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Annals of Oncology 29.2% PRs. Median time to progression (TTP) was 6.1 months (range, 3.2-9.0 months) in group NP and 6.3 months (range, 4.1-8.5 months) in group NX(P = 0.783). COX regression showed no statistically significant difference (P = 0.782, OR = 0.920). Median overall survival (OS) was 28.8 months (range, 21.6-36.0 months) in group NP and 15.1 months (9.6-20.6 months) in group NX(P = 0.027, OR = 0.495). COX regression showed a statistically significant difference(P = 0.045). Neutropenia was the most frequent hematologic toxicity, with 57.9% grade 3/4 neutropenia observed in group NP and 38.1% in group NX(P = 0.145). 13.2% grade 3/4 vomiting was seen in group NP and no grade 3/4 vomiting in group NX. No grade 3/4 nephrotoxicity or hand-foot syndrome was noted in both groups. Conclusion: Better OS was seen in group NP than in group NX. Treatment-related toxicity in both groups was manageable. Disclosure: All authors have declared no conflicts of interest. 395 DOCETAXEL (D), GEMCITABINE (G) AND BEVACIZUMAB (BEV) AS SALVAGE CHEMOTHERAPY (CT) FOR HER-2 NEGATIVE METASTATIC BREAST CANCER (MBC) E. Kontopodis 1 , C. Christophylakis 1 , N. Kentepozidis 1 , I. Boukovinas 1 , S. Giassas 1 , E. Saloustros 1 , A. Kalykaki 1 , V. Bozionelou 2 , V. Georgoulias 1 , D. Mavroudis 1 1 Medical Oncology, Hellenic Oncology Research Group (HORG), Athens, GREECE, 2 Medical Oncology, University General Hospital of Heraklion, Athens, GREECE Introduction: The combination of D and G is a valid salvage CT regimen for the treatment of mBC. When combined with CT, Bev has increased the response rate and progression-free survival (PFS) in both first and second line treatment of mBC. In this multicenter study, we evaluated the combination of D, G, and Bev, administered biweekly, as second or further line CT in patients (pts) with HER-2 negative mBC. Methods: Women with HER-2 negative mBC, who had received at least one prior line of CT, were treated with D 50 mg/m2, G 1500 mg/m2 and Bev 10 mg/Kg, in cycles every two weeks. Bev was continued until disease progression. This was a study with Simon’s optimal two step statistical design. Results: Forty-eight pts have been enrolled. Median age was 61 years, performance status was 0-1 in 95.8% and 2 in 4.2% of pts, 83.3% had hormone receptor positive disease, and 47.9% had received one prior line of CT. All pts were evaluable for toxicity and 43 for response. Objective response rate was 44.2% (95% confidence interval [CI], 29.3-59%), median PFS was 6.8 months (95% CI, 4.5-9.1 months), and median overall survival 20.1 months (95% CI, 9.9-30.3 months). Grade 3-4 hematologic toxicity consisted of neutropenia (39.6%) and febrile neutropenia (4.2%). Most common grade 2-3 non-hematologic adverse events included nausea (10.4%), diarrhea (10.5%), neurotoxicity (12.5%), fatigue (31.3%), allergic reactions (6.3%), hemorrhage (4.2%), and hypertension (4.2%). No grade 4 non-hematologic toxicities or toxic deaths were recorded. Conclusion: The combination of D, G and Bev has promising activity and a manageable toxicity profile as salvage CT for HER-2 negative mBC. Updated results will be presented at the congress. Disclosure: All authors have declared no conflicts of interest. 396 EFFICACY OF TRASTUZUMAB CONTAINING RETREATMENT AFTER PROGRESSION ON LAPATINIB THERAPY IN JAPANESE PATIENTS WITH HER2-POSITIVE METASTATIC BREAST CANCER M. Hattori 1 ,H.Iwata 1 , T. Fujita 1 , M. Sawaki 1 , N. Kondo 1 , A. Horio 1 , K. Muro 2 1 Breast Oncology, Aichi Cancer Center, Nagoya, JAPAN, 2 Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, JAPAN Background: Lapatinib has been approved for HER2 positive metastatic breast cancer patients with refractory to trastuzumab (T) therapy in Japan. Currently, it has been proposed that lapatinib can resensitize trastuzumab–mediated antibody-dependent cellular cytotoxicity (ADCC). Recent clinical data suggest the efficacy of T containing retreatment after progression on lapatinib therapy in patients with HER2-positive metastatic breast cancer. Here, we present a retrospective review of data from 25 patients who received T containing retreatment after progression on lapatinib therapy. Methods: We reviewed the data of 