Timing, hosts and locations of (grouped) events of NanoImpactNet

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NanoSafetyCluster - Compendium 2012 6 Work performed and Results Following is a detailed description of two important components of NHECD, Information Extraction and NHECD User Interface. These components synthesize the investment of all NHECD work- packages and are reviewed in detail. The detailed description of the other components was given in previous publications. 6.1 Information Extraction Information Extraction (IE) is a type of information retrieval whose goal is to automatically extract structured information from unstructured and/or semi-structured machine-readable documents. In most cases, this activity concerns processing natural language texts using NLP. Information extraction has numerous potential applications. For example, information available as unstructured text can be transformed into traditional databases that users can probe through standard queries. 6.1.1 IE system flow The IE component is built in a modular linear flow. Each module can work independently. If needed, any of the modules can be separately changed. 6.1.2 The process Figure 1 -IE System Flow The aim of NHECD IE component is to extract, from every scientific paper gathered by the NHECD crawler, a comprehensive, full and precise list of relations. NHECD text mining tasks are in fact information extraction tasks, namely, to extract entities and relations (which are, by nature, structured information) from unstructured Nanoparticle-toxicity related documents. The information extraction system expected results include the following entities or relations: (1) Nano particle, (2) Model – Cell model or animal, (3) Attributes – NP size, Zeta potential, animal age, etc. and (4) Experiment attributes – mode of exposure, measurement assay etc. See the following example of the information extraction task. The examined text: Under phase-contrast microscope, HT-1080 cells (control) appeared polyhydric or stellate showing slender lamellar expansions (Fig. 1A) that joined neighboring cells. With increasing concentration of SNP (from 6.25 to 50 µ g/mL ), cells were seen as less polyhydric; and more fusiform, shrunken and rounded. The results of XTT assays (Fig. 3) showed a dosedependent cytotoxicity for both the cell types with IC50 values of SNP working out as 10.6 and 11.6 µg/mL for HT-1080 and A431 cells, respectively Figure 2- IE examined text Should result in the extraction of the following relations: Figure 3- IE relations result 6.2 The NHECD User Interface The NHECD user interface offers different possibilities to retrieve efficiently knowledge on the health, safety and environmental impact of nanoparticles. • A BASIC SEARCH interface to perform keyword and/or taxonomy based queries. • An ADVANCED SEARCH interface for experienced users to extend the capabilities of the basic search using advanced search features such as logical operators (AND, OR, NOT), as well as allowing to search through extended metadata. • The INTELLIGENT SEARCH is a unique method especially adapted to the needs of researchers in the nano-science field. This feature includes, among other capabilities, the power to search by model, experiment and nanoparticles attributes. The target is the exact data taken from the results of all experiments described in the corpus (shown in figure 4). 238 Compendium of Projects in the European NanoSafety Cluster
Further functionality allows for: • Features such as save searches, recall of recent queries, managing a clipboard and organizing the data in collections. • Tutorials guide the user to efficiently use the interface. In addition to the search functionalities provided, a variety of further information resources related to the health, safety and environmental impact of nanoparticles is available: • A White Paper Forum allowing registered • Users to comment on White Papers entered by a moderator. • Further features include an introduction to the field, information on corresponding rules and regulations, news and events, and inform the users on relevant developments and activities related to the potential impact of nanoparticles on health, safety and the environment. The User interface homepage is shown in the next figure: Figure 4- Frontend website-Home page NanoSafetyCluster - Compendium 2012 Figure 5 -Frontend website -intelligent search Compendium of Projects in the European NanoSafety Cluster 239
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Compendium of Projects in the Europ
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EDITED BY Michael Riediker, PD Dr.s
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CONTENTS NanoSafetyCluster - Compen
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Project Acronym ENNSATOX ENPRA EURO
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Foreword NanoSafetyCluster - Compen
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ENNSATOX ENgineered Nanoparticle Im
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The biological membrane and its dep
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distinguishes between the interacti
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Figure 10. Schematic representation
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WP5: • Permeability of NPs in hyd
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NanoSafetyCluster - Compendium 2012
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ENPRA RISK ASSESSMENT OF ENGINEERED
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vitro findings with in vivo models;
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protocols with real biological samp
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and it was organised in the frame o
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First Name Last Name Affiliation Ad
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EURO-NanoTox European Center for Na
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silver nanoparticles, iron nanopart
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The core functions of the Center, h
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8 Directory Table 1 Directory of pe
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HINAMOX Health Impact of Engineered
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High Resolution Electron Microscopy
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integrated risk assessment. Integra
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powders: What is the difference in
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InLiveTox Intestinal, Liver and End
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- to develop and validate a novel m
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environments, IEEE Industrial Elect
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INSTANT Innovative Sensor for the f
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complementary research which will l
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7 Copyright NanoSafetyCluster - Com
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ITS-NANO Intelligent testing strate
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approach to conveying the appropria
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in the discussion. The integration
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MARINA MANAGING RISKS of NANOMATERI
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for risk analysis, these tools need
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environmental ENM toxicity, but tox
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propose it as a Method Validation F
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and SiO2-NM200 and NM203, and a SiO
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ModNanoTox Modelling nanoparticle t
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3) To model environmental exposure
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Nanodetector European Network on th
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measurement interval. Measurements
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5 Directory Table 1 Directory of pe
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NANODEVICE Novel Concepts, Methods,
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ENP in order to be sure of their sa
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4.3 Exploring the association betwe
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NanoFATE Nanoparticle Fate Assessme
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or proteins associated with particu
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sludge. Information on rates of slu
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The exposures to be conducted will
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NanoFATE progression beyond the “
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Timing, hosts and locations of (grouped) events of NanoImpactNet

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