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Annals of Oncology progression – 2). In patients with low rate of BF in the tumor (luminal A, HER2(+) type) effect was the worst (PR – 2, stabilization – 7, progression – 4 patients in both groups). The correlation coefficient was statistically significant for BF as increased ACBFV, IR, IP, and the frequency of CR + PR to nPCT of luminal B type. Conclusions: There is a correlation between the velocity of BF and degree of destruction of tumor by cytostatics. While the rate of BF depended on the molecular type of the tumor and did not depend on the size of the primary tumor. Disclosure: All authors have declared no conflicts of interest. 380 IMPACT OF BODY MASS INDEX (BMI) ON DISEASE FREE SURVIVAL AND LIKELIHOOD OF PATHOLOGIC COMPLETE RESPONSE IN PATIENTS WITH LOCALLY ADVANCED BREAST CANCER TREATED WITH NEOADJUVANT CHEMOTHERAPY A. Armengol-Alonso 1 , A. Arance 1 , M. Campayo 1 , X. González-Farré 1 , A. García-Herrera 2 , P.L. Fernández 2 , X. Caparros 3 , I. Alonso 3 , B. Farrus 4 , M. Muñoz 1 1 Oncologia Medica, Hospital Clinic y Provincial de Barcelona, Barcelona, SPAIN, 2 Pathology, Hospital Clinic y Pronvincial Barcelona, Barcelona, SPAIN, 3 Gynecology and Obstetrics Department, Hospital Clinic Barcelona, Barcelona, SPAIN, 4 Department of Radiation Oncology, Hospital Clinic Barcelona, Barcelona, SPAIN Background: The BMI is a clinical parameter that although not perfect is often used to measure adiposity. In breast cancer there are multiple studies indicating that overweight/obesity (O/O) is related with lower survival and increased risk of relapse. It has been also reported less likely to achieve a pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in O/O patients. Methods: We retrospectively reviewed the records of 108 patients diagnosed with invasive locally advanced breast cancer (ILABC) who had been treated with NAC (anthracycline + taxane ± trastuzumab). The aim of our study was to review the impact of BMI on the pCR and the possibility of recurrence. pCR was defined as the criterion of strict pCR breast+nodes. Results: From 2004 to 2011, 108 patients received NAC. Based on their weight and height at baseline we divided into two groups; group 1: underweight/normal (BMI
383 WHY DO WOMEN WITH BREAST CANCER IN SARAWAK, MALAYSIA PRESENT LATE? B.C. Devi Radiotherapy, Oncology & Palliative Care, Sarawak General Hospital, Sarawak, MALAYSIA Introduction: Breast cancer (BC) is the most common cancer in Sarawak. We explore the reasons of late stage presentation in this study. Methods: Based on a 175 questions questionnaire, information on barriers to late presentation were collected as a prospective study on 626 cases (2009 to 2011). Descriptive statistics and statistical tests were performed using the SPSS ver 17.0. Results: The stage at diagnosis differed significantly with 71% of the Chinese being diagnosed at early stage compared to only 50% in Malay and 45% in Natives (p < 0.0004). The delay between first symptom and first medical consultation (DELAY 1) was more than one month in 57% of the patients and it differed significantly among ethnic groups (50% for Chinese, 64% for Malay and 65% for Natives, p < 0.002). The highest delay were: women aged 50 years (53%, p < 0.037); from rural area (65%) vs urban areas (55%, p < 0.04).The main variables affecting this delay were knowledge about BC (p < 0.004), lack of interest in one’s health ( p < 0.0005) and choice of first professional consulted (doctor/nurse vs traditional healer, p < 0.03). The delay between first medical consultation and effective diagnosis (DELAY 2) for > 1 month was 14% of the patients and it differed significantly among ethnic groups (14% for Chinese, 23% for Malay and 13% for Natives, p < 0.0008). The main reasons: the number of doctors consulted before diagnosis (less the better, p < 0.0003); Malays (66.4%) and natives (64.4%) consulted more than two doctors when compared to Chinese (42.6%, p < 0.0001) and were less likely to follow the recommendations given by the doctors (p < 0.06). The impact of teaching Breast self-examination (BSE) on DELAY 1 and 2: Seventy-eight percent of patients were taught BSE and by 80% of government nurses. The age group (30-40 years) had been taught BSE more than other age groups. For DELAY 1, 72% were not taught BSE, p < 0.0001. There was no difference for those with DELAY 2. However for both DELAY 1 and 2, 42% were not taught BSE, p < 0.0001. Conclusions: More than 50% of the patients had DELAY 1 and 14% for DELAY 2. Learning BSE had an impact on DELAY 1 but not for DELAY2. Those in age groups (>40 to 60 years) had less BSE taught and this finding is crucial for public health education as most BC occur after 45 years. Disclosure: All authors have declared no conflicts of interest. 