50 patients with HER2-positive metastatic breast cancer who received lapatinib therapy in our institution from August 2004 through March 2012. Of these, 25 patients received T containing retreatment after progression on lapatinib therapy. We retrospectively assessed the clinical benefit of this treatment regimen in these patients. Results: Luminal-HER2 and HER2-enriched subtypes were identified in 13 (52%) and 12 (48%) of these cases, respectively. The median duration of lapatinib therapy was 5.9 months (range, 1.8-20.2 months). The median number of preceding regimens was 3 (range, 2-8) in metastatic setting. Seven patients (31.8%) responded to T containing retreatment; all 7 patients achieved PR and none achieved CR. There were no significant differences in subtype, number of preceding regimens and brain metastases; however, responders achieved higher clinical response from lapatinib therapy than non-responders (response rate of 84% versus 13%, respectively). The median time to progression of T containing retreatment was 3.0 months (95% CI, 2.4-3.5 months). Among seven responders to T containing retreatment, one patient responded to refractory T containing regimen. All patients tolerated T containing retreatment with no occurrence of Grade 3/4 toxicities. Conclusion: T containing retreatment could be a favorable treatment regimen which can achieve clinical response in patients with HER2-positive metastatic breast cancer who experienced progression on prior trastuzumab and following lapatinib therapy. Disclosure: All authors have declared no conflicts of interest. 397 LOW DOSES OF GEMCITABINE (G) WITH CISPLATIN (C) IN TREATMENT OF METASTATIC BREAST CANCER (MBC) PROGRESSING AFTER ANTHRACYCLINES, TAXANES, CAPECITABINE AND OTHER ANTINEOPLASTIC AGENTS T.Y. Semiglazova 1 , M.L. Gershanovich 1 , D.H. Latipova 1 , L.V. Filatova 1 ,V. A. Chubenko 1 , V.F. Semiglazov 2 , V.V. Semiglazov 3 , P.V. Krivorotko 2 ,D. E. Matsko 4 , V.V. Klimenko 3 1 Department of Chemotherapy, N.N.Petrov Research Inst. of Oncology, St. Petersburg, RUSSIAN FEDERATION, 2 Breast Cancer Department, N.N. Petrov Research Inst. of Oncology, St. Petersburg, RUSSIAN FEDERATION, 3 Department of Oncology, Pavlov Medical University, St. Petersburg, RUSSIAN FEDERATION, 4 Department of Pathology, N.N.Petrov Research Inst. of Oncology, St. Petersburg, RUSSIAN FEDERATION Background: The highest synergism of G was registered with C, as G suppresses DNA reparation after its damage from C, which leads to apoptosis of tumor cell. The study of optimal doses of G and C combination continues for intensive pretreated MBC. Purpose: Evaluate efficiency and tolerability of the low doses of G and C in 131 patients with MBC progressing after anthracyclines, taxanes, capecitabine and other antineoplastic agents. Methods: G 600-750 mg/m 2 and C 30 mg/m 2 were administered on days 1 and 8 every 3 weeks in the 2 nd line for 28 patients, in the 3 rd for 54 patients and in the 4 th for 49 patients. Groups were comparable in age, performance status (PS), ER/PgR and HER2 expressions, localization and number of metastatic sites prior to treatment. Results: Total amount of cycles: 549, median 4.2 per patient (range: 2-12). The overall response (OR) of all patients was 27%, clinical benefit (OR + stable disease) – 71.7%, with median time to progression (TTP) 4.8 months (95% CI 3.9-5.7 months) and median overall survival (OS) 14.6 months (95% CI 12.1-17.1 months). The OR in the 2 nd line was observed in 39.3%, in the 3 rd – 27.8% and in the 4 th – 18.4% (р < 0.05), clinical benefit – in 85.7, 59.3 and 77.6% (р > 0.05) respectively. Pain intensity reduction and improvement of PS were noted in patients in spite of the lines. Linear discriminant and regression analyses showed that OR, TTP and OS didn’t depend on the ER/PgR and HER2 expressions, but ECOG 2-3, pain syndrome, metastases in the lymph nodes and liver were the factors of poor prognosis. The treatment-related adverse events were neutropenia, anemia, thrombocytopenia, alopecia, nausea, vomiting, peripheral neuropathy and fatigue. Toxicities with grade 3-4 intensity were neutropenia (31.6% of patients), vomiting (0.8%), anemia (2.3%), thrombocytopenia (3.1%). No febrile neutropenia and deaths related to the study treatment occurred. Conclusions: The low doses of G with C are effective and tolerable in treatment of MBC progressing after antracycline, taxanes, capecitabine, other antineoplastic agents not only in the 2 nd and 3 rd ,butalsointhe4 th lines and are suitable for outpatient therapy. Disclosure: All authors have declared no conflicts of interest. 