Timing, hosts and locations of (grouped) events of NanoImpactNet

characterization as well as exposure and risk assessment of bulk
chemicals. Also new methods and schemes will be developed and
validated by using relevant and representative industrial and/or
newly synthesized NPs and by testing the impact of relevant test
media and environmental conditions.
NanoValid is organized in five technical Work Packages (WPs) and
three non-technical (management, coordination and
dissemination) WPs, as follows:
WP1 Project management
WP2 Fabrication of test materials and selection of test
methods
WP3 Validation of pc methods, in vitro, in vivo and
computational methods (in silico)
WP4 Application of validated methods to risk (RA) and life
cycle assessment (LCA)
WP5 Development of reference methods and certified
reference materials
WP6 Case studies to assess the feasibility of validated methods
WP7 Dissemination, exploitation, training, networking and
clustering
WP8 Scientific coordination
Table 1 Work packages (WP) of NanoValid
WP Title Topic
1 Project
coordination and
management
2 Fabrication of test
materials and
selection of test
methods
3 Validation of pc
methods, in vitro,
in vivo and
computational
methods (in silico)
NanoSafetyCluster - Compendium 2012
Although each individual WP has its own distinct focus, function,
objectives, tasks, deliverables and milestones, all WPs will closely
interact with, support and complement each other in an
overarching holistic approach required to match the complexity
and multidisciplinary nature of the proposed project. A bottom up
approach will be used to gradually link tasks that start with a lower
level of complexity (e.g. primary data generation, method and
material survey and selection in WP2) with tasks of increasingly
higher levels of mutual interaction (e.g. validation of methods and
testing their applicability to RA and LCA (in WP3 and WP4), until
the intended objectives (verified by specific deliverables and
milestones) are achieved and results generated (e.g., establishing
reference methods and materials in WP5 and proving their
applicability in WP6).
A global dissemination and exploitation strategy (WP7) including
internet-based interfaces for all relevant stakeholders (academia,
industry, regulatory authorities policy-makers, the public) and
events organized at different levels around the project will foster
the take-up and exploitation of project results already during the
course of the project.
The following Table1 gives a short overview and description of the
work plan broken down into WPs, tasks and methodology and how
it will lead participants to achieve project objectives:
Work package 1 (WP1) will organize and coordinate the consortium and the planned work to achieve project
objectives, implement tasks, mobilize the necessary personnel and resources, process and evaluate
collected and generate new data, and ensure reporting and quality assurance, according to main topics of
the Call, scope of the work, time schedule, and costs. The project management will build upon direct and
free communication among participants, and with the Commission, and on a smooth information flow,
including regular project meetings and monitoring, progress control and risk evaluation, and strict
compliance with milestones and deadlines for deliverables.
Work package 2 (WP2) will provide the project with a constant and updated review of the existing
knowledge and data about nanomaterials fabrication and characterization methods. This will be realized by
preparing critical periodic reviews of the relevant literature and of specific databases, which will be
distributed to all the partners. Based on the evaluation of obtained results, relevant and most promising test
materials and methods will be selected by partners involved in this WP. A group of high-priority industrial
nanomaterials will be prepared and synthesized comprising a range of different sizes, structures, coatings
and compositions. These materials will be fully characterized in WP2 before being used for validation (WP3),
applicability testing (WP4), reference method and material development (WP5) and assessment of their
feasibility (WP6). Finally, this WP will provide and evaluate a suite of screening bio-tests for initial profiling of
toxicological properties of the prepared NPs.
Work package 3 (WP3) will be the main validation work package, acting as a link between WP2, where
materials and methods will be selected, and subsequent WPs, where the validated materials and methods
will be utilized in applications. In summary, WP3 will instigate inter laboratory cross checking of protocols,
methods, materials and results (round-robins) aiming to generate cross-referenced and fully validated
materials, media and methods across the full spectrum of nanosafety (synthesis, characterization,
stabilization, human toxicology and environmental toxicology testing). The focus will be on potentially
innovative methods relevant and dedicated to nanosafety. A particular necessity for this task is the
participation of several state-of-the-art laboratories with suitable facilities and experience.
Compendium of Projects in the European NanoSafety Cluster 209