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Bibliography 258 Mechanical factors infl uencing the incidence of burst abdomen. Eur. J. Surg. 1995, 161:655- 661. 13. Helbing WA, Rebergen SA, Maliepaard C, Hansen B, Ottenkamp J, Reiber JHC, de Roos A. Quantifi cation of right ventricular function with magnetic resonance imaging in children with normal hearts and with congenital heart disease. Am Heart J. 1995, 130:828-837. 14. Reijnierse M, Bloem JL, Dijkmans BAC, Kroon HM, Holscher HC, Hansen B, Breedveld FC. The cervical spine in rheumatoid arthritis: relationship between neurologic signs and morphology on MR imaging and radiographs. Skeletal Radiol. 1996; 25: 113-118. 15. de Waard-Siebinga I, Hilders CGJM, Hansen BE, v Delft JL, Jager MJ. HLA expression and tumor-infi ltrating immune cells in uveal melanoma. Graefe’s Arch Clin Exp Ophthalmol. 1996;234:34-42. 16. Hagen EC, Andrassy K, Csernok E, Daha MR, Gaskin G, Gross WL, Hansen B, v.d. Woude FJ et al. Development and standardization of solid phase assays for the detection of antineutrophil cytoplasmic antibodies (ANCA). A report on the second phase of an international cooperative study on the standardization of ANCA assays. Journal of Immunological Methods 1996, 196 1-15. 17. Bajema I, Hagen EC, Hansen BE, Hermans J, Noël LH, Waldherr R, Ferrario F, v.d. Woude FJ, Bruijn JA. The renal histopathology in systemic vasculitis: an international survey study of inter- and intra-observer agreement. Nephrol Dial Transplant 1996, 11: 1989-1995. 18. Schalm SW, Hansen BE, Chemello L, Bellobuono A, Brouwer JT, Weiland O, Cavalletto L, Schvarcz R, Ideo G, Alberti A. Ribavirin enhances the effi cacy but not the adverse effects of interferon in chronic hepatitis C. Meta-analysis of individual patient data from European centers. J. Hepatl 1997; 26: 961-6. 19. Brouwer JT, Nevens F, Kleter B, Elewaut A, Adler M, Brenard R, Chamuleau RA, Michielsen PP, Pirotte J, Hautekeete ML, Weber J, Bourgeois N, Hansen BE, Bronkhorst CM, ten Kate FJ, Heijtink RA,Fevery J, Schalm SW. Effi cacy of interferon dose and prediction of response in chronic hepatitis C: Benelux study in 336 patients.. Journal of Hepatology. 28(6):951-9, 1998 Jun. 20. Kuijpens JL, Hansen B, Hamming JF, Ribot JG, Haak HR, Coebergh J-WW. Trends in treatment and long-term survival of thyroid cancer in Southeastern Netherlands, 1960-1992. European Journal of Cancer. 34(8): 1235-1241, 1998 21. Referaat: Hansen B, de Man RA. Het effect van interferon alfa op het ontstaan van hepatocellulair carcinoom bij patienten met virale hepatitis en cirrose. Ned Tijdschr Geneeskd 1998 28 nov; 142(48) 22. van Hoogstraten HJ, Hansen BE, van Buuren HR, ten Kate FJ, van Berge-Henegouwen GP, Schalm SW. Prognostic factors and long-term effects of ursodeoxycholic acid on liver biochemical parameters in patients with primary biliary cirrhosis. Dutch Multi-Centre PBC Study Group. J Hepatol. 1999 Aug;31(2):256-62. 23. Schalm SW, Weiland O, Hansen BE, Milella M, Lai MY, Hollander A, Michielsen PP, Bellobuono A, Chemello L, Pastore G, Chen DS, Brouwer JT.
Bibliography 259 Interferon-ribavirin for chronic hepatitis C with and without cirrhosis: analysis of individual patient data of six controlled trials. Eurohep Study Group for Viral Hepatitis. Gastroenterology. 1999 Aug;117(2):408-13. 24. Brouwer JT, Hansen BE, Niesters HG, Schalm SW. Early prediction of response in interferon monotherapy and in interferon-ribavirin combination therapy for chronic hepatitis C: HCV RNA at 4 weeks versus ALT. J Hepatol. 1999 Feb;30(2):192-8. 25. van Overhagen H. Ludviksson MA. Lameris JS. Zwamborn AW. Tilanus HW. Dees J. Hansen BE. US and fl uoroscopic-guided percutaneous jejunostomy: Experience in 49 patients. Journal of Vascular & Interventional Radiology. 11(1):101-106, 2000 Jan. 26. Post PN. Hendrikx AJM. Hansen BE. van der Heijden LH. Coebergh JWV. Long-term survival of prostate cancer in southeastern Netherlands. Acta Oncologica. 39(1):101-104, 2000. 27. Reijnierse M. Breedveld FC. Kroon HM. Hansen B. Pope TL. Bloem JL. Are magnetic resonance fl exion views useful in evaluating the cervical spine of patients with rheumatoid arthritis?. Skeletal Radiology. 29(2):85-89, 2000 Feb. 28. Bekkering FC, Brouwer JT, Hansen BE, Schalm SW. Hepatitis C viral kinetics in diffi cult to treat patients receiving high dose interferon and ribavirin. J Hepatol. 2001 Mar;34(3):435-40. 29. Janssen HL, Wijnhoud A, Haagsma EB, van Uum SH, van Nieuwkerk CM, Adang RP,Chamuleau RA, van Hattum J, Vleggaar FP, Hansen BE, Rosendaal FR, van Hoek B. Extrahepatic portal vein thrombosis: aetiology and determinants of survival. Gut. 2001 Nov;49(5):720-4. 30. Post PN, Hansen BE, Kil PJ, Janssen-Heijnen ML, Coebergh JW. The independent prognostic value of comorbidity among men aged < 75 years with localized prostate cancer: a population-based study. BJU Int. 2001 Jun;87(9):821-6. 31. Wolters LM, Hansen BE, Niesters HG, DeHertogh D, de Man RA. Corrigendum to “Viral dynamics during and after entecavir therapy in patients with chronic hepatitis B” J Hepatol. 2002 Nov;37(5):708. 32. Wolters LM, Hansen BE, Niesters HG, de Man RA. Viral dynamics in chronic hepatitis B patients treated with lamivudine,lamivudine-famciclovir or lamivudine-ganciclovir. Eur J Gastroenterol Hepatol. 2002 Sep;14(9):1007-11. 33. Wolters LM, Hansen BE, Niesters HG, Levi-Drummer RS, Neumann AU, Schalm SW, de Man RA. The infl uence of baseline characteristics on viral dynamic parameters in chronic hepatitis B patients treated with lamivudine. J Hepatol. 2002 Aug;37(2):253-8. 34. Wolters LM, Hansen BE, Niesters HG, DeHertogh D, de Man RA. Viral dynamics during and after entecavir therapy in patients with chronic hepatitis B. J Hepatol. 2002 Jul;37(1):137-44.
