Timing, hosts and locations of (grouped) events of NanoImpactNet

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NanoSafetyCluster ‐ Compendium 2012 institute can be performed to an acceptable standard, as the baseline measurements prior to undertaking more advance characterisation in situ using the state of the art facilities at the host institutions. Partners provided data using Dynamic Light Scattering, Transmission Electron Microscopy, Nanoparticle Tracking Analysis and/or Differential Centrifugal Sedimentation. � The RR for benchmarking of participating laboratories in their proficiency to maintain in vitro cell culture and perform cell viability testing is under way. A second physico‐chemical characterisation RR, where protocols are compared to identify the best dispersion protocol for Aerosil 200 silica nanoparticles, is also under way. A RR to validate a potential positive control nanomaterial for apoptosis is planned and will commence shortly. Table 1. Preliminary schedule of QNano training events. Exact dates and titles may change slightly. � Nanomaterials Hub: Processes for sourcing commercial and in‐ house nanoparticles have been developed; 1 st Nanomaterials Technical Specifications and Materials Safety Data Sheets are being completed for the QNano selected nanoparticles, including full characterisation data, both pristine and in situ in representative biofluids (e.g. cell culture medium containing different amounts of foetal calf serum and in river water containing natural organic matter). � Terms of Reference and Table of Contents for the first QNano State of Art report have been agreed and responsibilities assigned among the partners for drafting the text. The title of the first report will be State Of the Art in characterisation of nanomaterials for safety assessment. What When Where D3.8 Modelling School #1 Feb 2012 Dublin D3.9 Training module GLP / best practice #1 Feb 2012 Dublin D3.2 Hands‐on training in nanomaterials characterisation for toxicity testing #2 Apr 2012 Edinburgh D3.10 Training module for industry / SMEs #1 Apr 2012 Edinburgh D4.6 Industry needs workshop #1 Apr 2012 Edinburgh D4.7 Risk Management Hands‐on training #1 Apr 2012 Edinburgh D3.5 Training in best practice for young researchers #1 Jun 2012 TBC D3.12 Hands‐on training in biological assays #1 Jun 2012 TBC D3.2 Hands‐on training in nanomaterials characterisation for toxicity testing ( #1 in series) Mid 2012 TBC D3.8 Modelling School #2 Jan 2013 Edinburgh D3.2 Hands‐on training in characterisation / tox testings #3 Jan 2013 Edinburgh D3.11 Training modules for researchers from contiguous areas Jan 2013 Karlsruhe D3.5 Training in best practice for young researchers #2 Jan 2013 Karlsruhe D3.7 Occupational Exposure Management training #1 Feb 2013 Dublin D4.6 Workshop on assessing industry needs #2 Feb 2013 Dublin D3.7 Occupational Exposure Management training #2 Jun 2013 Pisa D3.12 Hands‐on training in biological assays #2 June 2013 Pisa D3.9 Training module GLP / best practice #2 Oct 2013 Edinburgh D3.2 Hands‐on training in nanomaterials characterisation for toxicity testing #4 Oct 2013 Edinburgh D3.10 Training module for industry / SMEs #2 Oct 2013 Edinburgh 248 Compendium of Projects in the European NanoSafety Cluster
Transnational Access: � QNano aims to provide approximately 400 Users with access to state of the art characterisation equipment across the 15 Transnational Access Facilities shown in Figure 2, and to promote the need for characterisation of nanomaterials in situ in the medium in which they will be exposed to living systems. 7 � Funding for approved applicants will cover the costs of International travel, accommodation, living costs for the researcher, and the cost of provision of the access for the host Transnational Access Facility. Average visits 5‐10 working days. � Visits are fully supported with the technical expertise in the institute of equipment being accessed, and with protocols and nanomaterials as needed. � The first Transnational Access call opened November 1 st 2011 for 3 months. The second call will open May 1 st 2012 and close July 31 st 2012. Further calls will be held every 6 months for the duration of the project. Figure 2: Map showing the locations of the institutes offering QNano‐funded Transnational Access to state of the art characterisation facilities for nanomaterials in contact with living systems. Note that a potential User cannot request to visit a facility in the country in which they work. � Figure 3. Categories of QNano Transnational Access. The categories of access offered by each Transnational Access Facility (TAF) are shown in the graph (left). A legend explaining the categories of access is shown on the right. NanoSafetyCluster ‐ Compendium 2012 � Transnational Access is provided according to four thematic categories: nanomaterial synthesis, labelling and processing, characterisation in situ, exposure assessment. As shown in figure 3 the 15 Transnational Access Facilities offer access under one or more of these categories. � Details of the application process can be found on the QNano website: http://www.qnano‐ri.eu/access.html. � Briefly, after contacting the Technology Expert at the host institution of interest the applicant (User) submits a project, which was previously agreed with the Technology Expert, through the online application system. The application undergoes an eligibility check and is afterwards evaluated by an external unbiased panel of experts, the User Selection Panel (USP). The USP provides feedback on the application through the online application system. Successful applicants are notified by the QNano project office, and have 1 year in which to complete their visit. Exact timing of the visit must be agreed between the User and the relevant Technology Expert at the host institution. The