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Annals of Oncology trial (TIVO-1) comparing TIVO with sorafenib (SOR) in patients (pts) with mRCC showed superior efficacy to SOR and a favorable safety profile with a low incidence of off-target adverse events (AEs). Here we provide detailed drug-related AE data from the TIVO-1 trial. Methods: Pts were randomized 1:1 to TIVO 1.5 mg once daily for 3 weeks (wks) followed by 1 wk rest, or SOR 400 mg twice daily continuously in a 4-wk cycle. AEs were recorded from the time pts signed the informed consent until 30 days after last dose of study drug. Blood pressure (mm Hg) was measured after a 5-minute rest period and taken on Days 1 and 15 of Cycle 1, on Day 1 of subsequent cycles, at the end-of-treatment visit, and at the 30-day follow-up visit. Descriptive statistics of drug-related AEs are presented. Results: Pts on the TIVO arm (175 [67.6%]) had fewer drug-related AEs than pts on the SOR arm (214 [83.3%]). The most common (≥10%) drug-related AEs and discontinuations are shown in the table. TIVO (n = 259) n (%) SOR (n = 257) n (%) AE All Grades Grade ≥3 All Grades Grade ≥3 Hypertension 109 (42.1) 61 (23.6) 79 (30.7) 39 (15.2) Dysphonia 47 (18.1) – 11 (4.3) – Diarrhea 47 (18.1) 5 (1.9) 71 (27.6) 15 (5.8) Hand–foot syndrome 34 (13.1) 5 (1.9) 137 (53.3) 43 (16.7) Fatigue 28 (10.8) 7 (2.7) 28 (10.9) 7 (2.7) Alopecia 6 (2.3) – 53 (20.6) – Discontinuations 11 (4.2) – 14 (5.4) – Hypertension was the most frequent TIVO-related AE but was easily managed with standard antihypertensives. Fewer pts in the TIVO arm had ≥Grade 3 drug-related AEs than in the SOR arm (94 [36.3%] and 131 [51.0%], respectively). Pts in the TIVO arm required fewer overall dose reductions than did pts in the SOR arm (36 [13.9%] vs 114 [44.4%], respectively). Two deaths in the TIVO arm were due to myocardial infarction; cardiac failure was responsible for 2 deaths in each arm. Conclusion: Pts on the TIVO arm experienced more hypertension and dysphonia, but less diarrhea, hand-foot syndrome, alopecia and discontinuations than pts on the SOR arm. Pts on the TIVO arm also had fewer overall dose reductions. These data demonstrate that TIVO is well-tolerated in pts with mRCC. Disclosure: T.Q.G. Eisen: Consultancy fee/honorarium: AVEO before trial period, Bayer Support for travel to mtgs for the study or other purposes: AVEO Board Membership: AVEO, Bayer (ad boards) Grants/pending: Bayer Payment for lectures, service on speakers bureau: Bayer. C.N. Sternberg: Consultancy: Astellas. B. Esteves: AVEO Pharmaceuticals employee with stock options. R.J. Motzer: Consultant: Pfizer Research Funding: AVEO, GSK, Novartis. All other authors have declared no conflicts of interest. 796PD TIVOZANIB PHARMACOKINETIC (PK)/PHARMACODYNAMIC (PD) ANALYSIS OF BLOOD PRESSURE (BP) AND SOLUBLE VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (SVEGFR2) IN PATIENTS WITH ADVANCED RENAL CELL CARCINOMA (RCC) D. Nosov 1 , R.J. Motzer 2 , J. Loewy 3 , L. Hodge 3 , B. Esteves 4 , A. Berkenblit 4 , W. Yin 5 , K. Dykstra 6 , T.E. Hutson 7 , M. Cotreau 5 1 Clinical Pharmacology and Chemotherapy, N.N. Blokhin Russian Cancer Research Center, Moscow, RUSSIAN FEDERATION, 2 Genitourinary Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, UNITED STATES OF AMERICA, 3 Biostatistics, qPharmetra, Andover, MA, UNITED STATES OF AMERICA, 4 Clinical Research, AVEO Pharmaceuticals, Cambridge, MA, UNITED STATES OF AMERICA, 5 Oncology, AVEO Pharmaceuticals, Inc, Cambridge, MA, UNITED STATES OF AMERICA, 6 qPharmetra, Andover, MA, UNITED STATES OF AMERICA, 7 GU Center of Excellence Texas Oncology, Charles A. Sammons Cancer Center / Baylor University Medical Center / Texas AM Health Science Center College of Medicine, Dallas, TX, UNITED STATES OF AMERICA Background: Tivozanib is a potent, selective, long half-life tyrosine kinase inhibitor of VEGF receptors (VEGFRs) 1, 2, and 3, demonstrating activity against advanced RCC in Phase (Ph) II–III trials. This analysis explored the relationship between tivozanib PK and BP, as hypertension is a mechanism-based adverse event and a potential surrogate of response. The relationship between exposure and sVEGFR2 also was explored. Methods: Pharmacokinetic, BP, and sVEGRF2 data from tivozanib-treated RCC patients (pts) from a Ph II (n = 21) and a Ph III (n = 259) study were pooled; pts were treated with 1.5 mg tivozanib daily for 21 days followed by a 7-day rest (28-day treatment cycle) in each study. A population PK model of tivozanib was constructed from PK data from Ph I–III studies, to obtain individualized predictions of steady-state values for Cavg. BP was measured at baseline and on Cycle 1 Day 15 (C1D15), C2D1, and C3D1 in the Ph II and Ph III studies, and was binned to the