Small Animal Clinical Pharmacology - CYF MEDICAL DISTRIBUTION

PRINCIPLES OF ANTIBACTERIAL THERAPY
Table 8.4 Dosage regimens for antibacterial drugs in dogs and cats
Drug Route Dose
Penicillins
Narrow spectrum
Penicillin G, Na, K IV, IM, SC 20,000–40,000 U/kg q.6–8 h
Penicillin G, procaine IM, SC 20,000 U/kg q.12–24 h
Penicillin G, benzathine IM 40,000 U/kg every 3–5 days
Penicillin V PO 10 mg/kg q.8 h
Antistaphylococcal
Cloxacillin, flucloxacillin PO 10–40 mg/kg q.6–8 h
Dicloxacillin PO 10–40 mg/kg q.8 h
Aminopenicillins
Amoxicillin PO, IV, IM, SC 10–20 mg/kg q.8–12 h
Ampicillin IV, IM, SC, PO 10–20 mg/kg q.6–12 h
Amoxicillin-clavulanate (e.g. Synulox®, Clavulox®) PO, IM, SC 12.5–25 mg/kg q.8–12 h
Antipseudomonal
Carbenicillin IV, IM, SC 50 mg/kg q.6–8 h
Ticarcillin IV, IM, SC 50–75 mg/kg q.6–8 h
Infusion: 15–25 mg/kg given over 15 min, then at constant rate of
7.5–15 mg/kg/h
Ticarcillin-clavulanate (Timentin®) IV Dogs: 40–110 mg/kg IV q.6–8 h
Cats: 40–75 mg/kg IV q.6–8 h
Cephalosporins and cephamycins
First generation
Cefachlor PO 10–25 mg/kg q.8–12 h
Cefadroxil (e.g. Cefa-Tabs®) PO 10–30 mg/kg q.8–12 h
Cefalexin (e.g. Keflex®, Ceporex®) PO Dogs: 20–40 mg/kg q.8–12 h
Cats: 22–50 mg/kg q.8–12 h
Cefazolin IV, IM 10–30 mg/kg q.4–8 h
Cefapirin IV, IM, SC 10–30 mg/kg q.6–8 h
Second generation
Cefotetan IV 30 mg/kg q.6–8 h
Cefoxitin IV, IM, SC 10–30 mg/kg q.6–8 h
Cefuroxime (Zinacef ® ) IV, IM, SC 20–50 mg/kg q.8–12 h
Third generation
Cefixime PO 5–12.5 mg/kg q.12 h
Cefotaxime IV, IM, SC 20–80 mg/kg q.6–8 h
Cefovecin (Convenia®) SC 8 mg/kg (repeated every 14 days depending on indication)
Cefpodoxime proxetil (Simplicef ® ) PO 5–10 mg/kg q.12–24 h
Ceftazidime IV, IM 20–50 mg/kg q.8–12 h
Ceftiofur (Naxcel ® ) SC 2.2–4.4 mg/kg q.12–24 h
Ceftriaxone IV, IM 15–50 mg/kg q.12–24 h
Third generation antipseudomonal
Cefoperazone IV, IM 22 mg/kg q.6–12 h
Aminoglycosides
Amikacin IV, IM, SC 10 mg/kg q.8 h
Gentamicin IV, IM, SC 6 mg/kg q.24 h
Neomycin PO 10 mg/kg q.6 h
Streptomycin
PO
IM, SC
20 mg/kg q.6 h
10 mg/kg q.12 h
Tobramycin IV, IM, SC 1–2 mg/kg q.8 h
Fluoroquinolones
Ciprofloxacin PO 5–15 mg/kg q.12 h
Difloxacin PO 5–10 mg/kg q.24 h
Enrofloxacin PO, IM, SC Dogs: 2.5–10 mg/kg q.12 h
Cats: 2.5–5.0 mg/kg q.12 h
Ibafloxacin PO 2–5 mg/kg q.24 h
Norfloxacin PO 5–20 mg/kg q.12 h
Marbofloxacin PO 2.75–5.5 mg/kg q.24 h
Orbifloxacin PO 2.5–7.5 mg/kg q.24 h
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