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Annals Of Oncology translational research index PARP: 7IN, 20IN, 21IN, 35IN, 36IN, 55IN, 61IN, 66IN, 428, 972PD, 988P Paxillin: 1659P PBRM1: 51IN PC1/2: 236 P-cadherin: 1026P PD-1: 22IN, 53IN, 71IN, 453P, 459P, 784O, 915P, 1109O, 1237PD PDGF: 92IN, 102IN, 152P, 203P, 505, 507, 663TiP, 732P, 814P, 835P, 865P, 1657P PDGFR: 92IN, 174O, 417PD, 446PD, 720P, 737P, 744P, 880, 1027P, 1157O, 1349, 1478O, 1479PD, 1486PD, 1494P, 1496P, 1516, 1687P PDK1: 185P PD-L1: 453P PDX1: 215P p-EGFR: 1668P p-ER: 534P p-ERK: 443PD, 451P, 475P PGD: 1701 PGF: 720P PGK1: 1170P P-glycoprotein: 364P, 481P, 486P, 873, 1678P PI3K: 2IN, 7IN, 13IN, 20IN, 2IN, 62IN, 65IN, 70IN, 76IN,78IN, 83IN, 107IN, 108IN, 119IN, 148P, 154P, 173O, 185P, 204P, 214P, 237, 318O, 343P, 347P, 350P, 405TiP, 419PD, 442O, 450PD, 452P, 454P, 457P, 458P, 483P, 532P, 664TiP, 781TiP, 807P, 812P, 890TiP, 917P, 1017O, 1030P, 1491P, 1656P, 1668P, 1675P, 1676P, 1685P, 1693P PIAS4: 686P, 1661P PIGF: 203P, 1154O PIK: 548P PIK3CA: 20IN, 50IN, 102IN, 108IN, 119IN, 180P, 202P, 204P, 243, 406TiP, 442O, 452P, 457P, 574P, 630, 667PD, 675P, 696P, 812P, 1017O, 1030P, 1193P, 1649P, 1656P PIP3: 2IN PKM2: 1308P PLGF: 1236PD p-MAPK: 406TiP p-MEK: 475P p-MET: 443PD PMS1/2: 516P PNPO: 915P POSTN: 914P PPARγ: 590P PPP2R1B: 1701 PR: 21IN, 197P, 199P, 201P, 205P, 248O, 249PD, 257P, 258P, 259P, 264P, 265P, 266P, 278P, 279P, 284P, 291P, 298P, 302, 323PD, 343P, 353P, 357P, 370P, 376, 377, 378, 381, 386, 397, 406TiP, 414PD, 513PD, 1398P, 1702 PROM1: 720P PS6: 154P, 443PD, 457P PSA: 46IN, 87IN, 893O, 900PD, 901PD, 902P, 905P, 906P, 907P, 908P, 911P, 912P, 914P, 917P, 918P, 919P, 920P, 922P, 923P, 925P, 929P, 930P, 934P, 935P, 938P, 940P, 950, 951, 952, 953, 961, 962TiP, 963TiP, 964TiP PSF: 233 PSMA: 915P pSTAT3: 501 PTCH1: 25IN, 720P, 1032P, 1119P, 1121P, 1309P, 1663P PTCH2: 720P PTEN: 7IN, 12IN, 20IN, 55IN, 107IN, 108IN, 119IN, 173O, 202P, 204P, 343P, 406TiP, 457P, 458P, 532P, 548P, 630, 890TiP, 917P, 922P, 1026P, 1031P, 1656P PTGR1: 1701 PTK7: 539P PTPN12: 20IN, 353P p-VHL: 835P Rad51: 1662P Raf: 92IN, 143PD, 173O, 475P, 874, 1349, 1647PD RANKL: 49IN, 316TiP, 348P, 1108TiP RAP1A: 1701 RAP80: 807P RARB2: 293P, 1211 Ras: 143PD, 173O, 242, 1146, 1349, 1491P, 1647PD RASSF: 221P, 1211 RB1: 7IN, 50IN RDH5: 928P RESISTIN: 190P, RET: 7IN, 81IN, 119IN, 417PD, 445PD, 737P, 814P RFC: 1211 RHO: 947 RIZ1: 221P RNA: 2IN, 100IN, 145P, 147P, 159P, 177PD, 216P, 223P, 245O, 426P, 769, 803P, 1025P, 1031P, 1032P, 1393P, 1673P, 1684P RNF113: 1701 RNF43: 12IN, 144PD, 460P Robo4: 178P RON: 471P, 492P, 1532P RORA: 225P ROS: 7IN, 78IN, 81IN, 82IN, 119IN, 195P, 1119PD RPS3: 1701 RPS5: 1701 Rrca1: 290P RRM1: 77IN, 144PD, 187P, 1645PD RRM2: 187P RSK: 1674P RUNX1: 102IN RyR2: 1682P S100: 227P, 919P S1PR: 1651P S6: 1491P, 1674P S6K: 1491P Sca-1: 1685P SCC: 1203P, SCGF-B: 865P, SDF-1: 865P, 1033P SDH: 92IN SELENBP1: 910P SERCA2a: 1682P SF3B1: 102IN SHH: 720P SHP-1: 1075P shRNA: 30IN, 539P siRNA: 144PD, 145P, 169O, 185P, 188P, 205P, 1659P, 1673P SKDR: 1194P SLC34A2: 195P SLC3A2: 1701 SLC44A4: 963TiP SLCAM: 1194P SLCO1B1: 17IN SLD5: 233 Slug: 145P SMAD: 12IN, 605, 720P SMARCA4: 25IN SMO: 720P, 1309P SMRP: 192P Snail: 145P SOCS: 153P, 1030P Somatostatin receptor: 1164P, 1703IN SOX-2: 149P, 216P SPARC: 720P SPHK1: 1651P sRAGE: 919P SRC: 44IN, 53IN, 501, 1481PD, 1659P, 1686P STAT: 150P, 153P, 483P STK11: 7IN, 180P, 22OP STNF-RS: 488P Survivin: 156P, 979P SWI-SNF: 51IN, 186P SYK: 65IN T2E: 922P T6235C: 374P TAK1: 348P Tau: 291P TCL1A: 17IN TGASE-2: 830P TGF beta: 169O, 197P, 865P, 919P, 1209, 1695P TGFBR1: 615 TGF-α: 143PD, 1027P, 1209 TGM2: 1701 TIE-2: 471P, 492P, 975PD, 1027P, 1194P TIMP-1/2: 146P, 791PD, 833P TK1: 645 TLG: 567P TLR: 719P, 813P Tn: 619 TNFa: 163P, 190P, 476P, 480P TNFSF: 228P TOMM34: 460P Topoisomerase IIα: 202P, 245O, 291P, 406TiP, 485P, 1170P TP: 542P, 550P TPS: 302 TR4: 463P T-regulatory cells (TREG): 174O TRIK128: 1701 TrkB: 188P TROLOX: 473P TS: 187P, 