Small Animal Clinical Pharmacology - CYF MEDICAL DISTRIBUTION

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INDEX Flumazenil 120 and propoxur 221 Flumethasone (Flumetasone) 262 Flumethrin 236 Flunixin meglumine 287, 300 ocular therapy 563 Fluocinolone acetonide 555 5-fluorouracil 9, 336, 359–360 Fluoroquinolones 9, 151, 155, 180–183 antiprotozoal 240 ocular therapy 565–566 Fluoxetine 138–140 Flurazepam 134–136, 135 Flurbiprofen 558 Flutamide 539–540 Fluticasone propionate 462–463 Fluvoxamine 138–140 Follicle-stimulating hormone (FSH) 528, 531, 532 Follow-up 25 Food–drug interactions 15–16 oral antibacterials and feeding 154 Formamidines 224–225 Formestane 543 Formulation, food–drug interaction 16 Framycetin 172 FSH see Follicle-stimulating hormone Fungal cell wall synthesis inhibitors 196 Furazolidone 156, 185, 238, 243 Furosemide 9, 390–393 adverse effects 49, 50, 55, 392–393 clinical applications 390 drug interactions 168, 393 formulations and dose rates 384, 386, 391–392 in hypercalcemia 505 mechanism of action 390–391 pharmacokinetics 392 special considerations 393 Fusidic acid 564, 566 G G protein-coupled receptors (GPCR) 8 adrenergic receptors 70, 121 amitraz action 224 cholinergic receptors 66 emodepside action 204, 214 neurotransmitter actions 62 opioid receptors 310 GABA (γ-aminobutyric acid) and behavior 128–129 and benzodiazepines 134 mediated inhibition 98 receptors 9, 63, 96, 101–102, 118 sedative action 114, 118 Gabapentin 368, 378 Ganglion blockers 67 Gastric acid 16, 30 Gastric adaptation, NSAIDs 295 Gastric dissolution, food–drug interactions 15 Gastric emptying 29–30 food–drug interactions 15 Gastric pH 15, 16 Gastric ulceration, NSAIDs 294–296 Gastrin releasing peptide (GRP) 63 Gastrointestinal drugs 469–497 antidiarrheal 487–490 antiulcer 477–483 appetite stimulants 490–491 combinations 483 emetics 496–497 Helicobacter species eradication 483 laxatives, enemas and bowel cleansers 485–486 prokinetic 483–485 see also Antiemetics Gastrointestinal tract (GIT) absorption 29–30 cytotoxic agents 333 drug interaction mechanisms 17 muscarinic receptors 476 opioid effects 321 serotonin (5-hydroxytryptamine) receptors 470, 471 Gated ion channels 7 Gemcitabine 360 Genetics, influence on pharmacokinetics 19, 53–54 Gentamicin 172–173 adverse effects combination therapy 45 nephrotoxicity 152 ocular therapy 564, 565 therapeutic drug monitoring (TDM) 37 Gingivitis, antibacterial drug choice 153 Glaucoma therapy 558, 570–571 Glucocorticoids 261–265 adjunctive treatments antibacterials 156–157 antihistamines 267 adverse effects 264 anti-inflammatory effects 261–262 clinical applications 263 contraindications and precautions 265 examples 262–263 formulations and dose rate 263–264 immune system effects 262 known drug interactions 265 mechanism of action 263 metabolic effects 261 pathophysiology 261–262 pharmacokinetics 264 receptor 9 treatment hypercalcemia 505 otitis externa 555 see also Corticosteroids; Steroids α-glucosidase inhibitors 515 Glucuronidation 32, 47, 48, 51 Glutamate 114 Glutamate receptor 9 Glycine 114 Glycopeptides 169–170 P-glycoprotein (P-gp) 54 drug transport 28, 29, 210, 211 gene mutation and pharmacogenomics 19, 54, 212, 337, 473, 475 resistance by drug efflux 212, 333 CGMP 65, 458 Gold 276–277 Gonadotropin-releasing hormone (GnRH) 528, 