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Annals of Oncology (visceral and nodes). The most common Grade 3/4 adverse events (AEs) were neutropenia (64.5%, 20 Pts) leukopenia (45.2%, 14 Pts), and febrile neutropenia (9.7%, 3 Pts). G3/4 diarrhoea was reported 3.2%, 1 pt. Pain response was 64.3%. PSA response 6 cycles (32 Pts) decline ≥50% PSA response by Gleason (decline >50%) 53% GS 4-6 ( 9 Pts) 44% GS 7 (10 Pts) 60% GS 8-10 (13 Pts) PSA response by previous D regimen 54% 1 (17 Pts) 12 (71%) >1 (15 Pts) 5 (33%) Tumor Response (RECIST) 22 Pts PR + SD 19 (86.4%) PD 3 (13.6%) Conclusions: Our results indicate a high activity of cabazitaxel in terms of PSA, tumor and pain responses in all subgroups of pts analysed; cabazitaxel shows globally a clinically manageable safety profile in daily clinical practice. Disclosure: All authors have declared no conflicts of interest. 963TiP PHASE I TRIAL OF ASG-5ME IN METASTATIC CASTRATION RESISTANT PROSTATE CANCER (CRPC) M. Morris 1 , J. Bruce 2 , L. Reyno 3 , B. Anand 3 , A. Hartford 3 , K. Jelaca-Maxwell 3 , J. Lackey 3 , M. Eisenberger 4 1 Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, UNITED STATES OF AMERICA, 2 Medicine, University of Wisconsin Center for Health Sciences Medical School UW Carbone Cancer Center, Madison, WI, UNITED STATES OF AMERICA, 3 Development, Agensys, Santa Monica, CA, UNITED STATES OF AMERICA, 4 Medicine, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medical Center, Baltimore, MD, UNITED STATES OF AMERICA Background: SLC44A4 is a 710 amino acid protein expressed on prostate, pancreas and other cancers. SLC44A4 is found in 95% of primary prostate tumors (75% express moderate to high levels). ASG-5ME is an antibody drug conjugate (ADC) comprised of a fully human antibody against SLC44A4, conjugated to the microtubule-disrupting agent monomethyl auristatin E. ASG-5ME has dose-dependent cytotoxic effects in vitro and significant anti-tumor activity in xenograft models. We report results of a phase I study of ASG-5ME for CRPC, conducted by the Prostate Cancer Clinical Trials Consortium. Methods: Patients (pts) had progressive metastatic CRPC. Prior chemotherapy was allowed. Treatment cohorts were 0.3, 0.6, 1.2, 1.8, 2.4, 2.7 and 3.0 mg/kg. ASG-5ME was given IV q3 weeks. Safety, pharmacokinetic properties, anti-tumor effects, circulating tumor cell (CTC) enumeration, and CTC molecular profiles were assessed. Pts were treated until disease progression or unacceptable toxicity. Dose limiting toxicity (DLT) was defined by cycle 1 toxicity. Results: 26 pts have been treated (3, 3, 3, 3, 6, 6, and 2 pts per respective cohort). Mean age was 69.5 (range 56-87), median Gleason score 8 (6-10), mean baseline PSA 82.25 (4.4-1987). Pts received a mean of 3.8 doses (1-12). A DLT occurred at 2.7 mg/ kg: Grade (Gr) 4 neutropenia, Gr 3 constipation and diarrhea. 2 DLTs occurred at 3 mg/kg: one with Gr 3 troponin elevation and the second with Gr 3 maculopapular rash, hypoxia, constipation, and Gr 4 neutropenia. Common Gr 1 and 2 adverse events included fatigue, anorexia, peripheral neuropathy, dyspnea and nausea. Gr 3 events included: fatigue (2 pts), peripheral neuropathy (1), dyspnea (1) and nausea (1). Serum concentrations of ASG-5ME decreased multi-exponentially and the exposure was dose-proportional. The half-life of the ADC was 7.01 days (range-3.93-15.9, n = 17) after the first dose and 11.2 days (range-7.75-19.1 days, n = 10) after the last dose. PSA declines of >50% were seen in 3/8 pts treated in the last 3 cohorts and one >50% decrease in retroperitoneal nodes. Conclusions: The maximum tolerated dose (MTD) was exceeded at 3 mg/kg. The drug appears to have anti-cancer activity above 2.4 mg/kg. Disclosure: L. Reyno: The author is the CMO and Sr Vice President of Agensys, Inc, B. Anand: The author is a director of Agensys, IncA. Hartford: The author is a director of Agensys, Inc, K. Jelaca-Maxwell: The author is a paid safety consultant of Agensys, Inc, J. Lackey: The author is a director of Agensys, Inc. All other authors have declared no conflicts of interest. 