Small Animal Clinical Pharmacology - CYF MEDICAL DISTRIBUTION

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APPENDIX: PARASITES OF DOGS AND CATS Parasite* Polysystemic Leishmania braziliense (prot) (d) Leishmania chagasi (prot) (d) Leishmania infantum (prot) (d) Neospora caninum (prot) (d) Sarcocystis spp (prot) (d,c) Toxoplasma gondii (prot) (c) Toxoplasma gondii (prot) (d) Serous cavities Dioctophyma renale (nem) (d) Acanthocheilonema (Dipetalonema) dracunculoides (nem) (d) Mesocestoides spp (cest) (d,c) Spirometra spp (cest) (d,c) Taenia crassiceps (cest) (d) Potential sources of infection Vector borne (sandflies: Lutzomyia spp) Vector borne (sandflies: Lutzomyia spp) Vector borne (sandflies: Phlebotomus spp) Public health significance Signal (mucocutaneous leishmaniasis) Signal Dog is reservoir host (visceral leishmaniasis) Signal Dog is reservoir host (infantile visceral leishmaniasis, adult infection in the immunocompromised) Treatment options in dogs and cats Pentavalent antimonials, allopurinol, amphotericin B, paromomycin Pentavalent antimonials, allopurinol, amphotericin B, paromomycin Pentavalent antimonials, allopurinol, amphotericin B, paromomycin IH (herbivore), TP Unknown No rigorous study, but expect T. gondii regimens to be similarly effective IH (bradyzoites in tissues of mammals, birds) TP, TM (tachyzoites) FO (sporozoites), PH (e.g. cockroaches) IH, FO, TP IH (metacestode in any vertebrate) FO (esp. fox feces), ingestion of infected rodents Food borne, water borne Ingestion of sporozoites from cat feces. Main risk factor in pregnancy: inadequately cooked or cured meat Signal (no direct transmission, unless dog consumed by human) Signal Systemic: clindamycin, doxycycline, sulfonamide + trimethoprim or pyrimethamine Enteric: above, toltrazuril, monensin Clindamycin, doxycycline, sulfonamide + trimethoprim or pyrimethamine Metacestocide: fenbendazole Praziquantel + mebendazole Comments New World leishmaniasis. Recurrence of infection after treatment usual New World leishmaniasis. Recurrence of infection after treatment usual Old World leishmaniasis. Recurrence of infection after treatment usual Significant cause of abortion in cattle See Small intestine Cat is only definitive host. No correlation between cat ownership and human infection. Excreted oocysts not infective for 24 h and very resistant to environmental conditions Extraintestinal infection only Rarely, adults found free in peritoneal cavity. See Urogenital system Adults in peritoneal cavity. For microfilaria, see Skin Metacestodes can populate peritoneal cavity and multiply asexually to enormous numbers. See also Small intestine Proliferative sparganosis within peritoneal cavity. See Small intestine Signal (Praziquantel) Metacestode infection (cysticercosis) of skin and peritoneal and thoracic cavities. 259
CHAPTER 10 ANTIPARASITIC DRUGS Parasite* Potential sources of infection Public health significance Treatment options in dogs and cats ABBREVIATIONS d dog IH intermediate host HGE human granulocytic BZs benzimidazoles c cat PH paratenic host ehrlichiosis OPs organophosphates nem nematode FO fecal–oral VLM visceral larva migrans SPs synthetic pyrethroids cest cestode TM transmammary CLM cutaneous larva MLs macrocyclic lactones migrans trem trematode TP transplacental OLM ocular larva migrans IGRs insect growth regulators phth phthirapteran SP skin penetration CE cystic echinococcosis DEC diethyl carbamezine (louse) ix ixodid tick L3 third stage larvae AE alveolar echinococcosis prot protozoan RMSF Rocky Mountain spotted fever ( ) suggestion only, drug not thoroughly tested for this indication 260
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An imprint of Elsevier Limited © E
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CONTRIBUTORS Matthias J Kleinz Depa
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Dedication To Tom, Rosalind and Jim
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CHAPTER 1 PRINCIPLES OF CLINICAL PH
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CHAPTER 2 CLINICAL PHARMACOKINETICS
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CHAPTER 3 ADVERSE DRUG REACTIONS Un
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CHAPTER 3 ADVERSE DRUG REACTIONS
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CHAPTER 4 THE PHARMACOLOGY OF THE A
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CHAPTER 5 ANESTHETIC AGENTS However
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CHAPTER 5 ANESTHETIC AGENTS Table 5
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CHAPTER 5 ANESTHETIC AGENTS doses.
