Chapter-1 / Physiological Foundations - WHNLive Public Library

eM/rot gro"/!.Histologicallyconfirmed.lymph nodemetastases28%30%72%l'/ortalil,y rateIfetoslasis rolesurvival rote (> 5yrs.)8%16%97%Fig.83 Reduction in rate of metastasis in histologically proven cervical carcinomas (mainly stage lib) by meansof 02 multistep immunostimulation 02MT (BCG and 32 h 02MT) + CMT (concept 1974) 1 from 30 to 60%02MT + CMT as adjuvant therapy to the conventional oncotherapy (OP according to Wertheim-Meigs, radiationtherapy). Treatments between 1974 and 1978 at the Gynecological Clinic of the Medical Academy, Dresden(Director: Prof. Dr. B. Sarembe), M.D. thesi~ by C. Kaiser, 19851 Since 1974 the efficacy of the concept has been significantly improved through methodological and technicaldevelopment (thymus preparations, e.g. Neythymun instead of BeG, Selectotherm equipment of the 3rdgeneration)cardial infarction leads to the destruction oftissue highly important to life, and which alsooccurs during irreversible shock.Since we realized in 1970 that conditions ofcollapse do not occur after several hours of40-41 °c whole body hyperthermia if 02 isapplied during the hyperthermic phase [2], thesteps of the 02MT and, from 1974 [143], thesteps of the 02MT immunostimulation havebeen included in the CMT program. The efficacyof this measure was increased in 1977[125] by replacing BCG as an immunomodulatorwith thymus extracts, CEH or Neythymun.The addition of the 02MT immunostimulationin the CMT program was successful, on the onehand in that it enabled us to aim for as high a, 0body core temperature as possible (e. g. 41.5 C)for, e.g. 3 h, well tolerated by the patient and,on the other hand, in the immunological destructionof the cancer cells which have survivedthe therapy. That is, we are striving for areduction of the probability of metastasis andrecurrences. Our ideas on the reduction of therate of metastasis and the increase in the urrate by means of the adjuvant procedure of02MT immunostimulation have been clini allconfirmed, as Fig. 83 show . The tud arriedout between 1974 and 1978 on patient ithhistologically proven cervical carcinoma (m t1stage JIb) showed a reduction in th rat fmeta tasis from 30 to 16 % and a dr p in thmortality rate from 28 to 8 %. Thi r ultwhich wa obtain d 5-6 ar aft r tr atm ntcarrie great wight for th ran th t th1974 concept of th 02MT immun timul ti nand CMT ha b n greatly improv d in th nby methodologi al and t hni al d 1 pm nt .