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Dynamic prediction of response using longitudinal profi les 103<br />

13. Buster EH, Hansen BE, Zeuzem S, Schalm SW, Steyerberg EW, Janssen HL. Predicting sustained<br />

hepatitis B virus eAg loss after treatement with peginterferon alpha-2b: development<br />

and validation of a pratical model European Journal of Gastroenterology & Hepatology Jul,<br />

2008;20:A69-A70.<br />

14. Buster EH, Hansen BE, Lau GK, Piratvisuth T, Zeuzem S, Steyerberg EW, Janssen HL. Factors<br />

that predict response of patients with hepatitis B e antigen-positive chronic hepatitis B to<br />

peginterferon-alfa. Gastroenterology 2009;137:2002-9.<br />

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longitudinal profi les. Biostatistics 2008;9:419-31.<br />

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models.Technical report 0356. IAP Statistics Network.<br />

17. Komárek A, Hansen BE, Kuiper EM, van Buuren HR, Lesaffre E. Discriminant analysis using a<br />

multivariate linear mixed model with a normal mixture in the random effects distribution.<br />

Statistics in Medicine 2010;in press.<br />

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Acknowledgement<br />

The authors would like to thank Marek Molas, department of Biostatistics, <strong>Erasmus</strong><br />

MC, <strong>Rotterdam</strong> , the Netherlands who wrote the SAS program for the adjustment<br />

of the predictions in the direct approach using the pattern approach.<br />

Foundation for Liver Research (SLO), <strong>Rotterdam</strong>, The Netherlands (HBV9901),<br />

Ministry of Education, Youth and Sports of the Czech Republic (MSM 0021620839),<br />

Czech Science Foundation (GAČR 201/09/P077), Belgian State – Federal Office for<br />

Scientific, Technical and Cultural Affairs (Interuniversity Attraction Poles Program<br />

P6/03).

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