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Annals of Oncology adjusting on CIS, sentinel lymph node biopsy became significantly associated with longer TD (HR: 0.64[0.43-0.94]) as compared to axillary lymph node dissection, radiotherapy to a shorter TD (HR: 0.63[0.42-0.95] and the type of surgery had no effect on TD. For global health, cognitive and social functioning dimensions, patients expecting deterioration in their QoL had a significantly shorter TD. For fatigue and breast symptom scales, patients expecting no change had a significantly shorter TD, as compared to patients expecting an improvement. Sensitivity analyses using a MDCS of 5 or 10 confirmed these results. Conclusions: Our results suggest that it would be more accurate to take into account CIS component of RS as well as QoL expectancies to estimate TD of QoL scores in patient with BC. Disclosure: All authors have declared no conflicts of interest. 332P HEALTH STATE UTILITY DETERMINATION IN ADVANCED STAGE BREAST CANCER PATIENTS W.R. Simons Global Health Technology Assessment, Eisai, Inc., Woodcliff Lake, NJ, UNITED STATES OF AMERICA Background: Quality-adjusted Time Without Symptoms of disease and Toxicity (Q-TWiST) survival analysis where time without disease progression is rewarded while time without disease progression but with toxicities is penalized by applying a utility weight is increasingly common in health technology assessments of cancer treatments. AIM: We assess women’s preferences for health states specific to advanced stage breast cancer including a baseline diagnoses of ABC, treatment response, no treatment response but no disease progression, disease progression and hormonal therapy specific toxicities. Method: Using FACT-B quality of life data from a randomized clinical trial in ABC univariate statistics were obtained for each item for each health state without regard to treatment. These item scores were paired to the actual narrative in the FACT-B to construct health state narratives consisting of physical, social, emotional, functional well-being and additional concerns content domains. The order of the content domains was varied to prevent order bias. One hundred and nine peri- or post-menopausal women were recruited and interviewed by a single woman in their age group using visual analogue and standard gamble techniques. Univariate and multivariate analyses were performed to control for age, marital status, menopausal status and whether the interviewee has had breast cancer or any other cancer. Results: Of the 109 recruited 100 women completed the interview, mean age was 55.76 years, 64% were postmenopausal, 11% had breast cancer previously and 16% had another type of cancer previously. Multiple regressions results for the VAS scores yielded values of 51.8 (p < 0.01) for baseline ABC diagnosis, 82.5 (p < 0.01) for treatment response, 57.5 (p < 0.01) for no response no progression and 38.4 (p < 0.01) for disease progression. The SG results were 0.64 (p < 0.01), 0.76 (p < 0.01), 0.67 (p < 0.01), and 0.50 (p < 0.01), respectively. Women who previously had breast cancer related the health states consistently higher (p < 0.05) in the VAS and SG analyses. The trade-off between a chance of treatment response yet the possibility of toxicity yielded a utility score of 0.34 (p < 0.01). Conclusion: These VAS and SG scores can be used to better assess women’s preference for treatment options in ABC. Disclosure: W.R. Simons: This research was conducted independent of Eisai Inc. 333P COST EFFECTIVENESS OF ADJUVANT CYCLOPHOSPHAMIDE CONTAINING REGIMES TO AT IN THE TREATMENT OF BREAST CANCER IN GERMANY E. Walter IPF, IPF Institute for Pharmaeconomic Research, Vienna, AUSTRIA Objectives: 58,000 women in Germany are diagnosed with breast cancer each year. Anthracycline-containing regimes - in addition to other treatment options - have been standard adjuvant breast cancer regimens. The purpose of this analysis was to estimate the cost-effectiveness of AT (doxorubicin, docetaxel) compared with AC (doxorubicin, cyclophosphamide), CMF (cyclophosphamide, methotrexat, 5-fluoruracil) and FEC (5-fluoruracil, epirubicin, cyclophosphamide) administered as adjuvant therapy to women with node-positive breast cancer in Germany. Methods: We developed a multi-country