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Cha pter 4.1 Viral dynamics during and after entecavir therapy in patients with chronic hepatitis B Leonieke M.M. Wolters 1 , Bettina E. Hansen 1,2 , Hubert G.M. Niesters 3 , Deborah DeHertogh 4 , Robert A. de Man 1 Departments of 1 Gastroenterology and Hepatology, 2 Epidemiology and Biostatistics, and 3 Virology, <strong>Erasmus</strong> MC University Medical Center, <strong>Rotterdam</strong>, the Netherlands, 4Bristol Myers Squibb, Wallington, CT, USA Journal of Hepatology 2002; 37:137-144
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Statistical Models of Treatment Eff
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ISBN: 978-90-8559-069-9 © Bettina
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PROMOTIECOMMISSIE Promotor: Prof.dr
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CONTENTS Chapter 1. Introduction 11
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Cha pter 1 Introduction
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Chapter 1 14 Epidemiology Worldwide
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Chapter 1 16 Prediction models with
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Chapter 1 18 standard method fails
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Chapter 1 20 The extended non-linea
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Chapter 1 22 References 1. Blumberg
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Cha pter 2 Prediction of response t
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Chapter 2.1 28 ABSTRACT The aim of
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Chapter 2.1 30 been hepatitis B sur
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Chapter 2.1 32 HBV DNA decline The
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Chapter 2.1 34 Figure 2 continued.
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Chapter 2.1 36 Figure 4. Estimated
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Chapter 2.1 38 DNA was observed in
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Chapter 2.1 40 15. Kao JH. Role of
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Chapter 2.2 44 ABSTRACT Background:
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Chapter 2.2 46 low baseline HBV DNA
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Chapter 2.2 48 patient subgroups wa
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Chapter 2.2 50 p=0.002). Previous I
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Chapter 2.2 52 Application of the m
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Chapter 2.2 54 PEG-IFN, the proport
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Chapter 2.2 56 References 1. Lavanc
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Chapter 2.2 58 26. Bonino F, Lau GK
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Chap ter 2.3 Prediction of the resp
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INTRODUCTION Dynamic prediction of
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Statistical analysis Dynamic predic
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Dynamic prediction of response to P
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References Dynamic prediction of re
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Cha pter 2.4 Dynamic prediction of
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INTRODUCTION Dynamic prediction of
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For the indirect approach we rewrit
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logit pi,j = logit Pr(Ri =1|visit =
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Dynamic prediction of response usin
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Table 1. Results of different stopp
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Chapter 2.5 106 ABSTRACT Peginterfe
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Chapter 2.5 108 and placebo daily.
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Chapter 2.5 110 for patients with a
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Chapter 2.5 112 Mean HBV DNA declin
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Chapter 2.5 114 peginterferon and n
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Chapter 2.5 116 hepatocellular carc
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Chapter 2.5 118 13. Werle-Lapostoll
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Chapter 2.5 120 Greece - G Germanid
Page 127 and 128: Chap ter 3.1 Long-term clinical out
Page 129 and 130: INTRODUCTION Glycyrrhizin for IFN-n
Page 131 and 132: Statistics Glycyrrhizin for IFN-non
Page 133 and 134: Glycyrrhizin for IFN-non responders
Page 135 and 136: Table 2. Time dependent Cox regress
Page 143 and 144: Cha pter 3.2 Discriminant analysis
Page 145 and 146: Introduction Discriminant analysis
Page 147 and 148: Discriminant analysis using a MLMM
Page 149 and 150: Estimation Discriminant analysis us
Page 153 and 154: where wi,k(y i, θ) = (k =1,...,K).
Page 171 and 172: Appendix Discriminant analysis usin
Page 175: Cha pter 4 Statistical models of ea
Page 179 and 180: INTRODUCTION Viral dynamics during
Page 181 and 182: V(t) = V 0 { A exp (-λ 1 t ) + (1-
Page 183 and 184: Table 2. Dynamic parameters during
Page 185 and 186: Figure 1. Viral dynamics during and
Page 187 and 188: Viral dynamics during and after ent
Page 189 and 190: References Viral dynamics during an
Page 191: Viral dynamics during and after ent
Page 194 and 195: Chapter 4.2 192 ABSTRACT Tenofovir,
Page 196 and 197: Chapter 4.2 194 PATIENTS AND METHOD
Page 198 and 199: Chapter 4.2 196 2 Slow: decline bet
Page 200 and 201: Chapter 4.2 198 Table 2. Parameter
Page 202 and 203: Chapter 4.2 200 9.0 8.0 7.0 6.0 5.0
Page 204 and 205: Chapter 4.2 202 release. Although w
Page 206 and 207: Chapter 4.2 204 References 1. Perri
Page 208: Chapter 4.2 206 29. Lewin SR, Ribei
Page 212 and 213: Chapter 4.3 210 ABSTRACT Treatment
Page 214 and 215: Chapter 4.3 212 HBV DNA quantifi ca
Page 216 and 217: Chapter 4.3 214 The resulting model
Page 218 and 219: Chapter 4.3 216 Figure 1. Median HB
Page 220 and 221: Chapter 4.3 218 Table 2: Pharmacoki
Page 222 and 223: Chapter 4.3 220 Figure 3. effects r
Page 224 and 225: Chapter 4.3 222 13-14 This model ta
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Chapter 4.3 224 References 1. Kane
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Chapter 4.3 226 25. Wolters LM, Han
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Cha pter 5 Summary and conclusion
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Summary and conclusion 232 Therapy
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Summary and conclusion 234 who deve
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Summary and conclusion 236 fi t mod
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Cha pter 6 Samenvatting en conclusi
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Samenvatting en conclusie 242 posit
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Samenvatting en conclusie 244 De ve
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Samenvatting en conclusie 246 en na
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Samenvatting en conclusie 248 In ee
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DANKWOORD Dankwoord 253 Met oplucht
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CUR RICULUM VITAE Curriculum Vitae
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Bibliography 258 Mechanical factors
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Bibliography 260 35. Wolters LM, Ha
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Bibliography 262 Volume Measurement
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Bibliography 264 Quantitative HBV D
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Bibliography 266 to Peginterferon-a
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ISBN: 978-90-8559-069-9
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