964TiP ARN-509 IN MEN WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER (CRPC) D. Rathkopf 1 , E.S. Antonarakis 2 , N.D. Shore 3 , R. Tutrone 4 , J. Alumkal 5 , C.J. Ryan 6 , M. Saleh 7 , R. Hauke 8 , E. Chow-Maneval 9 , H.I. Scher 1 1 Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, UNITED STATES OF AMERICA, 2 Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, UNITED STATES OF AMERICA, 3 Urology, Carolina Urologic Research Center, Myrtle Beach, SC, UNITED STATES OF AMERICA, 4 Urology, Chesapeake Urology Research Associates, Baltimore, MD, UNITED STATES OF AMERICA, 5 Medicine, Oregon Health & Science University Knight Cancer Institute, Portland, OR, UNITED STATES OF AMERICA, 6 Ucsf Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, UNITED STATES OF AMERICA, 7 Medicine, Georgia Cancer Specialists, Atlanta, GA, UNITED STATES OF AMERICA, 8 Medicine, Nebraska Cancer Specialists, Omaha, NE, UNITED STATES OF AMERICA, 9 Clinical Development, Aragon Pharmaceuticals, San Diego, CA, UNITED STATES OF AMERICA Background: ARN-509 is a novel second-generation anti-androgen that binds directly to the ligand-binding domain of the androgen receptor, impairing nuclear translocation and DNA binding. The Phase II portion of a multicenter Phase I/II study is evaluating the activity of ARN-509 in 3 distinct patient populations of men with CRPC: 1) non-metastatic treatment-naïve CRPC; 2) mCRPC treatment-naïve (tx-naïve); and 3) mCRPC abiraterone acetate pre-treated (AA). Preliminary results for the 2 cohorts of patients with metastatic CRPC are presented here. Methods: All patients had metastatic CRPC with progressive disease based on rising PSA and/or imaging. No prior chemotherapy for metastatic prostate cancer was allowed. Patients on the AA pre-treated cohort had to have been treated with AA for at least 6 months. All patients received ARN-509 at the recommended Phase II dose of 240 mg/day (Rathkopf et al, GU ASCO 2012). The primary endpoint was PSA response rate at 12 weeks according to the Prostate Cancer Working Group 2 Criteria in each of the treatment groups. Secondary endpoints included safety, time to PSA progression and objective response rates. PSA assessments were collected every 4 weeks and tumor imaging was performed every 16 weeks. Results: To date, 32 patients have been enrolled: 25 on the tx-naïve and 7 on the post-AA cohorts, respectively. The combined median age was 67 (range 51-91) and at baseline, patients presented with ECOG performance status 0 (55%), Gleason Score 8-10 (54%), and median PSA of 14.7 (tx-naïve) and 69.6 (post-AA) ng/mL. All patients received prior treatment with a LHRH analog with or without a first-generation anti-androgen. At a median treatment duration of 16 weeks, 4 patients discontinued the study due to disease progression, 2 in each cohort. The most common treatment-related adverse events (AE) were abdominal pain (36%), diarrhea (19%), nausea (16%) and fatigue (10%). There was only 1 treatment-related Grade 3 AE of abdominal pain. At 12 weeks, the PSA response was 91% (tx-naïve) and 60% (post-AA), respectively. Conclusion: In men with CRPC, ARN-509 is safe and well tolerated with promising preliminary activity in metastatic, chemo-naïve patients both before and after treatment with abiraterone. Disclosure: E. Chow-Maneval: Dr. Chow Maneval is an employee of Aragon and holds stock in the company. All other authors have declared no conflicts of interest. 