Cost-Utility-Model to simulate the long-term consequences from initiation of adjuvant chemotherapy over 10 years. Markov modelling techniques were used to estimate incidence of complications during chemotherapy (febrile neutropenia, chemotherapy induced nausea/vomiting, dose-reduction, dose-delay, other grade 3/4 adverse events) and long-term consequences like local or distant relapse, secondary acute myelogenous leukemia, chronic heart failure and death. Monte-Carlo-simulation accounted for uncertainty. Probabilities were derived from clinical and epidemiological studies; direct costs from published sources from the payer’s perspective. QALYs, life years and costs were discounted at 3% p.a. Results: Over a 10-year timeframe, costs and outcomes associated with AT amounts to 21,055.91 € and 6.3 QALYs (7 LYs). Costs associated with AC are 17,018.04 €, while outcomes are comparable to AT. The cost saving potential associated to AC vs. AT amounts to 4,037.87 € per patient. Costs and outcomes associated with CMF are 17,790.42 € and 6.3 QALYs (6.94 LYs), leading to a cost saving potential of € 3,265.49 with CMF vs AT. FEC associated total costs are 18,471.84 €. Quality-adjusted life expectancy increases to 6.5 years, which represents a QALY gain of 0.2 QALYs over 10 years vs. AT. The increase in life expectancy without quality adjustment amounts to 7.4 years and leads to 0.4 LYs gained with FEC versus AT. Accordingly, FEC dominates AT. Conclusion: Cyclophosphamide-based regimens (FEC, AC and CMF) demonstrate a better performance from cost-effectiveness perspective vs. AT (doxorubicin, docetaxel). Disclosure: All authors have declared no conflicts of interest. 334P HEALTH-RELATED QUALITY OF LIFE (QOL) IN METASTATIC BREAST CANCER PATIENTS TREATED WITH EVEROLIMUS AND EXEMESTANE VERSUS EXEMESTANE MONOTHERAPY H. Burris 1 , J.T. Beck 2 ,H.Rugo 3 , J. Baselga 4 , F. Lebrun 5 , T. Taran 6 , L. Bennett 7 , J. Ricci 8 , T. Sahmoud 9 , G.N. Hortobagyi 10 1 Highlands Oncology Group, Highlands Oncology Group, Nashville, TN, UNITED STATES OF AMERICA, 2 Highlands Oncology Group, Highlands Oncology Group, Fayetteville, AR, UNITED STATES OF AMERICA, 3 Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, UNITED STATES OF AMERICA, 4 Massachusetts General Hospital Cancer Center and Harvard Medical School, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, UNITED STATES OF AMERICA, 5 Jules Bordet Institute, Institute Jules Bordet, Brussels, BELGIUM, 6 Sr Global Clinical Leader, Novartis Pharmaceuticals Corporation, East Hanover, NJ, UNITED STATES OF AMERICA, 7 Biometrics, RTI Health Solutions, Research Triangle Park, NC, UNITED STATES OF AMERICA, 8 Wellmera Ag, Wellmera AG, Basel, SWITZERLAND, 9 Gbl Clin Program Head, Novartis Pharmaceuticals Corporation, East Hanover, NJ, UNITED STATES OF AMERICA, 10 The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Houston, TX, UNITED STATES OF AMERICA Background: The phase 3 BOLERO-2 study randomized 724 patients with hormone-receptor–positive (HR + ) advanced breast cancer and recurrence or progression during/after nonsteroidal aromatase inhibitor therapy to everolimus (EVE) plus exemestane (EXE) or EXE and placebo (PBO). Interim analysis after 12 months’ median follow up demonstrated that EVE + EXE significantly improved progression-free survival (PFS) vs EXE + PBO, with a higher rate of grade 3/4 adverse events but no deterioration in QOL. We report here on additional post hoc analyses of patient-reported QOL. Methods: Using the EORTC QLQ-C30 questionnaire and QLQ-BR23 module, QOL was assessed at baseline and every 6 weeks thereafter until progression or discontinuation. The QLQ-C30 consists of 30 items combined into 15 subscales, including Global Health Status (GHS). The BR23 consists of 23 items specific to breast cancer combined into symptom and functioning subscales, including breast symptom (BS) and arm symptom (AS) scales. Average difference in change from baseline between treatment groups was evaluated using linear mixed models with several adjustment covariates. Sensitivity analysis was conducted using pattern-mixture models to examine the effect of study dropout on or before week 24. Treatments were compared using differences of least squares mean (LSM) changes from baseline at each timepoint and