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Samenvatting en conclusie 248 In een Japans cohort van chronische hepatitis C patiënten die gedurende een lange periode behandeld waren met glycyrrhizine werd de heptocellulair carcinoom vrije periode bestudeerd. Vanwege de cohort structuur van de data werd de G schattingsmethode toegepast. Deze geavanceerde methode biedt een bevredigende oplossing voor het probleem van het schatten van zuivere behandel effecten wanneer de behandeling gegeven wordt op indicatie. Ten behoeve van de vroege termijn respons werd in een pharmacokinetiek model de virusafname in het bloed van chronische hepatitis B patiënten de eerste weken gedurende de behandeling met entecavir, tenofovir en PEG-IFN bestudeerd. Beschikbare mathematische modellen werden herschreven om te gebruiken in het kader van niet-lineaire mixed regressie modellering van herhaalde metingen. De geschatte parameters beschrijven duidelijk het patroon van virusdaling gedurende de eerste 4 weken. Zowel entacavir en tenofovir zijn effectief in het blokkeren van de virusreplicatie. De pharmacokinetiek voor PEG-IFN is meer gecompliceerd. Ondanks de beperkte antivirale activiteit gedurende de eerste weken induceert PEG-IFN een blijvende respons in een aanzienlijk aantal patiënten.
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Statistical Models of Treatment Eff
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ISBN: 978-90-8559-069-9 © Bettina
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PROMOTIECOMMISSIE Promotor: Prof.dr
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CONTENTS Chapter 1. Introduction 11
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Cha pter 1 Introduction
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Chapter 1 14 Epidemiology Worldwide
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Chapter 1 16 Prediction models with
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Chapter 1 18 standard method fails
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Chapter 1 20 The extended non-linea
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Chapter 1 22 References 1. Blumberg
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Cha pter 2 Prediction of response t
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Chapter 2.1 28 ABSTRACT The aim of
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Chapter 2.1 30 been hepatitis B sur
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Chapter 2.1 32 HBV DNA decline The
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Chapter 2.1 34 Figure 2 continued.
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Chapter 2.1 36 Figure 4. Estimated
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Chapter 2.1 38 DNA was observed in
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Chapter 2.1 40 15. Kao JH. Role of
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Chapter 2.2 44 ABSTRACT Background:
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Chapter 2.2 46 low baseline HBV DNA
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Chapter 2.2 48 patient subgroups wa
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Chapter 2.2 50 p=0.002). Previous I
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Chapter 2.2 52 Application of the m
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Chapter 2.2 54 PEG-IFN, the proport
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Chapter 2.2 56 References 1. Lavanc
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Chapter 2.2 58 26. Bonino F, Lau GK
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Chap ter 2.3 Prediction of the resp
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INTRODUCTION Dynamic prediction of
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Statistical analysis Dynamic predic
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Dynamic prediction of response to P
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References Dynamic prediction of re
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Cha pter 2.4 Dynamic prediction of
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INTRODUCTION Dynamic prediction of
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For the indirect approach we rewrit
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logit pi,j = logit Pr(Ri =1|visit =
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Dynamic prediction of response usin
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Table 1. Results of different stopp
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Chapter 2.5 106 ABSTRACT Peginterfe
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Chapter 2.5 108 and placebo daily.
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Chapter 2.5 110 for patients with a
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Chapter 2.5 112 Mean HBV DNA declin
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Chapter 2.5 114 peginterferon and n
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Chapter 2.5 116 hepatocellular carc
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Chapter 2.5 118 13. Werle-Lapostoll
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Chapter 2.5 120 Greece - G Germanid
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Chap ter 3.1 Long-term clinical out
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INTRODUCTION Glycyrrhizin for IFN-n
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Statistics Glycyrrhizin for IFN-non
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Glycyrrhizin for IFN-non responders
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Table 2. Time dependent Cox regress
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Cha pter 3.2 Discriminant analysis
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Introduction Discriminant analysis
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Discriminant analysis using a MLMM
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Estimation Discriminant analysis us
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where wi,k(y i, θ) = (k =1,...,K).
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Appendix Discriminant analysis usin
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Cha pter 4 Statistical models of ea
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Chapter 4.1 176 ABSTRACT Nucleoside
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Chapter 4.1 178 at day 1 at t =0 an
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Chapter 4.1 180 Table 1. Baseline c
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Chapter 4.1 182 Figure 1.
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Chapter 4.1 184 Figure 1. Viral dec
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Chapter 4.1 186 suppression in seru
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Chapter 4.1 188 13. Seifer M, Hamat
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Cha pter 4.2 Viral dynamics during
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INTRODUCTION Viral dynamics during
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Viral dynamics during tenofovir the
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Page 211 and 212: Chap ter 4.3 Modelling of early vir
Page 213 and 214: INTRODUCTION HBV viral kinetics dur
Page 215 and 216: HBV viral kinetics during PEG-IFN 2
Page 229: HBV viral kinetics during PEG-IFN 2
Page 233 and 234: SUMMARY AND CONCLUSION Summary and
Page 235 and 236: Summary and conclusion 233 The mode
Page 237 and 238: Summary and conclusion 235 The infe
Page 239: Summary and conclusion 237 Early st
Page 243 and 244: SAMENVATTING EN CONCLUSIE Samenvatt
Page 245 and 246: Samenvatting en conclusie 243 Er we
Page 247 and 248: Samenvatting en conclusie 245 Data
Page 249: Samenvatting en conclusie 247 Behan
Page 255 and 256: DANKWOORD Dankwoord 253 Met oplucht
Page 257: CUR RICULUM VITAE Curriculum Vitae
Page 260 and 261: Bibliography 258 Mechanical factors
Page 262 and 263: Bibliography 260 35. Wolters LM, Ha
Page 264 and 265: Bibliography 262 Volume Measurement
Page 266 and 267: Bibliography 264 Quantitative HBV D
Page 268 and 269: Bibliography 266 to Peginterferon-a
Page 272: ISBN: 978-90-8559-069-9
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