965TiP A PHASE II STUDY (PERSEUS) OF TWO DOSES OF EMD 525797 (DI17E6) IN PATIENTS (PTS) WITH ASYMPTOMATIC OR MILDLY SYMPTOMATIC METASTATIC CASTRATE-RESISTANT PROSTATE CANCER (MCRPC) K. Miller 1,* , M. Hussain 2,* , G. Mordenti 3 , H. Lannert 4 1 Charité, Department of Urology, Berlin, GERMANY, 2 University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI, UNITED STATES OF AMERICA, 3 Merck Serono S.A., Global Biostatistics, Geneva, SWITZERLAND, 4 Merck KGaA, Global Clinical Development Unit Oncology, Darmstadt, GERMANY, * on behalf of the PERSEUS Study Group Purpose: Expression and function of αv-integrins are deregulated in prostate cancer, and αv-integrins are thought to play an important role in prostate cancer metastasis. EMD 525797 (DI17E6) is a humanized monoclonal IgG2 antibody specifically directed against αv integrin receptors (αvß1, αvß3, αvß5, αvß6, and αvß8). It has been shown to target tumor cells, the tumor’s environment (e.g. osteoclasts and osteoblasts), as well as angiogenic blood vessels. Previous studies with EMD 525797 have shown a favorable tolerability profile in healthy volunteers and in mCRPC pts. A phase II trial is investigating the anticancer activity of 2 dose levels of EMD 525797 in asymptomatic or mildly symptomatic mCRPC pts. Methods: Adult pts with CRPC who show radiologic progression of bone lesions with/without soft tissue lesions within 28 days prior to randomization are eligible for inclusion. Exclusion criteria are: acute pathologic fracture, spinal cord compression, Volume 23 | Supplement 9 | September 2012 doi:10.1093/annonc/mds400 | ix317
or hypercalcemia at screening; prior chemotherapy, biologic, or experimental therapy for mCRPC; or radiotherapy to bone lesions and/or orthopedic surgery for pathologic fractures. A total of 216 pts receiving standard of care (luteinizing hormone-releasing hormone [LHRH] antagonists) and bisphosphonate therapy will be randomized 1:1:1 to receive in a blinded manner placebo, 1500 mg or 750 mg EMD 525797 (all 1-h intravenous [IV] infusions) on day 1 of every 3-week cycle until radiographic disease progression (PD). At progression, therapy will be unblinded and pts in the placebo group who show asymptomatic or mildly symptomatic radiographic confirmed PD can receive open-label therapy with 1500 mg EMD 525797. The primary endpoint is composite progression-free survival, defined as the time (months) from randomization date to first documented sign of Annals of Oncology objective radiographic PD or death from any cause. Secondary endpoints include efficacy (e.g. overall survival and time to progression), safety, the pharmacokinetic profile of EMD 525797, and the exploration of a relationship between the number of circulating tumor cells and clinical outcomes. As of April 2012, 106 pts have entered the trial. Disclosure: K. Miller: Membership on an advisory board for Merck KGaA, Darmstadt, Germany, G. Mordenti: Employee of Merck KGaA, Darmstadt, Germany, H. Lannert: Employee of Merck KGaA, Darmstadt, Germany. All other authors have declared no conflicts of interest. ix318 | Abstracts Volume 23 | Supplement 9 | September 2012
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Annals of Oncology www.annonc.oxfor
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subscriptions A subscription to Ann
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Annals of Oncology Official Journal
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The European Society for Medical On
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Audit Committee Chair: Fortunato Ci
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Familial cancer Judith Balmaña, Ba
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ESMO 2012 Congress Travel Grants 47
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Exhibitors The following companies
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ESMO Fellowships, 1989-2011 The Eur
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Ondrej Gojis, Czech Republic 2008-2
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abstracts hpv biology and implicati
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abstracts the characterization of l
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abstracts description of intra-tumo
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prevent cell death. It is anticipat
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22IN TARGETING THE HOST IN TNBC G.