overall. Results: Linear mixed models indicated no statistically significant overall difference between EVE + EXE and EXE + PBO for GHS (LSM difference = –2.0; 95% CI = –4.8, 0.9), breast symptoms (LSM difference = 0.3; 95% CI = –2.8, 2.4), or arm symptoms (LSM difference = –0.2; 95% CI = –2.8, 2.4). Pattern-mixture models indicated that patients who dropped out early had worsening QOL over time in both treatment arms; EVE + EXE patients who did not drop out early had stable QOL, whereas EXE + PBO was associated with worsening QOL over time. Conclusions: These additional analyses from the BOLERO-2 study confirm that compared with EXE alone, EVE + EXE improved PFS without adversely impacting QOL in patients with HR + advanced breast cancer progressing despite nonsteroidal aromatase inhibitors. Disclosure: J.T. Beck: Has received grant support from Pfizer and Novartis. H. Rugo: Has received grant support from Pfizer and Merck, and has received travel support from Novartis. J. Baselga: Is a consultant to Novartis, Roche, Merck, sanofi-aventis, Verastem, Bayer, Chugai, Exelixis, Onyx, and Constellation. T. Taran: Is an employee of Novartis with stock options. L. Bennett: Is an employee of RTI Health Solutions, which contracted with Novartis for data analysis services. J. Ricci: Is a consultant to Novartis. T. Sahmoud: Is an employee of Novartis with stock options. G.N. Hortobagyi: Member of the Sci Ad Board of Allergan; consultant to Allergan, Novartis, Genentech, and sanofi-aventis; has received grant support from Novartis; travel expense reimbursement from Volume 23 | Supplement 9 | September 2012 doi:10.1093/annonc/mds393 | ix121
Novartis, Genentech, and sanofi-aventis. All other authors have declared no conflicts of interest. 335P DYSPHONIA AS A PREVIOUSLY UNREPORTED SIDE EFFECT OF BEVACIZUMAB TREATMENT IN PATIENTS WITH METASTATIC BREAST CANCER S.A. Radema 1 , P. Souverein 2 , R. Meyboom 2 , F. Ahmadizar 2 , C. Onland-Moret 2 , A. Maitland-Vd Zee 2 1 Internal Medicine, Gelre Ziekenhuizen, Apeldoorn, NETHERLANDS, 2 Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, NETHERLANDS Introduction: Bevacizumab is a humanized monoclonal antibody directed against vascular endothelial growth factor A and has been approved for the treatment of several metastatic tumours. There is considerable heterogeneity in the response to treatment with bevacizumab, both in effectiveness and in toxicity. Here we describe a previously unreported adverse drug reaction (adr) in pts with MBC treated with bevacizumab. Methods: In a teaching hospital in the Netherlands (from Sep 2009 to Jul 2011), 32 consecutive pts with MBC treated with chemotherapy and bevacizumab were registered in a retrospective database. TNM stage, comorbidities, concomitant medication, prior treatment for the primary tumour, date of metastatic disease, prior treatment for metastatic disease and toxicities were recorded. The WHO global individual case safety report database, VigiBase, contains summaries of suspected spontaneous case reports summated by health care professionals and pts to national pharmacovigilance centres . As of May 2010, VigiBase contained >5 million case reports. . We searched the VigiBase extraction of Dec 2011 for dysphonia. Reporting odds ratios (ROR) were calculated for the occurrence of dysphonia compared with other adr for bevacizumab and paclitaxel. Results: In total, 9/32 pts (28%) reported dysphonia during treatment with bevacizumab and 5/9 pts underwent ENT examination. In several pts marked oedema of the vocal cords and/or chronic laryngitis were found. As of Dec 2011, 6,880,361 reports were available in VigiBase, of which16,239 were related to dysphonia. For bevacizumab there were 51 reports for dysphonia and 46,041 reports for other adr. Corresponding figures for all other drugs were 22,108 reports for dysphonia and 25,151,628 reports for other adverse effects: ROR of 1.26 (95% CI: 0.95-1.66). For paclitaxel there were 45 reports for dysphonia and 85,988 reports for other adr. Corresponding figures for all other drugs were 22,114 reports for dysphonia and 25,111,681 reports for other adverse effects: ROR of 0.59 (95% CI: 0.44-0.80)meaning that the risk of angiooedema is significantly higher in bevacizumab users compared to paclitaxel users. Conclusion: Dysphonia is a previously unreported side-effect in pts with MBC treated with bevacizumab and paclitaxel. Disclosure: S.A. Radema: I am member of an advisory board for Roche. All other authors have declared no conflicts of interest. 