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Annals of Oncology 801P COMPARISON BETWEEN STANDARD AND REDUCED VOLUME RADIOTHERAPY IN BLADDER PRESERVATION TRIMODALITY PROTOCOL FOR MUSCLE INVASIVE BLADDER CANCER PATIENT W. Arafat, A. Darwish, G. El Hussiny Clinical Oncology, University of Alexandria, Alexandria, EGYPT Invasive bladder cancer is the most common tumor in Egypt. Preservation protocol consists of transurethral resection followed by concomitant chemo/ radiotherapy. The induction part of Radiotherapy is usually delivered to the whole pelvis, The role of omitting pelvic nodal irradiation has not been addressed before. Aim: To compare the toxicity, pelvic nodal relapse and overall survival of whole bladder irradiation only to standard technique of whole pelvis irradiation followed by bladder boost in patients with muscle invasive bladder carcinoma undergoing bladder preservation protocol. Material and method: A total of 63 patients with transitional cell carcinoma, stage T2-3,N0,M0 bladder cancer were subjected to maximal TURB. Then, patients randomized into two groups: group I (32 patients) to receive whole pelvis radiotherapy 44Gy followed by 20 Gy bladder boost. While Group II (31 patients) were randomized to receive whole bladder radiotherapy alone for a total dose of 64 Gy. In both groups, concomittant cisplatin and paclitaxel were given weekly throughout the whole course of radiotherapy where conventional 2 Gy/ fraction were used. additionally, 4 cycles of Adjuvant cisplatin and paclitaxel were given after the end of chemo radiotherapy induction course. Results: Three patients, two in group I and one in group II discontinued due to grade 3 toxicity. After a median follow up of 2 years, regional relapse occurred in 7.1% of patients in group I and 10.3% in group II. (p = 1). Distant metastases were detected in 17.9% of patient in group 1 and 13.8% in group II.(p = 0.73). The 2-year disease free survival was 60% in group I and 63.3% in group II (p = 0.79). The whole 2-years overall survival was 75% in group I and 79.3% in group II (p = 0.689). Radiation gastrointestinal (GI) Acute toxicity was higher in group I than in group II (p = 0.001), while late GI radiation toxicity was comparable in both groups. Conclusion: treating the bladder only without elective pelvic nodal irradiation, did not compromise pelvic control rate, but significantly decreased the acute radiation toxicity. Disclosure: All authors have declared no conflicts of interest. 802P EFFICACY AND PROGNOSTIC FACTORS OF NEOADJUVANT CHEMOTHERAPY IN RESECTABLE LOCALLY-ADVANCED MUSCLE-INVASIVE BLADDER CANCER (MIBC) PATIENTS (P) IN AN OFF-PROTOCOL CLINICAL SETTING J.L. Cuadra Urteaga 1 , M. Domenech 2 , P. Celiz 1 , J.J. Sánchez 3 , N. Pardo 1 , C. Buges 1 , J. Malet 4 , M. Arzoz 5 , J. Areal 5 , A. Font 1 1 Medical Oncology, Catalan Institute of Oncology ICO Badalona Hospital Germans Trias i Pujol, Medical Oncology, Badalona, SPAIN, 2 Oncology, ALthaia, Xarxa Assistencial de Manresa, Manresa, SPAIN, 3 Statistics, Autonomous University of Madrid, Madrid, SPAIN, 4 Urology, ALthaia, Xarxa Assistencial de Manresa, Manresa, SPAIN, 5 Urology, Hospital Germans Trias i Pujol, Badalona, SPAIN Introduction: Although neoadjuvant chemotherapy is a recommended treatment in MIBC, it has not gained widespread acceptance in clinical practice, due to the lack of predictive markers of efficacy and the absence of a standard chemotherapy regimen. Furthermore, since few studies have assessed the role of neoadjuvant chemotherapy in an off-protocol setting, there may be doubts about its feasibility. Material and methods: We retrospectively analyzed 124 p with MIBC treated with neoadjuvant cisplatin-based chemotherapy at two centers from 1991 to 2010. Clinical and pathological variables were correlated with survival. All patients were classified as stage cT2-4N0M0 based on TUR (trans-urethral resection) and CT scan findings and were candidates for neoadjuvant chemotherapy followed by cystectomy. Results: 10 p (8%) were cT2N0, 83 p (66%) cT3N0, and 31 p (26%) cT4aN0. 60 p (48%) were treated with CMV (cisplatin, methotrexate and vinblastine) and 64 p (52%) with cisplatin/gemcitabine (CG). One patient died from treatment-related toxicity. A complete resection was performed in 109 p (87%). A significant pathological response (pR) (pT0-1) was obtained in 60 p (48%). Median survival (MS) and 5-year (5y) survival were 59 months (m) and 50%, respectively. Median cancer-specific survival (CSS) was not reached and 5y CSS was 64%. 5y overall survival was similar (50.3% vs 50.9%) in p treated with CMV or CG. In p with a significant pR, 5y survival was 77%, while for p who did not respond to chemotherapy (pT3-4NO or N+), it was 8.3%. Only complete resection (HR:3.36, P = 0.006) and lymphovascular invasion (LVI) (HR:17.29, P < 0.0001) were significant in the multivariate analysis. Conclusions: Neoadjuvant chemotherapy followed by cystectomy is feasible in p with locally-advanced MIBC. Both CMV and CG are active regimens, with 5-y survival that compares favorably with surgery alone. p responding to neoadjuvant chemotherapy have an excellent prognosis, while those who do not respond should be considered for non-cross-resistant adjuvant chemotherapy. Disclosure: All authors have declared no conflicts of interest. 