Chapter-1 / Physiological Foundations - WHNLive Public Library

Basic mechanisms and functionsOr flON to set740 r--r---"--~--+-----r-­ IfPa130 t-----+--18{"allure rote as top02-ortincrease, roughly~20%120 t------1--~,.--t7=----+_-~+_--.J.76~33%170 t----i.-~\)/ 0t~· \)~ ,ff\c1Ir--~-I---+-t~~~ 5~\~\(,IIF-----+---I-~.~t\~ {1·;-l--'1.-01-.-.14---+---+120< ?J ••v.... ----If---------I1 60 0'-100%/~~\S ~ *.Q •• iOO~er 1)• ~ •• •·MaiO 570 t-----oO ~ • •• ell•· Heasuremenl 20milS after• :~. slartof~-Innalation60 t-I--+-----+--------j~---+----+----1-850 ......__~__.l--__~_--l.__--l.__......1o 1 2 3 4 5 6 {mirr'Oz-flow-......~~10Fig.49 Improvement of the pul·monary diffusion/perfusion systemof a normal person (NP)aged 53 with the increasing numberof treatment hours, exemplifiedby the P02 ' at rest, as-illtfunction of the U2 flow duringtreatment in dependence on thetreatment time1 Treatment not indicated forthese types of patientsA P02-art responder is an individual in whom,after 02MT, the P02-art under resting conditionsis measured at more than 5 mmHg(0.67 kPa) higher than before 02MT. Atherapy nonresponder is a person in whomthis increase is not achieved. The non-responder rate is the proportion (in per cent)of patients without respon e among the totalnumber of individuals in the group underconsideration. Corre pondingly, the responderrate is the proportion (in per cent)of responders in the population under consideration.UnselectedNo ofindiYlduo/s 7 23 48 44 15 sub'eelsAge from- to 35-45 46-55 56 - 65 66 -75 76 - 64 years%100801V6040200ageFig.50 Dependence of the non-responderrate (V) of the 36 h 02MT processon age (discriminative index: 6.PO,-< 5 mmHg). 137 individuals tested-8rtbetween 1977-80; treatment conditionspartially not yet optimal at the beginningof the series