336P PATTERNS OF CLINICAL MANAGEMENT AND RESOURCE UTILIZATION FOR POSTMENOPAUSAL HORMONE-RECEPTOR–POSITIVE HER2-NEGATIVE (HR+ HER2–) ADVANCED BREAST CANCER (ABC) IN EUROPE G. Jerusalem 1 , N. Marinsek 2 , J. Ricci 3 , J. Etchberger 2 , R. Degun 2 , G. Benelli 4 , S. Saletan 5 , F. André 6 1 Centre Hospitalier Universitaire du Sart Tilman, Centre Hospitalier Universitaire du Sart Tilman, Liège, BELGIUM, 2 Navigant Consulting, Inc, Navigant Consulting, Inc, London, UNITED KINGDOM, 3 Wellmera AG, Wellmera AG, Basel, SWITZERLAND, 4 Novartis Farma S.p.a., Saronno, ITALY, 5 Onco Ex Dir Clinical Res Phys, Novartis Pharmaceuticals Corporation, East Hanover, NJ, UNITED STATES OF AMERICA, 6 Breast Cancer Unit, Institut Gustave Roussy, Villejuif, FRANCE Objective: To understand treatment patterns and quantify resource utilization of HR + HER2 − aBC, with the overall aim of comparing costs and disease burden as patients progress from hormonal therapy (HT) to chemotherapy (CT). Methods: We conducted a chart audit in France, Germany, The Netherlands, Belgium, and Sweden of 375 living and deceased postmenopausal female patients (75 per country) diagnosed with ER + HER2 − aBC in the past 4 years. Patients were required to have progressed on ≥ 1 line of prior HT either in the adjuvant or advanced setting and to have completed ≥ 1 line of CT treatment (minimum 2 full cycles) in the aBC setting. The chart audit was completed online using a standardized form developed with the assistance of European academic physicians, pharmacy directors, and hospital administrators. Participation was sought from 25 oncologists per country, except in Germany (15 oncologists and 10 gynecologists to reflect local clinical practice). Data collection was compliant with European and country market research regulations. Results: Our report details the patient care pathway, CT side effects, and resource utilization in the inpatient and outpatient settings throughout the continuum of aBC Annals of Oncology care. Preliminary analyses indicate that 55% of HR + HER2 − aBC patients are first treated with HT and switch to CT after 1.5 lines of HT. This switch is primarily influenced by the extent (56%) and progression rate (36%) of metastases. The switch from HT to CT is associated with increased resource utilization and the associated costs of treating aBC. In addition to cost of drug therapies, the main drivers of cost are treatment for CT side effects (chiefly febrile neutropenia and diarrhea) and related hospitalization events. CT side effects that have the greatest impact on the overall disease burden of aBC include alopecia, nausea, vomiting, fatigue, and peripheral neuropathy. Conclusions: Our results highlight the increased costs and disease burden for postmenopausal ER + HER2 − aBC patients treated with CT versus HT. Disclosure: G. Jerusalem: Consultant, Novartis Pharmaceuticals Corporation. N. Marinsek: Consultant, Novartis Pharmaceuticals Corporation. J. Ricci: Advisor, consultant, Novartis Pharmaceuticals Corporation. J. Etchberger: Consultant, Novartis Pharmaceuticals Corporation. R. Degun: Consultant, Novartis Pharmaceuticals Corporation. G. Benelli: Employees of Novartis with stock/stock options. S. Saletan: Employee of Novartis with stock/stock options. F. André: Financial support from sanofi-aventis, Novartis, Roche, AstraZeneca 337P EFFICIENCY FRONTIER ANALYSIS (EFA) OF METASTATIC BREAST CANCER (MBC) TREATMENTS: A UK PERSPECTIVE C. Burudpakdee 1 , D. Bertwistle 2 1 Health Economics and Outcomes Research, IMS Health, Philadelphia, PA, UNITED STATES OF AMERICA, 2 Heor, IMS Health, London, UNITED KINGDOM Background: As newer therapies for mBC become available, understanding the efficiency of these therapies will be important for HTA recommendations and treatment decisions. EFA may be a useful method of assessing the efficiency of newer interventions. The EFA displays the outlay (cost) and gains with technologies, and displays the next most efficient option going forward. This study was designed to evaluate whether EFA could be useful