529–531 Gonadotropins 531–532 Good <strong>Clinical</strong> Practice (GCP) code 21 Good Laboratory Practice (GLP) code 21 Good Manufacturing Practice (GMP) code 21 Granisetron 475 Granulocyte colony-stimulating factor (G-CSF) 282–283 Griseofulvin 194–195 adverse effects 49, 50, 194 clinical applications 194 contraindications and precautions 194 drug interactions 194–195 formulations and dose rates 194 mechanism of action 194 pharmacokinetics 194 Guaifenisin 467 H H 1 -receptor blockers 266 H 2 -receptor blockers 478–479 Half-life 2–3, 34, 38–39 NSAIDs 295 Haloperidol 131 and fluoxetine, interaction 140 Halothane 89–90 adverse effects 51, 90 clinical applications 89 contraindications and precautions 90 drug interactions 90 pharmacokinetics 89–90 hCG 531 Heart failure 380–387 backward (WET) 381, 385–386 causes 381 forward (COLD) 381–386 new/experimental drugs 423–424 preclinical 386–387 Helicobacter species eradication 483 Hematology cytotoxic agents 333 NSAIDs 296–297 Hemoglobin 48 Henry’s law 85 Heparin caution/avoidance in renal and hepatic disease 53 drug interactions 454 low molecular weight (LMWH) 455 unfractionated 453–455 Hepatic disease 36, 52, 53 management 491–496 Hepatic enzymes see Cytochrome P450/CYP enzymes; Enzyme induction; Enzyme inhibition 581
INDEX Hepatic excretion 33 Hepatic extraction 50–51 Hepatic shunting 50–51 Hepatotoxicity 51–52 inhalational anesthesia 88 NSAIDs 296 Hetacillin 162–163 Hexachlorophene 47 Hexamethonium 65, 67 Histamine release, opioid analgesics 315, 321 sedative action 114 Histamine receptor antagonists 8, 478–479 Hormones, behavior modification 142–143 5-HT see Serotonin 5-HT 2A antagonists 517 5-HT 3 agonists 484 antagonists 475 5-HT 4 agonists 484 Hyaluronic acid (HA) 306–307 Hydralazine 384, 403, 405–407 Hydrochlorothiazide 384, 386, 393–394 Hydrocodone 133 Hydrocodone tartrate 464–465 Hydrocortisone 263, 525 antipruritic therapy 553–554 ocular therapy 561 Hydrocortisone sodium succinate (HSS) 524–525 5-hydroxytryptamine see Serotonin (5-HT) Hydroxycarbamide (hydroxyurea) 336, 363–364 Hydroxyl daunorubicin see Doxorubicin Hydroxynaphthoquinone 238 Hydroxyquinoline 238 Hydroxyzine 129–130 Hyoscine 68 and dipyrone 483 Hyperadrenocorticism 517–524 Hypercalcemia 504 treatment 505–506 diuretics 505 glucocorticoids 505 IV fluids 505 Hyperosmotic laxatives 486 Hypersensitivity antibacterials 149–150 sulfonamides 149, 152 Type B adverse drug reactions (ADRs) 41, 55–56 Hypertension 67 Hyperthyroidism 499 Hypertrophic cardiomyopathy 383 Hypnotics see Sedatives Hypoadrenocorticism 524–527 Hypocalcemia 504–505 treatment 507–508 Hypotension 407 Hypothalamic-pituitary axis, drugs acting on 517–519 Hypothyroidism 499 582 I Ibuprofen 304 adverse effects 297, 304 Idarubicin 336 and epirubicin 352 Idoxuridine, ocular therapy 568 Ifosfamide 336, 344 Imidacloprid 203, 206, 222, 228 Imidazole carboxamide see DTIC chemotherapy Imidazoles 189 adverse effects 51 mechanism of action 190 ocular therapy 567 Imidocarb dipropionate 237 Imipenem 168 Imipenem-cilastin 168 Imipramine 136–138 Immune complex deposition 150 Immune complex formation 55 Immune response genes 54 Immune system effects of glucocorticoids 262 Immunoglobulins 466 intravenous 277 Immunomodulatory therapy 270–286 future 285 pathophysiology 270 Immunoregulin 280 Immunostimulatory