HerzSupplement - Pentalong von Actavis

Literatur
1. Schwemmer M, Bassenge E. New approaches to overcome
tolerance to nitrates. Cardiovasc Drugs Ther
2003;17:159–173
2. Zeiher AM, Dabrowski M, Lehmacher W. Das Langzeitnitrat
PETN (Pentalong® 80) ist ISDN-SR nicht unterlegen
und zeigt therapeutische Vorteile in der Langzeitbehandlung
der stabilen Angina pectoris. Z. Kardiol
2004;93 (suppl. 5):112
3. Mullenheim J, Muller S, Laber U, Thamer V, Meyer W,
Bassenge E, Fink B, Kojda G. The effect of high-dose
pentaerythritol tetranitrate on the development of
nitrate tolerance in rabbits. Naunyn Schmiedebergs
Arch Pharmacol 2001;364:269–275
4. Keimer R, Stutzer FK,Tsikas D,Troost R, Gutzki FM, Frolich
JC. Lack of oxidative stress during sustained
therapy with isosorbide dinitrate and pentaerythrityl
tetranitrate in healthy humans: a randomized, double-blind
crossover study. J Cardiovasc Pharmacol
2003;41:284–292.
5. Fink B, Bassenge E. Unexpected, tolerance-devoid vasomotor
and platelet actions of pentaerythrityl tetranitrate.
J Cardiovasc Pharmacol 1997;30:831–836
6. Jurt U, Gori T, Ravandi A, Babaei S, Zeman P, Parker JD.
Differential effects of pentaerythritol tetranitrate and
nitroglycerin on the development of tolerance and
evidence of lipid peroxidation: a human in vivo study.
J Am Coll Cardiol 2001;38:854–859
7. Munzel T, Daiber A, Mulsch A. Explaining the phenomenon
of nitrate tolerance. Circ Res 2005;97:618–628
8. Oberle S, Abate A, Grosser N, Hemmerle A. Vreman HJ,
Dennery PA, Schneider HT, Stalleicken D, Schroder H.
Endothelial protection by pentaerithrityl trinitrate:
bilirubin and carbon monoxide as possible mediators.
Exp Biol Med (Maywood) 2003;228:529–534
9. Oberle S, Schwartz P, Abate A, Schroder H. The antioxidant
defense protein ferritin is a novel and specific
target for pentaerithrityl tetranitrate in endothelial
cells. Biochem Biophys Res Commun 1999;261:28–34
10. Hacker A, Muller S, Meyer W, Kojda G. The nitric oxide
donor pentaerythritol tetranitrate can preserve endothelial
function in established atherosclerosis. Br J
Pharmacol 2001;132:1707–1714
11. Thum T, Fraccarollo D, Thum S, Schultheiss M, Daiber,
A, Wenzel P, Munzel T, Ertl G.; Bauersachs, J. Differential
Effects of Organic Nitrates on Endothelial Progenitor
Cells Are Determined by Oxidative Stress. Arterioscler
Thromb Vasc Biol 2007;27:748–754
12. Munzel T, Sayegh H, Freeman BA,Tarpey MM, Harrison
DG. Evidence for enhanced vascular superoxide anion
production in nitrate tolerance. A novel mechanism
underlying tolerance and cross-tolerance. J Clin Invest
1995;187–194
13. DaiberA, Oelze M, Coldewey M, Bachschmid M, Wenzel
P, Sydow K, Wendt M, Kleschyov AL, Stalleicken D,
UllrichV, Mulsch A, Munzel T. Oxidative stress and mitochondrial
aldehyde dehydrogenase activity: a comparison
of pentaerythritol tetranitrate with other
organic nitrates. Mol Pharmacol 2004;66:1372–1382
14. Daiber A, Oelze M, Sulyok S, Coldewey M, Schulz E,
Treiber N, Hink U, Mulsch A, Scharffetter-Kochanek K,
Munzel T. Heterozygous deficiency of manganese
superoxide dismutase in mice (Mn-SOD+/-): A novel
approach to assess the role of oxidative stress for the
development of nitrate tolerance. Mol Pharmacol
2005;68:579-588; 2005.
15. Daiber A, Oelze M, Coldewey M, Kaiser K, Huth C,
Schildknecht S, Bachschmid M, Nazirisadeh Y, Ullrich
V, Mulsch A, Munzel T, Tsilimingas N. Hydralazine is
a powerful inhibitor of peroxynitrite formation as a
possible explanation for its beneficial effects on prognosis
in patients with congestive heart failure.