in identifying the efficiency of mBC therapies adopted by the NHS, and to identify the efficiency frontier for newer technologies. Methods: A literature search was performed to identify mBC treatments that underwent HTA in the UK. Reports were reviewed to identify treatment efficacy and HTA recommendations. Costs were determined for a course of treatment. The incremental costs per patient were plotted on the horizontal axis and incremental median overall survival (ΔOS) of each treatment was plotted on the vertical axis to construct the EFA line. Treatments below this line are considered inefficient options. Treatments above this line have better OS and may redefine the efficiency frontier. Treatments in the upper right quadrant beyond the frontier line are in an area where ceiling price has not been defined. Treatments in the lower right quadrant beyond the frontier line are inefficient due to higher cost for lower OS. Results: Ten reports that evaluated efficacy in terms of median OS were included in the EFA. The therapies are paclitaxel albumin, gemcitabine, trastuzumab, bevacizumab, lapatinib, eribulin and fulvestrant. On the frontier line are paclitaxel albumin (ΔOS of 2.3 months at £2020), gemcitabine (ΔOS of 2.8 months at £6020), and trastuzumab (ΔOS of 4 months at £16939); all received positive recommendations. Lapatinib (ΔOS of 1.9 months at £10180), bevacizumab (ΔOS of 1.7 months at £36560), eribulin (ΔOS of 2.5 months at £4834) and fulvestrant (ΔOS of 2.3 months at £2481) are all below the frontier line and received negative recommendations. Conclusion: EFA may be a useful method for assessing the efficiency of new mBC treatment options for clinical use. Further studies are needed to better understand value in terms of efficiency of treatments in other tumor types and disease areas. Disclosure: All authors have declared no conflicts of interest. 338P A CONJOINT ANALYSIS OF WILLINGNESS TO PAY TO AVOID METASTATIC BREAST CANCER SIDE EFFECTS D. Lalla 1 , M. Brammer 1 , R. Carlton 2 , T. Bramley 2 ,A.D’Souza 3 1 Health Outcomes, Genentech/Roche, South San Francisco, CA, UNITED STATES OF AMERICA, 2 Global Value Strategies, Xcenda, Palm Harbor, FL, UNITED STATES OF AMERICA, 3 Data Analytics, Xcenda, Palm Harbor, FL, UNITED STATES OF AMERICA Background: Patients with metastatic breast cancer (MBC) are treated with a variety of regimens with differing side effect profiles. In addition to efficacy, side effect profile can be an important consideration in therapy choice. Conjoint analysis is a research method used to evaluate how trade-offs are made between different attributes. This study assessed the willingness to pay (WTP) to avoid side effects related to MBC treatment using conjoint analysis. The WTP thus informs clinicians of patients’ preferences and which side effects they are most desirous of avoiding. Methods: An online, self-administered survey of MBC patients in the US was conducted. The survey was fielded with a sample of adult female patients with a diagnosis of MBC. Key variables (attributes) included in the analysis and with levels described in lay terms were: Alopecia, Diarrhea, Fatigue, Pain, Nausea, Neuropathy, Neutropenia and Out of pocket costs. 15 scenarios (choice-based conjoint questions) ix122 | Abstracts Volume 23 | Supplement 9 | September 2012
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Annals of Oncology Official Journal
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The European Society for Medical On
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Audit Committee Chair: Fortunato Ci
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Familial cancer Judith Balmaña, Ba
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ESMO 2012 Congress Travel Grants 47
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Exhibitors The following companies
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ESMO Fellowships, 1989-2011 The Eur
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anti-EGFR treatment. The present st
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minutes. In a previous study, 30-mi
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Conclusions: In pts with RCC treate
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physicians in the U.S. and Europe.