398 LONG TERM USE OF CAPECITABINE IN PATIENTS WITH LOCALLY RECURRENT OR METASTATIC BREAST CANCER D.H. Josephs 1 , R. Mir 2 , T. Siow 1 , L.E. Dumas 1 , V. Michalarea 1 , E. Sawyer 2 ,J. L. Mansi 1 1 Medical Oncology Offices, 4th Floor Bermondsey Wing, Guys Hospital, Guys and St Thomas’s NHS Trust, London, UNITED KINGDOM, 2 Clinical Oncology, Guy’s and St Thomas’ NHS Trust, London, UNITED KINGDOM Background: Capecitabine monotherapy is considered standard treatment in anthracycline- and taxane-pretreated locally recurrent or metastatic breast cancer and has proven efficacy in this setting. Here we report the findings of a retrospective study to evaluate the impact of continuing capecitabine treatment beyond the standard 6 cycles until disease progression, on efficacy and outcomes in patients with locally recurrent or metastatic breast cancer. In addition we sought to consolidate the information known about capecitabine dose modification and efficacy outcomes in this patient population. Patients and methods: Clinical databases in two institutions were used to identify all patients with locally advanced or metastatic breast cancer treated with capecitabine over the period July 2006 – July 2011. Baseline characteristics, progression-free (PFS) and overall survival (OS) were recorded. Results: In total, 150 patients met the inclusion criteria. Of these patients 67 (45%) received less than 6 cycles, 17 (11%) received 6 cycles only and 66 (44%) received Volume 23 | Supplement 9 | September 2012 doi:10.1093/annonc/mds393 | ix139
more than 6 cycles of capecitabine. 65 (43%) patients commenced treatment at a dose less than 1250mg/m2 twice daily and 60 patients (40%) received a dose reduction during treatment. Median overall survival was longer in those patients who received more than 6 cycles of capecitabine treatment (20.9 months) compared to those who stopped at 6 cycles by clinical decision (16.3 months) although this did not reach significance (P = 0.088). PFS and OS were similar among patients who received lower vs. full-dose capecitabine (PFS P = 0.32, OS P = 0.71). Conclusions: In this retrospective analysis, patients receiving more than 6 cycles of treatment had a better OS than those who stopped at 6 cycles (by clinical decision). Continuing capecitabine monotherapy beyond the standard 6 cycles if well tolerated, should be considered in patients with locally recurrent or metastatic breast cancer as this may prolong PFS. In addition, these data support the practice of dose-reducing capecitabine, including the possibility of starting at a lower dose (
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Annals of Oncology www.annonc.oxfor
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subscriptions A subscription to Ann
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Annals of Oncology Official Journal
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The European Society for Medical On
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Audit Committee Chair: Fortunato Ci
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Familial cancer Judith Balmaña, Ba
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ESMO 2012 Congress Travel Grants 47
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Exhibitors The following companies
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ESMO Fellowships, 1989-2011 The Eur
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Ondrej Gojis, Czech Republic 2008-2
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abstracts hpv biology and implicati
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abstracts the characterization of l
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abstracts description of intra-tumo
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prevent cell death. It is anticipat
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22IN TARGETING THE HOST IN TNBC G.