550P, 1211, 1242P, 1243P TSC1: 5OIN TSC2: 12IN TSP-1: 354P, 919P TSPYL5: 17IN TTF1: 181P TTK: 1671P Twist: 1693P TX: 313 TXR: 1170P TYMS: 1170P UBA6: 1701 UBC9: 686P, 1661P URLC10: 1671P USP5: 1701 VCAM-1: 732P VEGF: 52IN, 54IN, 57IN, 91IN, 109IN, 152P,155P, 156P, 174O, 184P, 194P, 197P, 203P, 222P, 292P, 323PD, 354P, 377, 417PD, 435TiP, 448PD, 493P, 501, 505, 507, 529PD, 532P, 578P, 581P, 594P, 600P, 633, 642, 659, 663TiP, 696P, 734P, 737P, 751, 752, 791PD, 796PD, 814P, 822P, 829P, 831P, 835P, 837P, 840P, 841P, 842P, 843P, 855P, 869, 876, 829TiP, 966O, 1080P, 1154O, 1159P, 1160P, 1194P, 1245P, 1687 VEGF-A: 155P, 198P, 241, 546P, 720P, 724P, 734P, 794PD, 829P, 830P, 919P, 1026P, 1154O, 1194P, 1236PD, 1239P, 1657P, 1687 VEGF-B: 720P VEGF-C: 734P, 829P, 919P, 1026P, 1657P, 1687P VEGF-D: 1687P VEGFR: 91IN, 174O, 198P, 200P, 222P, 319O, 347P, 354P, 417PD, 445PD, 446PD, 448PD, 460P, 471P, 492P, 545P, 609P, 617, 659, 720P, 724P, 734P, 737P, 740P, 744P, 794PD, 796PD, Volume 23 | Supplement 9 | September <strong>2012</strong> doi:10.1093/annonc/mds480 | ix607 translational research index
translational research index translational research index 811P, 814P, 821P, 823P, 829P, 830P, 835P, 837P, 841P, 842P, 875, 880, 897O, 1026P, 1027P, 1115PD, 1154O, 1157O, 1194P, 1236PD, 1239P, 1245P, 1287P, 1349, 1479PD, 1496P, 1648P, 1652P, 1657P, 1687P VGLL3: 906P VHL: 52IN, 501, 794PD, 830P, 832P, 835P, 869 ViViD: 163P WEE1: 20IN WIF1: 221P Wnt: 463P, 545P, 617, 720P, 1700 WT1: 490P, 1533P XIAP: 156P XPD: 1244P XRCC: 527PD, 1052 YEATS4: 93IN YPK-1: 723P ZEB-1/2: 145P, 1693P ZNF415: 1032P, 1119P αv integrins: 965TiP Annals Of Oncology ix608 | translational research index Volume 23 | Supplement 9 | September <strong>2012</strong>
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Annals of Oncology www.annonc.oxfor
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subscriptions A subscription to Ann
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Annals of Oncology Official Journal
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The European Society for Medical On
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Audit Committee Chair: Fortunato Ci
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Familial cancer Judith Balmaña, Ba
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ESMO 2012 Congress Travel Grants 47
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Exhibitors The following companies
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ESMO Fellowships, 1989-2011 The Eur
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Ondrej Gojis, Czech Republic 2008-2
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abstracts hpv biology and implicati
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abstracts the characterization of l
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abstracts description of intra-tumo
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prevent cell death. It is anticipat
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22IN TARGETING THE HOST IN TNBC G.
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abstracts a paradigm shift in early
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abstracts how can medical oncologis
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feasibility), but by how high the c
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abstracts re-inventing the medical
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abstracts emerging diagnostic and t
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abstracts biologically based treatm
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abstracts molecular targets in mali
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abstracts melanoma therapy: from fr
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diagnosis and can also be used for
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analysis at 11 months median follow
