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Annals of Oncology model. Specifically, external variables have an impact on adherence behaviour. However, this relationship is moderated by cognitive variables. Central to the theoretical model is the dynamic influence of AEs. AEs are proposed as having an impact on clinical outcomes and HRQoL, directly and indirectly through adherence behaviour, as well as impacting on external factors and may influence cognitive variables. Improving patient preference may improve clinical outcomes/HRQoL in oncology patients. The proposed theoretical model provides the opportunity to identify such hypotheses for further research with a view to improving adherence and clinical outcomes in oncology. Disclosure: S.L. Shingler: Oxford Outcomes were paid a fixed fee for conducting this research project. B. Bennett: Oxford Outcomes were paid a fixed fee to conduct this research project. J. Cramer: Prof Cramer was paid a fixed honorary payment for her expert input on this study. C. Twelves: Prof Twelves was paid a fixed honorary fee for his expert input into this study. A. Towse: Prof towse was paid a fixed honorary fee forhis expert input into the study. A.J. Lloyd: Oxford Outcomes were paid a fixed fee for conducting this research project. 1474 MORBIDITY IN ADVANCED BASAL CELL CARCINOMA (BCC) AND BCC NEVUS SYNDROME (BCCNS) FROM THE PATIENT (PT) AND PHYSICIAN PERSPECTIVE: DEVELOPMENT OF A PATIENT-REPORTED OUTCOME (PRO) QUESTIONNAIRE S.D. Mathias 1 , M. Chren 2 , Y.M. Yim 3 , H. Colwell 1 ,C.Reyes 3 , D.M. Chen 4 and S. W. Fosko 5 1 Health Outcomes, Health Outcomes Solutions, Winter Park, FL, UNITED STATES OF AMERICA, 2 Dermatology, University of California, San Francisco, San Francisco, CA, UNITED STATES OF AMERICA, 3 Biometrics, Health Outcomes and Payer Support, Genentech/Roche, South San Francisco, CA, UNITED STATES OF AMERICA, 4 U.S. Medical Affairs, Genentech, South San Francisco, CA, UNITED STATES OF AMERICA, 5 Dermatology, St. Louis University, School of Medicine, St. Louis, MO, UNITED STATES OF AMERICA Purpose: Although BCC is the most common skin cancer, the pt experience is not well understood. In a small subset of BCC pts, extensive invasion to subcutaneous structures can lead to locally advanced disease or metastases (advanced BCC (aBCC)). BCCNS is a rare genetic condition associated with life long, multiple BCCs. BCCNS pts may also develop aBCC. Lesions are common in sun-exposed areas such as the face and upper trunk and may result in disfiguring scars. To inform the development of a PRO questionnaire, qualitative concept elicitation interviews were conducted with aBCC and BCCNS pts and physicians. Methods: In an IRB approved study, interviews were conducted in pts > 18 yr diagnosed with aBCC or BCCNS and physicians using an interview guide containing open-ended questions about impact of symptoms on functioning and well-being. Transcripts from each 1 hr interview were analyzed. Results: A total of 30 pts were interviewed, comprised of 14 aBCC (locally advanced, n = 8 and metastatic, n = 6; 73% male) and 16 BCCNS (50% male) pts. Mean (SD) age for aBCC pts was 64 (11) and 51 (10) for BCCNS pts. A variety of patient experiences were reported (eg, bleeding, oozing wounds, vision problems). Physical appearance, including scarring and disfigurement affected 73% of pts. 80% of pts made lifestyle changes such as avoidance of outdoor activities, meeting new people, and intimate relationships. Assistance in tasks was often needed. Emotional effects, including worry about when and where the next lesion would appear, were evident in BCCNS pts (81%). Physicians (n = 4) noted that aBCC pts worry about cancer in general and the possibility of more tumors, while BCCNS pts face tumor recurrence, multiple surgeries and disfigurement. Based on the interview results and lack of existing PRO questionnaires capturing these concepts, 2 questionnaires were developed for aBCC and BCCNS. Conclusion: aBCC and BCCNS can have significant and unique impacts on well-being, appearance, daily and emotional functioning, and overall quality of life. Results from an ongoing validation