HerzSupplement - Pentalong von Actavis
HerzSupplement - Pentalong von Actavis
HerzSupplement - Pentalong von Actavis
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Herz Supplement<br />
Cardiovascular Diseases<br />
5. Chung SJ, Fung HL. Identification of the sub�<br />
cellular site for nitroglycerin metabolism to<br />
nitric oxide in bovine coronary smooth mus�<br />
cle cells. J Pharmacol Exp Ther 1990;253(2):<br />
614–619<br />
6. Dupuis J, Lalonde G, Lemieux R, Rouleau JL.<br />
Tolerance to intravenous nitroglycerin in<br />
patients with congestive heart failure: role<br />
of increased intravascular volume, neurohu�<br />
moral activation and lack of prevention<br />
with N�acetyl�cysteine. J Am Coll Cardiol<br />
1990;16(4):923–931<br />
7. Packer M, Lee WH, Kessler PD, Gottlieb SS, Me�<br />
dina N, Yushak M. Prevention and reversal of<br />
nitrate tolerance in patients with congestive<br />
heart failure. N Engl J Med 1987;317(13):<br />
799–804<br />
8. Parker JD, Farrell B, Fenton T, Cohanim M,<br />
Parker JO. Counter�regulatory responses to<br />
continuous and intermittent therapy with<br />
nitroglycerin. Circulation 1991;84(6):<br />
2336–2345<br />
9. Molina CR, Andresen JW, Rapoport RM, Wald�<br />
man S, Murad F. Effect of in vivo nitroglycerin<br />
therapy on endothelium�dependent and in�<br />
dependent vascular relaxation and cyclic<br />
GMP accumulation in rat aorta. Journal of<br />
Cardiovascular Pharmacology 1987;10(4):<br />
371–378<br />
10. Axelsson KL, Andersson RG. Tolerance towards<br />
nitroglycerin, induced in vivo, is correlated to<br />
a reduced cGMP response and an alteration in<br />
cGMP turnover. Eur J Pharmacol 1983;88(1):<br />
71–79<br />
11. Mulsch A, Busse R, Bassenge E. Desensitiza�<br />
tion of guanylate cyclase in nitrate toler�<br />
ance does not impair endothelium�de�<br />
pendent responses. Eur J Pharmacol 1988;<br />
158(3):191–198<br />
12. Munzel T, Daiber A, Mulsch A. Explaining the<br />
phenomenon of nitrate tolerance. Circ Res<br />
2005;97(7):618–628<br />
13. Mollnau H, Wenzel P, Oelze M, Treiber N,<br />
Pautz A, Schulz E, Schuhmacher S, Reifen�<br />
berg K, Stalleicken D, Scharffetter�Kochanek<br />
K, Kleinert K, Munzel T, Daiber A, Mitochon�<br />
drial oxidative stress and nitrate toler�<br />
ance�comparison of nitroglycerin and pen�<br />
taerithrityl tetranitrate in Mn�SOD+/– mice.<br />
BMC Cardiovasc Disord 2006;6:44<br />
14. Wenzel P, Oelze M, Coldewey M, Hortmann<br />
M, Seeling A, Hink U, Mollnau H, Stalleicken<br />
D, Weiner H, Lehmann J, Li H, Forstermann U,<br />
Munzel T, Daiber A, Heme oxygenase�1: a<br />
novel key player in the development of tol�<br />
erance in response to organic nitrates. Arte�<br />
rioscler Thromb Vasc Biol 2007;27(8):<br />
1729–1735<br />
15. Fink B, Bassenge E. Unexpected, tolerance�<br />
devoid vasomotor and platelet actions of<br />
pentaerythrityl tetranitrate. J Cardiovasc<br />
Pharmacol 1997;30(6):831–836<br />
16. Schwemmer M, Bassenge E. New approach�<br />
es to overcome tolerance to nitrates. Cardio�<br />
vasc Drugs Ther 2003;17(2):159–173<br />
17. Dikalov S, Fink B, Skatchkov M, Stalleicken D,<br />
Bassenge E. Formation of reactive oxygen<br />
species by pentaerithrityltetranitrate and<br />
glyceryl trinitrate in vitro and development<br />
of nitrate tolerance. J Pharmacol Exp Ther<br />