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mouse model of Kras mutant NSCLC. I
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abstracts subtyping soft tissue sar
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abstracts key topics in supportive
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ESMO-CSCO Joint Symposium: Building
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ESMO-EANM-ESR Joint Symposium: Imag
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ESMO-ESTRO Joint Symposium: Innovat
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ESMO-MASCC Joint Symposium: Integra
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ESO Society Symposium: Celebrating
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Results: TIMP-1 expression was incr
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will benefit from this targeted the
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cytomegalovirus (CMV). Analysis of
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functional consequences of Endoglin
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elationship between the ROR score,
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183P EPIDERMAL GROWTH FACTOR RECEPT
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Plasma adiponectin level on the pre
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Table: 198P PFS OS Median, mo HR Me
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204P EVALUATION OF PTEN AND PIK3CA
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Material and methods: We searched P
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Results: The median concentration o
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Table: 226P Methods: Pts were rando
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However, additional analysis sugges
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number of biomarkers have been trie
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Table: 248O 249PD PROTEOMIC PREDICT
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Conclusions: BW and serum Ctrough o
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261P BREAST CANCER SUBTYPES AND OUT
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90 mg/m2-cyclophophamide 600 mg/m2
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to 9 weeks after dosing. Trastuzuma
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Patients and methods: We reviewed d
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sector patients. The aim of this st
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Linear Logistic Model with Relaxed
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Results: The median CTC fold change
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312: Table: Chemotherapy uptake wit
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abstracts breast cancer, locally ad
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Results: 8 trials (2092 pts) with 1
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absolute difference of median value
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Novartis, Genentech, and sanofi-ave
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Results: Three RCTs with 1023 patie
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collected from all patients for det
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355P FIRST REPORT OF LONG-TERM RESP
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361P A RETROSPECTIVE ANALYSIS OF PL
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publications and aggregated in a me
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Thus the primary aim to target BCSC
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383 WHY DO WOMEN WITH BREAST CANCER
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Results: We evaluated 76 pts with M
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more than 6 cycles of capecitabine.
