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Annals of Oncology Results: Median age at diagnosis was 51 years (27 to 72 years); all the patients had PS1 due to local pain, asthenia or genital discharge. Neoadjuvant treatment was feasible in all patients with manageable toxicities; the dose intensity delivered was 97% of the preplanned dose. Only 2 episodes of grade III anemia were observed. In the first radiologic evaluation 4 patients had a complete response, 12 had partial response and 3 disease stabilization. Patients received external radiotherapy in fractions of 1.8 Gy achieving a dose of 66 GY in patients that could not receive brachytherapy. Mean EQD2C for those who did (68%) was 72 GY. Only 68% of the patients received the full preplanned concomitant dose due to toxicity, mainly grade III anemia and diarrhea. In the second radiological evaluation 9 patients had a complete response, 9 partial and only 1 stable disease. At a mean of 24 months of follow up only 5 patients (26%) thus far have developed recurrent disease, all of the recurrences were simultaneously local as well as systemic. Conclusion: Our weekly cisplatin-paclitaxel regimen has been demonstrated to be feasible and effective in terms of dose delivery, tolerance and radiological responses without compromising definitive treatment with chemor-radiation. Disclosure: All authors have declared no conflicts of interest. 1001P A PHASE II MULTICENTER RANDOMIZED OPEN-LABEL STUDY OF ORAL STEROID SULPHATASE (STS) INHIBITOR IROSUSTAT (BN83495) VERSUS MEGESTROL ACETATE (MA) IN WOMEN WITH ADVANCED/RECURRENT ENDOMETRIAL CANCER (EC) P. Pautier 1 , F. Joly Lobbedez 2 , B. Melichar 3 , E. Kutarska 4 , G. Hall 5 , N. Reed 6 1 Medical Department, Institut Gustave-Roussy, Villejuif, FRANCE, 2 Service d’Oncologie Médicale, Centre François Baclesse, Caen, FRANCE, 3 Oncology, University Hospital Olomouc Palacky University, Faculty of Medicine, Olomouc, CZECH REPUBLIC, 4 Oddział Onkologii Ginekologicznej Radioterapii I Chemioterapii, Centrum Onkologii Ziemi Lubelskiej im. s´ w. Jana z Dukli, Lublin, POLAND, 5 St James’s Institute of Oncology, St James’s University Hospital, Leeds, UNITED KINGDOM, 6 Beatson Oncology Centre, Gartnavel General Hospital, Glasgow, UNITED KINGDOM Background: Despite the progress in the diagnosis and therapy of early EC, advanced (metastatic) or recurrent EC remains an incurable disease. Irosustat (also known as BN83495, STX64 and 667-coumate) is a selective irreversible STS inhibitor developed for the treatment of hormone-dependent tumors. Objective: A phase II, randomized, open-label study was designed to explore the safety and efficacy of irosustat as a single agent in advanced/recurrent EC. Methods: Post-menopausal women with histologically verified estrogen and/or progesterone receptor-positive EC (defined as ≥10% positive cells in primary tumor or metastasis), with recurrent/advanced disease, at least one measurable target lesion, life expectancy ≥6 months, not eligible for surgery or radiotherapy and no prior systemic treatment for EC (except adjuvant chemotherapy if completed ≥1 year before randomization) were randomized 1:1 to daily oral irosustat 40 mg or MA 160 mg. The primary endpoint was the percentage of patients alive without progression after 6 months of treatment. Blinded central review of responses (evaluated using RECIST 1.0) was performed. Secondary endpoints included progression-free survival (PFS), time to progression, overall survival, quality of life and safety. Results: 73 patients were enrolled in 11 European countries, 36 were randomized to irosustat and 37 to MA. Median age was 68 years (range 37-85 years). Treatment-related severe toxicities (grade 3-4) were symptomatic hyponatremia, asthenia, dry skin and worsening of hypertension for irosustat (n = 1) and pulmonary embolism (n = 3, 1 led to death) and hyperglycemia with MA. Conclusion: This study demonstrates clinical benefit of hormonal treatment (irosustat and MA) in selected patients with advanced/recurrent EC with a different toxicity profile. Irosustat(n = 36) Megestrol acetate(n = 37) Alive without progression at 6 months n (%) 13 (36.1) 21 (56.8) Response (CR + PR) n (%) 4 (11.1) 12 (32.4) Stable disease n (%) 17 (47.2) 12 (32.4) Median PFS (weeks) [90% CI] 16 [9-34] 32 [16-63] Disclosure: P. Pautier: Author is an advisory board member for Roche and Ipsen. F. Joly Lobbedez: Author is an advisory board member for Sanofi, Roche, Novartis, Janssen, Ferring, Pfizer. No conflit of interest with Ipsen or BN83495. N. Reed: Consultancy fees and lecturing for Novartis, Roche, AZ, Johnson and Johnson, Otsuka. All other authors have declared no conflicts of interest. 1002P THE ROLE OF INTRAVAGINAL BRACHYTHERAPY IN SURGICALLY-STAGED 1988 FIGO STAGE IC GRADE 3 ENDOMETRIAL CANCER B. Barney 1 , I.A. Petersen 1 , J.A. Call 1 , A. Grothey 2 , M.G. Haddock 1 1 Radiation Oncology, Mayo Clinic, Rochester, MN, UNITED STATES OF AMERICA, 2 Medical Oncology, Mayo Clinic, Rochester, MN, UNITED STATES OF AMERICA Purpose/objectives: Patients with 1988 International Federation of Gynecology and Obstetrics (FIGO) Stage IC grade 3 (ICgr3) endometrial cancer (EC) were excluded or underrepresented on practice-defining intermediate-risk EC trials due to relatively high rates of occult nodal and/or distant metastasis. Adjuvant therapy recommendations in this population vary widely, but standard practice is to offer adjuvant pelvic external beam radiotherapy (EBRT) +/- chemotherapy. We report our single-institution’s experience using adjuvant high-dose rate (HDR) vaginal brachytherapy (VBT) alone +/- chemotherapy for patients with surgically-staged 1988 FIGO ICgr3 