1998;286(2):938–944<br />
18. Oberle S, Abate A, Grosser N, Hemmerle A,<br />
Vreman HJ, Dennery PA, Schneider HT, Stal�<br />
leicken D, Schroder H. Endothelial protection<br />
by pentaerithrityl trinitrate: bilirubin and<br />
carbon monoxide as possible mediators.<br />
Exp Biol Med (Maywood) 2003;228(5):<br />
529–534<br />
19. Oberle S, Schwartz P, Abate A, Schroder H.<br />
The antioxidant defense protein ferritin is a<br />
novel and specific target for pentaerithrityl<br />
tetranitrate in endothelial cells. Biochem<br />
Biophys Res Commun 1999;261(1):28–34<br />
20. Bassenge E, Schneider HT, Daiber A. Oxida�<br />
tive stress and cardiovascular diseases.<br />
Dtsch Med Wochenschr 2005;130(50):<br />
2904–2909<br />
21. Jurt U, Gori T, Ravandi A, Babaei S, Zeman P,<br />
Parker JD. Differential effects of pentaeryth�<br />
ritol tetranitrate and nitroglycerin on the<br />
development of tolerance and evidence of<br />
lipid peroxidation: a human in vivo study. J<br />
Am Coll Cardiol 2001;38(3):854–859<br />
22. Gori T, Al�Hesayen A, Jolliffe C, Parker JD.<br />
Comparison of the effects of pentaerythri�<br />
tol tetranitrate and nitroglycerin on endo�<br />
thelium� dependent vasorelaxation in male<br />
volunteers. Am J Cardiol 2003;91(11):<br />
1392–1394<br />
23. Thomas GR, DiFabio JM, Tommaso T, Parker<br />
JD. Once Daily Therapy with Isosor�<br />
bide�5�Mononitrate Causes Endothelial<br />
Dysfunction in Humans: Evidence of a Free<br />
Radical Mediated Mechanism. J Am Coll Car�<br />
diol 2007; in press<br />
24. Sekiya M, Sato M, Funada J, Ohtani T, Akutsu<br />
H, Watanabe K. Effects of the long�term ad�<br />
ministration of nicorandil on vascular endo�<br />
thelial function and the progression of ar�<br />
teriosclerosis. J Cardiovasc Pharmacol 2005;<br />
46(1):63–67<br />
25. Thum T, Fraccarollo D, Thum S, Schultheiss<br />
M, Daiber A, Wenzel P, Munzel T, Ertl G, Bau�<br />
ersachs J. Differential Effects of Organic Ni�<br />
trates on Endothelial Progenitor Cells Are<br />
Determined by Oxidative Stress. Arterioscler<br />
Thromb Vasc Biol 2007;27:748–754<br />
26. DiFabio JM, Thomas GR, Zucco L, Kuliszewski<br />
MA, Bennett BM, Kutryk MJ, Parker JD. Nitro�<br />
glycerin attenuates human endothelial pro�<br />
genitor cell differentiation, function, and<br />
survival. J Pharmacol Exp Ther 2006;318(1):<br />
117–123<br />
26a. S. Schuhmacher, P. Wenzel, E. Schulz, M. Oelze,<br />
C. Mang, J. Kamuf, T. Gori, T. Jansen, M. Knorr,<br />
S. Karbach, M. Hortmann, F. Mäthner, A. Bhat�<br />
nagar, U. Förstermann, H. Li, T. Münzel, A.<br />
Daiber. Pentaerithrityl tetranitrate improves<br />
angiotensin II induced vascular dysfunction<br />
via induction of heme oxygenase�1.<br />
Hypertension 2010; DOI: 10.1161/Hyperten�<br />
sionAHA.109. 149542<br />
26b. B. Schnorbus, R. Schiewe, M. A. Ostad, C.<br />
Medler, D. Wachtlin, P. Wenzel, A. Daiber, T.<br />
Münzel, A. Warnholtz. Effects of pentaeryth�<br />
ritol tetranitrate on endothelial function in<br />
coronary artery disease: Results of the PEN�<br />
TA study. Clin. Res. Cardiol. 2010; DOI<br />
10.1007/s00392�009�0096�z<br />
27. Pautz A, Rauschkolb P, Schmidt N, Art J, Oelze<br />
M, Wenzel P, Forstermann U, Daiber A, Klei�<br />
nert H. Effects of nitroglycerin or pentae�<br />
rithrityl tetranitrate treatment on the gene<br />
expression in rat hearts: evidence for car�<br />
