Chapter-1 / Physiological Foundations - WHNLive Public Library

1tJD908070~~'"/~~/ I,../'~ B~Ih ~'y-,"..... ~vRtlatiw chfl1tJdlrislic IJr ~1/k-_10zIicisiw fry4-1nJnsptJrt IDfissur.s JlJlllifti IJy 'or1rriJl­Oz·tlff/asiM,t. g.orItrii WSSlIwolls, ttns 0/tilt qtttl.17 =24% =25%=27%/vRe/alive ChflfQcferislic for fJ/lt 01PJ~ll!yJOzDecisivt for Oz-tron3fXT! riahemoglobin 10 tlte othtr tissues533020 20~30~ ~iXttl Ilren ,alftsttrQ-/eQtr. faHifnoefereta/.7J6J40 50age60-7080Fig. 58 The dependence of themean arterial and the mean mixedwnous P02 (both at rest), as wellas of the arteriownous 02 satu-90 ytors ration difference 71 on age. Untreated,healthy individuals1.1.9.3 The increase in P02.ven due to stressful influences, particularly in conditions of weaknessThe strong dynamics of the resting P02.ven arevery striking, and have a great influence on theutilization factor of the O 2 binding capacity ofthe blood, due to the great steepness of the O2dissociation curve in the area of the venouspressures. Examples of the course of P02.venin lack of exercise, operation and in a phasewith a 'flu infection are shown in Fig. 59. Inall cases the '11 value sinks critically. The feelingof weakness in illness (energy deficiency),which forces the patient to stay in bed, correlateswith the low 'I1-values. The main contributorto the drop in '11 is the significant risein the resting P02.ven, which has been observedin all cases so far. From the course of the P02levels after the end of the 'flu infection, we candraw conclusions about the speed ofrehabilitation.The resting P0 2 - art reducing effect of the veryvaried stressful influences which we discoveredin [20, 21] and have commented upon in Paragraph1.1.8.2, is reflected in the increase in theresting P02-ven' The O2 transport to the bodytissue is even more severely reduced by strongstressors than we had earlier suspected.The great drop in the 1'1-value in operations dueto general anesthesia, leads us to recommendthe implementation of 02MT before and aftersurgical interventions on older patients in orderto reduce the risks [108].Figure 60 shows an example from the fi Id ofcancer therapy, of the wor ening of th O 2status due to the distre s of h m th rapradiation therapy or urg ry whi h i tillhardly known or taken into on id rati n.