Chapter-1 / Physiological Foundations - WHNLive Public Library

Basic mechanisms and func Ions 37in ly appli able. Thi ea ilyD8I'amleter an been as generally• ll1cal1l int re ting, a changes in thevascular system due to event of e mvaried kind (e.g. 02MT) are reflected in i .We are still far from a standardization of themethodol gy of the biological age [67, 11 0].of assessing the blood microcirculationuantitative or even just qualitative assesstheblood microcirculation is of veryormative value. Examples are:~lrelct determination of the increase in the6;tU~od microcirculation in the tissues of theanism by means of triggering the capillaryitching mechanism of the oxygen multieptherapy.ecognition of placenta insufficiencies andeir elimination using 02MT.ecognition of the time point of the selectivevascular occlusion in the cancer tissuesafter cancer multistep therapy (CMT).. Recognition and elimination of peripheralcirculatory disorders, etc.simple way to assess the blood microcircula­:.,··:-Ao;··.....n in tissue near the body surface (maximumpth approximately 2 mm) is the method ofer Doppler [lowmetry [68]. One instrument'table for this is the Periflux made by Peried,Sweden. The nail fold of the 3rd or 4thinger is a suitable site to detect all the flowchanges [69]. Exactly the same point ofmeasurement an be easily re-found by micromarkhlg,the temperature can be measuredusing a thermistor and can be kept constant bya thermostat. This method is well suited todocument directly the increase in the bloodmicrocirculation due to the triggering of thecapillary switching mechanism of the 02MT.This technique can also be used to determinethe increase in the blood microcirculation duringphysical exertion and under medicationwith sympathicomimetics, such as Alupent.A further way to assess the blood microcirculationin tissue which can extend to approximately20 mm under the body surface is themethod of ultrasound Doppler [lowmetry. Herea small portion of ultrasound radiation is scatteredor reflected by the disturbed blood corpusclesand thus, in accordance with the sizeand orientation of speed, Doppler-shifted. Withincreasing frequency and hence decreasingwavelength A the back-scattered portion in-Icreases and 0 beys the -- dependency (Ra-A 4s80706050II- /30/men -Ii women/ /',JIP201020JOVI/ IJI B +V/--L ..-cIJ/ !150 60 70 8090ytorJFig. 25 Smoothing time M for askinfold on the back of the handcaused by pulling uP. dependent onage. M as a marker 1 of skin elasti·city1 Mean over many preceedin months