diotoxic and cardioprotective effects. Physi�<br />
ol Genomics 2009;38(2):176–185<br />
28. Oppermann M, Balz V, Adams V, Dao VT, Bas<br />
M, Suvorava T, Kojda G. Pharmacological in�<br />
duction of vascular extracellular superoxide<br />
dismutase expression in vivo. J Cell Mol Med<br />
2009;13(7):1271–1278<br />
29. Dovinova I, Cacanyiova S, Faberova V, Kristek<br />
F. The effect of an NO donor, pentaerythrityl<br />
tetranitrate, on biochemical, functional, and<br />
morphological attributes of cardiovascular<br />
system of spontaneously hypertensive rats.<br />
Gen Physiol Biophys 2009;28(1):86–93<br />
30. Wenzel P, Schulz E, Gori T, Ostad MA, Math�<br />
ner F, Schildknecht S, Gobel S, Oelze M, Stal�<br />
leicken D, Warnholtz A, Munzel T, DaiberA.<br />
Monitoring white blood cell mitochondrial<br />
aldehyde dehydrogenase activity: implica�<br />
tions for nitrate therapy in humans. J Phar�<br />
macol Exp Ther 2009;330(1):63–71<br />
31. Koenig A, Lange K, Konter J, Daiber A, Stal�<br />
leicken D, Glusa E, Lehmann J. Potency and<br />
in vitro tolerance of organic nitrates: par�<br />
tially denitrated metabolites contribute to<br />
the tolerance�devoid activity of pentaery�<br />
thrityl tetranitrate. J Cardiovasc Pharmacol<br />
2007; 50(1):68–74<br />
32. Daiber A, Oelze M, Coldewey M, Bachschmid<br />
M, Wenzel P, Sydow K, Wendt M, Kleschyov<br />
AL, Stalleicken D, Ullrich V, Mulsch A, Munzel<br />
T. Oxidative stress and mitochondrial alde�<br />
hyde dehydrogenase activity: a comparison<br />
of pentaerythritol tetranitrate with other<br />
organic nitrates. Mol Pharmacol 2004;66(6):<br />
1372–1382<br />
33. Nakamura Y, Moss AJ, Brown MW, Kinoshita<br />
M, Kawai C. Long�term nitrate use may be<br />
deleterious in ischemic heart disease: a<br />
study using the databases from two<br />
large�scale postinfarction studies. Multi�<br />
center Myocardial Ischemia Research Group.<br />
Am Heart J 1999;138(3 Pt 1):577–585<br />
34. Munzel T, Sayegh H, Freeman BA, Tarpey<br />
MM, Harrison DG. Evidence for enhanced<br />
vascular superoxide anion production in<br />
nitrate tolerance. A novel mechanism un�<br />
derlying tolerance and cross�tolerance. J<br />
Clin Invest 1995;95(1):187–194<br />
35. Chen Z, Zhang J, Stamler JS. Identification of<br />
the enzymatic mechanism of nitroglycerin<br />
bioactivation. Proc Natl Acad Sci U S A 2002;<br />
99(12):8306–8311<br />
36. Gori T, Daiber A. Non�hemodynamic effects<br />
of organic nitrates and the distinctive char�<br />
acteristics of pentaerithrityl tetranitrate.<br />
Am J Cardiovasc Drugs 2009;9(1):7–15<br />
37. Daiber A, Wenzel P, Oelze M, Schuhmacher<br />
S, Jansen T, Munzel T. Mitochondrial alde�<br />
hyde dehydrogenase (ALDH�2) – maker of<br />
and marker for nitrate tolerance in response<br />
to nitroglycerin treatment. Chem Biol Inter�<br />
act 2009;178(1–3):40–47<br />
38. Daiber A, Oelze M, Wenzel P, Wickramanay�<br />
ake JM, Schuhmacher S, Jansen T, Lackner KJ,<br />
Torzewski M, Munzel T. Nitrate tolerance as<br />
a model of vascular dysfunction: roles for<br />
mitochondrial aldehyde dehydrogenase and<br />
mitochondrial oxidative stress. Pharmacol<br />
Rep 2009;61(1):33–48<br />
39. Kollau A, Beretta M, Russwurm M, Koesling<br />
D, Keung WM, Schmidt K, Mayer B. Mito�<br />
34 Herz 35 · 2010 · Supplement II © Urban & Vogel