803P SELECTIVE BLADDER PRESERVATION BY TRI-MODALITY THERAPY FOR MUSCLE INVASIVE BLADDER CARCINOMA A. Darwish 1 , G. Elhussiny 1 ,W.Arafat 2 1 Clinical Oncology, University of Alexandria, Alexandria, EGYPT, 2 Clinical Oncology, Alexandria International Hospital, Alexandria, EGYPT Purpose: To access safety, tolerance, local control and survival of transurethral resection of Bladder tumor (TURB) followed by concomitant cisplatin, paclitaxel and radiation therapy as selective organ preservation in patients with Muscle Invasive bladder. Addionally, Surviving and ERCC1 gene expression analysis and response to treatmentis also studied. Methods and materials: A total of 63 patients with transional cell carcinoma (TCC), stage T2–T3, No, Mo bladder carcinoma were enrolled in a protocol of TURP followed by one daily radiotherapy (2Gy/ fraction for a total dose of 44 GY) with concomitant cis-platin 15mg/m2/ day,d1-3 weekly and paclitaxel 50mg/m2/day, weekly.Four weeks later, all patients were evaluated by cytoscopy and biopsy. Patients with complete response proceeded to consolidation Radiotherapy (2Gy/fr for a total 20GY with concomitant cisplatin and paclitaxel, while those with recurrent tumor went on to salavage. Cystectomy. Following consolidation or salvage surgery, all patients went to complete 4 cycles of cisplatin75mg/m2/ day and paclitaxel 175 mg/day every 21 days. RNA extraction from Biopsy before and after treatment was analysed for survivin and ERCC1 gene expression using real time PCR. Results: Three patients could not tolerate the treatment and discontinued the protocol during the induction phase while the remaining sixty patients complete the induction phase. The complete response after the induction phase was 75%. Eleven percent of the complete responders developed superficial relapse with a median time of relapse of 16 months, while 8.9% developed invasive relapse with a median time of 18 months. 2-year disease for survival was 61.7%. Distant metastases we detected in 15.8% the patients. 2year overall survival was 77.2%. RNA was succifully extracted from 65% of patient, real time PCR for ERCC1 and survivin was done, interpretation of data will be presented. Conclusion: Maximal transurethral resection followed by concomitant cis-platin and paclitaxel, as a bladder preservation therapy, can be considered a valid alternative for treating selected patients with localized muscle invasive TCC of the bladder. ERCC1 and survivn might be a predictive model of treatment response. Disclosure: All authors have declared no conflicts of interest. 804P PROGNOSTIC STRATIFICATION OF ADVANCED UROTHELIAL CARCINOMA (UC) RECEIVING SECOND-LINE SYSTEMIC THERAPY INCLUDING TIME FROM PRIOR CHEMOTHERAPY (TFPC) AS A PROGNOSTIC FACTOR G. Sonpavde 1 , G.R. Pond 2 , T.K. Choueiri 3 , R. Fougeray 4 , G. Niegisch 5 , Y. Wong 6 , S.S. Sridhar 7 , W.M. Stadler 8 , C.N. Sternberg 9 , J. Bellmunt 10 1 Medical Oncology, Texas Oncology, Baylor College of Medicine, Webster, TX, UNITED STATES OF AMERICA, 2 Biostatistics, Ontario Clinical Oncology Group and McMaster University, Hamilton, CANADA, 3 Medical Oncology, Dana Farber Cancer Institute, Boston, MA, UNITED STATES OF AMERICA, 4 Statistics, Institut de Recherche Pierre Fabre, Boulogne, FRANCE, 5 Urologic Oncology, Heinrich Heine University, Dusseldorf, GERMANY, 6 Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA, UNITED STATES OF AMERICA, 7 Medical Oncology, Princess Margaret Hospital, Toronto, ON, CANADA, 8 Medical Oncology, University of Chicago, Chicago, IL, UNITED STATES OF AMERICA, 9 Medical Oncology, San Camillo Forlanini Hospital, Rome, ITALY, 10 Medical Oncology, University Hospital del Mar, Barcelona, SPAIN Background: Prognostic factors for overall survival (OS) in patients receiving second-line chemotherapy for advanced platinum-pretreated urothelial carcinoma (UC) include ECOG performance status (PS) >0, hemoglobin (Hb)
Hb, PS and LM. Median PFS for patients with 0, 1, 2 and 3-4 factors (PS > 0, Hb < 10g/dL, LM, TFPC 0, Hb
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Annals of Oncology www.annonc.oxfor
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subscriptions A subscription to Ann
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Annals of Oncology Official Journal
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The European Society for Medical On
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Audit Committee Chair: Fortunato Ci
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Familial cancer Judith Balmaña, Ba
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ESMO 2012 Congress Travel Grants 47
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Exhibitors The following companies
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ESMO Fellowships, 1989-2011 The Eur
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Ondrej Gojis, Czech Republic 2008-2
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abstracts hpv biology and implicati
