Chapter-1 / Physiological Foundations - WHNLive Public Library

~mO,·~1normal function"........ full-sca!e furnorerI~'IIostructure -consemngturnoyer(large mhighlydiffertntiafed. (tlls )endofstructural integrityreyersible damagetirreYersible damoge•Moder;stit titnt inter·f'S for (mrsiblt and brain myocardliverkidneyskeletalrrtWrsilJle domaDe ium muscleCD symptom fret t,s~ paralysis 8-11 s~ reactiration a-10min swera! h 3-4h 3-t, h(at rest)~ IDlencyrriod tor 10minrecorer (+min slflll),hours~ recovery todo'ls sertmldOJs StYtraldo!s--serero! hFig.95 Behavior of cellular turnoverafter stop in 02 supply [32]. Brokenline: recovery of cellular turnoverafter early enough release of the stopin O 2 supply==-==",160~~~mmHg{a 140lungIJloodfissue120100 l'80po]60somlFig.96 Scheme of the oxygen distributionin the human body [174]. The 02is presented as fluid, the height ofwhich indicates the partial pressure inthe respective reservoir. The arterialblood in the pulmonary vein, the leftheart and in the arterial system, containsca. 280 mi. The venous blood stillincludes a mean of 600 ml (!). Themyoglobin binds approximately240 ml, whilst the lung on average containsanother ca. 370 ml1.4 Reactions in tissue to local oxygen deficiency1.4.1 Reversible and irreversible cell damageAfter a short symptom-free interval, in whichthe cell function remains in full, every total topin O supply cau es 2damage which is at firstreversible but which soon cau es the organ[unction to cease and the structure to disintegrate.If the O 2supply re-occurs befor thructural di integration, th organ functionurn, a in ig. 95. If thi tim point i ex-; · i Ie dama e occur .Figure 96 how a h m of th di tributi n fthe 02 cont nt in th b d . Th r ti all thwhol oxyg n wo~ld b 'n um d in ppr i­mat ly 5 min with a r ting O 2 n umpti nrat of 300 ml/min.In th appli ati n f th 02Md aling with a w ak n d 0with a ttl int rQlpti n. Ju tr u u 11uppi nd n tf w t f