EC. Methods: From 1998 to 2011, 47 women with FIGO ICgr3 EC underwent TAH/BSO with pelvic/paraaortic lymph node dissection (median nodes evaluated, 47; range, 5-88) followed by VBT. All VBT was performed using a multi-channel cylinder, treating the entire vaginal mucosa from the cuff to within 1-2 cm of urethral meatus to 21 Gy in 3 fractions. No patient received pelvic EBRT. Twenty-one patients (45%) also received 3 to 6 cycles of adjuvant platinum-based chemotherapy. Results: At a median follow-up of 30 months (range, 1 to 127 months), 3 patients had experienced a vaginal relapse (VR), and the 3-year Kaplan-Meier (KM) estimate of VR was 8%. Rates of isolated pelvic (PR), locoregional (LRR, VR + PR), and distant relapse (DR) were similarly low, with 3-year estimates of 3, 10, and 14%, respectively. Estimates for 3-year disease-free (DFS) and overall survival (OS) were 87 and 80%, respectively. On univariate analysis, administration of chemotherapy significantly correlated with improved DFS (p = 0.03). Conclusions: Rates of isolated vaginal and pelvic relapse after VBT +/chemotherapy in these women with surgically-staged 1988 FIGO ICgr3 EC were comparable to those seen with pelvic EBRT, implying additional radiotherapy is likely unnecessary. Adjuvant platinum-based chemotherapy was associated with improved disease-free survival. While VBT reduced the rate of pelvic relapse, the vagina remained the most common pelvic site of recurrence. Disclosure: All authors have declared no conflicts of interest. 1003P TREATMENT OUTCOMES AND PROGNOSTIC FACTORS IN MEXICAN PATIENTS WITH ENDOMETRIAL CARCINOMA: THE LATIN AMERICAN EXPERIENCE C. Flores-Balcázar 1 , A. Alvarado-Zermeño 2 , M. Blake-Cerda 2 , A. Mota-García 2 , A. Poitevin-Chacón 3 , S. Rosales-Pérez 4 , G. Trejo-Duran 2 1 Radioterapia, Instituto Nacional de Cancerologia, Mexico City, MEXICO, 2 Radioterapia, Instituto Nacional de Cancerelogía, Mexico City, MEXICO, 3 Radioterapia, Hospital Medica Sur, Mexico City, MEXICO, 4 Depto. Radioterapia, Instituto Mexicano del Seguro Social, Mexico City, MEXICO Aim: To analyze the clinical characteristics and treatment outcomes in patients with endometrial carcinoma treated in a Latin American institute with emphasis on patients receiving radiotherapy and chemotherapy after surgery. Methods: A total of 412 patients with endometrial carcinoma admitted to our hospital between 1999 and 2008 were evaluated retrospectively. The mean age was 55 years (28-87). Two hundred seventy patients received RT following surgery. Stage distribution was as follows: 221 patients (54%) stage I, 86 patients (21%) stage II, and 103 patients (24.5%) stage III and 2 patients (0.5%) stage IVA. Results: Overall survival rate was 95% at 2 years, 84% at 5 years and 79% at 10 years. By the end of follow up, 338 patients (82%) were disease-free, and 13 (3%) were alive with disease. Univariate and multivariate analyses identified age, grade, serosal and adnexial involvement as significant predictors for overall survival. Conclusion: The results of our study suggests that early stage, low-grade endometrial cancer with no risk factors should not receive external beam radiotherapy, intermediate risk patients should receive only vaginal vault brachytherapy and the use of chemotherapy with radiotherapy for patients high risk and advanced stage carcinoma the addition of radiotherapy is associated with a better survival being an effective therapeutic option. To our knowledge this is the largest series exploring the characteristics of Mexican patients treated for endometrial carcinoma in literature. We conclude that adjuvant radiotherapy should be considered an integral component of definitive treatment for women with unfavorable disease as a mean to decrease mortality and improve patient outcome. Disclosure: All authors have declared no conflicts of interest. Volume 23 | Supplement 9 | September 2012 doi:10.1093/annonc/mds401 | ix329
1004P CASE CONTROL STUDY ON TWO DIFFERENT CHEMOTHERAPY REGIMENS IN ADVANCED MIXED MULLERIAN TUMOURS M. Mancini 1 , S. Ramondino 1 , R. Di Rocco 1 , M. Ratti 1 , D. Lorusso 1 , F. Raspagliesi 2 1 Gynecology Oncology, Fondazione IRCCS National Cancer Institute of Milan, Milan, ITALY, 2 Department of Gynaecologic Oncology, National Cancer Institute of Milan, Milan, ITALY Background: Malignant mixed Mullerian tumours (MMMTs) of the uterus and adnexa represent aggressive gynaecologic malignancies with a high rate of loco-regional and distant failure. There is no consensus in the community about the preferred chemotherapy regimen in this population. We evaluated two different chemotherapy combinations in terms of toxicity and oncologic outcome in patients with advanced MMMTs. Methods: Female patients with advanced MMMTs, residual tumor < 1 cm at cytoreductive surgery, no prior chemotherapy, normal haemopoietic and organ function were eligible. Chemotherapy was administered according to two different regimens: Cisplatin 20 mg/mq- Ifosfamide 1500 mg/mq d 1-4 q 21+ Pegfilgrastim (Group A) and Carboplatin AUC 5-Paclitaxel at 175 mg/m2 day 1 q21 (Group B). Results: Twenty-four patients (pts) of a median age 64 (49-75) years, performance status
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Annals of Oncology www.annonc.oxfor
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subscriptions A subscription to Ann
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Annals of Oncology Official Journal
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The European Society for Medical On
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Audit Committee Chair: Fortunato Ci
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Familial cancer Judith Balmaña, Ba