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abstracts the characterization of l
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abstracts description of intra-tumo
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prevent cell death. It is anticipat
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22IN TARGETING THE HOST IN TNBC G.
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abstracts a paradigm shift in early
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abstracts how can medical oncologis
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feasibility), but by how high the c
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abstracts re-inventing the medical
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abstracts emerging diagnostic and t
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abstracts biologically based treatm
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abstracts molecular targets in mali
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abstracts melanoma therapy: from fr
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diagnosis and can also be used for
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analysis at 11 months median follow
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mouse model of Kras mutant NSCLC. I
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abstracts subtyping soft tissue sar
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abstracts key topics in supportive
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ESMO-CSCO Joint Symposium: Building
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ESMO-EANM-ESR Joint Symposium: Imag
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ESMO-ESTRO Joint Symposium: Innovat
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ESMO-MASCC Joint Symposium: Integra
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ESO Society Symposium: Celebrating
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Results: TIMP-1 expression was incr
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will benefit from this targeted the
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cytomegalovirus (CMV). Analysis of
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functional consequences of Endoglin
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elationship between the ROR score,
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183P EPIDERMAL GROWTH FACTOR RECEPT
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Plasma adiponectin level on the pre
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Table: 198P PFS OS Median, mo HR Me
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204P EVALUATION OF PTEN AND PIK3CA
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Material and methods: We searched P
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Results: The median concentration o
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Table: 226P Methods: Pts were rando
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However, additional analysis sugges
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number of biomarkers have been trie
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Table: 248O 249PD PROTEOMIC PREDICT
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Conclusions: BW and serum Ctrough o
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261P BREAST CANCER SUBTYPES AND OUT
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90 mg/m2-cyclophophamide 600 mg/m2
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to 9 weeks after dosing. Trastuzuma
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Patients and methods: We reviewed d
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sector patients. The aim of this st
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Linear Logistic Model with Relaxed
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Results: The median CTC fold change
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312: Table: Chemotherapy uptake wit
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abstracts breast cancer, locally ad
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Results: 8 trials (2092 pts) with 1
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absolute difference of median value
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Novartis, Genentech, and sanofi-ave
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Results: Three RCTs with 1023 patie
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collected from all patients for det
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355P FIRST REPORT OF LONG-TERM RESP
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361P A RETROSPECTIVE ANALYSIS OF PL
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publications and aggregated in a me
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Thus the primary aim to target BCSC
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383 WHY DO WOMEN WITH BREAST CANCER
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Results: We evaluated 76 pts with M
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more than 6 cycles of capecitabine.