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abstracts a paradigm shift in early
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abstracts how can medical oncologis
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feasibility), but by how high the c
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abstracts re-inventing the medical
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abstracts emerging diagnostic and t
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abstracts biologically based treatm
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abstracts molecular targets in mali
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abstracts melanoma therapy: from fr
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diagnosis and can also be used for
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analysis at 11 months median follow
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mouse model of Kras mutant NSCLC. I
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abstracts subtyping soft tissue sar
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abstracts key topics in supportive
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ESMO-CSCO Joint Symposium: Building
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ESMO-EANM-ESR Joint Symposium: Imag
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ESMO-ESTRO Joint Symposium: Innovat
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ESMO-MASCC Joint Symposium: Integra
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ESO Society Symposium: Celebrating
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Results: TIMP-1 expression was incr
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will benefit from this targeted the
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cytomegalovirus (CMV). Analysis of
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functional consequences of Endoglin
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elationship between the ROR score,
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183P EPIDERMAL GROWTH FACTOR RECEPT
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Plasma adiponectin level on the pre
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Table: 198P PFS OS Median, mo HR Me
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204P EVALUATION OF PTEN AND PIK3CA
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Material and methods: We searched P
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Results: The median concentration o
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Table: 226P Methods: Pts were rando
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However, additional analysis sugges
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number of biomarkers have been trie
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Table: 248O 249PD PROTEOMIC PREDICT
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Conclusions: BW and serum Ctrough o
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261P BREAST CANCER SUBTYPES AND OUT
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90 mg/m2-cyclophophamide 600 mg/m2
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to 9 weeks after dosing. Trastuzuma
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Patients and methods: We reviewed d
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sector patients. The aim of this st
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Linear Logistic Model with Relaxed
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Results: The median CTC fold change
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312: Table: Chemotherapy uptake wit
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abstracts breast cancer, locally ad
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Results: 8 trials (2092 pts) with 1
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absolute difference of median value
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Novartis, Genentech, and sanofi-ave
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Results: Three RCTs with 1023 patie
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collected from all patients for det
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355P FIRST REPORT OF LONG-TERM RESP
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361P A RETROSPECTIVE ANALYSIS OF PL
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publications and aggregated in a me
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Thus the primary aim to target BCSC
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383 WHY DO WOMEN WITH BREAST CANCER
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Results: We evaluated 76 pts with M
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more than 6 cycles of capecitabine.