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406TiP PHASE II TRIAL OF PRIMARY SY
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abstracts CNS tumors 410O CONDITION
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Conclusions: Our data suggested tha
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Conclusions: As in other cancer typ
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432 GAMMA KNIFE RADIOSURGERY AS A M
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abstracts developmental therapeutic
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1PR), but no responses were seen in
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RO and Cd, as well as PD data for c
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and vulvar Ca), and 11 SDs were obs
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knowing HLA-A status double-blindly
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Acquired-resistance to EGFR inhibit
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474P PHASE 1 STUDY OF THE SELECTIVE
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TST is active in breast and gastric
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Treatment-induced shedding of circu
Page 171 and 172:
Methods: Either co-cultures of peri
Page 173 and 174:
501 PRECLINICAL DATA INVESTIGATING
Page 175 and 176:
509TiP LUX-LUNG 8: A RANDOMIZED, OP
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(P = 0.64). Synchronous BBC was sig
Page 179 and 180:
abstracts gastrointestinal tumors,
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Disclosure: M. Lee: I am an employe
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plus intravenous Bev(7.5mg/kg q 21d
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anti-EGFR treatment. The present st
Page 187 and 188:
patients harboring a T/T genotype t
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551P ADJUVANT CHEMOTHERAPY (AC) USE
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experienced significantly more ≥
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functioning scales. Exploratory ana
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oxaliplatin (100 mg/m 2 )/raltitrex
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572P PANERB STUDY: WHICH CATEGORY O
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Results: 92/114 patients were preop
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585P CHANGES IN THE INTESTINAL ENVI
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592P PHASE II TRIAL OF COMBINED CHE
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minutes. In a previous study, 30-mi
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Patients and methods: Chemotherapy-
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612P ARE PATIENTS WITH RESECTABLE R
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Conclusions: AMPK and ACC activatio
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of surgical monotherapy in patients
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Table: 632 633 AFLIBERCEPT/FOLFIRI
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factors play the determining role i
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Abstract withdrawn in exceptional c
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were respectively 10.6 vs 8.5 vs 3.
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Results: 20 gastrointestinal cancer
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abstracts gastrointestinal tumors,
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Day 8. A second identical course wa
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proven in stage I GC. The aim of th
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Conclusions: Longer OS to FOLFOX wa
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692P PRELIMINARY SAFETY DATA FROM A
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subgroup. Taking into consideration
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Results: Three years of adjuvant im
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considered sufficient to give an 80
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721P FIRST-LINE TREATMENT WITH FOLF
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after Gem-based therapy. The additi
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735P RADIOGRAPHIC PARAMETERS IN PRE
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validate the revised AJCC 7th stagi
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Results: Among 862 MM we identified
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Results: Frequently reported advers
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gastric cancer patients with CNS me
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discriminate the prognosis of HCC p
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prospective, non-interventional stu
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abstracts genitourinary tumors, non
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787O EXTERNAL VALIDATION OF THE ASS
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patient preference for P over S, an
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798PD OPEN-LABEL PHASE II TRIAL OF
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Hb, PS and LM. Median PFS for patie
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may have led to reduced dose and sh
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Results: 1,622 patients were identi
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RCC) was designed to address an unm
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Patients and methods: This is a sin
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treatment at week 4, and week 12 by
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effective in second or further line
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Conclusions: In pts with RCC treate
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using Drug inCode ® pharmacogeneti
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Table: 857P standard, but is not av
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efused HDCT. Of 23 patients, 20 com
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we identified 49 and 220 patients w
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879 TREATMENT OF PATIENTS WITH META
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Median overall survival (OS) was 26
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abstracts Genitourinary tumors, pro
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and week 13 BPI-SF Q3 scores), 28%
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Working Group (PCWG)-2 guidelines r
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atio HR 0.39; CI 0.18, 0.83, p = 0.
