Small Animal Clinical Pharmacology - CYF MEDICAL DISTRIBUTION

REFERENCES
Known drug interactions
● Concurrent use of progestins may reduce the
efficacy of prostaglandins.
● Concurrent use of other ecbolic agents (e.g.
oxytocin) may have additional myotonic effects.
MISCELLANEOUS DRUGS
Methylergometrine
Oral methylergometrine maleate (0.5 mL PO, q.8 h)
has been proposed as an adjuvant therapy in cases of
moderate uterine hemorrhage, for example after
parturition.
In women, it displays a uterotonic effect, probably via
a stimulation of myometrial α-adrenergic receptors. Its
action remains effective for 4–6 h.
This drug should not be used with sympathomimetics,
ergotamine or dopaminergic drugs. No adverse
effect has been observed with the concomitant use of
oxytocin. It should not be given during pregnancy.
Phenylpropanolamine
Phenylpropanolamine, an α-adrenergic compound commonly
used to treat urinary incontinence in spayed
bitches, has been proved to be effective in cases of
retrograde ejaculation in infertile male dogs. The dose
is 2 mg/kg q.24 h PO for 5 consecutive days or 3 mg/kg
twice daily orally. The onset of action may take several
days. Adverse effects may include restlessness, aggressiveness,
irritability and hypertension.
Aromatase inhibitors
Aromatase inhibitors, such as formestane, exert an antiandrogenic
effect by inhibiting the conversion of testosterone
to estradiol 17β in peripheral tissues.
Recently, some of these compounds (4-androsten-4-
ol-3,17-dione) have been successfully used experimentally
to improve spermatogenic function in
oligozoospermic and azoospermic dogs.
REFERENCES
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