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406TiP PHASE II TRIAL OF PRIMARY SY
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abstracts CNS tumors 410O CONDITION
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Conclusions: Our data suggested tha
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Conclusions: As in other cancer typ
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432 GAMMA KNIFE RADIOSURGERY AS A M
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abstracts developmental therapeutic
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1PR), but no responses were seen in
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RO and Cd, as well as PD data for c
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and vulvar Ca), and 11 SDs were obs
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knowing HLA-A status double-blindly
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Acquired-resistance to EGFR inhibit
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474P PHASE 1 STUDY OF THE SELECTIVE
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TST is active in breast and gastric
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Treatment-induced shedding of circu
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Methods: Either co-cultures of peri
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501 PRECLINICAL DATA INVESTIGATING
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509TiP LUX-LUNG 8: A RANDOMIZED, OP
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(P = 0.64). Synchronous BBC was sig
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abstracts gastrointestinal tumors,
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Disclosure: M. Lee: I am an employe
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plus intravenous Bev(7.5mg/kg q 21d
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anti-EGFR treatment. The present st
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patients harboring a T/T genotype t
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551P ADJUVANT CHEMOTHERAPY (AC) USE
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experienced significantly more ≥
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functioning scales. Exploratory ana
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oxaliplatin (100 mg/m 2 )/raltitrex
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572P PANERB STUDY: WHICH CATEGORY O
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Results: 92/114 patients were preop
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585P CHANGES IN THE INTESTINAL ENVI
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592P PHASE II TRIAL OF COMBINED CHE
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minutes. In a previous study, 30-mi
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Patients and methods: Chemotherapy-
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612P ARE PATIENTS WITH RESECTABLE R
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Conclusions: AMPK and ACC activatio
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of surgical monotherapy in patients
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Table: 632 633 AFLIBERCEPT/FOLFIRI
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factors play the determining role i
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Abstract withdrawn in exceptional c
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were respectively 10.6 vs 8.5 vs 3.
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Results: 20 gastrointestinal cancer
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abstracts gastrointestinal tumors,
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Day 8. A second identical course wa
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proven in stage I GC. The aim of th
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Conclusions: Longer OS to FOLFOX wa
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692P PRELIMINARY SAFETY DATA FROM A
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subgroup. Taking into consideration
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Results: Three years of adjuvant im
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considered sufficient to give an 80
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721P FIRST-LINE TREATMENT WITH FOLF
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after Gem-based therapy. The additi
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735P RADIOGRAPHIC PARAMETERS IN PRE
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validate the revised AJCC 7th stagi
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Results: Among 862 MM we identified
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Results: Frequently reported advers
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gastric cancer patients with CNS me
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discriminate the prognosis of HCC p
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prospective, non-interventional stu
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abstracts genitourinary tumors, non
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787O EXTERNAL VALIDATION OF THE ASS
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patient preference for P over S, an
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798PD OPEN-LABEL PHASE II TRIAL OF
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GlaxoSmithKline, Merck Sharp & Dohm
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advisor for Merck Sharp & Dohme, an
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or cutaneous melanoma. A survival u
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systemic therapy or were intolerant
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abstracts neuroendocrine tumors and
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morbidity, with G3 tumors behaving
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pts. Poorly differentiated endocrin
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Adenocarcinoma was present in 25 pa
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Method: Endobronchial ultrasound gu
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widely used by single agent or plat
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disease after surgery were treated
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stage IIIA NSCLC, EML4-ALK fusion-p
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1200P CONCOMITANT CHEMORADIATION GI
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Patients and methods: The study was
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months (95% CI:13-25). The PFS and
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maintenance therapy had favourable
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abstracts non-small cell lung cance
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Ingelheim, GSK Biologicals (compens
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1234PD RANDOMIZED PHASE III TRIAL O
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GlaxoSmithKline (myself, compensate
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1243P IDENTIFICATION OF MICRORNA (M
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N-arm n=34 P-arm n=32 All n=66 Male
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1255P POPULATION BASED EVALUATION O
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1262P DISTINCT SPREAD OF EGFR MUTAT
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1268P VISUAL DISTURBANCES IN PATIEN
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MERCK SERONO: Advisor, speaker in s
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Conclusions: These data from SAiL a