study will be used to finalize these PRO questionnaires. Disclosure: S.D. Mathias: Susan D Mathias is an employee of Health Outcomes Solutions, which was paid by Genentech Inc to undertake this study. M. Chren: Consultant for Genentech Y.M. Yim: Roche employment and stock ownership H. Colwell: Consultant for Genentech and Health Outcomes Solutions C. Reyes: Roche employment and stock ownership D.M. Chen: Roche employment and stock ownership S.W. Fosko: Consultant for Genentech 1475 SOMATIC VULNERABILITY IN ONCOLOGICAL PATIENTS L. Onganía 1 , P. Climentzos 2 , M.P. Bramajo 2 , O. Osores 1 and M. Blanco Villalba 3 1 Psychooncology, Lucha Contra el Cáncer Ushuaia, Ushuaia, ARGENTINA, 2 Psychooncology, Centro Médico Austral Omi, Buenos Aires, ARGENTINA, 3 Oncology, Centro Médico Austral Omi, Buenos Aires, ARGENTINA Introduction: Making a complete psychosocial diagnosis in oncological patients, at the beginning of medical treatment enriches the approach of interdisciplinary teams. It gives important information that may be used to decide future interventions. Somatic vulnerability is a psychoanalytic concept that shows some dimensions of the personality and environment that may put the patient in risk. Some of them are alexitimia (difficulty to express emotions), operatory thinking, over-adaptation, depression, anxiety, stress and supportive environment. Doctors are fairly used to detect some depressive symptoms, but no so familiarized with the detection of the other kind of dimensions that are also risky for the patient evolution or quality of life. Objectives: Observe the presence of somatic vulnerability in cancer patients. Material and methods: Descriptive, transversal and randomized study. Sample: 103 cancer patients that attend to a private cancer center between April and June of 2011. Instruments: Somatic Vulnerability Scale (EVS-25) and specifically designed questionnaire. Results: 50 of 103 patients show somatic vulnerability. The 54% of the vulnerable ones, doesn’t evidence any depressive disorder. Only 15% of the vulnerable patients are in psychological treatment. Most of them give high results for the other dimensions that involve somatic vulnerability (alexitimia, operatory thinking, over-adaptation, anxiety, stress or unsupportive environment in different percentages). Conclusion: This study shows that a high percentage of the patients have somatic vulnerability. The somatic vulnerability seems to be hard to be detected by doctors because it involves many specific mental dimensions. In fact, only 15% of the patients in risk are in psychological treatment. The intervention of a trained professional seems to be relevant to make an earlier diagnosis of the patients in risk, affecting directly in the evolution and quality of life of them and their families. Disclosure: All authors have declared no conflicts of interest. 1476 SEXUALITY OF BREAST CANCER PATIENTS TREATED WITH MASTECTOMY M. Yassine 1 , L. Védrine 2 , C. Chargari 2 , B. Ceccaldi 2 , S. Le Moulec 3 , M. Ichou 4 and H. Errihani 1 1 Department of Oncology, National Institute of Oncology, Rabat, MOROCCO, 2 Oncology and Radiation Oncology, Hôpital d’instruction des armées du Val-de-Grâce, Paris, FRANCE, 3 Department of Oncology, Val de Grace Hospital, Paris, FRANCE, 4 Department of Oncology, Hôpital d’instruction des armées Mohamed V, Rabat, MOROCCO Background: Approximately 20% of breast cancer diagnoses are made in women younger than 45 years of age. Anticancer treatments are associated with serious problems in the sexual functioning of breast cancer patients. We assessed the sexual functioning of breast cancer patients treated with mastectomy. Patients and methods: We performed a prospective study in 110 women who had been treated with mastectomy for a breast cancer using a self-administered questionnaire on how the mastectomy had changed their sexual life since the primary diagnosis of breast cancer. Results: All patients expressed not having received sufficient information about how the disease and treatment including surgery might affect their sexual life. Sixty eight percent reported being still sexually active, but 62% revealed that the cancer treatment had affected their sexual desire or possibility to reach orgasm; 25% observed that their partner was afraid of sexual intercourse and 18% felt an emotional separation in the couple during the course of the disease. Conclusion: Problems related to body image and sexuality were identified in all women post mastectomy. It is time to better take into account quality of life, and more particularly the sexual function in breast cancer survivors. Disclosure: All authors have declared no conflicts of interest. Volume 23 | Supplement 9 | September 2012 doi:10.1093/annonc/mds413 | ix477