384 THE ROLE OF ANTIESTROGENS IN BREAST CANSER CELLS’ INVASIVENESS D.V. Lymperatou Department of Medicine, Division of Oncology, University Hospital of Patras, Patras, GREECE Aim: The current study investigates the effect of two selective antagonists of the estrogen receptor (ER), fulvestrant (FL) and tamoxifen (Tam), on the invasive ability of breast cancer cells. ER blockage using anti-estrogens is associated with a small induction of invasiveness. Moreover, matrix metalloproteinases (MMPs) contribute to this procedure by cleaving components of the extracellular matrix, forming a path for the migrating cells. In addition, the focal adhesion kinase (FAK) plays a central role in invasiveness. Methods: We used two ER+ breast cancer cell lines, MCF7 and T47D. Cells were stimulated by estradiol (E2) and then treated with FL, Tam and the metabolites endoxifen (End) and 4OH-tamoxifen (4OHT). The invasiveness was evaluated using the matrigel assay and MMPs expression with gelatin zymography assay. Using immunofluoresence, we study the expression and localization of phospho FAK and its correlation with F-actin. Results: We found that E2 exerts a protective role in invasiveness. On the contrary, the anti-estrogens, as well as their metabolites reversed the effect of E2, a finding that was more obvious with Tam. The effect of the agents on MMPs expression was more pronounced at 48 h, when Tam and 4OHT were found to reduce the levels of both MMP-2 and MMP-9 compared to FL. Following E2 exposure, the maximum autophosphorylation of FAK (Y397) was observed at 10 min. At the same time point we assessed the effect of our agents, regarding the spatial organization of actin fibers. The concurrent administration of E2 with FL, Tam or End was associated with rearrangement of cytoskeleton, a finding that was not observed in untreated cells, as well as after the use of 4OHT and E2 or E2 alone. Conclusions: Our results indicate that the metabolite 4OHT is superior to the pro-drug Tam as well as the pure anti-estrogen FL with respect to invasiveness, MMPs induction and actin rearrangement. Regarding the comparison of Tam with FL, the effect on MMPs and rearrangement was similar. However, FL was found to be slightly superior to Tam concerning invasiveness. Disclosure: All authors have declared no conflicts of interest. Annals of Oncology 385 CANCER STEM CELL-LIKE CELLS: A THERAPEUTIC MODEL IN BREAST CANCER PATIENTS, WHERE ANY OTHER RECOMMENDED THERAPY HAS FAILED I. Papasotiriou 1 , M. Chatziioannou 2 , M. Toloudi 2 , E. Ioannou 2 , R. Hammon 3 , U. Jacob 4 , N. Hembry 5 , A. Kopic 4 1 Research & Development-Clinical, Research Genetic Cancer Centre Ltd, Filotas, GREECE, 2 Research & Development, Research Genetic Cancer Centre Ltd, Filotas, GREECE, 3 Clinical, ATMC, Texas, TX, UNITED STATES OF AMERICA, 4 Clinical, Privatklinik AMC, Dornstetten-Hallawangen, GERMANY, 5 Clinical, Litfield Medical House, Bristol, UNITED KINGDOM Introduction: Nowadays, the difficulty to treat metastatic breast cancers is high. Many clinical therapeutic lines have failed and there is no suggested therapeutic approach (in literature) concerning this type of tumors. The last decades, circulating tumor cells (CTCs) are the state – of – the –art in cancer therapy. In the present study, CTCs were isolated and identified. CSCs (cancer stem cells) were isolated from the above population of CTCs and their gene pattern was compared with those from the primary tumor as well as with those from the metastatic tumor. This study attempts to find a correlation between the CTCs and the metastatic regions in comparison with the primary tumor as well as to find out