nearest 5 mm Hg. Analysis focused on BP shifts in 5 mm Hg increments. Serum samples for sVEGFR2 (Ph III only) were collected at baseline and on C1D15, C2D1, and C2D22–28. Models of drug exposure as predictors of longitudinal changes in BP and/or sVEGFR2 were constructed by non-linear mixed-effects modeling. Results: Across pts, there was a statistically significant median 5 mm Hg increase in diastolic BP on C1D15, with similar increases noted on C2D1. There was a curvilinear decrease in sVEGFR2 with time. An Emax model vs time showed a half-maximal effect occurring in 19.4 (SE = 1.7) days, and a maximal 53% (%CV = 4%) decrease in sVEGFR2. There was a statistically significant effect of Cavg on Emax, with the magnitude of Emax increasing 6% per 10 ng/mL increase in Cavg. Conclusion: PK/PD analysis of data from tivozanib Ph II–III studies showed that pts had a median increase in diastolic BP of 5 mm Hg on C1D15 and C2D1. Levels of serum sVEGFR2 were found to decrease significantly with time, and the effect size increased with tivozanib exposure. Relationships between exposure, BP, and sVEGFR2 and outcome are being explored. Disclosure: R.J. Motzer: Only disclosure is research funding from AVEO Oncology. J. Loewy: Consulting fee or honoraria from qPharmetra LLC. L. Hodge: Consulting or honoraria from qPharmetra LLC. B. Esteves: AVEO Pharmaceuticals employee with stock options. A. Berkenblit: AVEO Pharmaceuticals employee with stock options. W. Yin: AVEO Pharmaceuticals employee with stock options. K. Dykstra: -Consultancy fee or honorarium: qPharmetra LLC -Fees for participation in review activities such as data monitoring boards, statistical analysis, end point committees and the like: qPharmetra LLC. T.E. Hutson: - Consultancy or honoraria: AVEO Pharmaceuticals - Consultancy: Pfizer, Bayer, GSK, Novartis – Grants, grants pending: Pfizer, Bayer, GSK, Novartis – Payment for lectures includes service on speakers bureau:Pfizer, Bayer, GSK, Novartis. M. Cotreau: AVEO Pharmaceuticals employee with stock options. All other authors have declared no conflicts of interest. 797PD FIRST LINE SUNITINIB IN TYPE I AND II PAPILLARY RENAL CELL CARCINOMA (PRCC): SUPAP- A PHASE II STUDY OF THE FRENCH GENITO-URINARY GROUP (GETUG) AND THE GROUP OF EARLY PHASE TRIALS (GEP) A. Ravaud 1 , S. Oudard 2 , M. De Fromont 3 , C. Chevreau 4 , G. Gravis 5 , S. Zanetta 6 , C. Theodore 7 , M. Jimenez 8 , E. Sevin 9 , B. Escudier 10 1 Oncology Unit, C.H.U. Bordeaux Hopital St. André, Bordeaux, FRANCE, 2 Oncology Department, Georges Pompidou Hospital and Rene Descartes University, Paris, FRANCE, 3 Pathology, Prado-Pathologie, Marseille, FRANCE, 4 Medical Oncology, Institut Claudius Régaud, Toulouse, FRANCE, 5 Department of Medical Oncology, Institut Paoli Calmettes, Marseille, FRANCE, 6 Oncology Department, Centre Georges François Leclerc, Dijon, FRANCE, 7 Medical Oncology, Hôpital Foch, Suresnes, FRANCE, 8 R&D, Unicancer, Paris, FRANCE, 9 Medical Oncology, Centre François Baclesse, Caen, FRANCE, 10 Service d’Immunotherapie, Institut Gustave Roussy, Villejuif, FRANCE Background: Sunitinib has been approved in metastatic clear cell carcinoma due to a prolonged progression-free survival (PFS). Subgroups analysis of previous studies hypothesized that sunitinib may be active in PRCC. This is the first prospective clinical trial reported with an anti-angiogenic agent in PRCC, which is an unmet need. Methods: SUPAP is a single-arm study using a 2-stage design including 21 patients (pts) to achieve a 20% ORR and if ≥ 2 pts have an OR, 20 additional pts would be included. Type I and II PRCC were included separately with an identical design. Main eligibility criteria included type I and II PRCC confirmed by central pathological review, PS 0-1, measurable disease, 1st line treatment. Sunitinb was given at 50mg/d, 4/6 weeks. Primary endpoint was ORR, while safety, PFS and overall survival (OS) were secondary endpoints. Results: From 10/07 to 02/11, 15 and 46 pts with type I and II were included, respectively. The median age was 64 year-old. Fifty-three (87%) pts had a nephrectomy. PS was 0 on 31 (50%) pts and 1 in 30 pts. Fifty-five (90%) pts had ≥ 1 metastatic site. Using the MSKCC scoring system: 12 (19%), 33 (54%) and 9 (14%) pts were in the favorable, intermediate or poor risk group and 7 undetermined. With a median follow-up of 12.2 months [0.2-46.4], 60 and 61 pts were evaluable for efficacy and toxicity respectively. The median number of cycles was 4 [1-30] and 23 pts (37.7%) required a dose reduction. In type I PRCC, 2/15 (13%) pts had a partial response (PR), 10 had a stable disease (SD) with 5 (33%) ≥ 12 weeks. In type II PRCC, 5/45 (11%) pts had a PR, 25 had a SD with 10 (22%) ≥ 12 weeks and 15 a progression. The