Chapter-1 / Physiological Foundations - WHNLive Public Library

ventieFig. 112 pH decrease between the arteriand venous ends of the capillaries in tiwith severe 02 deficiencyAn approximation of the connection betweenthe tissue pH measured at a certain capillarydistance r, and the pH level at the venous endof capillaries in glycolyzing tissue, also calculated according to [140], can be found .Fig. Ill.1.4.6 Reduction in the microcirculation of the bloodThe lowest pH level in the capillaries of thetissue area with O 2 deficiency always exists, ascan be seen from Figs 110 and 112, at theirvenous end, where the lactic acid formed byglycolysis in the intercapillary space flows away[140]. A further reduction of this lowered level,roughly over the whole length of the capillaries,occurs, according to the preceding paragraph, inlarger tissue areas affected by O 2 deficien(V = 10 mm 3 ). Then there exist conditiowhich result in a drastic deterioration in themicrocirculation of the blood in O 2 deficienttissue (cf. Figs 1 and 75), and thereby and a ­cumulation of lactic acid. The physiologicalfoundations for this have been given in detailabove, particularly in Paragraphs 1.1.1 and1.2.1.1.4.7 Triggering of the non-specific mesenchyme reaction02 deficiency is one of the sclerogenous noxaewhich trigger the non-specific mesenchymereaction discovered and described by Hauss[] 72, ] 94]. It can even be ascertained from ourinvestigations (Paragraph 1.] .8.2) that most ofthe sclerogenous noxae in Table 11 cause O 2deficiency (example Fig. 34) or contribute toit. The mesenchyme reaction must therefore beadded to the consequences of O 2 deficiency inthe organism which often intrude deep intohuman life, as it instigates the process ofarteriosclerosis, which has serious consequences,and, according to speculative ideas, thereaction co ld also be involved in the emergenceof ~lterations in the lung function parametersafter noxae and physical exertion, or02MT in the framework of the cellular vesselwall switching mechanism (swelling of the capillaryendothelial cells in O 2 deficiency, Fig. 2).The reactivity of the cells included under thenotion of me enchyme cells (e.g. endothelialcelis of the vascular intima, fibroblasts, fibrocyte, pericytes, smooth mu de cell of thva cular m dia etc.) exceed that of all oth r. cells of our organism in many respects.factors compiled in Table 11 lead to the amprocess, i. e. the mesenchyme reaction. In thaorta wall, as example Fig. 113 shows t'reaction can proceed within approximatel90 min after the impact of a strong sclerogenousnoxa. In the endothelial cells of thcapillaries (smaller volume involved) threaction rate should be near to 10 min ac ortiingto our findings with the 15 min O 2quick procedure. The incorporation of thmesenchyme, e.g. into the aorta wall i folIo ­ed by the incorporation of lipid but onl afa delay of approximately 6 h. The t nt. the triggered incorporation of the me n h minto the vessel wall, and the quantit f thinitially gradually gath ring d p iti n pr·ducts, depend on the tr ngth and durati nthe cl rogenou irritation. Thu th d r·mine wh th r or not th urring h n intructur hould b d m d a path 1Th tm tural hang in th 1 11 u u 11r gr aft r th 1 r nou influ nfad d away (r v ibl ph' . If howl~ve