if all the CSCs have the same hallmarks in the selected breast cancer stem cell populations. Materials and methods: In order the protocol to be performed, CTCs from patient’s blood samples were isolated and then cultured in appropriate conditions. CSCs were identified and isolated from the population of CTCs. mRNA was extracted and was used for Microarray hybridization assays. The same procedure was repeated for primary tumor as well for metastatic tumor samples. The expression pattern of primary tumor cells was compared with those in the metastatic tumor. Finally, the therapeutic approach which was based on the above findings, was designed. Results: The results showed that the gene expression pattern of metastatic sites is similar to that of metastatic sites and less to that of the primary site. Then, the patients followed a therapeutic approach based on the data of the clinical results which were evaluated within a six- month period showing that the patients showed an objective response rate. Conclusion: The results showed that the entity that determines the clinical outcome in breast cancer, is the sub-population of CTCs, the circulating CSCs. Moreover, there are various types of CSCs in one patient, and not only one, as they have different growth mechanisms in primary and secondary tumors. Disclosure: All authors have declared no conflicts of interest. 386 BREAST CANCER PATIENTS WITH HER2NEU OVEREXPRESSION: RELATIONSHIP AMONG CLINICOPATHOLOGICAL CHARACTERISTICS AND LOCAL/ DISTANT RECURRENCES AND SURVIVAL C. Bellido-Ribes 1 , S. Gonzalez 2 , A. Garcia 3 , V. Obadia 2 , R. Bastus 4 , J. Fernández 4 , A. Aguilar 4 , L. Cirera 4 1 Medical Oncology, Mutua Terrassa University Hospital, Terrassa, SPAIN, 2 Medical Oncology, Hospital Mutua Terrassa, Terrassa, SPAIN, 3 Breast Unit, Departament of Gynecology, Hospital Mutua Terrassa, Terrassa, SPAIN, 4 Hospital Mutua Terrassa, Terrassa, SPAIN Objectives: The aim of this study was to correlate the overexpression of HER2 with clinical pathologic characteristics and its influence on local/distant recurrence and survival. Methods: From 1998 to 2010, prospective data of 146 patients with invasive breast cancer with HER-2 overexpression was studied. The sample was divided into three groups: Negative hormonal receptors (NHR); Luminal B1 (Estrogen receptor +/-, Progesterone receptor +), Luminal B2 (Estrogen receptor +, Progesterone receptor -). Histological type (HT), size tumor (T), differentiation grade (DG), and nodal status were determined. Correlation with local and distant recurrence, and 5-year overall survival was done. Results: NHR: 33.5%, luminal B1: 47.5%; Luminal B2: 19% Clinical pathologic characteristics: Age (%) Size(%) HT (%) 70 T1 T2 T3 T4 Ductal Lobular NHR 23 51 26 39 37 4 10 98 2 Luminal B1 33 51 16 51 39 9 1 99 1 Luminal B2 22 64 14 53 43 30 4 96 4 ix136 | Abstracts Volume 23 | Supplement 9 | September 2012
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Annals of Oncology www.annonc.oxfor
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subscriptions A subscription to Ann
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Annals of Oncology Official Journal
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The European Society for Medical On
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Audit Committee Chair: Fortunato Ci
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Familial cancer Judith Balmaña, Ba
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ESMO 2012 Congress Travel Grants 47
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Exhibitors The following companies
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ESMO Fellowships, 1989-2011 The Eur
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Ondrej Gojis, Czech Republic 2008-2
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abstracts hpv biology and implicati
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abstracts the characterization of l
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abstracts description of intra-tumo
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prevent cell death. It is anticipat
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22IN TARGETING THE HOST IN TNBC G.