Biochem Biophys Res Commun 2005;338:1865–1874
16. Wenzel P, Hink U, Oelze M, Seeling A, Isse T, Bruns K,
Steinhoff L, Brandt M, Kleschyov AL, Schulz E, Lange K,
Weiner H, Lehmann J, Lackner KJ, Kawamoto T, Munzel
T, Daiber A. Number of nitrate groups determines reactivity
and potency of organic nitrates: a proof of
Herz 35 · 2010 · Supplement II © Urban & Vogel
concept study in ALDH-2-/- mice. Brit J Pharmacol
2007;150:526–533
17. Koenig A, Lange K, Konter J, Daiber A, Stalleicken D,
Glusa E, Lehmann J. Potency and in vitro tolerance of
organic nitrates: partially denitrated metabolites contribute
to the tolerance-devoid activity of pentaerythrityl
tetranitrate. J Cardiovasc Pharmacol
2007;50:68–74
18 Wenzel P, Oelze M, Coldewey M, Hortmann M, Seeling
A, Hink U, Mollnau H, Stalleicken D, Weiner H, Lehmann
J, Li H, Forstermann U, Munzel T, Daiber A. Heme
oxygenase-1: a novel key player in the development
of tolerance in response to organic nitrates. Arterioscler
Thromb Vasc Biol 2007;27:1729–1735
19. Mollnau H, Wenzel P, Oelze M, Treiber N, Pautz A,
Schulz E, Schuhmacher S, Reifenberg K, Stalleicken D,
Scharffetter-Kochanek K, Kleinert H, Munzel T, Daiber
A. Mitochondrial oxidative stress and nitrate tolerance
– comparison of nitroglycerin and pentaerithrityl
tetranitrate in Mn-SOD+/- mice. BMC Cardiovasc
Disord 2006;6:44
20. Naeije R. Pulmonary hypertension and right heart
failure in chronic obstructive pulmonary disease. Proc
Am Thorac Soc 2005;2:20-22
21. Christou H, Morita T, Hsieh CM, Koike H, Arkonac B,
Perrella MA, Kourembanas S. Prevention of hypoxiainduced
pulmonary hypertension by enhancement of
endogenous heme oxygenase-1 in the rat. Circ Res
2000;86:1224–1229
22. Jankov RP, Kantores C, Pan J, Belik, J. Contribution of
xanthine oxidase-derived superoxide to chronic hypoxic
pulmonary hypertension in neonatal rats. Am J
Physiol Lung Cell Mol Physiol 2008;294:L233–245
23. Shimzu K, Takahashi T, Iwasaki T, Shimizu H, Inoue K,
Morimatsu H, Omori E, Matsumi M, Akagi R, Morita K.
Hemin treatment abrogates monocrotaline-induced
pulmonary hypertension. Med Chem 2008;4:572–
576
24. Lopez-Lopez JG, Moral-Sanz J, Frazziano G, Gomez-Villalobos
MJ, Flores-Hernandez J, Monjaraz E, Cogolludo
A, Perez-Vizcaino F. Diabetes induces pulmonary artery
endothelial dysfunction by NADPH oxidase induction.
Am J Physiol Lung Cell Mol Physiol 2008;295:
L727–732
25. Brennan LA, Steinhorn RH,Wedgwood S, Mata-Greenwood
E, Roark EA, Russell JA, Black SM. Increased superoxide
generation is associated with pulmonary
hypertension in fetal lambs: a role for NADPH oxidase.
Circ Res 2003;92:683–691
26. Khoo JP, Zhao L, Alp NJ, Bendall JK, Nicoli T, Rockett K,
Wilkins MR, Channon KM. Pivotal role for endothelial
tetrahydrobiopterin in pulmonary hypertension. Circulation
12005;11:2126–2133
27. Dragoni S, Gori T, Lisi M, Di Stolfo G, Pautz A, Kleinert H,
Parker JD.Pentaerythrityl tetranitrate and nitroglycerin,
but not isosorbide mononitrate, prevent endothelial
dysfunction induced by ischemia and reperfusion. Arterioscler
Thromb Vasc Biol 2007;27:1955–1959
Für die Verfasser:
Prof. Dr. Andreas Daiber
Universitätsmedizin der Johannes Gutenberg-
Universität Mainz
II. Medizinische Klinik – Labor für Molekulare
Kardiologie
Obere Zahlbacher Str. 63
55101 Mainz, Germany
Tel.: +49 (0)6131 17 9722
Fax: +49 (0)6131 17 97 23
E-Mail: daiber@uni-mainz.de
Organische Nitrate
49