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Chapter 4.3 226 25. Wolters LM, Hansen BE, Niesters HG, DeHertogh D, de Man RA. Viral dynamics during and after entecavir therapy in patients with chronic hepatitis B. J Hepatol 2002;37:137-44. 26. van der Eijk AA, Hansen BE, Niesters HG, Janssen HL, van de Ende M, Schalm SW, de Man RA. Viral dynamics during tenofovir therapy in patients infected with lamivudine-resistant hepatitis B virus mutants. J Viral Hepat 2005;12:364-72. 27. Colombatto P, Civitano L, Bizzarri R, Oliveri F, Choudhury S, Gieschke R, Bonino F, Brunetto MR. A multiphase model of the dynamics of HBV infection in HBeAg-negative patients during pegylated interferon-alpha2a, lamivudine and combination therapy. Antivir Ther 2006;11:197-212. Acknowledgements In addition to the authors, the HBV 99-01 Study Group includes the following investigators: The Netherlands: H.G.M. Niesters, P.E. Zondervan (Erasmus MC, University Medical Center Rotterdam), B.C.M. Vroom (University Medical Center Utrecht) C.M.J. van Nieuwkerk (VU University Medical Center Amsterdam), R.A. de Vries (Rijnstate Hospital Arnhem), J. Jansen, J.Drenth, S.J.van den Hazel (University Medical Centre Radboud Nijmegen), J.W. den Ouden-Muller (St. Franciscus Hospital Rotterdam), A.C. Tan (Canisius Wilhelmina Hospital Nijmegen); Belgium: D.M. Adler (Hopital Erasme Brussels), P. Michielsen (University Hospital Antwerp), H. van Vlierberghe (University Hospital Gent), F. Nevens (University Hospital Leuven), J. Delwaide (Centre Hospitalier Universitaire Liège), J. Henrion (Hopital de Jolimont, Haine St. Paul); Germany: G.Gerken, S Bein, U. Treichel (University Hospital Essen), J. Trojan (J.W. Goethe Universität Frankfurt), M.P. Manns, J. Hadem (Medizinische Hochschule Hannover), C. Niederau (St. Jozef Hospital Oberhausen); Denmark: M.R. Buhl, I.M. Hansen (Skejby Hospital, Arhus), K. Krogsgaard (Copenhagen University Hospital Hvidovre); Poland: J. Cianciara, J. Jablonska, J Kozlowska (Medical Academy of Warsaw), D. Prokopowicz (Medical Academy of Bialystok), T. Mach (Collegium Medicum UJ Kraków), C. Simon (Medical University Wroclaw); Spain: M. Buti, A. Valdes, R Esteban (Hospital Valle Hebron, Barcelona), M. Rodriguez, M. Garcia Espiga (Hospital Central de Asturias, Oviedo); Italy: A. Andriulli, G. Stornaiulo, G.B. Gaeta (Ospe. Gesù e Maria, Napoli), G. Montalto, F. D’Antona (Università di Palermo); Greece: G.E. Kitis, P. Xiarchos Panagiotis (George Papanikolaou General Regional Hospital,Thessaloniki), N.C. Tassopoulos (West Attica Hospital Athens); Turkey: U.S. Akarca, G. Ersöz (Ege University Faculty of Medicine Izmir), C. Yurdayin, H. Bozkaya (Medical School Cebeci Kampusu Ankara), H. Simsek, Y. Balaban (Hacettepe University Faculty of Medicine Ankara), F. Tabak, H. Senturk (Istanbul University Cerrahpasa Medical School, Istanbul); Israel: Y. Lurie (Sauraski Medical Center Tel-Aviv); Canada:
HBV viral kinetics during PEG-IFN 227 J. Heathcote (Toronto Western Hospital, Toronto); S.V. Feinman (Mount Sinai Hospital Toronto); S. Greenbloom (General Hospital Etobicoke); Indonesia: D.A. Sulaiman (Ciptomangunkusomo Hospital Jakarta); Singapore: R. Guan (Mount Elizabeth Medical Center Singapore); Malaysia: I. Merican (Institute for Medical Research Kuala Lumpur); China: T.M.K. So (Princess Margaret Hospital, Hong Kong). This study was supported in part by the German Network of Competence of Viral Hepatitis Hep-Net (Federal Ministry of Education and Research, BMBF), and the clinical research unit KFO 129 (German Research Foundation, DFG).