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We observed tumor responses and pro
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Here we report emerging data from t
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928P LHRH AGONIST-INDUCED SUPPRESSI
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Disclosure: S. Oudard: Has acted as
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939P NEOADJUVANT SIPULEUCEL-T IN LO
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945 BONE TURNOVER MARKERS AND POTEN
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952 SEQUENTIAL ANDROGEN DEPRIVATION
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managed in a multidisciplinary (MD)
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or hypercalcemia at screening; prio
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meeting. The prevalence of LGSC is
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Table: 975PD Continued AMG 386 + pa
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physicians in the U.S. and Europe.
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989P PHASE II STUDY OF COMBINATION
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elated with stage, nodal involvemen
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1004P CASE CONTROL STUDY ON TWO DIF
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eight patients who had infertility
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abstracts head and neck cancer 1016
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same CT/RT; Arm B2: 3 cycles of ind
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induction chemotherapy in the treat
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patients. We have developed a rando
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evaluated by the screening instrume
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morbidities that radiation would le
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Conclusions: Through adequate selec
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abstracts hematological malignancie
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anthracyclines in vitro. A favorabl
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1076P RITUXIMAB PLUS SUBCUTANEOUS C
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than the standard target of ≥2.5
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Patients: From November 2002 to May
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lymphadenopathy and multiple cutane
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prospective non-interventional stud
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Funding: GSK Biologicals Disclosure
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survival rates of 13-25% (Prieto et
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high response rates and prolonged p
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GlaxoSmithKline, Merck Sharp & Dohm
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advisor for Merck Sharp & Dohme, an
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or cutaneous melanoma. A survival u
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systemic therapy or were intolerant
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abstracts neuroendocrine tumors and
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morbidity, with G3 tumors behaving
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pts. Poorly differentiated endocrin
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Adenocarcinoma was present in 25 pa
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Method: Endobronchial ultrasound gu
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widely used by single agent or plat
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disease after surgery were treated
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stage IIIA NSCLC, EML4-ALK fusion-p
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1200P CONCOMITANT CHEMORADIATION GI
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Patients and methods: The study was
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months (95% CI:13-25). The PFS and
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maintenance therapy had favourable
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abstracts non-small cell lung cance
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Ingelheim, GSK Biologicals (compens
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1234PD RANDOMIZED PHASE III TRIAL O
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GlaxoSmithKline (myself, compensate
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1243P IDENTIFICATION OF MICRORNA (M
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N-arm n=34 P-arm n=32 All n=66 Male
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1255P POPULATION BASED EVALUATION O
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1262P DISTINCT SPREAD OF EGFR MUTAT
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1268P VISUAL DISTURBANCES IN PATIEN
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MERCK SERONO: Advisor, speaker in s
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Conclusions: These data from SAiL a
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NSCLC diagnosis and time of BM diag
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1291P PHASE I/II DOSE-FINDING STUDY
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Network utilization of WBCGF in the