drugs 279–285 Immunosuppressive drugs 270–279 ocular therapy 563 Indoleamines 128 Indometacin (indomethacin) articular cartilage injury 297 and copper indometacin (indomethacine) 300–301 Infectious tracheobronchitis, antibacterial drug choice 153 Infiltrative block 110 Information sources 10–11 Inhalational administration 30 Inhalational anesthetics adverse effects 87–88 see also named drugs agents 89–95 anesthetic potency: minimum alveolar concentration 87 chemical structure 84 clinical applications 83 hazards 88–89 metabolism and elimination 87 physical properties 84–86 solubility 85–86 vapor pressure 84–85 physiological principles 83–84 rate of change of anesthetic depth 86–87 Injectable anesthetics 95 administration guidelines 97 adverse effects 97 see also named drugss agents 97–108 chemical structure 96 mechanism of action 96–97 pharmacokinetics 96 physical properties 96 Inodilators 398–402, 411 Inositol 1,4,5-triphosphate (ITP) 458–459 Inotropy, pimobendan 399 Insect growth regulators/development inhibitors (IGR/IDI) 225–226 Inspired concentration of inhalational anesthesia 86 Instructions to client, prescribing principles 25 Insulin 509–510 classes 510–512 deficiency 509–515 glargine 512 isophane 510–11 neutral/soluble 510 lente 511 Lispro 510 protamine zinc 511 receptor 9 ultralente 511–512 Interferon 568 Interferon-α 283 Interferon-ω 283–284 Interleukin-2 284 Intermittent intravenous bolus, opioids 316 Interpleural blockade 110 Intestinal mucosal enzyme activity 15 Intra-arterial administration 30–31 Intra-articular analgesia 110 Intra-articular morphine 317 Intra-ocular pressure (IOP) see Glaucoma Intramuscular administration 30 Intraoperative uses of opioids 316 Intrathecal administration 30 opioids 316–317 Intravenous administration 30 Intravenous immunoglobulins 277 Iodine 552–553 stable 503 see also Povidone-iodine Ion channels 7, 9 Ipecac syrup 496–497 Ipodate 503 Ipratropium 68–69 Irbesartan 422 Isoflurane 89, 90–91 Isophane insulin 510–511 Isoprenaline (isoproterenol) 452 Isopropamide 68, 475–476 Isosorbide mononitrate/dinitrate 409–410 ITP (inositol 1,4,5-triphosphate) 458–459 Itraconazole 189, 191–192 adverse effects 191, 192 ocular therapy 567 pharmacokinetics 190 Ivermectin 211–212, 280 adverse effects 45, 54, 211–212, 280 clinical applications antiparasitic 211–212 immunoregulatory 280
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An imprint of Elsevier Limited © E
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CONTRIBUTORS Matthias J Kleinz Depa
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Dedication To Tom, Rosalind and Jim
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CHAPTER 1 PRINCIPLES OF CLINICAL PH
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CHAPTER 2 CLINICAL PHARMACOKINETICS
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CHAPTER 3 ADVERSE DRUG REACTIONS Un
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CHAPTER 3 ADVERSE DRUG REACTIONS
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CHAPTER 4 THE PHARMACOLOGY OF THE A
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CHAPTER 5 ANESTHETIC AGENTS However
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CHAPTER 5 ANESTHETIC AGENTS Table 5
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CHAPTER 5 ANESTHETIC AGENTS doses.