abstracts sarcoma 1477O ADHESION TO CLINICAL PRACTICES GUIDELINES (CPG’S) AND ROLE ON SURVIVAL FOR SOFT TISSUE SARCOMA PATIENTS. ANALYSIS OF A POPULATION BASED COHORT FROM RHONE-ALPES REGION O. Derbel 1 , C. Cropet 2 , P. Meeus 3 , F-N. Gilly 4 ,G.Vaz 5 , P. Thiesse 6 , D. Cellier 7 , D. Vince-Ranchere 8 , J-Y. Blay 9 , I. Ray-Coquard 9 1 Department of Medical Oncology, Centre Léon Bérard, Lyon, FRANCE, 2 Biostatistic Department, Centre Léon Bérard, Lyon, FRANCE, 3 Department of Surgery, Centre Léon Bérard, Lyon, FRANCE, 4 Department of Digestive Surgery, University Hospital Lyon Sud, Lyon, FRANCE, 5 Department of Surgery, Hopital Edouard Herriot, Lyon, FRANCE, 6 Department of Imaging, Centre Léon Bérard, Lyon, FRANCE, 7 Merck Serono, Lyon, FRANCE, 8 Department of Pathology, Centre Léon Bérard, Lyon, FRANCE, 9 University of Lyon, Department of Medical Oncology, Centre Léon Bérard, Lyon, FRANCE Sarcoma treatment has been suggested to be improved by the management in a multidisplinary expert team and adhesion to CPG’s (ann oncol 04). To confirm the strong relation between medical practices and survival, an exhaustive analysis of the outcome of the sarcoma patients population was performed in the Rhône–Alpes region. Patients and methods: From March 2005 to February 2007, 634 patients > 18 years old, diagnosed with localized sarcoma in Rhone-Alpes were included (Soft tissue sarcoma (STS): n = 472; GIST: n = 129; bone primary site: n = 33). Adhesion to national CPG’s was analysed for all patients. Prognostic impact of conformity to CPG’s on overall survival (OS) and progression free survival (PFS) was analyzed for STS patients, in in a univariate analysis and a Cox model regression. Results: Institutional records of 472 patients with localized STS sarcoma were reviewed., The sex ratio (male/female) was 1.1 and varied with the type of sarcoma. The median age was 60 years (range from 18 to 92).The most frequent histological subtypes were liposarcoma (N= 133, 28%), unclassified sarcoma (N= 98, 20.7%), and leiomyosarcoma (N= 70, 14.8%). Conformity to CPGs for patients with localized sarcoma was 40, 62, 87, 94 and 82% for global conformity, initial surgery, radiation therapy, chemotherapy and follow-up, respectively. In multivariate analysis, conformity of surgery to CPG’s was an independent prognostic factor of PFS in patients with STS, along with age at diagnosis, grade and histological subtype (HR: 0.5, 95%CI: 0.36-0.67) (p < 0.0001). Conformity of surgery (HR: 2.6), Age (HR: 1.07) and grade (HR: 0.06) are independents factors for overall survival in multivariate analysis for patients with liposarcomas. Conclusion: Conformity to CPG’s improves progression free survival for sarcoma patients. Conformity of surgical procedure to CPG’s is a major independent factor predicting PFS for STS patients and OS for patients with liposarcomas. Disclosure: All authors have declared no conflicts of interest. Annals of Oncology 23 (Supplement 9): ix478–ix491, 2012 doi:10.1093/annonc/mds414 1478O CLINICAL BENEFIT WITH REGORAFENIB ACROSS SUBGROUPS AND POST-PROGRESSION IN PATIENTS WITH ADVANCED GASTROINTESTINAL STROMAL TUMOR (GIST) AFTER PROGRESSION ON IMATINIB (IM) AND SUNITINIB (SU): PHASE 3 GRID TRIAL UPDATE P.G. Casali 1 , P. Reichardt 2 , Y. Kang 3 , J. Blay 4 , P. Rutkowski 5 , H. Gelderblom 6 , P. Hohenberger 7 , M. Leahy 8 , M. von Mehren 9 , H. Joensuu 10 , G. Badalamenti 11 , M. Blackstein 12 , A. Le Cesne 13 , P. Schöffski 14 , R. Maki 15 ,J.Xu 16 , T. Nishida 17 , I. Kuss 18 , D. Laurent 18 , G.D. Demetri 19 1 Struttura Semplice Trattamento Medico dei Sarcomi dell’Adulto, Istituto Nazionale Tumori, Milano, ITALY, 2 Hematology, Oncology and Palliative, HELIOS Klinikum Bad Saarow, Bad Saarow, GERMANY, 3 Dept. of Oncology and Hematology, Asan Medical Center, Seoul, KOREA, 4 Medical Oncology, Centre Léon Bérard, Lyon Cedex, FRANCE, 5 Centrum Onkologii-, Instytut im. Marii Sklodowskiej – Curie, Warszawa, POLAND, 6 Medical Oncology, Leiden University Medical Center, Leiden, NETHERLANDS, 7 Dept. of Surgery, UniversitaetsMedizin Mannheim, Mannheim, GERMANY, 8 The Christie Hospital NHS Foundation Trust, Manchester, UNITED KINGDOM, 9 Fox Chase Cancer Center, Philadelphia, PA, UNITED STAES OF AMERICA, 10 Dept. of Oncology, Helsinki University Central Hospital, Helsinki, FINLAND, 11 U.O. di Oncologia Medica, Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone, Palermo, ITALY, 12 Mount Sinai Hospital, Toronto, CANADA, 13 Institut Gustave Roussy, Villejuif, FRANCE, 14 Universitaire Ziekenhuis Gasthuisberg, Leuven, BELGIUM, 15 Departments of Medicine and Pediatrics, Mount Sinai School of Medicine, New York, NY, UNITED STATES OF AMERICA, 16 307 Hospital of PLA, Beijing, CHINA, 17 Osaka Police Hospital, Osaka, JAPAN, 18 Global Clinical Development Oncology 2, Bayer HealthCare Pharmaceuticals, Berlin, GERMANY, 19 Ludwig Center at Dana-Farber/Harvard Cancer Center and Sarcoma Center, Dana-Farber Cancer Institute, Boston, MA, UNITED STATES OF AMERICA Background: Regorafenib (REG) therapy significantly improved progression-free survival (PFS) in patients (pts) with GIST after failure of both IM and SU (J Clin Oncol 2012; 30: suppl; abstr LBA10008). Results of subgroup and post-progression analyses are presented here. Methods: Pts were randomized (2:1) to receive best supportive care plus either REG 160 mg or placebo (PL) po once daily (3 wks on/1 wk off). The primary endpoint was PFS. Upon progression in either arm, unblinding could occur. Pts on PL were eligible for crossover to open-label (OL) REG and progressive pts on REG were allowed to continue REG upon local physician’s choice. Results: GRID screened 234 pts and randomized 199 (REG: 133, PL: 66), well balanced for baseline characteristics. The PFS primary endpoint (according to RECIST) was met both per central review (median PFS 4.8 mo for REG vs. 0.9 mo for PL), and by investigator assessment (median PFS 7.4 mo for REG vs. 1.7 mo for PL). Exploratory sensitivity analyses demonstrate similar positive impact on PFS across pre-specified subgroups by number of prior systemic therapy, geographical region, age, baseline ECOG score, duration of prior treatment with imatinib, or KIT/ PDGFRA mutation. Median overall survival has not been reached in either arm. Taking the double-blind and OL periods together, 188 pts received REG. © European Society for Medical Oncology 2012. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com
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subscriptions A subscription to Ann
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Annals of Oncology Official Journal
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The European Society for Medical On
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Audit Committee Chair: Fortunato Ci
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Familial cancer Judith Balmaña, Ba
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ESMO 2012 Congress Travel Grants 47
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Exhibitors The following companies
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ESMO Fellowships, 1989-2011 The Eur
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Ondrej Gojis, Czech Republic 2008-2
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abstracts hpv biology and implicati
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abstracts the characterization of l
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abstracts description of intra-tumo
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prevent cell death. It is anticipat
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22IN TARGETING THE HOST IN TNBC G.
