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HerzSupplement - Pentalong von Actavis

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Herz Supplement<br />

Cardiovascular Diseases<br />

4. Thum T. Bauersachs J. Microarray-based gene<br />

expression profiling to elucidate cellular responses<br />

to nitric oxide – a review from an analytical<br />

and biomedical point of view. J Chromatogr<br />

B Analyt Technol Biomed Life Sc 2007;<br />

851(1–2):3–11<br />

5. Pilz R.B. Casteel D.E. Regulation of gene expression<br />

by cyclic GMP. Circ Res 2003;93(11):1034–<br />

1046<br />

6. Dhakshinamoorthy S et al. Protein/DNA arrays<br />

identify nitric oxide-regulated cis-element and<br />

trans-factor activities some of which govern<br />

neuroblastoma cell viability. Nucleic Acids Res<br />

2007;35(16):5439–5451<br />

7. Akool el S et al. Nitric oxide increases the decay<br />

of matrix metalloproteinase 9 mRNA by inhibiting<br />

the expression of mRNA-stabilizing factor<br />

HuR. Mol Cell Biol 2003;23(14):4901–4916<br />

8. Kuwano Y et al. Analysis of nitric oxide-stabilized<br />

mRNAs in human fibroblasts reveals HuRdependent<br />

heme oxygenase 1 upregulation.<br />

Mol Cell Biol 2009;29(10):2622–2635<br />

9. Hentze MW, Kuhn LC. Molecular control of vertebrate<br />

iron metabolism: mRNA-based regulatory<br />

circuits operated by iron, nitric oxide, and<br />

oxidative stress. Proc Natl Acad Sci U S A 1996;<br />

93(16):8175–8182<br />

10. Zhou J et al. NO and TNF-alpha released from<br />

activated macrophages stabilize HIF-1alpha in<br />

resting tubular LLC-PK1 cells. Am J Physiol Cell<br />

Physiol 2003;284(2):C439–446<br />

11. Wang EQ et al. cDNA microarray analysis of vascular<br />

gene expression after nitric oxide donor<br />

infusions in rats: implications for nitrate tolerance<br />

mechanisms. AAPS PharmSci 2002; 4(2):<br />

E10<br />

12. Stalleicken D, Schröder H. In-vivo- und Humanstudien<br />

bestätigen das antioxidative und toleranzfreie<br />

Wirkprofil <strong>von</strong> PETN. Perfusion 2008;<br />

21:4–6<br />

13. Dhakshinamoorthy S, Porter AG. Nitric oxideinduced<br />

transcriptional up-regulation of protective<br />

genes by Nrf2 via the antioxidant response<br />

element counteracts apoptosis of neuroblastoma<br />

cells. J Biol Chem 2004;279(19):<br />

20096–20107<br />

14. Misquitta CM et al. The role of 3‘-untranslated<br />

region (3‘-UTR) mediated mRNA stability in cardiovascular<br />

pathophysiology. Mol Cell Biochem<br />

2001;224(1–2):53–67<br />

15. Khabar KS. The AU-rich transcriptome: more than<br />

interferons and cytokines, and its role in disease.<br />

J Interferon Cytokine Res 2005;25(1):1–10.<br />

16. Pautz A et al. Effects of nitroglycerin or pentaerithrityl<br />

tetranitrate treatment on the gene<br />

expression in rat hearts: evidence for cardiotoxic<br />

and cardioprotective effects. Physiol Genomics<br />

2009;38(2):176–185<br />

17. Clarke PA et al. Gene expression microarray analysis<br />

in cancer biology, pharmacology, and drug<br />

development: progress and potential. Biochem<br />

Pharmacol 2001;62(10):1311–1336<br />

18. Gupta S et al. Activation of nuclear factor-kappaB<br />

is necessary for myotrophin-induced cardiac<br />

hypertrophy. J Cell Biol 2002;159(6):1019–<br />

1028<br />

19. Wang J et al. Convergence of protein kinase<br />

C and JAK-STAT signaling on transcription factor<br />

GATA-4. Mol Cell Biol 2005;25(22):9829–<br />

9844.<br />

20. Thuerauf DJ et al. p38 Mitogen-activated protein<br />

kinase mediates the transcriptional induction<br />

of the atrial natriuretic factor gene through<br />

a serum response element. A potential role for<br />

the transcription factor ATF6. J Biol Chem 1998;<br />

273(32):20636–20643<br />

21. Xu J et al. Myocyte enhancer factors 2A and 2C<br />

induce dilated cardiomyopathy in transgenic<br />

mice. J Biol Chem 2006;281(14): 9152–9162<br />

22. Aerts S et al. TOUCAN 2: the all-inclusive open<br />

source workbench for regulatory sequence analysis.<br />

Nucleic Acids Res 2005;33(Web Server issue):W393–396<br />

23. Chekmenev DS et al. P-Match: transcription factor<br />

binding site search by combining patterns<br />

and weight matrices. Nucleic Acids Res 2005;<br />

33(Web Server issue):W432–437<br />

24. Nunez C et al. Discrepancies between nitroglycerin<br />

and NO-releasing drugs on mitochondrial<br />

oxygen consumption, vasoactivity,<br />

and the release of NO. Circ Res 2005; 97(10):<br />

1063–1069<br />

25. Kleschyov AL et al. Does nitric oxide mediate the<br />

