Chapter-1 / Physiological Foundations - WHNLive Public Library

Table 7 The change in the architectu;e of bio-membranes as a pH-sensitive basic process for the multi-functional,extre":,ely pH-sensitive stop of microcirculation, plasma leakage in capillaries at low pH, red cell aggregation(see FIg. 7S)Basic process1.Change in the architectureof bio-membranes duringthe transition from thenormal pH =7.4 to thevalue pH =6.5 1Findings of physicalanalysis (Kreutz,Hoelzl-Wallach,Freiburg 14.9.1976)Elements involved inthe starting process1.1Erythrocytes1.2Leucocytes1.3Platelets1.4Surface layersEndotheliumFibrinogen1. Effects2. Additional influencesGreat reduction offlexibilityReduced flexibility,adhesion to thevenular endothelium;jamming of erythrocytesIncreased formationof microthrombiIncreased stickiness,non-enzymatic adhesionof fibrinogen toendotheliumOverall effectThe combination ofand interactions betweenthese stronglypH-dependent andblood flow-reducingeffects finally conditionthe pH-sensitive stopin microcirculation2.Additional factors for theselective triggering of theirreversible stop of bloodmicrocirculation in thecancer tissues2.1Blood picture2.2Blood flow2.3 .Endothelial swell ingNumber of leucocytesand thrombocytesnormal or (artificially)increasedWhen blood flow isreduced, influx ofleucocytes into thecapillaries is greatlyincreased