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406TiP PHASE II TRIAL OF PRIMARY SY
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abstracts CNS tumors 410O CONDITION
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Conclusions: Our data suggested tha
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Conclusions: As in other cancer typ
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432 GAMMA KNIFE RADIOSURGERY AS A M
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abstracts developmental therapeutic
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1PR), but no responses were seen in
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RO and Cd, as well as PD data for c
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and vulvar Ca), and 11 SDs were obs
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knowing HLA-A status double-blindly
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Acquired-resistance to EGFR inhibit
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474P PHASE 1 STUDY OF THE SELECTIVE
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TST is active in breast and gastric
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Treatment-induced shedding of circu
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Methods: Either co-cultures of peri
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501 PRECLINICAL DATA INVESTIGATING
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509TiP LUX-LUNG 8: A RANDOMIZED, OP
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(P = 0.64). Synchronous BBC was sig
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abstracts gastrointestinal tumors,
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Disclosure: M. Lee: I am an employe
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plus intravenous Bev(7.5mg/kg q 21d
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anti-EGFR treatment. The present st
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patients harboring a T/T genotype t
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551P ADJUVANT CHEMOTHERAPY (AC) USE
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experienced significantly more ≥
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functioning scales. Exploratory ana
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oxaliplatin (100 mg/m 2 )/raltitrex
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572P PANERB STUDY: WHICH CATEGORY O
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Results: 92/114 patients were preop
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585P CHANGES IN THE INTESTINAL ENVI
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592P PHASE II TRIAL OF COMBINED CHE
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minutes. In a previous study, 30-mi
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Patients and methods: Chemotherapy-
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612P ARE PATIENTS WITH RESECTABLE R
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Conclusions: AMPK and ACC activatio
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of surgical monotherapy in patients
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Page 223 and 224: Results: 20 gastrointestinal cancer
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Page 231 and 232: Conclusions: Longer OS to FOLFOX wa
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Page 235 and 236: subgroup. Taking into consideration
Page 237 and 238: Results: Three years of adjuvant im
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Page 243 and 244: after Gem-based therapy. The additi
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Page 247 and 248: validate the revised AJCC 7th stagi
Page 249 and 250: Results: Among 862 MM we identified
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Page 281 and 282: Conclusions: In pts with RCC treate
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Page 287 and 288: efused HDCT. Of 23 patients, 20 com
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Page 293 and 294: Median overall survival (OS) was 26
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managed in a multidisciplinary (MD)
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or hypercalcemia at screening; prio
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meeting. The prevalence of LGSC is
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Table: 975PD Continued AMG 386 + pa
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physicians in the U.S. and Europe.
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989P PHASE II STUDY OF COMBINATION
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elated with stage, nodal involvemen
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1004P CASE CONTROL STUDY ON TWO DIF
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eight patients who had infertility
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abstracts head and neck cancer 1016
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same CT/RT; Arm B2: 3 cycles of ind
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induction chemotherapy in the treat
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patients. We have developed a rando
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evaluated by the screening instrume
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morbidities that radiation would le
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Conclusions: Through adequate selec
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abstracts hematological malignancie
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anthracyclines in vitro. A favorabl
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1076P RITUXIMAB PLUS SUBCUTANEOUS C
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than the standard target of ≥2.5
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Patients: From November 2002 to May
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lymphadenopathy and multiple cutane
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prospective non-interventional stud
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Funding: GSK Biologicals Disclosure
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survival rates of 13-25% (Prieto et
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high response rates and prolonged p
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GlaxoSmithKline, Merck Sharp & Dohm
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advisor for Merck Sharp & Dohme, an
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or cutaneous melanoma. A survival u
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systemic therapy or were intolerant
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abstracts neuroendocrine tumors and
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morbidity, with G3 tumors behaving
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pts. Poorly differentiated endocrin
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Adenocarcinoma was present in 25 pa
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Method: Endobronchial ultrasound gu
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widely used by single agent or plat
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disease after surgery were treated
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stage IIIA NSCLC, EML4-ALK fusion-p
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1200P CONCOMITANT CHEMORADIATION GI
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Patients and methods: The study was
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months (95% CI:13-25). The PFS and
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maintenance therapy had favourable
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abstracts non-small cell lung cance
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Ingelheim, GSK Biologicals (compens
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1234PD RANDOMIZED PHASE III TRIAL O
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GlaxoSmithKline (myself, compensate
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1243P IDENTIFICATION OF MICRORNA (M
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N-arm n=34 P-arm n=32 All n=66 Male
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1255P POPULATION BASED EVALUATION O