median PFS was 6.6 months [CI 95%: 2.8–14.8] in type I and 5.5 months [CI 95%: 3.8–7.1] in type II. The median overall survival was 17.8 [CI 95%: 5.7–26.1] and 12.4 [CI 95%: 8.2–16] months in type I and II respectively. Toxicity was similar as in pivotal phase III with sunitinib in metastatic RCC. One patient died from a pulmonary embolism eventually due to sunitinib. Conclusion: Sunitinib has a modest activity in PRCC whatever type I or II, but still represents a treatment option in the lack of better therapy. Disclosure: A. Ravaud: myself ADVISORY ROLE Pfizer Novartis Bayer Schering GSK Astellas Dendreon Compensated HONORARIA Pfizer Novartis Bayer Schering Roche GSK Astellas Dendreon OTHER Travel financial support Pfizer Novartis Institution RESEARCH FUNDING Pfizer Novartis. S. Oudard: Myself ADVISORY ROLE Pfizer Bayer-Schering Roche GSK Novartis Sanofi Aventis Compensated HONORARIA Pfizer Bayer-Schering Roche GSK Novartis Sanofi Aventis. B. Escudier: Honoraria from Pfizer, Novartis, GSK, Bayer, Aveo, BMS. All other authors have declared no conflicts of interest. Volume 23 | Supplement 9 | September 2012 doi:10.1093/annonc/mds399 | ix263
798PD OPEN-LABEL PHASE II TRIAL OF FIRST-LINE EVEROLIMUS MONOTHERAPY IN PATIENTS WITH ADVANCED PAPILLARY RENAL CELL CARCINOMA: RAPTOR INTERIM ANALYSIS B. Escudier 1 , S. Bracarda 2 , J.P. Maroto 3 , C. Szczylik 4 , P. Nathan 5 , S. Negrier 6 , K. Slimane 7 , C. May 8 , C. Porta 9 , V. Grünwald 10 1 Oncology, Institut Gustave Roussy, Villejuif, FRANCE, 2 Medical Oncology, Ospedale San Donato, Arezzo, ITALY, 3 Medical Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, SPAIN, 4 Clinical Oncology, Wojskowy Instytut Medyczny, Warsaw, POLAND, 5 Cancer Services, Mount Vernon Cancer Centre, Northwood, UNITED KINGDOM, 6 Oncology, Centre Leon Berard, Lyon, FRANCE, 7 Oncology, Novartis Pharmaceuticals, Rueil-Malmaison, FRANCE, 8 Oncology, Novartis Pharma GmbH, Nuremberg, GERMANY, 9 Medical Oncology, IRCCS San Matteo University Hospital Foundation, Pavia, ITALY, 10 Clinic for Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, GERMANY Background: Treatment options for patients with papillary renal cell carcinoma (RCC) are limited. Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, has demonstrated efficacy in clear cell metastatic RCC; mTOR signaling is also dysregulated in papillary RCC. The ongoing RAPTOR (RAD001 in Advanced Papillary Tumor Program in Europe; ClinicalTrials.gov, NCT00688753) trial is evaluating everolimus monotherapy in treatment-naive patients with advanced papillary RCC. Here, we present the results of a preliminary analysis. Patients and methods: RAPTOR is an open-label, single-arm, multicentre phase II trial. Adult patients with advanced type I or type II papillary RCC and ECOG performance status of 0 or 1 were enrolled. Prior systemic therapy for RCC was not permitted. Patients received oral everolimus 10 mg once daily until disease progression or unacceptable toxicity. The primary end point is proportion of patients progression free at 6 months. Results: At data cut-off (April 11, 2012), 71 of 92 (77%) enrolled patients were eligible for analysis according to central pathology review (confirmed papillary renal cancer); 16 of the 92 patients were still on treatment. Most patients were men (73%) and most were
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Annals of Oncology www.annonc.oxfor
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subscriptions A subscription to Ann
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Annals of Oncology Official Journal
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The European Society for Medical On
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Audit Committee Chair: Fortunato Ci
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Familial cancer Judith Balmaña, Ba
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ESMO 2012 Congress Travel Grants 47
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Exhibitors The following companies
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ESMO Fellowships, 1989-2011 The Eur
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Ondrej Gojis, Czech Republic 2008-2
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abstracts hpv biology and implicati
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abstracts the characterization of l
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abstracts description of intra-tumo
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prevent cell death. It is anticipat
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22IN TARGETING THE HOST IN TNBC G.
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abstracts a paradigm shift in early
