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NanoSafetyCluster - Compendium 2012 2 Risk Analysis 3 Worker Exposure Assessment 4 Design for Risk Control 5 Toxicological hazard assessment Project Consortium in order to track the project progress and meet its administrative objectives. The main objective of this work package is to assess the risks caused by the NMs studied in SANOWORK in all the stages of their life cycle. The risk assessment characterization will be done on the different NMs before and after applying the risk management strategies proposed by SANOWORK. The data obtained from the risk assessment will be used to inform the industrial partners about the strategies to implement in their processes to create a safer workplace environment. In this WP, we will develop databases for NMs along their life cycle which will be versatile to include new data from other sources. These databases will include description of materials and processes, their applications, their physico-chemical properties and their toxicological profile. These data will be generated in the project as well as included from literature sources and will be used in the risk characterization. The collected information and risk characterization transfer to insurance companies will be one of the relevant objectives of this WP2. Strictly connected with the sustainability assessment of the proposed strategies is the Cost / Benefit evaluation of the proposed strategies, that will be based on cost analysis and evaluation of process efficiency and NMs functional properties BEFORE and AFTER the introduction of Risk Remediation Strategies. The aim of this work package is to assess risks associated with chronic and accidental worker exposure scenarios applied to Processing Lines 1-6 at pilot-scale levels. Therefore the following specific objectives are proposed: • Devise a qualitative worker exposure assessment method based on design or control approaches; • Develop a control banding risk assessment methodology to evaluate risks at the pilot industrial scale level; • Develop a quantitative worker exposure methodology by performing on-site exposure measurements, to provide inputs to the control banding (CB) risk assessment methodology. The main objective of this WP is the development of the following Risk Remediation Strategies and their integration within the target processing lines: Strategy I: Coating by organic or inorganic based additives. Strategy II: Control of colloidal forces and disintegration of NPs. Strategy III: Integration of spray-drying process. Strategy IV: Immobilization by organic film coating deposition. Strategy V: Wet milling. Target Processing Lines: Processing Line 1: ZrO2 NPs as additives in the chemical industry . Processing Line 2: ZrO2 NPs as additives in ceramic materials. Processing Line 3: Polyamide Nanofibers as membrane components for filter industry. Processing Line 4: TiO2 Nanofibers as photocatalytic components in Solar Cells. Processing Line 5: TiO2 NPs as photocatalytic additives and Ag NPs as antibacterial additives in the ceramic industry. Processing Line 6: MWCNTs as additives in plastic industry. Strictly connected with the above described objective is the assessment of process efficiency as well as of NMs functional properties. This objective aims to provide useful information for COST / BENEFIT evaluation performed by WP6. In order to assess the performance and the validity of proposed Risk Remediation Strategies (WP4) the WP5 will: 1) Identify the hazardous properties of NMs, by reviewing the available literature data and relying on the thorough physico-chemical characterization performed within WP4; 2) Assess the impact of pristine and surface modified NMs by using representative of exposure pathways in vitro models: a) primary human cells; b) established mammalian including human cell lines; 3) Determine how the cellular bio-reactivity of NMs relates to their physicochemical properties and give indications for the development of a safe and sustainable manufacturing of nanoproducts. The following specific objectives will be pursued: i) Review toxicological data on selected NMs and identify knowledge gaps in hazard which are expected for such newly synthesized NMs (e.g. nanofibers, new functionalized nanostructures); ii) Assess cellular responses to the pristine and surface modified NMs delivered by WP4 by developing a testing strategy based on in vitro tests, using human cell models representative of the pulmonary and cardio-vascular systems; iii) Implement an hazard characterization strategy in close collaborations with SMEs, by assess cellular 258 Compendium of Projects in the European NanoSafety Cluster
6 Implementation of Processing Lines 7 Dissemination and exploitation activities 8 Scientific Mangement 5 Expected Impact NanoSafetyCluster - Compendium 2012 responses of nanoproducts collected by WP3, during exposure assessment of processing lines implemented by WP6. The general objective of this WP is the implementation of target processing lines, BEFORE and AFTER the introduction of the Risk Remediation Strategies proposed in WP4. The activities of WP7 aim to disseminate information and results of the project within the partners and outside the Consortium to all relevant stakeholders: national, international and EU regulatory bodies, NGO and representatives of the Nanotechnology industry, as well as proposing exploitation transfer plans and managing the Intellectual Property Rights. Moreover, it aims to collaborate with existing EC funded activities such as NanoSafety Cluster. The general aim of WP8 is to coordinate the scientific and technical management of the project and maintain the project work plan and complete it within the agreed time schedule. Scientific coordination: • Scientific review of the work performed by the partners including scientific deliverables and milestones. • Monitor annual project meetings and regular interim, mid-term and final reporting, as well as the scientific quality. • The supervision of project global critical path. To develop practical and cost effective strategies for reduction of worker exposure to NMs during all stages of NMs production, use and disposal NMs design strategies developed by SANOWORK project will contribute effectively to reduce health hazard and exposure potential. In particular it will develop: 1) aggregation control strategy, especially addressed to decrease emission potential during production and use, also including accidental spills; 2) inorganic/organic coating especially addressed to decrease health impact and exposure during use and disposal inside and outside the workplace; 3) techniques for disintegration of NPs during washing, especially addressed to decrease emission potential of disposal treatment. To establish synergy with QNano: the European Union-funded infrastructure for NM safety testing The active participation of members of the SANOWORK consortium in the NanoSafety Cluster will strengthen the interaction