vasodilator activity of nitroglycerin? Circ Res<br />

2003;93(9):e104–112<br />

26. Munzel T et al. Explaining the phenomenon<br />

of nitrate tolerance. Circ Res 2005;97(7):618–<br />

628<br />

27. Daiber A et al. Oxidative stress and mitochondrial<br />

aldehyde dehydrogenase activity: a comparison<br />

of pentaerythritol tetranitrate with other<br />

organic nitrates. Mol Pharmacol 2004; 66(6):<br />

1372–1382<br />

28. Janero DR et al. Differential nitros(yl)ation of<br />

blood and tissue constituents during glyceryl<br />

trinitrate biotransformation in vivo. Proc Natl<br />

Acad Sci U S A 2004;101(48):16958–16963<br />

29. Wenzel P et al. Number of nitrate groups determines<br />

reactivity and potency of organic nitrates:<br />

a proof of concept study in ALDH-2-/-<br />

mice. Br J Pharmacol 2007;150(4):526–533<br />

30. Gori T, Daiber A. Non-hemodynamic effects of<br />

organic nitrates and the distinctive characteristics<br />

of pentaerithrityl tetranitrate. Am J Cardiovasc<br />

Drugs, 2009;9(1):7–15<br />

31. Tassorelli C, Joseph SA. NADPH-diaphorase activity<br />

and Fos expression in brain nuclei following<br />

nitroglycerin administration. Brain Res 1995;<br />

695(1):37–44<br />

32. Tassorelli C et al. A role for brain cyclooxygenase-2<br />

and prostaglandin-E2 in migraine: effects<br />

of nitroglycerin. Int Rev Neurobiol 2007;82:373–<br />

382<br />

33. Greco R et al. Neuroprotective effect of nitroglycerin<br />

in a rodent model of ischemic stroke:<br />

evaluation of Bcl-2 expression. Int Rev Neurobiol<br />

2007;82:423–435<br />

34. Munzel T et al. Effects of long-term nitroglycerin<br />

treatment on endothelial nitric oxide synthase<br />

(NOS III) gene expression, NOS III-mediated superoxide<br />

production, and vascular NO bioavailability.<br />

Circ Res 2000;86(1):E7–E12<br />

35. Prevotat L et al. Nitric oxide-induced down-regulation<br />

of beta-catenin in colon cancer cells by<br />

a proteasome-independent specific pathway.<br />

Gastroenterology 2006;131(4):1142–1152<br />

36. Suwattanasophon C et al. 5-HT(1B/1D) serotonin<br />

receptor agonist attenuates nitroglycerin-evoked<br />

nitric oxide synthase expression in trigeminal<br />

pathway. Cephalalgia 2003;23(8):825–832<br />

37. Yamazaki A, Birnboim H.C. Potentiation of retinoic<br />

acid-induced U-937 differentiation into<br />

respiratory burst-competent cells by nitric oxide<br />

donors. Leuk Res 1995;19(5):325–335<br />

38. Otto A et al. Rosuvastatin treatment protects<br />

against nitrate-induced oxidative stress in<br />

eNOS knockout mice: implication of the<br />

NAD(P)H oxidase pathway. Br J Pharmacol 2006;<br />

148(4):544–552.<br />

39. Li J et al. Nitroglycerin protects small intestine<br />

from ischemia-reperfusion injury via NO-cGMP<br />

pathway and upregulation of alpha-CGRP. J<br />

Gastrointest Surg 2009;13(3):478–485<br />

40. Death AK et al. Nitroglycerin upregulates matrix<br />

metalloproteinase expression by human<br />

macrophages. J Am Coll Cardiol 2002;39(12):<br />

1943–1950.<br />

41. Szocs K et al. Increased superoxide production<br />

in nitrate tolerance is associated with NAD(P)H<br />

oxidase and aldehyde dehydrogenase 2 downregulation.<br />

J Mol Cell Cardiol 2007;42(6):1111–<br />

1118<br />

42. Pi X et al. Differential expression of genes from<br />

nitrate-tolerant rat aorta. J Vasc Res 2002; 39(4):<br />

304–310<br />

43. Oberle S et al. The antioxidant defense protein<br />

ferritin is a novel and specific target for pentaerithrityl<br />

tetranitrate in endothelial cells. Biochem<br />

Biophys Res Commun 1999;261(1):28–34<br />

44. Oberle S et al. Heme oxygenase-1 induction may<br />

explain the antioxidant profile of pentaerythrityl<br />

trinitrate. Biochem Biophys Res Commun<br />

2002;290(5):1539–1544<br />

45. Mollnau H et al. Mitochondrial oxidative stress<br />

and nitrate tolerance – comparison of nitroglycerin<br />

and pentaerithrityl tetranitrate in<br />

Mn-SOD+/- mice. BMC Cardiovasc Disord 2006;<br />

6:44.<br />

46. Dragoni S et al. Pentaerythrityl tetranitrate and<br />

nitroglycerin, but not isosorbide mononitrate,<br />

prevent endothelial dysfunction induced by ischemia<br />

and reperfusion. Arterioscler Thromb<br />

Vasc Biol 2007;27(9):1955–1959<br />

Für die Verfasser:<br />

Prof. Dr. Hartmut Kleinert<br />

Institut für Pharmakologie, Universitätsmedizin<br />

der Johannes Gutenberg-<br />

Universität, Obere Zahlbacher Str. 63<br />

55101 Mainz, Germany<br />

Tel.: +49 (0) 6131 17 9276<br />

Fax: +49 (0) 6131 17 9042<br />

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