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abstracts a paradigm shift in early
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abstracts how can medical oncologis
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feasibility), but by how high the c
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abstracts re-inventing the medical
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abstracts emerging diagnostic and t
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abstracts biologically based treatm
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abstracts molecular targets in mali
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abstracts melanoma therapy: from fr
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diagnosis and can also be used for
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analysis at 11 months median follow
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mouse model of Kras mutant NSCLC. I
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abstracts subtyping soft tissue sar
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abstracts key topics in supportive
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ESMO-CSCO Joint Symposium: Building
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ESMO-EANM-ESR Joint Symposium: Imag
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ESMO-ESTRO Joint Symposium: Innovat
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ESMO-MASCC Joint Symposium: Integra
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ESO Society Symposium: Celebrating
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Results: TIMP-1 expression was incr
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will benefit from this targeted the
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cytomegalovirus (CMV). Analysis of
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functional consequences of Endoglin
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elationship between the ROR score,
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183P EPIDERMAL GROWTH FACTOR RECEPT
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Plasma adiponectin level on the pre
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Table: 198P PFS OS Median, mo HR Me
Page 85 and 86: 204P EVALUATION OF PTEN AND PIK3CA
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Page 89 and 90: Results: The median concentration o
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Page 125 and 126: Results: Three RCTs with 1023 patie
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Page 133 and 134: publications and aggregated in a me
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Page 145 and 146: abstracts CNS tumors 410O CONDITION
Page 147 and 148: Conclusions: Our data suggested tha
Page 149 and 150: Conclusions: As in other cancer typ
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Page 163 and 164: Acquired-resistance to EGFR inhibit
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Page 167 and 168: TST is active in breast and gastric
Page 169 and 170: Treatment-induced shedding of circu
Page 171 and 172: Methods: Either co-cultures of peri
Page 173 and 174: 501 PRECLINICAL DATA INVESTIGATING
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Page 181 and 182: Disclosure: M. Lee: I am an employe
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Page 185 and 186: anti-EGFR treatment. The present st
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patients harboring a T/T genotype t
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551P ADJUVANT CHEMOTHERAPY (AC) USE
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experienced significantly more ≥
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functioning scales. Exploratory ana
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oxaliplatin (100 mg/m 2 )/raltitrex
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572P PANERB STUDY: WHICH CATEGORY O
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Results: 92/114 patients were preop
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585P CHANGES IN THE INTESTINAL ENVI
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592P PHASE II TRIAL OF COMBINED CHE
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minutes. In a previous study, 30-mi
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Patients and methods: Chemotherapy-
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612P ARE PATIENTS WITH RESECTABLE R
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Conclusions: AMPK and ACC activatio
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of surgical monotherapy in patients
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Table: 632 633 AFLIBERCEPT/FOLFIRI
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factors play the determining role i
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Abstract withdrawn in exceptional c
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were respectively 10.6 vs 8.5 vs 3.
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Results: 20 gastrointestinal cancer
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abstracts gastrointestinal tumors,
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Day 8. A second identical course wa
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proven in stage I GC. The aim of th
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Conclusions: Longer OS to FOLFOX wa
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692P PRELIMINARY SAFETY DATA FROM A
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subgroup. Taking into consideration
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Results: Three years of adjuvant im
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considered sufficient to give an 80
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721P FIRST-LINE TREATMENT WITH FOLF
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after Gem-based therapy. The additi
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735P RADIOGRAPHIC PARAMETERS IN PRE
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validate the revised AJCC 7th stagi
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Results: Among 862 MM we identified
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Results: Frequently reported advers
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gastric cancer patients with CNS me
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discriminate the prognosis of HCC p
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prospective, non-interventional stu
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abstracts genitourinary tumors, non
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787O EXTERNAL VALIDATION OF THE ASS
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patient preference for P over S, an
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798PD OPEN-LABEL PHASE II TRIAL OF
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Hb, PS and LM. Median PFS for patie
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may have led to reduced dose and sh
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Results: 1,622 patients were identi
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RCC) was designed to address an unm
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Patients and methods: This is a sin
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treatment at week 4, and week 12 by
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effective in second or further line
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Conclusions: In pts with RCC treate
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using Drug inCode ® pharmacogeneti
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Table: 857P standard, but is not av
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efused HDCT. Of 23 patients, 20 com
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we identified 49 and 220 patients w
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879 TREATMENT OF PATIENTS WITH META
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Median overall survival (OS) was 26
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abstracts Genitourinary tumors, pro
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and week 13 BPI-SF Q3 scores), 28%
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Working Group (PCWG)-2 guidelines r
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atio HR 0.39; CI 0.18, 0.83, p = 0.