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CHAPTER 5 ANESTHETIC AGENTS Pharmac
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CHAPTER 5 ANESTHETIC AGENTS Central
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CHAPTER 5 ANESTHETIC AGENTS Table 5
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CHAPTER 5 ANESTHETIC AGENTS FURTHER
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CHAPTER 6 SEDATIVES ● noradrenali
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CHAPTER 6 SEDATIVES treatment, with
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CHAPTER 6 SEDATIVES Benzodiazepines
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CHAPTER 6 SEDATIVES It is not misci
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CHAPTER 6 SEDATIVES respectively. H
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CHAPTER 6 SEDATIVES Table 6.1 Sugge
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7 Behavior-modifying drugs Kersti S
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CHAPTER 7 BEHAVIOR-MODIFYING DRUGS
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8 Antibacterial drugs Jill E Maddis
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CHAPTER 8 ANTIBACTERIAL DRUGS phary
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CHAPTER 8 ANTIBACTERIAL DRUGS dose
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CHAPTER 8 ANTIBACTERIAL DRUGS Table
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CHAPTER 8 ANTIBACTERIAL DRUGS Bacte
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CHAPTER 8 ANTIBACTERIAL DRUGS lacta
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CHAPTER 8 ANTIBACTERIAL DRUGS Antis
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CHAPTER 8 ANTIBACTERIAL DRUGS RIFAM
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9 Systemic antifungal therapy Josep
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CHAPTER 9 SYSTEMIC ANTIFUNGAL THERA
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10 Antiparasitic drugs Stephen W Pa
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CHAPTER 10 ANTIPARASITIC DRUGS ●
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CHAPTER 10 ANTIPARASITIC DRUGS Tabl
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CHAPTER 10 ANTIPARASITIC DRUGS leva
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CHAPTER 10 ANTIPARASITIC DRUGS ●
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CHAPTER 10 ANTIPARASITIC DRUGS 62.5
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CHAPTER 11 GLUCOCORTICOSTEROIDS AND
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12 Immunomodulatory therapy Michael
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CHAPTER 12 IMMUNOMODULATORY THERAPY
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CHAPTER 13 NONSTEROIDAL ANTI-INFLAM
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CHAPTER 14 OPIOID ANALGESICS inflam
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A Agonist opioid (morphine) B Parti
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CHAPTER 14 OPIOID ANALGESICS Small
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CHAPTER 14 OPIOID ANALGESICS Clinic
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CHAPTER 14 OPIOID ANALGESICS Advers
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CHAPTER 14 OPIOID ANALGESICS Advers
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15 Cancer chemotherapy Jane M Dobso
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CHAPTER 15 CANCER CHEMOTHERAPY to m
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CHAPTER 15 CANCER CHEMOTHERAPY curr
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CHAPTER 15 CANCER CHEMOTHERAPY Tabl
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CHAPTER 15 CANCER CHEMOTHERAPY Clin
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CHAPTER 15 CANCER CHEMOTHERAPY sion
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CHAPTER 15 CANCER CHEMOTHERAPY best
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CHAPTER 15 CANCER CHEMOTHERAPY Form
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CHAPTER 15 CANCER CHEMOTHERAPY D-MA
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CHAPTER 16 ANTICONVULSANT DRUGS sei
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CHAPTER 16 ANTICONVULSANT DRUGS bit
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17 Drugs used in the management of
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CHAPTER 17 DRUGS USED IN THE MANAGE
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CHAPTER 19 GASTROINTESTINAL DRUGS C
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CHAPTER 19 GASTROINTESTINAL DRUGS
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CHAPTER 19 GASTROINTESTINAL DRUGS F
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CHAPTER 19 GASTROINTESTINAL DRUGS Z
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CHAPTER 19 GASTROINTESTINAL DRUGS
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CHAPTER 21 DRUGS USED IN THE TREATM
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23 Drugs and reproduction Philip G
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Page 547 and 548: CHAPTER 23 DRUGS AND REPRODUCTION E
Page 551 and 552: 24 Topical dermatological therapy R
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Page 563 and 564: CHAPTER 25 OCULAR CLINICAL PHARMACO
Page 579 and 580: Index A α-adrenergic receptors 70,
Page 581 and 582: INDEX Antiplatelet drugs 456-457 pi
Page 583 and 584: INDEX Ceftazidime 168 Ceftiofur 166
Page 585: INDEX Drug receptors 4-8 Drug-drug
Page 589 and 590: INDEX Metabolism dogs vs cats 47 an
Page 591 and 592: INDEX Pentazocine 319, 327 Pentobar
Page 593 and 594: INDEX Semicarbazone 230 Septic arth
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Small Animal Clinical Pharmacology - CYF MEDICAL DISTRIBUTION

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