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lymphadenopathy and multiple cutane
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prospective non-interventional stud
Page 363 and 364:
Funding: GSK Biologicals Disclosure
Page 365 and 366:
survival rates of 13-25% (Prieto et
Page 367 and 368:
high response rates and prolonged p
Page 369 and 370:
GlaxoSmithKline, Merck Sharp & Dohm
Page 371 and 372:
advisor for Merck Sharp & Dohme, an
Page 373 and 374:
or cutaneous melanoma. A survival u
Page 375 and 376:
systemic therapy or were intolerant
Page 377 and 378:
abstracts neuroendocrine tumors and
Page 379 and 380:
morbidity, with G3 tumors behaving
Page 381 and 382:
pts. Poorly differentiated endocrin
Page 383 and 384:
Adenocarcinoma was present in 25 pa
Page 385 and 386:
Method: Endobronchial ultrasound gu
Page 387 and 388:
widely used by single agent or plat
Page 389 and 390:
disease after surgery were treated
Page 391 and 392:
stage IIIA NSCLC, EML4-ALK fusion-p
Page 393 and 394:
1200P CONCOMITANT CHEMORADIATION GI
Page 395 and 396:
Patients and methods: The study was
Page 397 and 398:
months (95% CI:13-25). The PFS and
Page 399 and 400:
maintenance therapy had favourable
Page 401 and 402:
abstracts non-small cell lung cance
Page 403 and 404:
Ingelheim, GSK Biologicals (compens
Page 405 and 406:
1234PD RANDOMIZED PHASE III TRIAL O
Page 407 and 408:
GlaxoSmithKline (myself, compensate
Page 409 and 410:
1243P IDENTIFICATION OF MICRORNA (M
Page 411 and 412:
N-arm n=34 P-arm n=32 All n=66 Male
Page 413 and 414:
1255P POPULATION BASED EVALUATION O
Page 415 and 416:
1262P DISTINCT SPREAD OF EGFR MUTAT
Page 417 and 418:
1268P VISUAL DISTURBANCES IN PATIEN
Page 419 and 420:
MERCK SERONO: Advisor, speaker in s
Page 421 and 422:
Conclusions: These data from SAiL a
Page 423 and 424:
NSCLC diagnosis and time of BM diag
Page 425 and 426:
1291P PHASE I/II DOSE-FINDING STUDY
Page 427 and 428:
Network utilization of WBCGF in the
Page 429 and 430:
1303P COST EFFECTIVENESS OF PEMETRE
Page 431 and 432:
Results: The patients’ characteri
Page 433 and 434:
EGFR mut at exons 18, 19, 21, and K
Page 435 and 436:
Methods: EML4-ALK fusion was screen
Page 437 and 438:
Results: The median survival time (
Page 439 and 440:
enefit from sustained EGFR blockade
Page 441 and 442:
epresented by 19 pts (32%) female,
Page 443 and 444:
and at least one prior course of ch
Page 445 and 446:
Methods: NSCLC patients with radiog
Page 447 and 448:
1367TiP LONG-TERM ERLOTINIB THERAPY
Page 449 and 450:
Austria, Czech Republic, Finland, G
Page 451 and 452:
were every 6 weeks (wk) (S1), every
Page 453 and 454:
Advantage enrollees (83% vs. 25%) [
Page 455 and 456:
Results: Based on 10,000 simulation
Page 457 and 458:
cancer tumors 12%, Germ cell tumor
Page 459 and 460:
Material and methods: 50 lung cance
Page 461 and 462:
1414TiP IMPLEMENTATION OF CANCER RE
Page 463 and 464:
abstracts palliative care 1422O EFF
Page 465 and 466:
Method and results: A total of 317
Page 467 and 468:
1436P SURVEY ON MODELS OF INTEGRATI
Page 469 and 470:
care unit (PCU) at the National Can
Page 471 and 472:
Characteristic No. % Total 63 1 st
Page 473 and 474:
hysterectomised-9.10% and cervix ca
Page 475 and 476:
abstracts psycho-oncology 1462PD IN
Page 477 and 478:
events, tumour response, and surviv
Page 479 and 480:
abstracts sarcoma 1477O ADHESION TO
Page 481 and 482:
1481PD A PHASE II STUDY OF DOVITINI