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We observed tumor responses and pro
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Here we report emerging data from t
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928P LHRH AGONIST-INDUCED SUPPRESSI
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Disclosure: S. Oudard: Has acted as
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939P NEOADJUVANT SIPULEUCEL-T IN LO
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945 BONE TURNOVER MARKERS AND POTEN
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952 SEQUENTIAL ANDROGEN DEPRIVATION
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managed in a multidisciplinary (MD)
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or hypercalcemia at screening; prio
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meeting. The prevalence of LGSC is
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Table: 975PD Continued AMG 386 + pa
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physicians in the U.S. and Europe.
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989P PHASE II STUDY OF COMBINATION
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elated with stage, nodal involvemen
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1004P CASE CONTROL STUDY ON TWO DIF
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eight patients who had infertility
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abstracts head and neck cancer 1016
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same CT/RT; Arm B2: 3 cycles of ind
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induction chemotherapy in the treat
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patients. We have developed a rando
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evaluated by the screening instrume
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morbidities that radiation would le
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Conclusions: Through adequate selec
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abstracts hematological malignancie
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anthracyclines in vitro. A favorabl
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1076P RITUXIMAB PLUS SUBCUTANEOUS C
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than the standard target of ≥2.5
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Patients: From November 2002 to May
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lymphadenopathy and multiple cutane
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prospective non-interventional stud
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Funding: GSK Biologicals Disclosure
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survival rates of 13-25% (Prieto et
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high response rates and prolonged p
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GlaxoSmithKline, Merck Sharp & Dohm
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advisor for Merck Sharp & Dohme, an
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or cutaneous melanoma. A survival u
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systemic therapy or were intolerant
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abstracts neuroendocrine tumors and
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morbidity, with G3 tumors behaving
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pts. Poorly differentiated endocrin
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Adenocarcinoma was present in 25 pa
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Method: Endobronchial ultrasound gu
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widely used by single agent or plat
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disease after surgery were treated
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stage IIIA NSCLC, EML4-ALK fusion-p
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1200P CONCOMITANT CHEMORADIATION GI
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Patients and methods: The study was
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months (95% CI:13-25). The PFS and
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maintenance therapy had favourable
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abstracts non-small cell lung cance
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Ingelheim, GSK Biologicals (compens
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1234PD RANDOMIZED PHASE III TRIAL O
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GlaxoSmithKline (myself, compensate
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1243P IDENTIFICATION OF MICRORNA (M
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N-arm n=34 P-arm n=32 All n=66 Male
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1255P POPULATION BASED EVALUATION O
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1262P DISTINCT SPREAD OF EGFR MUTAT
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1268P VISUAL DISTURBANCES IN PATIEN
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MERCK SERONO: Advisor, speaker in s
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Conclusions: These data from SAiL a
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NSCLC diagnosis and time of BM diag
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1291P PHASE I/II DOSE-FINDING STUDY
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Network utilization of WBCGF in the
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1303P COST EFFECTIVENESS OF PEMETRE
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Results: The patients’ characteri
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EGFR mut at exons 18, 19, 21, and K
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Methods: EML4-ALK fusion was screen
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Results: The median survival time (
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enefit from sustained EGFR blockade
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epresented by 19 pts (32%) female,
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and at least one prior course of ch
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Methods: NSCLC patients with radiog
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1367TiP LONG-TERM ERLOTINIB THERAPY
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Austria, Czech Republic, Finland, G