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abstracts how can medical oncologis
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feasibility), but by how high the c
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abstracts re-inventing the medical
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abstracts emerging diagnostic and t
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abstracts biologically based treatm
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abstracts molecular targets in mali
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abstracts melanoma therapy: from fr
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diagnosis and can also be used for
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analysis at 11 months median follow
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mouse model of Kras mutant NSCLC. I
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abstracts subtyping soft tissue sar
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abstracts key topics in supportive
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ESMO-CSCO Joint Symposium: Building
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ESMO-EANM-ESR Joint Symposium: Imag
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ESMO-ESTRO Joint Symposium: Innovat
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ESMO-MASCC Joint Symposium: Integra
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ESO Society Symposium: Celebrating
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Results: TIMP-1 expression was incr
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will benefit from this targeted the
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cytomegalovirus (CMV). Analysis of
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functional consequences of Endoglin
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elationship between the ROR score,
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183P EPIDERMAL GROWTH FACTOR RECEPT
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Plasma adiponectin level on the pre
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Table: 198P PFS OS Median, mo HR Me
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204P EVALUATION OF PTEN AND PIK3CA
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Material and methods: We searched P
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Results: The median concentration o
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Table: 226P Methods: Pts were rando
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However, additional analysis sugges
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number of biomarkers have been trie
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Table: 248O 249PD PROTEOMIC PREDICT
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Conclusions: BW and serum Ctrough o
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261P BREAST CANCER SUBTYPES AND OUT
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90 mg/m2-cyclophophamide 600 mg/m2
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to 9 weeks after dosing. Trastuzuma
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Patients and methods: We reviewed d
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sector patients. The aim of this st
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Linear Logistic Model with Relaxed
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Results: The median CTC fold change
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312: Table: Chemotherapy uptake wit
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abstracts breast cancer, locally ad
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Results: 8 trials (2092 pts) with 1
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absolute difference of median value
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Novartis, Genentech, and sanofi-ave
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Results: Three RCTs with 1023 patie
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collected from all patients for det
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355P FIRST REPORT OF LONG-TERM RESP
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361P A RETROSPECTIVE ANALYSIS OF PL
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publications and aggregated in a me
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Thus the primary aim to target BCSC
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383 WHY DO WOMEN WITH BREAST CANCER
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Results: We evaluated 76 pts with M
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more than 6 cycles of capecitabine.