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Statistical Models of Treatment Eff
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ISBN: 978-90-8559-069-9 © Bettina
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PROMOTIECOMMISSIE Promotor: Prof.dr
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CONTENTS Chapter 1. Introduction 11
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Cha pter 1 Introduction
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Chapter 1 14 Epidemiology Worldwide
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Chapter 1 16 Prediction models with
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Chapter 1 18 standard method fails
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Chapter 1 20 The extended non-linea
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Chapter 1 22 References 1. Blumberg
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Cha pter 2 Prediction of response t
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Chapter 2.1 28 ABSTRACT The aim of
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Chapter 2.1 30 been hepatitis B sur
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Chapter 2.1 32 HBV DNA decline The
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Chapter 2.1 34 Figure 2 continued.
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Chapter 2.1 36 Figure 4. Estimated
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Chapter 2.1 38 DNA was observed in
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Chapter 2.1 40 15. Kao JH. Role of
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Chapter 2.2 44 ABSTRACT Background:
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Chapter 2.2 46 low baseline HBV DNA
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Chapter 2.2 48 patient subgroups wa
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Chapter 2.2 50 p=0.002). Previous I
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Chapter 2.2 52 Application of the m
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Chapter 2.2 54 PEG-IFN, the proport
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Chapter 2.2 56 References 1. Lavanc
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Chapter 2.2 58 26. Bonino F, Lau GK
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Chap ter 2.3 Prediction of the resp
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INTRODUCTION Dynamic prediction of
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Statistical analysis Dynamic predic
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Dynamic prediction of response to P
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References Dynamic prediction of re
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Cha pter 2.4 Dynamic prediction of
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INTRODUCTION Dynamic prediction of
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For the indirect approach we rewrit
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logit pi,j = logit Pr(Ri =1|visit =
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Dynamic prediction of response usin
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Table 1. Results of different stopp
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Chapter 2.5 106 ABSTRACT Peginterfe
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Chapter 2.5 108 and placebo daily.
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Chapter 2.5 110 for patients with a
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Chapter 2.5 112 Mean HBV DNA declin
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Chapter 2.5 114 peginterferon and n
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Chapter 2.5 116 hepatocellular carc
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Chapter 2.5 118 13. Werle-Lapostoll
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Chapter 2.5 120 Greece - G Germanid
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Chap ter 3.1 Long-term clinical out
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INTRODUCTION Glycyrrhizin for IFN-n
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Statistics Glycyrrhizin for IFN-non
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Glycyrrhizin for IFN-non responders
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Table 2. Time dependent Cox regress
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Cha pter 3.2 Discriminant analysis
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Introduction Discriminant analysis
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Discriminant analysis using a MLMM
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Estimation Discriminant analysis us
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where wi,k(y i, θ) = (k =1,...,K).
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Appendix Discriminant analysis usin
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Cha pter 4 Statistical models of ea
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Page 180 and 181: Chapter 4.1 178 at day 1 at t =0 an
Page 182 and 183: Chapter 4.1 180 Table 1. Baseline c
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Page 186 and 187: Chapter 4.1 184 Figure 1. Viral dec
Page 188 and 189: Chapter 4.1 186 suppression in seru
Page 190 and 191: Chapter 4.1 188 13. Seifer M, Hamat
Page 193 and 194: Cha pter 4.2 Viral dynamics during
Page 195 and 196: INTRODUCTION Viral dynamics during
Page 197 and 198: Viral dynamics during tenofovir the
Page 201 and 202: log HBV DNA (copies/mL) 10.0 9.0 8.
Page 211 and 212: Chap ter 4.3 Modelling of early vir
Page 213 and 214: INTRODUCTION HBV viral kinetics dur
Page 215 and 216: HBV viral kinetics during PEG-IFN 2
Page 227: HBV viral kinetics during PEG-IFN 2
Page 233 and 234: SUMMARY AND CONCLUSION Summary and
Page 235 and 236: Summary and conclusion 233 The mode
Page 237 and 238: Summary and conclusion 235 The infe
Page 239: Summary and conclusion 237 Early st
Page 243 and 244: SAMENVATTING EN CONCLUSIE Samenvatt
Page 245 and 246: Samenvatting en conclusie 243 Er we
Page 247 and 248: Samenvatting en conclusie 245 Data
Page 249 and 250: Samenvatting en conclusie 247 Behan
Page 253: Dan kwoord
Page 256 and 257: Dankwoord 254 Lieve Marion en Margr
Page 259 and 260: BIBLI OGRAPHY Bibliography 257 1. K
Page 261 and 262: Bibliography 259 Interferon-ribavir
Page 263 and 264: Bibliography 261 Long term clinical
Page 265 and 266: Bibliography 263 Flares in chronic
Page 267 and 268: Bibliography 265 Genetic characteri
Page 269: Bibliography 267 106. Reijnders JG,
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