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abstracts a paradigm shift in early
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abstracts how can medical oncologis
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feasibility), but by how high the c
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abstracts re-inventing the medical
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abstracts emerging diagnostic and t
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abstracts biologically based treatm
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abstracts molecular targets in mali
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abstracts melanoma therapy: from fr
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diagnosis and can also be used for
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analysis at 11 months median follow
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mouse model of Kras mutant NSCLC. I
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abstracts subtyping soft tissue sar
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abstracts key topics in supportive
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ESMO-CSCO Joint Symposium: Building
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ESMO-EANM-ESR Joint Symposium: Imag
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ESMO-ESTRO Joint Symposium: Innovat
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ESMO-MASCC Joint Symposium: Integra
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ESO Society Symposium: Celebrating
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Results: TIMP-1 expression was incr
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will benefit from this targeted the
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cytomegalovirus (CMV). Analysis of
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functional consequences of Endoglin
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elationship between the ROR score,
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Plasma adiponectin level on the pre
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Table: 198P PFS OS Median, mo HR Me
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204P EVALUATION OF PTEN AND PIK3CA
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Material and methods: We searched P
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Results: The median concentration o
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number of biomarkers have been trie
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Conclusions: BW and serum Ctrough o
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261P BREAST CANCER SUBTYPES AND OUT
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90 mg/m2-cyclophophamide 600 mg/m2
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to 9 weeks after dosing. Trastuzuma
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Patients and methods: We reviewed d
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sector patients. The aim of this st
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Linear Logistic Model with Relaxed
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Results: The median CTC fold change
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abstracts breast cancer, locally ad
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Results: 8 trials (2092 pts) with 1
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absolute difference of median value
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Novartis, Genentech, and sanofi-ave
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Results: Three RCTs with 1023 patie
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collected from all patients for det
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355P FIRST REPORT OF LONG-TERM RESP
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361P A RETROSPECTIVE ANALYSIS OF PL
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publications and aggregated in a me
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Thus the primary aim to target BCSC
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383 WHY DO WOMEN WITH BREAST CANCER
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Results: We evaluated 76 pts with M
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more than 6 cycles of capecitabine.
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406TiP PHASE II TRIAL OF PRIMARY SY
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abstracts CNS tumors 410O CONDITION
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Conclusions: Our data suggested tha
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Conclusions: As in other cancer typ
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432 GAMMA KNIFE RADIOSURGERY AS A M
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abstracts developmental therapeutic
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1PR), but no responses were seen in
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RO and Cd, as well as PD data for c
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and vulvar Ca), and 11 SDs were obs
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knowing HLA-A status double-blindly
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Acquired-resistance to EGFR inhibit
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474P PHASE 1 STUDY OF THE SELECTIVE
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TST is active in breast and gastric
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Treatment-induced shedding of circu
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Methods: Either co-cultures of peri
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501 PRECLINICAL DATA INVESTIGATING
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509TiP LUX-LUNG 8: A RANDOMIZED, OP
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(P = 0.64). Synchronous BBC was sig
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abstracts gastrointestinal tumors,
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Disclosure: M. Lee: I am an employe
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plus intravenous Bev(7.5mg/kg q 21d
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anti-EGFR treatment. The present st
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patients harboring a T/T genotype t
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551P ADJUVANT CHEMOTHERAPY (AC) USE
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experienced significantly more ≥
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functioning scales. Exploratory ana
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oxaliplatin (100 mg/m 2 )/raltitrex
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Results: 92/114 patients were preop
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592P PHASE II TRIAL OF COMBINED CHE
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minutes. In a previous study, 30-mi
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Patients and methods: Chemotherapy-
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Conclusions: AMPK and ACC activatio
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of surgical monotherapy in patients
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Table: 632 633 AFLIBERCEPT/FOLFIRI
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factors play the determining role i
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Abstract withdrawn in exceptional c
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were respectively 10.6 vs 8.5 vs 3.