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ESMO 2012 Congress Travel Grants 47
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Exhibitors The following companies
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ESMO Fellowships, 1989-2011 The Eur
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Ondrej Gojis, Czech Republic 2008-2
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abstracts hpv biology and implicati
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abstracts the characterization of l
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abstracts description of intra-tumo
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prevent cell death. It is anticipat
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22IN TARGETING THE HOST IN TNBC G.
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abstracts a paradigm shift in early
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abstracts how can medical oncologis
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feasibility), but by how high the c
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abstracts re-inventing the medical
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abstracts emerging diagnostic and t
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abstracts biologically based treatm
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abstracts molecular targets in mali
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abstracts melanoma therapy: from fr
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diagnosis and can also be used for
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analysis at 11 months median follow
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mouse model of Kras mutant NSCLC. I
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abstracts subtyping soft tissue sar
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abstracts key topics in supportive
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ESMO-CSCO Joint Symposium: Building
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ESMO-EANM-ESR Joint Symposium: Imag
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ESMO-ESTRO Joint Symposium: Innovat
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ESMO-MASCC Joint Symposium: Integra
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ESO Society Symposium: Celebrating
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Results: TIMP-1 expression was incr
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will benefit from this targeted the
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cytomegalovirus (CMV). Analysis of
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functional consequences of Endoglin
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elationship between the ROR score,
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183P EPIDERMAL GROWTH FACTOR RECEPT
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Plasma adiponectin level on the pre
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Table: 198P PFS OS Median, mo HR Me
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204P EVALUATION OF PTEN AND PIK3CA
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Material and methods: We searched P
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Results: The median concentration o
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Table: 226P Methods: Pts were rando
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However, additional analysis sugges
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number of biomarkers have been trie
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Table: 248O 249PD PROTEOMIC PREDICT
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Conclusions: BW and serum Ctrough o
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261P BREAST CANCER SUBTYPES AND OUT
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90 mg/m2-cyclophophamide 600 mg/m2
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to 9 weeks after dosing. Trastuzuma
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Patients and methods: We reviewed d
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sector patients. The aim of this st
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Linear Logistic Model with Relaxed
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Results: The median CTC fold change
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312: Table: Chemotherapy uptake wit
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abstracts breast cancer, locally ad
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Results: 8 trials (2092 pts) with 1
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absolute difference of median value
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Novartis, Genentech, and sanofi-ave
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Results: Three RCTs with 1023 patie
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collected from all patients for det
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355P FIRST REPORT OF LONG-TERM RESP
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361P A RETROSPECTIVE ANALYSIS OF PL
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publications and aggregated in a me
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Thus the primary aim to target BCSC
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383 WHY DO WOMEN WITH BREAST CANCER
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Results: We evaluated 76 pts with M
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more than 6 cycles of capecitabine.
