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Timing, hosts and locations of (grouped) events of NanoImpactNet

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NANOMMUNE<br />

Comprehensive Assessment <strong>of</strong> Hazardous<br />

Effects <strong>of</strong> Engineered Nanomaterials on<br />

the Immune System<br />

NanoSafetyCluster - Compendium 2012<br />

Contract Agreement: NMP4-SL-2008-214281 Website: http://www.nanommune.eu<br />

Coordinator: Pr<strong>of</strong>. Bengt Fadeel, Karolinska Institutet, Stockholm, Sweden<br />

No. Beneficiary name Short name Country<br />

1 Karolinska Institutet KI Sweden<br />

2 Royal Institute <strong>of</strong> Technology KTH Sweden<br />

3 Uppsala University UU Sweden<br />

4 University <strong>of</strong> Cologne UC Germany<br />

5 University <strong>of</strong> Turku UT Finl<strong>and</strong><br />

6 Swiss Federal Laboratories for Materials Testing <strong>and</strong> Research EMPA Switzerl<strong>and</strong><br />

7 Institute <strong>of</strong> Occupational Medicine IOM United Kingdom<br />

8 University <strong>of</strong> Pittsburgh UP United States<br />

9 National Institute for Occupational Safety <strong>and</strong> Health NIOSH United States<br />

10 North Carolina State University NCS United States<br />

Contents<br />

1 Summary ................................................................................... 150<br />

2 Overview <strong>of</strong> project .................................................................. 150<br />

2.1 Introduction, scientific/industry needs, problem addressed150<br />

2.2 Scope, objectives .................................................................... 151<br />

2.3 Technical approach, work description .................................. 152<br />

2.3.1 Synthesis <strong>and</strong> characterization <strong>of</strong> nanomaterials ........... 152<br />

2.3.2 In vitro effects <strong>of</strong> nanomaterials: focus on immunecompetent<br />

cells ................................................................ 152<br />

2.3.3 In vivo effects <strong>of</strong> nanomaterials: focus on immune<br />

responses.......................................................................... 153<br />

2.3.4 Novel biomarkers <strong>of</strong> nanomaterial exposure: genomics<br />

<strong>and</strong> lipidomics ................................................................... 153<br />

2.3.5 Risk assessment <strong>of</strong> nanomaterials: steps towards safe<br />

management .................................................................... 153<br />

2.4 Important achievements ....................................................... 154<br />

2.4.1 Interaction <strong>of</strong> carbon nanotubes with immunecompetent<br />

cells ............................................................... 154<br />

2.4.2 Gene expression pr<strong>of</strong>iling <strong>of</strong> nanoparticle-exposed<br />

cells <strong>and</strong> tissues ............................................................... 154<br />

2.4.3 Mapping the surface adsorption forces <strong>of</strong><br />

nanomaterials .................................................................. 155<br />

2.5 Conclusions ............................................................................ 155<br />

2.6 Dissemination <strong>of</strong> results ........................................................ 155<br />

2.7 Nanosafety Cluster activities ................................................. 155<br />

2.8 Selected publications ............................................................ 155<br />

3 Directory.................................................................................... 156<br />

4 Copyright ....................................................................................157<br />

Compendium <strong>of</strong> Projects in the European NanoSafety Cluster 149

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