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abstracts a paradigm shift in early
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abstracts how can medical oncologis
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feasibility), but by how high the c
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abstracts re-inventing the medical
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abstracts emerging diagnostic and t
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abstracts biologically based treatm
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abstracts molecular targets in mali
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abstracts melanoma therapy: from fr
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diagnosis and can also be used for
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analysis at 11 months median follow
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mouse model of Kras mutant NSCLC. I
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abstracts subtyping soft tissue sar
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abstracts key topics in supportive
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ESMO-CSCO Joint Symposium: Building
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ESMO-EANM-ESR Joint Symposium: Imag
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ESMO-ESTRO Joint Symposium: Innovat
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ESMO-MASCC Joint Symposium: Integra
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ESO Society Symposium: Celebrating
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Results: TIMP-1 expression was incr
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will benefit from this targeted the
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cytomegalovirus (CMV). Analysis of
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functional consequences of Endoglin
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elationship between the ROR score,
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183P EPIDERMAL GROWTH FACTOR RECEPT
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Plasma adiponectin level on the pre
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Table: 198P PFS OS Median, mo HR Me
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204P EVALUATION OF PTEN AND PIK3CA
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Material and methods: We searched P
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experienced significantly more ≥
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functioning scales. Exploratory ana
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oxaliplatin (100 mg/m 2 )/raltitrex
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572P PANERB STUDY: WHICH CATEGORY O
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Results: 92/114 patients were preop
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585P CHANGES IN THE INTESTINAL ENVI
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592P PHASE II TRIAL OF COMBINED CHE
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minutes. In a previous study, 30-mi
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Patients and methods: Chemotherapy-
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612P ARE PATIENTS WITH RESECTABLE R
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Conclusions: AMPK and ACC activatio
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of surgical monotherapy in patients
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Table: 632 633 AFLIBERCEPT/FOLFIRI
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factors play the determining role i
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Abstract withdrawn in exceptional c
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were respectively 10.6 vs 8.5 vs 3.
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Results: 20 gastrointestinal cancer
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abstracts gastrointestinal tumors,
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Day 8. A second identical course wa
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proven in stage I GC. The aim of th
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Conclusions: Longer OS to FOLFOX wa
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692P PRELIMINARY SAFETY DATA FROM A
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subgroup. Taking into consideration
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Results: Three years of adjuvant im
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considered sufficient to give an 80
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721P FIRST-LINE TREATMENT WITH FOLF
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after Gem-based therapy. The additi
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735P RADIOGRAPHIC PARAMETERS IN PRE
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validate the revised AJCC 7th stagi
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Results: Among 862 MM we identified
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Results: Frequently reported advers
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gastric cancer patients with CNS me
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discriminate the prognosis of HCC p
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prospective, non-interventional stu
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abstracts genitourinary tumors, non
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787O EXTERNAL VALIDATION OF THE ASS
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patient preference for P over S, an
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798PD OPEN-LABEL PHASE II TRIAL OF
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Hb, PS and LM. Median PFS for patie
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may have led to reduced dose and sh
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Results: 1,622 patients were identi
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RCC) was designed to address an unm
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Patients and methods: This is a sin
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treatment at week 4, and week 12 by
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effective in second or further line
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Conclusions: In pts with RCC treate
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using Drug inCode ® pharmacogeneti
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Table: 857P standard, but is not av
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efused HDCT. Of 23 patients, 20 com
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we identified 49 and 220 patients w
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879 TREATMENT OF PATIENTS WITH META
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Median overall survival (OS) was 26
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abstracts Genitourinary tumors, pro
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and week 13 BPI-SF Q3 scores), 28%
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Working Group (PCWG)-2 guidelines r
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atio HR 0.39; CI 0.18, 0.83, p = 0.
