Die Schwarze Liste der Pestizide - Greenpeace

Greenpeace e.V. – Die Schwarze Liste der Pestizide
characterization and the use of mode of action in the assessment of potential carcinogenesis. In addition, the guidelines
included consideration of risk to children, as well as addressing other issues such as nuances related to the amount and
adequacy of data on a chemical.
In March, 2005, EPA released its final Guidelines for Carcinogen Risk Assessment (EPA/630/P-03/001B). These
guidelines represent the culmination of a long development process, replacing EPA’s original cancer risk assessment
guidelines (1986) and its interim final guidelines (1999).
6. How do the different designations compare?
The short answer is that they cannot be directly compared. Each system’s designations refer to the reviews and criteria
it contains. A substance that is, for example, a “C” in the 1986 system may not be directly translatable to any particular
category in the later systems. The designation for any substance must be considered in the context of the system under
which it was reviewed.
A list of the descriptors from the various classification systems and their definitions follows.
Carcinogenicity Classification of Pesticides:
Derivation and Definition of Terms
2005 classification
The following descriptors from the 2005 Guidelines for Carcinogen Risk Assessment can be used as an introduction to
the weight of evidence narrative in the cancer risk assessment. The examples presented in the discussion of the
descriptors are illustrative. The examples are neither a checklist nor a limitation for the descriptor. The complete weight
of evidence narrative, rather than the descriptor alone, provides the conclusions and the basis for them.
Carcinogenic to humans. This descriptor indicates strong evidence of human carcinogenicity. It covers different
combinations of evidence.
This descriptor is appropriate when there is convincing epidemiologic evidence of a causal association between
human exposure and cancer.
Exceptionally, this descriptor may be equally appropriate with a lesser weight of epidemiologic evidence that is
strengthened by other lines of evidence. It can be used when all of the following conditions are met:
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(a) there is strong evidence of an association between human exposure and either cancer or the key
precursor events of the agent's mode of action but not enough for a causal association, and
(b) there is extensive evidence of carcinogenicity in animals, and
(c) the mode(s) of carcinogenic action and associated key precursor events have been identified in
animals, and
(d) there is strong evidence that the key precursor events that precede the cancer response in animals
are anticipated to occur in humans and progress to tumors, based on available biological information.