with nano-safety Infrastructure project. Preliminary contacts established by other complementary projects that could be funded under the same call and whose partners are, as well, deeply involved in NanoSafety Cluster activities, will ensure a strong cooperation and synergy with EU projects dealing with nano-safety. Most importantly, SANOWORK is pledged to report its findings to the NANOFUTURES platform and CEFIC and therefore will promote the ‘safe by design’ approach to all the relevant stakeholders. SANOWORK possess strong synergy with the EU NanoSafety Cluster by providing industrial stakeholders’ and ‘the general public’ appropriate knowledge of the risks of NMs for human health’ (workers). SANOWORK achieves through a strong participation from SMEs and industrial partners who have shown a high level commitment to the project by allowing exposure measurement field study. The SANOWORK project also implements a primary prevention of exposure of workers to NPs by intelligent design of NPs considering its processing pathways. To contribute to the advancement of the EU NanoSafety Cluster goals and agenda by: - providing data on toxicological effects of target NPs (pristine and modified ZrO2 NPs, polyamide and TiO2 nanofibers, TiO2 and Ag NPs and CNTs) to facilitate the formation of ‘a consensus on nanotoxicology in Europe’; - Creating Life Cycle Database on physico-chemical, and toxicological properties of these materials based on FP6 and FP7 research. This database will be made available to NanoSafety Cluster ‘to avoid duplicating work and improve efficiency’; - Identifying worker exposure scenarios and implementing the prevention/intervention measures to minimise Risk; - Participating in meetings and workshops organised by NanoSafety Cluster for ‘discussion, problem solving and planning R&D activities in Europe’; - Preparing and implementing a communication strategy to inform the identified stakeholders: industries, insurance companies, general public on risk remediation tools that prevent risks during production, use and disposal of NMs. To facilitate research cohesion and integration in this area The cohesion and integration of the results generated by SANOWORK will be facilitated by the active participation of the project members in the NanoSafety Cluster meetings and by dissemination activities of the project. More specifically, the Compendium of Projects in the European NanoSafety Cluster 259
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Compendium of Projects in the Europ
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EDITED BY Michael Riediker, PD Dr.s
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CONTENTS NanoSafetyCluster - Compen
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Project Acronym ENNSATOX ENPRA EURO
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Foreword NanoSafetyCluster - Compen
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ENNSATOX ENgineered Nanoparticle Im
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The biological membrane and its dep
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distinguishes between the interacti
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Figure 10. Schematic representation
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WP5: • Permeability of NPs in hyd
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NanoSafetyCluster - Compendium 2012
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ENPRA RISK ASSESSMENT OF ENGINEERED
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vitro findings with in vivo models;
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protocols with real biological samp
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and it was organised in the frame o
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First Name Last Name Affiliation Ad
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EURO-NanoTox European Center for Na
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silver nanoparticles, iron nanopart
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The core functions of the Center, h
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8 Directory Table 1 Directory of pe
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HINAMOX Health Impact of Engineered
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High Resolution Electron Microscopy
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integrated risk assessment. Integra
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powders: What is the difference in
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InLiveTox Intestinal, Liver and End
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- to develop and validate a novel m
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environments, IEEE Industrial Elect
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INSTANT Innovative Sensor for the f
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complementary research which will l
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7 Copyright NanoSafetyCluster - Com
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ITS-NANO Intelligent testing strate
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approach to conveying the appropria
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in the discussion. The integration
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MARINA MANAGING RISKS of NANOMATERI
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for risk analysis, these tools need
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environmental ENM toxicity, but tox
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propose it as a Method Validation F
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and SiO2-NM200 and NM203, and a SiO
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ModNanoTox Modelling nanoparticle t
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3) To model environmental exposure
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Nanodetector European Network on th
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measurement interval. Measurements
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5 Directory Table 1 Directory of pe
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NANODEVICE Novel Concepts, Methods,
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ENP in order to be sure of their sa
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4.3 Exploring the association betwe
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NanoFATE Nanoparticle Fate Assessme
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or proteins associated with particu
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sludge. Information on rates of slu
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The exposures to be conducted will
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NanoFATE progression beyond the “
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