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406TiP PHASE II TRIAL OF PRIMARY SY
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abstracts CNS tumors 410O CONDITION
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Conclusions: Our data suggested tha
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Conclusions: As in other cancer typ
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432 GAMMA KNIFE RADIOSURGERY AS A M
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abstracts developmental therapeutic
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1PR), but no responses were seen in
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RO and Cd, as well as PD data for c
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and vulvar Ca), and 11 SDs were obs
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knowing HLA-A status double-blindly
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Acquired-resistance to EGFR inhibit
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474P PHASE 1 STUDY OF THE SELECTIVE
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TST is active in breast and gastric
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Treatment-induced shedding of circu
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Methods: Either co-cultures of peri
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501 PRECLINICAL DATA INVESTIGATING
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509TiP LUX-LUNG 8: A RANDOMIZED, OP
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(P = 0.64). Synchronous BBC was sig
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abstracts gastrointestinal tumors,
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Disclosure: M. Lee: I am an employe
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plus intravenous Bev(7.5mg/kg q 21d
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anti-EGFR treatment. The present st
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patients harboring a T/T genotype t
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551P ADJUVANT CHEMOTHERAPY (AC) USE
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experienced significantly more ≥
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functioning scales. Exploratory ana
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oxaliplatin (100 mg/m 2 )/raltitrex
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572P PANERB STUDY: WHICH CATEGORY O
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Results: 92/114 patients were preop
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585P CHANGES IN THE INTESTINAL ENVI
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592P PHASE II TRIAL OF COMBINED CHE
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minutes. In a previous study, 30-mi
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Patients and methods: Chemotherapy-
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612P ARE PATIENTS WITH RESECTABLE R
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Conclusions: AMPK and ACC activatio
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Page 231 and 232: Conclusions: Longer OS to FOLFOX wa
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Page 243 and 244: after Gem-based therapy. The additi
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Page 281 and 282: Conclusions: In pts with RCC treate
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952 SEQUENTIAL ANDROGEN DEPRIVATION
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managed in a multidisciplinary (MD)
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or hypercalcemia at screening; prio
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meeting. The prevalence of LGSC is
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Table: 975PD Continued AMG 386 + pa
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physicians in the U.S. and Europe.
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989P PHASE II STUDY OF COMBINATION
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elated with stage, nodal involvemen
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1004P CASE CONTROL STUDY ON TWO DIF
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eight patients who had infertility
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abstracts head and neck cancer 1016
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same CT/RT; Arm B2: 3 cycles of ind
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induction chemotherapy in the treat
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patients. We have developed a rando
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evaluated by the screening instrume
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morbidities that radiation would le
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Conclusions: Through adequate selec
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abstracts hematological malignancie
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anthracyclines in vitro. A favorabl
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1076P RITUXIMAB PLUS SUBCUTANEOUS C
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than the standard target of ≥2.5
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Patients: From November 2002 to May
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lymphadenopathy and multiple cutane
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prospective non-interventional stud
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Funding: GSK Biologicals Disclosure
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survival rates of 13-25% (Prieto et
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high response rates and prolonged p
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GlaxoSmithKline, Merck Sharp & Dohm
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advisor for Merck Sharp & Dohme, an
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or cutaneous melanoma. A survival u
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systemic therapy or were intolerant
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abstracts neuroendocrine tumors and
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morbidity, with G3 tumors behaving
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pts. Poorly differentiated endocrin
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Adenocarcinoma was present in 25 pa
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Method: Endobronchial ultrasound gu
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widely used by single agent or plat
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disease after surgery were treated
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stage IIIA NSCLC, EML4-ALK fusion-p
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1200P CONCOMITANT CHEMORADIATION GI