process is shown schematically in Figure 3. A User Handbook and Frequently Asked Questions sheet are available on the QNano website, as well as the contact details for each Transnational Access Facility. Figure 4. Flow chart of the Application Process. The steps involved in the submission of a proposal and the evaluation process are shown in the graph. Shown are also the expected interactions between the applicant (User) and the Transnational Access Leader (TAL) and Technology Expert. Joint Research Activities: � All of the research WPs are underway, with WP meetings scheduled, round robin activities in progress, and first batches of well‐characterised nanomaterials available. � JRA1 ‐ strategies to eliminate and/or reduce nanomaterials batch‐to‐batch variability: Assessment of sources of variability in widely used synthesis methods is under way and strategies are being developed to eliminate or reduce such sources of variability. Different batches of Silica nanoparticles made via the Stöber synthesis route are being produced to verify the extent of variability among Compendium of Projects in the European NanoSafety Cluster 249
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Compendium of Projects in the Europ
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EDITED BY Michael Riediker, PD Dr.s
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CONTENTS NanoSafetyCluster - Compen
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Project Acronym ENNSATOX ENPRA EURO
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Foreword NanoSafetyCluster - Compen
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ENNSATOX ENgineered Nanoparticle Im
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The biological membrane and its dep
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distinguishes between the interacti
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Figure 10. Schematic representation
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WP5: • Permeability of NPs in hyd
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NanoSafetyCluster - Compendium 2012
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ENPRA RISK ASSESSMENT OF ENGINEERED
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vitro findings with in vivo models;
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protocols with real biological samp
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and it was organised in the frame o
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First Name Last Name Affiliation Ad
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EURO-NanoTox European Center for Na
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silver nanoparticles, iron nanopart
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The core functions of the Center, h
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8 Directory Table 1 Directory of pe
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HINAMOX Health Impact of Engineered
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High Resolution Electron Microscopy
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integrated risk assessment. Integra
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powders: What is the difference in
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InLiveTox Intestinal, Liver and End
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- to develop and validate a novel m
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environments, IEEE Industrial Elect
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INSTANT Innovative Sensor for the f
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complementary research which will l
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7 Copyright NanoSafetyCluster - Com
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ITS-NANO Intelligent testing strate
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approach to conveying the appropria
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in the discussion. The integration
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MARINA MANAGING RISKS of NANOMATERI
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for risk analysis, these tools need
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environmental ENM toxicity, but tox
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propose it as a Method Validation F
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and SiO2-NM200 and NM203, and a SiO
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ModNanoTox Modelling nanoparticle t
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3) To model environmental exposure
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Nanodetector European Network on th
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measurement interval. Measurements
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5 Directory Table 1 Directory of pe
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NANODEVICE Novel Concepts, Methods,
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ENP in order to be sure of their sa
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4.3 Exploring the association betwe
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NanoFATE Nanoparticle Fate Assessme
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or proteins associated with particu
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sludge. Information on rates of slu
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The exposures to be conducted will
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NanoFATE progression beyond the “
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Timing, hosts and locations of (grouped) events of NanoImpactNet

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