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Drug List Book

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Fosamax<br />

(Alendronate)<br />

a-LEN-dro-nate<br />

Classification: Bisphosphonate<br />

IFU: Osteoporosis<br />

Action: Suppresses osteoclast<br />

activity on newly formed<br />

resorption surfaces, which<br />

reduces bone turnover. Bone<br />

formation exceeds resorption at<br />

remodeling sites, leading to<br />

progressive gains in bone mass.<br />

Dosage: 5 mg, 10 mg, 40 mg<br />

Route: P.O.<br />

Adverse Reaction: headache,<br />

abdominal pain, nausea,<br />

constipation, musculoskeletal<br />

pain<br />

Interactions: NSAIDS: Increased<br />

risk of upper GI adverse reactions<br />

with drug doses about 10 mg/day.<br />

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