Timing, hosts and locations of (grouped) events of NanoImpactNet

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NanoSafetyCluster - Compendium 2011 Minna Vikman Technical Research Centre of Finland Margareta Wahlström Technical Research Centre of Finland Håkan Wallin National Research Centre for the Working Environment 9 Copyright PO Box 1000, Biologinkuja 7, FI-02044 VTT Espoo, Finland PO Box 1000, Biologinkuja 7, FI-02044 VTT Espoo, Finland Lersø Parkallé 105, 2100 Copenhagen, Denmark minna.vikman@vtt.fi margareta.wahlstrom@vtt.fi hwa@nrcwe.dk Disclaimer: Most parts of this document were published before under the creatives commons attribution license 3.0. © 2012, NordMiljö AB, Sunnemo, Sweden on behalf of the NanoSustain consortium. NanoSustain is a Collaborative Project (Small or medium-scale focused research projects) under the European Commission's 7th Framework Programme. This is an Open Access document distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Anyone is free: • to Share — to copy, distribute and transmit the work • to Remix — to adapt the work • to make commercial use of the work; Under the following conditions: Attribution. • NanoSustain and the European Commission's 7th Framework Programme must be given credit, but not in any way that suggests that they endorse you or your use of the work; • For any reuse or distribution, you must make clear to others the license terms of this work. The best way to do this is with a link to this web page: http://creativecommons.org/licenses/by/3.0. Statutory fair use and other rights are in no way affected by the above. 196 Compendium of Projects in the European NanoSafety Cluster
NanoTransKinetics Modelling the basis and kinetics of nanoparticle cellular interaction and transport NanoSafetyCluster - Compendium 2012 Contract Agreement: NMP4-2010- 266737 Website: http://www.nanotranskinetics.eu Coordinator: Kenneth Dawson, Centre for BioNano Interactions, University College Dublin, Belfield, Dublin 4, Ireland No. Beneficiary name Short name Country 1 National University of Ireland, Dublin / University College Dublin NUID UCD Ireland 2 Ludwig-Maximilians-Universität München [Ludwig-Maximilians University, Munich] LMU Germany 3 Universitat de Barcelona [University of Barcelona] UB Spain 4 Rice University * RU United States * EU-US modelling call – project is paired with the project “Nanoparticle Transport: From Cells to Organisms” funded via the the EPA STAR programme (EPA-G2010-STAR-N1 Fate, Transport, and Transformation). The NanoTransKinetics project is cooperating with ongoing projects in Duke University and University of North Carolina, as well as with the EU modelling cluster (initially ModNanotox coordinated by University of Birmingham). Contents 1 Summary ....................................................................................197 2 Introduction ..................................................................................197 3 Background ............................................................................... 198 4 Project Description and Organisation ...................................... 200 1 Summary NanoTransKinetics is a Small Collaborative Project funded by the European Commission 7th Framework Programme. The project started on November 1st 2011 and will run for 36 months. The project is paired with the US project “Nanoparticle Transport: From Cells to Organisms” funded via the the EPA STAR programme (EPA-G2010-STAR-N1 Fate, Transport, and Transformation). It is also linked with the ModNanoTox FP7 project via a memorandum of understanding, which agrees that the projects will have joint meetings, will share protocols and data, and will support the EU Nanosafety cluster efforts on modeling and databases. NanoTransKinetics and ModNanoTox held a joint kick-off meeting in London on the 1 st and 2 nd of December 2011. The meeting was attended by representatives of all partners of both projects, as well as a representative of the US project that is paired with both (coordinated by Prof. Vicki Colvin from Rice University). 5 NanoTransKinetics activities ..................................................... 201 6 References ................................................................................ 202 7 Directory ................................................................................... 202 8 Copyright .................................................................................. 203 2 Introduction Nanomedicine (and Nanodiagnostics) recognize the capacity to treat (and diagnose) most of the remaining intractable disease classes (viral, genetic, cancer).They are based on the central observation that objects of such small size can (uniquely) gain access to, and operate in all parts of the body (including the brain), 1 and within cells.Nanosafety acknowledges that (as with blue asbestos - a nano-rod that is non-toxic in bulk form but the agent for the increasingly common cancer, mesothelioma) there exists potential for new, serious and unpredictable diseases originating from the interaction of such small-scale objects with living organisms. There have been, as yet, limited numbers of clearly identified hazards from early phase nanoparticles, but caution is being shown worldwide in developing strategies to address the issues. It is becoming increasingly clear that Nanomedicine and Nanosafety will rely on the same fundamentally new scientific enterprise, based on understanding (and in the medium term, predicting) the interactions between nanoscale objects and living systems. Indeed, results from experimental projects (such Compendium of Projects in the European NanoSafety Cluster 197
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Compendium of Projects in the Europ
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EDITED BY Michael Riediker, PD Dr.s
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CONTENTS NanoSafetyCluster - Compen
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Project Acronym ENNSATOX ENPRA EURO
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Foreword NanoSafetyCluster - Compen
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ENNSATOX ENgineered Nanoparticle Im
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The biological membrane and its dep
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distinguishes between the interacti
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Figure 10. Schematic representation
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WP5: • Permeability of NPs in hyd
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NanoSafetyCluster - Compendium 2012
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ENPRA RISK ASSESSMENT OF ENGINEERED
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vitro findings with in vivo models;
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protocols with real biological samp
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and it was organised in the frame o
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First Name Last Name Affiliation Ad
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EURO-NanoTox European Center for Na
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silver nanoparticles, iron nanopart
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The core functions of the Center, h
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8 Directory Table 1 Directory of pe
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HINAMOX Health Impact of Engineered
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High Resolution Electron Microscopy
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integrated risk assessment. Integra
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powders: What is the difference in
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InLiveTox Intestinal, Liver and End
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- to develop and validate a novel m
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environments, IEEE Industrial Elect
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INSTANT Innovative Sensor for the f
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complementary research which will l
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7 Copyright NanoSafetyCluster - Com
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ITS-NANO Intelligent testing strate
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approach to conveying the appropria
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in the discussion. The integration
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MARINA MANAGING RISKS of NANOMATERI
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for risk analysis, these tools need
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environmental ENM toxicity, but tox
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propose it as a Method Validation F
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and SiO2-NM200 and NM203, and a SiO
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ModNanoTox Modelling nanoparticle t
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3) To model environmental exposure
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Nanodetector European Network on th
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measurement interval. Measurements
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5 Directory Table 1 Directory of pe
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NANODEVICE Novel Concepts, Methods,
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ENP in order to be sure of their sa
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4.3 Exploring the association betwe
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NanoFATE Nanoparticle Fate Assessme
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or proteins associated with particu
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sludge. Information on rates of slu
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The exposures to be conducted will
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NanoFATE progression beyond the “
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Timing, hosts and locations of (grouped) events of NanoImpactNet

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