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1303P COST EFFECTIVENESS OF PEMETRE
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Results: The patients’ characteri
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EGFR mut at exons 18, 19, 21, and K
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Methods: EML4-ALK fusion was screen
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Results: The median survival time (
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enefit from sustained EGFR blockade
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epresented by 19 pts (32%) female,
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and at least one prior course of ch
Page 445 and 446:
Methods: NSCLC patients with radiog
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1367TiP LONG-TERM ERLOTINIB THERAPY
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Austria, Czech Republic, Finland, G
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were every 6 weeks (wk) (S1), every
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Advantage enrollees (83% vs. 25%) [
Page 455 and 456:
Results: Based on 10,000 simulation
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cancer tumors 12%, Germ cell tumor
Page 459 and 460:
Material and methods: 50 lung cance
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1414TiP IMPLEMENTATION OF CANCER RE
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abstracts palliative care 1422O EFF
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Method and results: A total of 317
Page 467 and 468:
1436P SURVEY ON MODELS OF INTEGRATI
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care unit (PCU) at the National Can
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Characteristic No. % Total 63 1 st
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hysterectomised-9.10% and cervix ca
Page 475 and 476:
abstracts psycho-oncology 1462PD IN
Page 477 and 478:
events, tumour response, and surviv
Page 479 and 480:
abstracts sarcoma 1477O ADHESION TO
Page 481 and 482:
1481PD A PHASE II STUDY OF DOVITINI
Page 483 and 484:
1488P ORGANISATION OF SARCOMA PATIE
Page 485 and 486:
Patients and methods: From August 2
Page 487 and 488:
chemotherapy respectively. At a med
Page 489 and 490:
of this group Those with relapsed d
Page 491 and 492:
1515 PREDICTORS OF SURVIVAL IN ADOL
Page 493 and 494:
abstracts small cell lung cancer an
Page 495 and 496:
emaining receiving either CAV or to
Page 497 and 498:
1533P EXPRESSION OF WILM⍰TUMOUR G
Page 499 and 500:
more than 3 months after first line
Page 501 and 502:
lower recurrence rate of NE. Pegfil
Page 503 and 504:
egimens (HR = 2.5, p < 0.001). Phys
Page 505 and 506:
1561P PREDICTIVE DIAGNOSTICS FOR RE
Page 507 and 508:
Methods: A prospective multicentre
Page 509 and 510:
Table: 1574P Pharmacokinetic parame
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Novartis and unrestricted research
Page 513 and 514:
studies have shown that chemotherap
Page 515 and 516:
(Grade 1) and moderate to severe (G
Page 517 and 518:
declined to relatively lower level
Page 519 and 520:
1609P PHYSICAL ACTIVITY (PA) AND PH
Page 521 and 522:
patients were admitted to the oncol
Page 523 and 524:
Dicarbamin 100 mg/day on day 5 befo
Page 525 and 526:
Results: Anemia was detected in 83.
Page 527 and 528:
important to carry out randomized s
Page 529 and 530:
abstracts translational research 16
Page 531 and 532:
expression. Then, we analyzed PB sa
Page 533 and 534:
Table: 1657P TH BV + TH HR (95% CI)
Page 535 and 536:
BRAF mutations. Circulating free DN
Page 537 and 538:
1671P PHASE I CLINICAL TRIAL OF CAN
Page 539 and 540:
1678P PREDICTIVE VALUE OF TWO PHENO
Page 541 and 542:
theorized that the PI3K/AKT pathway
Page 543 and 544:
Material and methods: 101 patients
Page 545 and 546:
overexpressing and 232 had triple n
Page 547 and 548:
author index author index A Aamdal
Page 549 and 550:
author index Badran A. ix288 (874)
Page 551 and 552:
author index Bösmüller H. ix209 (
Page 553 and 554:
author index Chen A. ix319 (966O) C
Page 555 and 556:
author index De Droogh E. ix452 (13
Page 557 and 558: author index Esposito G. ix209 (618
Page 559 and 560: author index Geiges G. ix306 (930P)
Page 561 and 562: author index Hartono S. ix70 (155P)
Page 563 and 564: author index Iwasaki H. ix542 (1694
Page 565 and 566: author index Kodaira M. ix90 (228P)
Page 567 and 568: author index Lichtensztejn D. ix350
Page 569 and 570: author index Martinez A. ix496 (153
Page 571 and 572: author index Morishita N. ix432 (13
Page 573 and 574: author index Okamoto N. ix432 (1320
Page 575 and 576: author index Piau S. ix456 (1401P)
Page 577 and 578: author index Rodríguez Rodríguez
Page 579 and 580: author index Scoggins C.R. ix371 (1
Page 581 and 582: author index Stern L. ix272 (823P)
Page 583 and 584: author index Trypaki M. ix429 (1308
Page 585 and 586: author index Whitmore J.B. ix310 (9
Page 587 and 588: subject index subject index A AAV-H
Page 589 and 590: subject index ix115 (316TiP), ix116
Page 591 and 592: subject index diffuse large B-cell
Page 593 and 594: subject index (1033P), ix340 (1036P
Page 595 and 596: subject index medical information,
Page 597 and 598: subject index (612P), ix214 (633),
Page 599 and 600: subject index RCC, ix274 (830P) re-
Page 601 and 602: subject index TR-FRET, ix84 (206P)
Page 603 and 604: drug index drug index 1248P, 1250P,
Page 605 and 606: translational research index transl
Page 607: translational research index transl
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