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Statistical Models of Treatment Eff
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ISBN: 978-90-8559-069-9 © Bettina
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PROMOTIECOMMISSIE Promotor: Prof.dr
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CONTENTS Chapter 1. Introduction 11
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Cha pter 1 Introduction
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Chapter 1 14 Epidemiology Worldwide
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Chapter 1 16 Prediction models with
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Chapter 1 18 standard method fails
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Chapter 1 20 The extended non-linea
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Chapter 1 22 References 1. Blumberg
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Cha pter 2 Prediction of response t
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Chapter 2.1 28 ABSTRACT The aim of
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Chapter 2.1 30 been hepatitis B sur
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Chapter 2.1 32 HBV DNA decline The
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Chapter 2.1 34 Figure 2 continued.
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Chapter 2.1 36 Figure 4. Estimated
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Chapter 2.1 38 DNA was observed in
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Chapter 2.1 40 15. Kao JH. Role of
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Chapter 2.2 44 ABSTRACT Background:
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Chapter 2.2 46 low baseline HBV DNA
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Chapter 2.2 48 patient subgroups wa
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Chapter 2.2 50 p=0.002). Previous I
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Chapter 2.2 52 Application of the m
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Chapter 2.2 54 PEG-IFN, the proport
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Chapter 2.2 56 References 1. Lavanc
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Chapter 2.2 58 26. Bonino F, Lau GK
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Chap ter 2.3 Prediction of the resp
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INTRODUCTION Dynamic prediction of
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Statistical analysis Dynamic predic
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Dynamic prediction of response to P
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References Dynamic prediction of re
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Cha pter 2.4 Dynamic prediction of
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INTRODUCTION Dynamic prediction of
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For the indirect approach we rewrit
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logit pi,j = logit Pr(Ri =1|visit =
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Dynamic prediction of response usin
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Table 1. Results of different stopp
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Chapter 2.5 106 ABSTRACT Peginterfe
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Chapter 2.5 108 and placebo daily.
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Chapter 2.5 110 for patients with a
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Chapter 2.5 112 Mean HBV DNA declin
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Chapter 2.5 114 peginterferon and n
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Chapter 2.5 116 hepatocellular carc
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Chapter 2.5 118 13. Werle-Lapostoll
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Chapter 2.5 120 Greece - G Germanid
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Chap ter 3.1 Long-term clinical out
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INTRODUCTION Glycyrrhizin for IFN-n
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Statistics Glycyrrhizin for IFN-non
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Glycyrrhizin for IFN-non responders
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Table 2. Time dependent Cox regress
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Cha pter 3.2 Discriminant analysis
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Introduction Discriminant analysis
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Discriminant analysis using a MLMM
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Estimation Discriminant analysis us
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where wi,k(y i, θ) = (k =1,...,K).
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Appendix Discriminant analysis usin
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Cha pter 4 Statistical models of ea
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Chapter 4.1 176 ABSTRACT Nucleoside
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Chapter 4.1 178 at day 1 at t =0 an
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Chapter 4.1 180 Table 1. Baseline c
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Chapter 4.1 182 Figure 1.
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Chapter 4.1 184 Figure 1. Viral dec
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Chapter 4.1 186 suppression in seru
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Chapter 4.1 188 13. Seifer M, Hamat
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Cha pter 4.2 Viral dynamics during
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INTRODUCTION Viral dynamics during
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Viral dynamics during tenofovir the
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log HBV DNA (copies/mL) 10.0 9.0 8.
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Page 211 and 212: Chap ter 4.3 Modelling of early vir
Page 213 and 214: INTRODUCTION HBV viral kinetics dur
Page 215 and 216: HBV viral kinetics during PEG-IFN 2
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Page 233 and 234: SUMMARY AND CONCLUSION Summary and
Page 235 and 236: Summary and conclusion 233 The mode
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Page 239: Summary and conclusion 237 Early st
Page 243 and 244: SAMENVATTING EN CONCLUSIE Samenvatt
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Page 247 and 248: Samenvatting en conclusie 245 Data
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Page 259: BIBLI OGRAPHY Bibliography 257 1. K
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Page 265 and 266: Bibliography 263 Flares in chronic
Page 267 and 268: Bibliography 265 Genetic characteri
Page 269: Bibliography 267 106. Reijnders JG,
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