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CHAPTER 5 ANESTHETIC AGENTS concent
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CHAPTER 5 ANESTHETIC AGENTS X R 3 C
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CHAPTER 5 ANESTHETIC AGENTS Emergen
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CHAPTER 5 ANESTHETIC AGENTS inhalat
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CHAPTER 5 ANESTHETIC AGENTS and enh
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CHAPTER 5 ANESTHETIC AGENTS ● Exc
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CHAPTER 5 ANESTHETIC AGENTS Pharmac
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CHAPTER 5 ANESTHETIC AGENTS Central
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CHAPTER 5 ANESTHETIC AGENTS Table 5
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CHAPTER 5 ANESTHETIC AGENTS FURTHER
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CHAPTER 6 SEDATIVES ● noradrenali
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CHAPTER 6 SEDATIVES treatment, with
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CHAPTER 6 SEDATIVES Benzodiazepines
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CHAPTER 6 SEDATIVES It is not misci
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CHAPTER 6 SEDATIVES respectively. H
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CHAPTER 6 SEDATIVES Table 6.1 Sugge
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7 Behavior-modifying drugs Kersti S
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CHAPTER 7 BEHAVIOR-MODIFYING DRUGS
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8 Antibacterial drugs Jill E Maddis
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CHAPTER 8 ANTIBACTERIAL DRUGS phary
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CHAPTER 8 ANTIBACTERIAL DRUGS dose
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CHAPTER 8 ANTIBACTERIAL DRUGS Table
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CHAPTER 8 ANTIBACTERIAL DRUGS Bacte
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CHAPTER 8 ANTIBACTERIAL DRUGS Antis
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CHAPTER 8 ANTIBACTERIAL DRUGS Teico
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CHAPTER 8 ANTIBACTERIAL DRUGS forms
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CHAPTER 8 ANTIBACTERIAL DRUGS ● I
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CHAPTER 8 ANTIBACTERIAL DRUGS ● R
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CHAPTER 8 ANTIBACTERIAL DRUGS RIFAM
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9 Systemic antifungal therapy Josep
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CHAPTER 9 SYSTEMIC ANTIFUNGAL THERA
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10 Antiparasitic drugs Stephen W Pa
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CHAPTER 10 ANTIPARASITIC DRUGS ●
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CHAPTER 10 ANTIPARASITIC DRUGS Tabl
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Page 275 and 276: 12 Immunomodulatory therapy Michael
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CHAPTER 14 OPIOID ANALGESICS inflam
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A Agonist opioid (morphine) B Parti
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CHAPTER 14 OPIOID ANALGESICS admini
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CHAPTER 14 OPIOID ANALGESICS Small
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CHAPTER 14 OPIOID ANALGESICS Clinic
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CHAPTER 14 OPIOID ANALGESICS Contra
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CHAPTER 14 OPIOID ANALGESICS respon
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CHAPTER 14 OPIOID ANALGESICS Advers
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CHAPTER 14 OPIOID ANALGESICS Advers
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15 Cancer chemotherapy Jane M Dobso
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CHAPTER 15 CANCER CHEMOTHERAPY to m
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CHAPTER 15 CANCER CHEMOTHERAPY curr
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CHAPTER 15 CANCER CHEMOTHERAPY Tabl
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CHAPTER 15 CANCER CHEMOTHERAPY Clin
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CHAPTER 15 CANCER CHEMOTHERAPY sion
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CHAPTER 15 CANCER CHEMOTHERAPY Form
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CHAPTER 15 CANCER CHEMOTHERAPY ●
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CHAPTER 15 CANCER CHEMOTHERAPY Phar
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CHAPTER 15 CANCER CHEMOTHERAPY best
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CHAPTER 15 CANCER CHEMOTHERAPY Form
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CHAPTER 15 CANCER CHEMOTHERAPY D-MA
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CHAPTER 16 ANTICONVULSANT DRUGS sei
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CHAPTER 16 ANTICONVULSANT DRUGS Kno
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17 Drugs used in the management of
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CHAPTER 17 DRUGS USED IN THE MANAGE
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CHAPTER 19 GASTROINTESTINAL DRUGS C
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CHAPTER 19 GASTROINTESTINAL DRUGS
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CHAPTER 21 DRUGS USED IN THE TREATM
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23 Drugs and reproduction Philip G
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CHAPTER 23 DRUGS AND REPRODUCTION I
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CHAPTER 23 DRUGS AND REPRODUCTION F
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CHAPTER 23 DRUGS AND REPRODUCTION C
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CHAPTER 23 DRUGS AND REPRODUCTION M
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CHAPTER 23 DRUGS AND REPRODUCTION n
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CHAPTER 23 DRUGS AND REPRODUCTION E
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24 Topical dermatological therapy R
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CHAPTER 24 TOPICAL DERMATOLOGICAL T
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CHAPTER 25 OCULAR CLINICAL PHARMACO
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Index A α-adrenergic receptors 70,
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INDEX Antiplatelet drugs 456-457 pi
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INDEX Ceftazidime 168 Ceftiofur 166
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INDEX Drug receptors 4-8 Drug-drug
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INDEX Hepatic excretion 33 Hepatic
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INDEX Metabolism dogs vs cats 47 an
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INDEX Pentazocine 319, 327 Pentobar
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INDEX Semicarbazone 230 Septic arth
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