Chapter-1 / Physiological Foundations - WHNLive Public Library

Basic mechanisms and functions 73mewhat more in the reduction of2-\'en (influ nc on 02 utilization). Thepr edur is particularly indicated inng r) p r ons ( ubjected to severe distress)P02-ven levels:::::: 40 mmHg. Furthermorem that the increa e in P02 as a conse:n e of di tress is 0 pronou~ecned that theing el vation in this value makes more frentr~~etition of the procedure necessary.deCISion to undertake such repetitions canmuch more easily taken with the quickedure, a the time (also for the patient)d oxygen required are only roughly 5 % ofat required for the 36 h 02MT procedure.e aving of oxygen is of great practicalnificance for all areas and countries wheree 02 provision from pressure cylinders orntral facilities constitutes a bottleneck.ue to the great savings in time and oxygenith the quick procedure, the question ariseshether the 36 h procedure can be fullyplaced by it. This question must be answeredthe negative and not only due to the somehatdifferent effects discussed. The 36 h02MT procedure will be specifically indicated,n the future also, for patients with restrictedmobility (cardially or pulmonally limited perormancecapacity, diseases of the locomotorsystem such as coxarthrosis, gonarthrosis, peripheralcirculatory disorders in the lower extremities,conditions after amputation ofextremities, pronounced conditions of weak-ness, severe hypertension and other di ea ebeing incompatible with the application of thequick procedure). he 36 h procedure with itsupply of oxygen via the comfortable rna kapplicator will also be preferred in ca e ofrespiratory insufficiencies (advanced lungemphysema, bronchial a thma, lung fibro i ,chronic bronchitis, condition after pneumothorax),also in cases of limited psychic trecapacity (claustrophobia etc.).The 15 min 02MT quick procedure GK 2-1,to be repeated once or twice, if nece ary.is indicated for sufficiently able-bodied persons(elimination of acute condition of weakne inyounger and older persons, especially afteroperations, infectious disease, accident andother stressful events; further, to increase thephysical performance capacity before tre ofall types, like operations and particular physicalstrains, amelioration of jet-lag in journey fromeast to west etc.). The use of the quick procedurehas great possibilities in outpatient departments.For sufficiently able-bodied patientwithout much time, the 5 x 20 min 02MT cureprocedure GK 9-1 (see AppendiX) ha beendeveloped.In extreme situations (e.g. severe circulatorydisorders in the lower extremities po siblenecessity of amputation) it can be recommendedthat the variants of the 02MT becombined with the HOT* method a ha alreadybeen done (variant GK 4-IIl, [50. 4]).1.2 Total irreversible blood microcirculation inhibition and capillary damage.2.1 Ideas about and investigations into the mechanism of the total capillary occlusionis, for the most part, the same elementaryheological mechanism which causes the total,rreversible stoppage of the blood microcirculationand afterwards capillary damage, in cardiacnfarction, shock, inflammation and also in theodern concept of cancer multistep therapyMT). This mechanism is the continuation ofcellular capillary wall switching mechanism,pre enting the reversible phase and di 'cussedthe previous chapters, to an irreversible end.e difference 10 the triggering of the mechamcon i t mainly in the fact that the 02flclency-condit ioned endothelial swelling a.ndreduction of blood flow are accompamed. H i ..caused by a tronger or weaker tran iti n tofermentation metaboli m in the ti u urroundingthe capillaries, and b the hamp ringof the drainage of the lacti a id formed. In thiproce s pH level of ~ 6.6 an ur at thvenous end of th apillari, leading aft r alatent period to hem ta i'.Thi pH r du ti n cau: : a r arran m nt inthe architecture of the biom mbran [11_].This aU ration in th m mor n aff t thmicrocirculation . n rgL ti all' in m n 'b CallS , a- ording t ahl 7. hanboth in th blood - 11' and in th inn rof th endoth lium, hi -h imp d th