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Results: 20 gastrointestinal cancer
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abstracts gastrointestinal tumors,
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Day 8. A second identical course wa
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proven in stage I GC. The aim of th
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Conclusions: Longer OS to FOLFOX wa
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692P PRELIMINARY SAFETY DATA FROM A
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subgroup. Taking into consideration
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Results: Three years of adjuvant im
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considered sufficient to give an 80
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721P FIRST-LINE TREATMENT WITH FOLF
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after Gem-based therapy. The additi
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735P RADIOGRAPHIC PARAMETERS IN PRE
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validate the revised AJCC 7th stagi
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Results: Among 862 MM we identified
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Results: Frequently reported advers
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gastric cancer patients with CNS me
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discriminate the prognosis of HCC p
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prospective, non-interventional stu
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abstracts genitourinary tumors, non
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787O EXTERNAL VALIDATION OF THE ASS
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patient preference for P over S, an
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798PD OPEN-LABEL PHASE II TRIAL OF
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Hb, PS and LM. Median PFS for patie
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may have led to reduced dose and sh
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Results: 1,622 patients were identi
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RCC) was designed to address an unm
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Patients and methods: This is a sin
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treatment at week 4, and week 12 by
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effective in second or further line
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Conclusions: In pts with RCC treate
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using Drug inCode ® pharmacogeneti
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Table: 857P standard, but is not av
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efused HDCT. Of 23 patients, 20 com
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we identified 49 and 220 patients w
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879 TREATMENT OF PATIENTS WITH META
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Median overall survival (OS) was 26
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abstracts Genitourinary tumors, pro
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and week 13 BPI-SF Q3 scores), 28%
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Working Group (PCWG)-2 guidelines r
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atio HR 0.39; CI 0.18, 0.83, p = 0.
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We observed tumor responses and pro
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Here we report emerging data from t
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928P LHRH AGONIST-INDUCED SUPPRESSI
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939P NEOADJUVANT SIPULEUCEL-T IN LO
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952 SEQUENTIAL ANDROGEN DEPRIVATION
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managed in a multidisciplinary (MD)
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or hypercalcemia at screening; prio
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Table: 975PD Continued AMG 386 + pa
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physicians in the U.S. and Europe.
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989P PHASE II STUDY OF COMBINATION
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eight patients who had infertility
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abstracts head and neck cancer 1016
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same CT/RT; Arm B2: 3 cycles of ind
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induction chemotherapy in the treat
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patients. We have developed a rando
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evaluated by the screening instrume
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morbidities that radiation would le
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Conclusions: Through adequate selec
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abstracts hematological malignancie
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anthracyclines in vitro. A favorabl
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1076P RITUXIMAB PLUS SUBCUTANEOUS C
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than the standard target of ≥2.5
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Patients: From November 2002 to May
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lymphadenopathy and multiple cutane
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prospective non-interventional stud
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Funding: GSK Biologicals Disclosure
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survival rates of 13-25% (Prieto et
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high response rates and prolonged p
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GlaxoSmithKline, Merck Sharp & Dohm
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advisor for Merck Sharp & Dohme, an