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NSCLC diagnosis and time of BM diag
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1291P PHASE I/II DOSE-FINDING STUDY
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Network utilization of WBCGF in the
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1303P COST EFFECTIVENESS OF PEMETRE
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Results: The patients’ characteri
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EGFR mut at exons 18, 19, 21, and K
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Methods: EML4-ALK fusion was screen
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Results: The median survival time (
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enefit from sustained EGFR blockade
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epresented by 19 pts (32%) female,
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and at least one prior course of ch
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Methods: NSCLC patients with radiog
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1367TiP LONG-TERM ERLOTINIB THERAPY
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Austria, Czech Republic, Finland, G
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were every 6 weeks (wk) (S1), every
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Advantage enrollees (83% vs. 25%) [
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Results: Based on 10,000 simulation
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cancer tumors 12%, Germ cell tumor
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Material and methods: 50 lung cance
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1414TiP IMPLEMENTATION OF CANCER RE
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abstracts palliative care 1422O EFF
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Method and results: A total of 317
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1436P SURVEY ON MODELS OF INTEGRATI
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care unit (PCU) at the National Can
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Characteristic No. % Total 63 1 st
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hysterectomised-9.10% and cervix ca
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abstracts psycho-oncology 1462PD IN
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events, tumour response, and surviv
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abstracts sarcoma 1477O ADHESION TO
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1481PD A PHASE II STUDY OF DOVITINI
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1488P ORGANISATION OF SARCOMA PATIE
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Patients and methods: From August 2
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chemotherapy respectively. At a med
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of this group Those with relapsed d
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1515 PREDICTORS OF SURVIVAL IN ADOL
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abstracts small cell lung cancer an
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emaining receiving either CAV or to
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1533P EXPRESSION OF WILM⍰TUMOUR G
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more than 3 months after first line
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lower recurrence rate of NE. Pegfil
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egimens (HR = 2.5, p < 0.001). Phys
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1561P PREDICTIVE DIAGNOSTICS FOR RE
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Methods: A prospective multicentre
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Table: 1574P Pharmacokinetic parame
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Novartis and unrestricted research
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studies have shown that chemotherap
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(Grade 1) and moderate to severe (G
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declined to relatively lower level
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1609P PHYSICAL ACTIVITY (PA) AND PH
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patients were admitted to the oncol
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Dicarbamin 100 mg/day on day 5 befo
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Results: Anemia was detected in 83.
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important to carry out randomized s
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abstracts translational research 16
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expression. Then, we analyzed PB sa
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Table: 1657P TH BV + TH HR (95% CI)
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BRAF mutations. Circulating free DN
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1671P PHASE I CLINICAL TRIAL OF CAN
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1678P PREDICTIVE VALUE OF TWO PHENO
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theorized that the PI3K/AKT pathway
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Material and methods: 101 patients
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overexpressing and 232 had triple n
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author index author index A Aamdal
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author index Badran A. ix288 (874)
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author index Bösmüller H. ix209 (
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author index Chen A. ix319 (966O) C
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author index De Droogh E. ix452 (13
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author index Esposito G. ix209 (618
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author index Geiges G. ix306 (930P)
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author index Hartono S. ix70 (155P)
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author index Iwasaki H. ix542 (1694
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author index Kodaira M. ix90 (228P)
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author index Lichtensztejn D. ix350
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author index Martinez A. ix496 (153
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author index Morishita N. ix432 (13
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author index Okamoto N. ix432 (1320
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author index Piau S. ix456 (1401P)
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author index Rodríguez Rodríguez
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author index Scoggins C.R. ix371 (1
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author index Stern L. ix272 (823P)
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author index Trypaki M. ix429 (1308
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author index Whitmore J.B. ix310 (9
Page 587 and 588:
subject index subject index A AAV-H
Page 589 and 590:
subject index ix115 (316TiP), ix116
Page 591 and 592:
subject index diffuse large B-cell
Page 593 and 594:
subject index (1033P), ix340 (1036P
Page 595 and 596:
subject index medical information,
Page 597 and 598:
subject index (612P), ix214 (633),
Page 599 and 600:
subject index RCC, ix274 (830P) re-
Page 601 and 602:
subject index TR-FRET, ix84 (206P)
Page 603 and 604:
drug index drug index 1248P, 1250P,
Page 605 and 606:
translational research index transl
Page 607 and 608:
Page 609:
show all

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