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1262P DISTINCT SPREAD OF EGFR MUTAT
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1268P VISUAL DISTURBANCES IN PATIEN
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MERCK SERONO: Advisor, speaker in s
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Conclusions: These data from SAiL a
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NSCLC diagnosis and time of BM diag
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1291P PHASE I/II DOSE-FINDING STUDY
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Network utilization of WBCGF in the
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1303P COST EFFECTIVENESS OF PEMETRE
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Results: The patients’ characteri
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EGFR mut at exons 18, 19, 21, and K
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Methods: EML4-ALK fusion was screen
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Results: The median survival time (
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enefit from sustained EGFR blockade
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epresented by 19 pts (32%) female,
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and at least one prior course of ch
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Methods: NSCLC patients with radiog
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1367TiP LONG-TERM ERLOTINIB THERAPY
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Austria, Czech Republic, Finland, G
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were every 6 weeks (wk) (S1), every
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Advantage enrollees (83% vs. 25%) [
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Results: Based on 10,000 simulation
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cancer tumors 12%, Germ cell tumor
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Material and methods: 50 lung cance
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1414TiP IMPLEMENTATION OF CANCER RE
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abstracts palliative care 1422O EFF
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Method and results: A total of 317
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1436P SURVEY ON MODELS OF INTEGRATI
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care unit (PCU) at the National Can
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Characteristic No. % Total 63 1 st
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hysterectomised-9.10% and cervix ca
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abstracts psycho-oncology 1462PD IN
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events, tumour response, and surviv
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abstracts sarcoma 1477O ADHESION TO
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1481PD A PHASE II STUDY OF DOVITINI
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1488P ORGANISATION OF SARCOMA PATIE
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Patients and methods: From August 2
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chemotherapy respectively. At a med
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of this group Those with relapsed d
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1515 PREDICTORS OF SURVIVAL IN ADOL
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abstracts small cell lung cancer an
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emaining receiving either CAV or to
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1533P EXPRESSION OF WILM⍰TUMOUR G
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more than 3 months after first line
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lower recurrence rate of NE. Pegfil
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egimens (HR = 2.5, p < 0.001). Phys
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1561P PREDICTIVE DIAGNOSTICS FOR RE
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Methods: A prospective multicentre
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Table: 1574P Pharmacokinetic parame
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Novartis and unrestricted research
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studies have shown that chemotherap
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(Grade 1) and moderate to severe (G
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declined to relatively lower level
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1609P PHYSICAL ACTIVITY (PA) AND PH
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patients were admitted to the oncol
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Dicarbamin 100 mg/day on day 5 befo
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Results: Anemia was detected in 83.
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important to carry out randomized s
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abstracts translational research 16
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expression. Then, we analyzed PB sa
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Table: 1657P TH BV + TH HR (95% CI)
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BRAF mutations. Circulating free DN
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1671P PHASE I CLINICAL TRIAL OF CAN
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1678P PREDICTIVE VALUE OF TWO PHENO
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theorized that the PI3K/AKT pathway
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Material and methods: 101 patients
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overexpressing and 232 had triple n
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author index author index A Aamdal
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author index Badran A. ix288 (874)
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author index Bösmüller H. ix209 (
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author index Chen A. ix319 (966O) C
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author index De Droogh E. ix452 (13
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author index Esposito G. ix209 (618
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author index Geiges G. ix306 (930P)
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author index Hartono S. ix70 (155P)
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author index Iwasaki H. ix542 (1694
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author index Kodaira M. ix90 (228P)
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author index Lichtensztejn D. ix350
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author index Martinez A. ix496 (153
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author index Morishita N. ix432 (13
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author index Okamoto N. ix432 (1320
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author index Piau S. ix456 (1401P)
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author index Rodríguez Rodríguez
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author index Scoggins C.R. ix371 (1
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author index Stern L. ix272 (823P)
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author index Trypaki M. ix429 (1308
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author index Whitmore J.B. ix310 (9
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subject index subject index A AAV-H
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subject index ix115 (316TiP), ix116
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subject index diffuse large B-cell
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subject index (1033P), ix340 (1036P
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subject index medical information,
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subject index (612P), ix214 (633),
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subject index RCC, ix274 (830P) re-
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subject index TR-FRET, ix84 (206P)
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drug index drug index 1248P, 1250P,
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translational research index transl
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