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were every 6 weeks (wk) (S1), every
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Advantage enrollees (83% vs. 25%) [
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Results: Based on 10,000 simulation
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cancer tumors 12%, Germ cell tumor
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Material and methods: 50 lung cance
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1414TiP IMPLEMENTATION OF CANCER RE
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abstracts palliative care 1422O EFF
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Method and results: A total of 317
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1436P SURVEY ON MODELS OF INTEGRATI
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care unit (PCU) at the National Can
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Characteristic No. % Total 63 1 st
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hysterectomised-9.10% and cervix ca
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abstracts psycho-oncology 1462PD IN
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events, tumour response, and surviv
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abstracts sarcoma 1477O ADHESION TO
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1481PD A PHASE II STUDY OF DOVITINI
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1488P ORGANISATION OF SARCOMA PATIE
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Patients and methods: From August 2
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chemotherapy respectively. At a med
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of this group Those with relapsed d
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1515 PREDICTORS OF SURVIVAL IN ADOL
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abstracts small cell lung cancer an
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emaining receiving either CAV or to
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1533P EXPRESSION OF WILM⍰TUMOUR G
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more than 3 months after first line
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lower recurrence rate of NE. Pegfil
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egimens (HR = 2.5, p < 0.001). Phys
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1561P PREDICTIVE DIAGNOSTICS FOR RE
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Methods: A prospective multicentre
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Table: 1574P Pharmacokinetic parame
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Novartis and unrestricted research
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studies have shown that chemotherap
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(Grade 1) and moderate to severe (G
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declined to relatively lower level
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1609P PHYSICAL ACTIVITY (PA) AND PH
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patients were admitted to the oncol
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Dicarbamin 100 mg/day on day 5 befo
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Results: Anemia was detected in 83.
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important to carry out randomized s
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abstracts translational research 16
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expression. Then, we analyzed PB sa
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Table: 1657P TH BV + TH HR (95% CI)
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BRAF mutations. Circulating free DN
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1671P PHASE I CLINICAL TRIAL OF CAN
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1678P PREDICTIVE VALUE OF TWO PHENO
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theorized that the PI3K/AKT pathway
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Material and methods: 101 patients
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overexpressing and 232 had triple n
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author index author index A Aamdal
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author index Badran A. ix288 (874)
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author index Bösmüller H. ix209 (
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author index Chen A. ix319 (966O) C
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author index De Droogh E. ix452 (13
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author index Esposito G. ix209 (618
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author index Geiges G. ix306 (930P)
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author index Hartono S. ix70 (155P)
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author index Iwasaki H. ix542 (1694
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author index Kodaira M. ix90 (228P)
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author index Lichtensztejn D. ix350
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author index Martinez A. ix496 (153
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author index Morishita N. ix432 (13
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author index Okamoto N. ix432 (1320
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author index Piau S. ix456 (1401P)
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author index Rodríguez Rodríguez
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author index Scoggins C.R. ix371 (1
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author index Stern L. ix272 (823P)
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author index Trypaki M. ix429 (1308
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author index Whitmore J.B. ix310 (9
Page 587 and 588:
subject index subject index A AAV-H
Page 589 and 590:
subject index ix115 (316TiP), ix116
Page 591 and 592:
subject index diffuse large B-cell
Page 593 and 594:
subject index (1033P), ix340 (1036P
Page 595 and 596:
subject index medical information,
Page 597 and 598:
subject index (612P), ix214 (633),
Page 599 and 600:
subject index RCC, ix274 (830P) re-
Page 601 and 602:
subject index TR-FRET, ix84 (206P)
Page 603 and 604:
drug index drug index 1248P, 1250P,
Page 605 and 606:
translational research index transl
Page 607 and 608:
Page 609:
show all

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