Chapter-1 / Physiological Foundations - WHNLive Public Library

IonsFig. 74 Histological pictures showing the successful selective segregation of a cancer tissue (OS carcinosarcoma of radfrom the circulation through uniform triggering of irreversible hemostasis with the aid of extreme overacidification+ 42.5 °c local hyperthermia and further measures of the cancer multistep therapy concept. The blood vessels areexpanded and obstructed (B) (trichrome staining according to Goldner, green filter)1.2.2 Cancer multistep therapy (CMT) and oxygen multistep therapy (02MT),The central therapeutic mechanism in the CMTis the selective irreversible closure ofthe vesselsof the tumor growing in the body [22,23, 129).This new method, used by us clinically withsuccess for the first time in 1979, is fascinatingfor many reasons because:1. due to the vascular obstruction, a segregationof the cancer tissue from the circulationof the organism occurs; thus the toxic strainon the circulation due to the sudden inundationby tumor degradation products iseliminated and at the same time the dangerof internal bleeding is reduced.2. the direct therapy target is not only formedby the cancer cells with their enormousvariation in cell kinetic parameters, but additionallyand mainly by the blood andvessel wall cells with their greater uniformity.3. there exists justified hope that a universaltherapy principle will be achieved, with individualarrangements in terms of tumorhistology, vessel architecture, host tissue,stage and localization of the tumor, as allsolid tumors are nourished via the bloodve els and must perish when these vesselsare ob tructed.It i understandable that our ideas about thechani m of capillary/post-capillary va cularCMT research. Figure 7S gives a summary ofthe new ideas developed in close co-operationwith P.G. Reitnauer. We know today that boththe formation of pores and the aggregation ofred cells are favored by pH reduction. Comparedwith the course of the same mechanismin myocardiac infarction or inflammation [30]for example, the difference in CMT lies in thefact that the adjuvant step of local hyperthermiaof 42-43 °c is necessary for the triggeringof hemostasis, and to enable the contributionof endothelial swelling and red cell aggregationto become fully effective. This is obviousl aspecific characteristic of the cancer tissue capillaries(known to be previously dilated).In our research to optimize the selective as u­lar occlusion, many series of experiments recarried out, partly also on the basis of SURgestions kindly given to us by numerou colleaguesNone of these efforts met with radical uOne idea presented it elf at the beginn'1982 from the 02MT re arch ith hcovery of the bioenergetically c ntr 11 d ceUllllarwall switching me hani m and fr m .micro copic inv tigation: th 1concrete mea ure to increa th procclu ion th id of interruptition for a time at the start of thregional hyperth rmia pluu