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We observed tumor responses and pro
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Here we report emerging data from t
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928P LHRH AGONIST-INDUCED SUPPRESSI
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Disclosure: S. Oudard: Has acted as
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939P NEOADJUVANT SIPULEUCEL-T IN LO
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945 BONE TURNOVER MARKERS AND POTEN
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952 SEQUENTIAL ANDROGEN DEPRIVATION
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managed in a multidisciplinary (MD)
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or hypercalcemia at screening; prio
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meeting. The prevalence of LGSC is
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Table: 975PD Continued AMG 386 + pa
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physicians in the U.S. and Europe.
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989P PHASE II STUDY OF COMBINATION
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elated with stage, nodal involvemen
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1004P CASE CONTROL STUDY ON TWO DIF
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eight patients who had infertility
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abstracts head and neck cancer 1016
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same CT/RT; Arm B2: 3 cycles of ind
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induction chemotherapy in the treat
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patients. We have developed a rando
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evaluated by the screening instrume
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morbidities that radiation would le
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Conclusions: Through adequate selec
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abstracts hematological malignancie
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anthracyclines in vitro. A favorabl
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1076P RITUXIMAB PLUS SUBCUTANEOUS C
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than the standard target of ≥2.5
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Patients: From November 2002 to May
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lymphadenopathy and multiple cutane
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prospective non-interventional stud
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Funding: GSK Biologicals Disclosure
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survival rates of 13-25% (Prieto et
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high response rates and prolonged p
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GlaxoSmithKline, Merck Sharp & Dohm
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advisor for Merck Sharp & Dohme, an
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or cutaneous melanoma. A survival u
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systemic therapy or were intolerant
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abstracts neuroendocrine tumors and
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morbidity, with G3 tumors behaving
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pts. Poorly differentiated endocrin
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Adenocarcinoma was present in 25 pa
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Method: Endobronchial ultrasound gu
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widely used by single agent or plat
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disease after surgery were treated
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stage IIIA NSCLC, EML4-ALK fusion-p
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1200P CONCOMITANT CHEMORADIATION GI
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Patients and methods: The study was
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months (95% CI:13-25). The PFS and
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maintenance therapy had favourable
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abstracts non-small cell lung cance
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Ingelheim, GSK Biologicals (compens
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1234PD RANDOMIZED PHASE III TRIAL O
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GlaxoSmithKline (myself, compensate
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1243P IDENTIFICATION OF MICRORNA (M
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N-arm n=34 P-arm n=32 All n=66 Male
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1255P POPULATION BASED EVALUATION O
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1262P DISTINCT SPREAD OF EGFR MUTAT
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1268P VISUAL DISTURBANCES IN PATIEN
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MERCK SERONO: Advisor, speaker in s
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Conclusions: These data from SAiL a
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NSCLC diagnosis and time of BM diag
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1291P PHASE I/II DOSE-FINDING STUDY
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Network utilization of WBCGF in the
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1303P COST EFFECTIVENESS OF PEMETRE
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Results: The patients’ characteri
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EGFR mut at exons 18, 19, 21, and K
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Methods: EML4-ALK fusion was screen
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Results: The median survival time (
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enefit from sustained EGFR blockade
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epresented by 19 pts (32%) female,
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and at least one prior course of ch
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Methods: NSCLC patients with radiog
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1367TiP LONG-TERM ERLOTINIB THERAPY