Page 483 and 484:
1488P ORGANISATION OF SARCOMA PATIE
Page 485 and 486:
Patients and methods: From August 2
Page 487 and 488:
chemotherapy respectively. At a med
Page 489 and 490:
of this group Those with relapsed d
Page 491 and 492:
1515 PREDICTORS OF SURVIVAL IN ADOL
Page 493 and 494:
abstracts small cell lung cancer an
Page 495 and 496:
emaining receiving either CAV or to
Page 497 and 498:
1533P EXPRESSION OF WILM⍰TUMOUR G
Page 499 and 500:
more than 3 months after first line
Page 501 and 502:
lower recurrence rate of NE. Pegfil
Page 503 and 504:
egimens (HR = 2.5, p < 0.001). Phys
Page 505 and 506:
1561P PREDICTIVE DIAGNOSTICS FOR RE
Page 507 and 508:
Methods: A prospective multicentre
Page 509 and 510:
Table: 1574P Pharmacokinetic parame
Page 511 and 512:
Novartis and unrestricted research
Page 513 and 514:
studies have shown that chemotherap
Page 515 and 516:
(Grade 1) and moderate to severe (G
Page 517 and 518:
declined to relatively lower level
Page 519 and 520:
1609P PHYSICAL ACTIVITY (PA) AND PH
Page 521 and 522:
patients were admitted to the oncol
Page 523 and 524:
Dicarbamin 100 mg/day on day 5 befo
Page 525 and 526:
Results: Anemia was detected in 83.
Page 527 and 528:
important to carry out randomized s
Page 529 and 530:
abstracts translational research 16
Page 531 and 532:
expression. Then, we analyzed PB sa
Page 533 and 534:
Table: 1657P TH BV + TH HR (95% CI)
Page 535 and 536:
BRAF mutations. Circulating free DN
Page 537 and 538:
1671P PHASE I CLINICAL TRIAL OF CAN
Page 539 and 540:
1678P PREDICTIVE VALUE OF TWO PHENO
Page 541 and 542:
theorized that the PI3K/AKT pathway
Page 543 and 544:
Material and methods: 101 patients
Page 545 and 546:
overexpressing and 232 had triple n
Page 547 and 548:
author index author index A Aamdal
Page 549 and 550:
author index Badran A. ix288 (874)
Page 551 and 552:
author index Bösmüller H. ix209 (
Page 553 and 554:
author index Chen A. ix319 (966O) C
Page 555 and 556:
author index De Droogh E. ix452 (13
Page 557 and 558:
author index Esposito G. ix209 (618
Page 559 and 560:
author index Geiges G. ix306 (930P)
Page 561 and 562:
author index Hartono S. ix70 (155P)
Page 563 and 564:
author index Iwasaki H. ix542 (1694
Page 565 and 566:
author index Kodaira M. ix90 (228P)
Page 567 and 568:
author index Lichtensztejn D. ix350
Page 569 and 570:
author index Martinez A. ix496 (153
Page 571 and 572:
author index Morishita N. ix432 (13
Page 573 and 574:
author index Okamoto N. ix432 (1320
Page 575 and 576:
author index Piau S. ix456 (1401P)
Page 577 and 578:
author index Rodríguez Rodríguez
Page 579 and 580:
author index Scoggins C.R. ix371 (1
Page 581 and 582:
author index Stern L. ix272 (823P)
Page 583 and 584:
author index Trypaki M. ix429 (1308
Page 585 and 586:
author index Whitmore J.B. ix310 (9
Page 587 and 588:
subject index subject index A AAV-H
Page 589 and 590:
subject index ix115 (316TiP), ix116
Page 591 and 592:
subject index diffuse large B-cell
Page 593 and 594:
subject index (1033P), ix340 (1036P
Page 595 and 596:
subject index medical information,
Page 597 and 598:
subject index (612P), ix214 (633),
Page 599 and 600:
subject index RCC, ix274 (830P) re-
Page 601 and 602:
subject index TR-FRET, ix84 (206P)
Page 603 and 604:
drug index drug index 1248P, 1250P,
Page 605 and 606:
translational research index transl
Page 607 and 608:
Page 609:
show all

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