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or cutaneous melanoma. A survival u
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systemic therapy or were intolerant
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abstracts neuroendocrine tumors and
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morbidity, with G3 tumors behaving
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pts. Poorly differentiated endocrin
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Adenocarcinoma was present in 25 pa
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Method: Endobronchial ultrasound gu
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widely used by single agent or plat
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disease after surgery were treated
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stage IIIA NSCLC, EML4-ALK fusion-p
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1200P CONCOMITANT CHEMORADIATION GI
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Patients and methods: The study was
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months (95% CI:13-25). The PFS and
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maintenance therapy had favourable
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abstracts non-small cell lung cance
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Ingelheim, GSK Biologicals (compens
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1234PD RANDOMIZED PHASE III TRIAL O
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GlaxoSmithKline (myself, compensate
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1243P IDENTIFICATION OF MICRORNA (M
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N-arm n=34 P-arm n=32 All n=66 Male
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1262P DISTINCT SPREAD OF EGFR MUTAT
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1268P VISUAL DISTURBANCES IN PATIEN
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MERCK SERONO: Advisor, speaker in s
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Conclusions: These data from SAiL a
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NSCLC diagnosis and time of BM diag
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1291P PHASE I/II DOSE-FINDING STUDY
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Page 463 and 464: abstracts palliative care 1422O EFF
Page 465 and 466: Method and results: A total of 317
Page 467 and 468: 1436P SURVEY ON MODELS OF INTEGRATI
Page 469 and 470: care unit (PCU) at the National Can
Page 471 and 472: Characteristic No. % Total 63 1 st
Page 473 and 474: hysterectomised-9.10% and cervix ca
Page 475 and 476: abstracts psycho-oncology 1462PD IN
Page 477: events, tumour response, and surviv
Page 481 and 482: 1481PD A PHASE II STUDY OF DOVITINI
Page 483 and 484: 1488P ORGANISATION OF SARCOMA PATIE
Page 485 and 486: Patients and methods: From August 2
Page 487 and 488: chemotherapy respectively. At a med
Page 489 and 490: of this group Those with relapsed d
Page 491 and 492: 1515 PREDICTORS OF SURVIVAL IN ADOL
Page 493 and 494: abstracts small cell lung cancer an
Page 495 and 496: emaining receiving either CAV or to
Page 497 and 498: 1533P EXPRESSION OF WILM⍰TUMOUR G
Page 499 and 500: more than 3 months after first line
Page 501 and 502: lower recurrence rate of NE. Pegfil
Page 503 and 504: egimens (HR = 2.5, p < 0.001). Phys
Page 505 and 506: 1561P PREDICTIVE DIAGNOSTICS FOR RE
Page 507 and 508: Methods: A prospective multicentre
Page 509 and 510: Table: 1574P Pharmacokinetic parame
Page 511 and 512: Novartis and unrestricted research
Page 513 and 514: studies have shown that chemotherap
Page 515 and 516: (Grade 1) and moderate to severe (G
Page 517 and 518: declined to relatively lower level
Page 519 and 520: 1609P PHYSICAL ACTIVITY (PA) AND PH
Page 521 and 522: patients were admitted to the oncol
Page 523 and 524: Dicarbamin 100 mg/day on day 5 befo
Page 525 and 526: Results: Anemia was detected in 83.
Page 527 and 528: important to carry out randomized s
Page 529 and 530:
abstracts translational research 16
Page 531 and 532:
expression. Then, we analyzed PB sa
Page 533 and 534:
Table: 1657P TH BV + TH HR (95% CI)
Page 535 and 536:
BRAF mutations. Circulating free DN
Page 537 and 538:
1671P PHASE I CLINICAL TRIAL OF CAN
Page 539 and 540:
1678P PREDICTIVE VALUE OF TWO PHENO
Page 541 and 542:
theorized that the PI3K/AKT pathway
Page 543 and 544:
Material and methods: 101 patients
Page 545 and 546:
overexpressing and 232 had triple n
Page 547 and 548:
author index author index A Aamdal
Page 549 and 550:
author index Badran A. ix288 (874)
Page 551 and 552:
author index Bösmüller H. ix209 (
Page 553 and 554:
author index Chen A. ix319 (966O) C
Page 555 and 556:
author index De Droogh E. ix452 (13
Page 557 and 558:
author index Esposito G. ix209 (618
Page 559 and 560:
author index Geiges G. ix306 (930P)
Page 561 and 562:
author index Hartono S. ix70 (155P)
Page 563 and 564:
author index Iwasaki H. ix542 (1694
Page 565 and 566:
author index Kodaira M. ix90 (228P)
Page 567 and 568:
author index Lichtensztejn D. ix350
Page 569 and 570:
author index Martinez A. ix496 (153
Page 571 and 572:
author index Morishita N. ix432 (13
Page 573 and 574:
author index Okamoto N. ix432 (1320
Page 575 and 576:
author index Piau S. ix456 (1401P)
Page 577 and 578:
author index Rodríguez Rodríguez
Page 579 and 580:
author index Scoggins C.R. ix371 (1
Page 581 and 582:
author index Stern L. ix272 (823P)
Page 583 and 584:
author index Trypaki M. ix429 (1308
Page 585 and 586:
author index Whitmore J.B. ix310 (9
Page 587 and 588:
subject index subject index A AAV-H
Page 589 and 590:
subject index ix115 (316TiP), ix116
Page 591 and 592:
subject index diffuse large B-cell
Page 593 and 594:
subject index (1033P), ix340 (1036P
Page 595 and 596:
subject index medical information,
Page 597 and 598:
subject index (612P), ix214 (633),
Page 599 and 600:
subject index RCC, ix274 (830P) re-
Page 601 and 602:
subject index TR-FRET, ix84 (206P)
Page 603 and 604:
drug index drug index 1248P, 1250P,
Page 605 and 606:
translational research index transl
Page 607 and 608:
Page 609:
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