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406TiP PHASE II TRIAL OF PRIMARY SY
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abstracts CNS tumors 410O CONDITION
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Conclusions: Our data suggested tha
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Conclusions: As in other cancer typ
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432 GAMMA KNIFE RADIOSURGERY AS A M
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abstracts developmental therapeutic
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1PR), but no responses were seen in
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RO and Cd, as well as PD data for c
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and vulvar Ca), and 11 SDs were obs
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knowing HLA-A status double-blindly
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Acquired-resistance to EGFR inhibit
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474P PHASE 1 STUDY OF THE SELECTIVE
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TST is active in breast and gastric
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Treatment-induced shedding of circu
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Methods: Either co-cultures of peri
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501 PRECLINICAL DATA INVESTIGATING
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509TiP LUX-LUNG 8: A RANDOMIZED, OP
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(P = 0.64). Synchronous BBC was sig
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abstracts gastrointestinal tumors,
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Disclosure: M. Lee: I am an employe
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plus intravenous Bev(7.5mg/kg q 21d
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anti-EGFR treatment. The present st
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patients harboring a T/T genotype t
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551P ADJUVANT CHEMOTHERAPY (AC) USE
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experienced significantly more ≥
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functioning scales. Exploratory ana
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oxaliplatin (100 mg/m 2 )/raltitrex
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572P PANERB STUDY: WHICH CATEGORY O
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Results: 92/114 patients were preop
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585P CHANGES IN THE INTESTINAL ENVI
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592P PHASE II TRIAL OF COMBINED CHE
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minutes. In a previous study, 30-mi
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Patients and methods: Chemotherapy-
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612P ARE PATIENTS WITH RESECTABLE R
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Conclusions: AMPK and ACC activatio
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of surgical monotherapy in patients
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Table: 632 633 AFLIBERCEPT/FOLFIRI
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factors play the determining role i
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Abstract withdrawn in exceptional c
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were respectively 10.6 vs 8.5 vs 3.
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Results: 20 gastrointestinal cancer
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abstracts gastrointestinal tumors,
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Day 8. A second identical course wa
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proven in stage I GC. The aim of th
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Conclusions: Longer OS to FOLFOX wa
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692P PRELIMINARY SAFETY DATA FROM A
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subgroup. Taking into consideration
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Results: Three years of adjuvant im
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considered sufficient to give an 80
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721P FIRST-LINE TREATMENT WITH FOLF
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after Gem-based therapy. The additi
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735P RADIOGRAPHIC PARAMETERS IN PRE
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validate the revised AJCC 7th stagi
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Results: Among 862 MM we identified
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Results: Frequently reported advers
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gastric cancer patients with CNS me
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discriminate the prognosis of HCC p
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prospective, non-interventional stu
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abstracts genitourinary tumors, non
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787O EXTERNAL VALIDATION OF THE ASS
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patient preference for P over S, an
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798PD OPEN-LABEL PHASE II TRIAL OF
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Hb, PS and LM. Median PFS for patie
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may have led to reduced dose and sh
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Results: 1,622 patients were identi
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RCC) was designed to address an unm
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Patients and methods: This is a sin
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treatment at week 4, and week 12 by
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pts. Poorly differentiated endocrin
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Adenocarcinoma was present in 25 pa
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Method: Endobronchial ultrasound gu
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widely used by single agent or plat
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disease after surgery were treated
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stage IIIA NSCLC, EML4-ALK fusion-p
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1200P CONCOMITANT CHEMORADIATION GI
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Patients and methods: The study was
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months (95% CI:13-25). The PFS and
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maintenance therapy had favourable
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abstracts non-small cell lung cance
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Ingelheim, GSK Biologicals (compens
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1234PD RANDOMIZED PHASE III TRIAL O
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GlaxoSmithKline (myself, compensate
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1243P IDENTIFICATION OF MICRORNA (M
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N-arm n=34 P-arm n=32 All n=66 Male
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1255P POPULATION BASED EVALUATION O
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1262P DISTINCT SPREAD OF EGFR MUTAT
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1268P VISUAL DISTURBANCES IN PATIEN
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MERCK SERONO: Advisor, speaker in s
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Conclusions: These data from SAiL a
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NSCLC diagnosis and time of BM diag
