong>and</strong><br />

toxicological properties <strong>of</strong> ENP<br />

The Cytotoxicity (cell death, ATP-level, Cell cycle delay <strong>and</strong><br />

oxidative stress), genotoxicity (DNA damage, micronuclei), <strong>and</strong><br />

immunotoxicity (Pro-inflammatory reactions in cell models) <strong>of</strong><br />

engineered nanoparticles have been studied <strong>and</strong> a databank is<br />

created for the results <strong>and</strong> it is available. The results have been<br />

published in journals <strong>and</strong> in scientific meetings. Images <strong>of</strong> some<br />

samples are presented in Figure 11.<br />

Figure 11.SEM image <strong>of</strong> a sample <strong>of</strong> Mitsui MWCNT (left) <strong>and</strong> TEM<br />

image <strong>of</strong> a sample <strong>of</strong> Fe 2O 3-fiber (right)<br />

4.4 Analyzing industrial processes as a source <strong>of</strong> ENP in<br />

workplace air<br />

Experimental studies <strong>of</strong> source characterization, agglomeration<br />

<strong>and</strong> ventilation have been conducted <strong>and</strong> a data analysis on<br />

them has been completed. Computational Fluid Dynamic (CFD)<br />

modelling has been achieved with scenario building completed<br />

<strong>and</strong> simulation runs conducted.<br />

4.5 Developing methods for calibration <strong>and</strong> testing <strong>of</strong> the novel<br />

devices in real <strong>and</strong> simulated exposure situations<br />

A calibration tool "Characterization <strong>of</strong> Aerosol Instrumentation<br />

devoted for Measuring Aerosols <strong>of</strong> Nanoparticles (CAIMAN)"<br />

has been extensively used by the device developers in the<br />

project.<br />

A Nanotest facility has been validated with established aerosol<br />

measurement technology concerning ranges <strong>of</strong> particle sizes<br />

<strong>and</strong> concentrations as well as mixtures <strong>of</strong> particles. The first preprototypes<br />

have been tested with defined aerosols. This was<br />

done in the scope <strong>of</strong> a second, larger round robin test (“stress<br />

test”) under real conditions compared to those expected in the<br />

further course <strong>of</strong> the NANODEVICE project. The Nanotest facility<br />

has been extensively used by device developers <strong>and</strong> a third, <strong>and</strong><br />

final; round robin tests are yet expected. A pilot study shall be<br />

provided for the device developers on the test results.<br />

4.6 Dissemination <strong>of</strong> the results<br />

The project's website http://www.nano-device.eu is a<br />

communication channel to communities. A brochure<br />

introducing the project in a nutshell has been carefully<br />

developed <strong>and</strong> distributed (Figure 12). Multiple poster<br />

presentations have been held in several conferences <strong>and</strong><br />

scientific meetings on the results <strong>of</strong> the project (Figure 13). The<br />

NanoSafetyCluster - Compendium 2012<br />

NANODEVICE project peaks at organizing the SENN2012<br />

Congress Oct. 28-31, 2012 in Helsinki, Finl<strong>and</strong> (Figure 14).<br />

Figure 12. Image <strong>of</strong> the project website (left) <strong>and</strong> the cover <strong>of</strong> the<br />

brochure (right)<br />

Figure 13. The project poster<br />

Figure 14. International Congress on Safety <strong>of</strong> Engineered<br />

Nanoparticles <strong>and</strong> Nanotechnologies<br />

Compendium <strong>of</strong> Projects in the European NanoSafety Cluster 89

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