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Austria, Czech Republic, Finland, G
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were every 6 weeks (wk) (S1), every
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Advantage enrollees (83% vs. 25%) [
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Results: Based on 10,000 simulation
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cancer tumors 12%, Germ cell tumor
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Material and methods: 50 lung cance
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1414TiP IMPLEMENTATION OF CANCER RE
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abstracts palliative care 1422O EFF
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Method and results: A total of 317
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1436P SURVEY ON MODELS OF INTEGRATI
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care unit (PCU) at the National Can
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Characteristic No. % Total 63 1 st
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hysterectomised-9.10% and cervix ca
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abstracts psycho-oncology 1462PD IN
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events, tumour response, and surviv
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abstracts sarcoma 1477O ADHESION TO
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1481PD A PHASE II STUDY OF DOVITINI
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1488P ORGANISATION OF SARCOMA PATIE
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Patients and methods: From August 2
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chemotherapy respectively. At a med
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of this group Those with relapsed d
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1515 PREDICTORS OF SURVIVAL IN ADOL
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abstracts small cell lung cancer an
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emaining receiving either CAV or to
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1533P EXPRESSION OF WILM⍰TUMOUR G
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more than 3 months after first line
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lower recurrence rate of NE. Pegfil
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egimens (HR = 2.5, p < 0.001). Phys
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1561P PREDICTIVE DIAGNOSTICS FOR RE
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Methods: A prospective multicentre
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Table: 1574P Pharmacokinetic parame
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Novartis and unrestricted research
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studies have shown that chemotherap
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(Grade 1) and moderate to severe (G
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declined to relatively lower level
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1609P PHYSICAL ACTIVITY (PA) AND PH
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patients were admitted to the oncol
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Dicarbamin 100 mg/day on day 5 befo
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Results: Anemia was detected in 83.
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important to carry out randomized s
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abstracts translational research 16
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expression. Then, we analyzed PB sa
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Table: 1657P TH BV + TH HR (95% CI)
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BRAF mutations. Circulating free DN
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1671P PHASE I CLINICAL TRIAL OF CAN
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1678P PREDICTIVE VALUE OF TWO PHENO
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theorized that the PI3K/AKT pathway
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Material and methods: 101 patients
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overexpressing and 232 had triple n
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author index author index A Aamdal
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author index Badran A. ix288 (874)
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author index Bösmüller H. ix209 (
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author index Chen A. ix319 (966O) C
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author index De Droogh E. ix452 (13
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author index Esposito G. ix209 (618
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author index Geiges G. ix306 (930P)
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author index Hartono S. ix70 (155P)
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author index Iwasaki H. ix542 (1694
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author index Kodaira M. ix90 (228P)
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author index Lichtensztejn D. ix350
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author index Martinez A. ix496 (153
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author index Morishita N. ix432 (13
Page 573 and 574:
author index Okamoto N. ix432 (1320
Page 575 and 576:
author index Piau S. ix456 (1401P)
Page 577 and 578:
author index Rodríguez Rodríguez
Page 579 and 580:
author index Scoggins C.R. ix371 (1
Page 581 and 582:
author index Stern L. ix272 (823P)
Page 583 and 584:
author index Trypaki M. ix429 (1308
Page 585 and 586:
author index Whitmore J.B. ix310 (9
Page 587 and 588:
subject index subject index A AAV-H
Page 589 and 590:
subject index ix115 (316TiP), ix116
Page 591 and 592:
subject index diffuse large B-cell
Page 593 and 594:
subject index (1033P), ix340 (1036P
Page 595 and 596:
subject index medical information,
Page 597 and 598:
subject index (612P), ix214 (633),
Page 599 and 600:
subject index RCC, ix274 (830P) re-
Page 601 and 602:
subject index TR-FRET, ix84 (206P)
Page 603 and 604:
drug index drug index 1248P, 1250P,
Page 605 and 606:
translational research index transl
Page 607 and 608:
Page 609:
show all

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