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1291P PHASE I/II DOSE-FINDING STUDY
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Network utilization of WBCGF in the
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1303P COST EFFECTIVENESS OF PEMETRE
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Results: The patients’ characteri
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EGFR mut at exons 18, 19, 21, and K
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Methods: EML4-ALK fusion was screen
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Results: The median survival time (
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enefit from sustained EGFR blockade
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epresented by 19 pts (32%) female,
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and at least one prior course of ch
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Methods: NSCLC patients with radiog
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1367TiP LONG-TERM ERLOTINIB THERAPY
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Austria, Czech Republic, Finland, G
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were every 6 weeks (wk) (S1), every
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Advantage enrollees (83% vs. 25%) [
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Results: Based on 10,000 simulation
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cancer tumors 12%, Germ cell tumor
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Material and methods: 50 lung cance
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1414TiP IMPLEMENTATION OF CANCER RE
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abstracts palliative care 1422O EFF
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Method and results: A total of 317
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1436P SURVEY ON MODELS OF INTEGRATI
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care unit (PCU) at the National Can
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Characteristic No. % Total 63 1 st
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hysterectomised-9.10% and cervix ca
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abstracts psycho-oncology 1462PD IN
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events, tumour response, and surviv
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abstracts sarcoma 1477O ADHESION TO
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1481PD A PHASE II STUDY OF DOVITINI
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1488P ORGANISATION OF SARCOMA PATIE
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Patients and methods: From August 2
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chemotherapy respectively. At a med
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of this group Those with relapsed d
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1515 PREDICTORS OF SURVIVAL IN ADOL
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abstracts small cell lung cancer an
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emaining receiving either CAV or to
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1533P EXPRESSION OF WILM⍰TUMOUR G
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more than 3 months after first line
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lower recurrence rate of NE. Pegfil
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egimens (HR = 2.5, p < 0.001). Phys
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1561P PREDICTIVE DIAGNOSTICS FOR RE
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Methods: A prospective multicentre
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Table: 1574P Pharmacokinetic parame
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Novartis and unrestricted research
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studies have shown that chemotherap
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(Grade 1) and moderate to severe (G
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declined to relatively lower level
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1609P PHYSICAL ACTIVITY (PA) AND PH
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patients were admitted to the oncol
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Dicarbamin 100 mg/day on day 5 befo
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Results: Anemia was detected in 83.
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important to carry out randomized s
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abstracts translational research 16
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expression. Then, we analyzed PB sa
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Table: 1657P TH BV + TH HR (95% CI)
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BRAF mutations. Circulating free DN
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1671P PHASE I CLINICAL TRIAL OF CAN
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1678P PREDICTIVE VALUE OF TWO PHENO
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theorized that the PI3K/AKT pathway
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Material and methods: 101 patients
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overexpressing and 232 had triple n
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author index author index A Aamdal
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author index Badran A. ix288 (874)
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author index Bösmüller H. ix209 (
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author index Chen A. ix319 (966O) C
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author index De Droogh E. ix452 (13
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author index Esposito G. ix209 (618
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author index Geiges G. ix306 (930P)
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author index Hartono S. ix70 (155P)
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author index Iwasaki H. ix542 (1694
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author index Kodaira M. ix90 (228P)
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author index Lichtensztejn D. ix350
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author index Martinez A. ix496 (153
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author index Morishita N. ix432 (13
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author index Okamoto N. ix432 (1320
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author index Piau S. ix456 (1401P)
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author index Rodríguez Rodríguez
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author index Scoggins C.R. ix371 (1
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author index Stern L. ix272 (823P)
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author index Trypaki M. ix429 (1308
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author index Whitmore J.B. ix310 (9
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subject index subject index A AAV-H
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subject index ix115 (316TiP), ix116
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subject index diffuse large B-cell
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subject index (1033P), ix340 (1036P
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subject index medical information,
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subject index (612P), ix214 (633),
Page 599 and 600:
subject index RCC, ix274 (830P) re-
Page 601 and 602:
subject index TR-FRET, ix84 (206P)
Page 603 and 604:
drug index drug index 1248P, 1250P,
Page 605 and 606:
translational research index transl
Page 607 and 608:
Page 609:
show all

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