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Patients and methods: The study was
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months (95% CI:13-25). The PFS and
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maintenance therapy had favourable
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abstracts non-small cell lung cance
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Ingelheim, GSK Biologicals (compens
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1234PD RANDOMIZED PHASE III TRIAL O
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GlaxoSmithKline (myself, compensate
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1243P IDENTIFICATION OF MICRORNA (M
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N-arm n=34 P-arm n=32 All n=66 Male
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1255P POPULATION BASED EVALUATION O
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1262P DISTINCT SPREAD OF EGFR MUTAT
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1268P VISUAL DISTURBANCES IN PATIEN
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MERCK SERONO: Advisor, speaker in s
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Conclusions: These data from SAiL a
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NSCLC diagnosis and time of BM diag
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1291P PHASE I/II DOSE-FINDING STUDY
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Network utilization of WBCGF in the
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1303P COST EFFECTIVENESS OF PEMETRE
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Results: The patients’ characteri
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EGFR mut at exons 18, 19, 21, and K
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Methods: EML4-ALK fusion was screen
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Results: The median survival time (
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enefit from sustained EGFR blockade
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epresented by 19 pts (32%) female,
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and at least one prior course of ch
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Methods: NSCLC patients with radiog
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1367TiP LONG-TERM ERLOTINIB THERAPY
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Austria, Czech Republic, Finland, G
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were every 6 weeks (wk) (S1), every
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Advantage enrollees (83% vs. 25%) [
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Results: Based on 10,000 simulation
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cancer tumors 12%, Germ cell tumor
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Material and methods: 50 lung cance
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1414TiP IMPLEMENTATION OF CANCER RE
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abstracts palliative care 1422O EFF
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Method and results: A total of 317
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1436P SURVEY ON MODELS OF INTEGRATI
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care unit (PCU) at the National Can
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Characteristic No. % Total 63 1 st
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hysterectomised-9.10% and cervix ca
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abstracts psycho-oncology 1462PD IN
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events, tumour response, and surviv
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abstracts sarcoma 1477O ADHESION TO
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1481PD A PHASE II STUDY OF DOVITINI
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1488P ORGANISATION OF SARCOMA PATIE
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Patients and methods: From August 2
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chemotherapy respectively. At a med
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of this group Those with relapsed d
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1515 PREDICTORS OF SURVIVAL IN ADOL
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abstracts small cell lung cancer an
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emaining receiving either CAV or to
Page 497 and 498:
1533P EXPRESSION OF WILM⍰TUMOUR G
Page 499 and 500:
more than 3 months after first line
Page 501 and 502:
lower recurrence rate of NE. Pegfil
Page 503 and 504:
egimens (HR = 2.5, p < 0.001). Phys
Page 505 and 506:
1561P PREDICTIVE DIAGNOSTICS FOR RE
Page 507 and 508:
Methods: A prospective multicentre
Page 509 and 510:
Table: 1574P Pharmacokinetic parame
Page 511 and 512:
Novartis and unrestricted research
Page 513 and 514:
studies have shown that chemotherap
Page 515 and 516:
(Grade 1) and moderate to severe (G
Page 517 and 518:
declined to relatively lower level
Page 519 and 520:
1609P PHYSICAL ACTIVITY (PA) AND PH
Page 521 and 522:
patients were admitted to the oncol
Page 523 and 524:
Dicarbamin 100 mg/day on day 5 befo
Page 525 and 526:
Results: Anemia was detected in 83.
Page 527 and 528:
important to carry out randomized s
Page 529 and 530:
abstracts translational research 16
Page 531 and 532:
expression. Then, we analyzed PB sa
Page 533 and 534:
Table: 1657P TH BV + TH HR (95% CI)
Page 535 and 536:
BRAF mutations. Circulating free DN
Page 537 and 538:
1671P PHASE I CLINICAL TRIAL OF CAN
Page 539 and 540:
1678P PREDICTIVE VALUE OF TWO PHENO
Page 541 and 542:
theorized that the PI3K/AKT pathway
Page 543 and 544:
Material and methods: 101 patients
Page 545 and 546:
overexpressing and 232 had triple n
Page 547 and 548:
author index author index A Aamdal
Page 549 and 550:
author index Badran A. ix288 (874)
Page 551 and 552:
author index Bösmüller H. ix209 (
Page 553 and 554:
author index Chen A. ix319 (966O) C
Page 555 and 556:
author index De Droogh E. ix452 (13
Page 557 and 558:
author index Esposito G. ix209 (618
Page 559 and 560:
author index Geiges G. ix306 (930P)
Page 561 and 562:
author index Hartono S. ix70 (155P)
Page 563 and 564:
author index Iwasaki H. ix542 (1694
Page 565 and 566:
author index Kodaira M. ix90 (228P)
Page 567 and 568:
author index Lichtensztejn D. ix350
Page 569 and 570:
author index Martinez A. ix496 (153
Page 571 and 572:
author index Morishita N. ix432 (13
Page 573 and 574:
author index Okamoto N. ix432 (1320
Page 575 and 576:
author index Piau S. ix456 (1401P)
Page 577 and 578:
author index Rodríguez Rodríguez
Page 579 and 580:
author index Scoggins C.R. ix371 (1
Page 581 and 582:
author index Stern L. ix272 (823P)
Page 583 and 584:
author index Trypaki M. ix429 (1308
Page 585 and 586:
author index Whitmore J.B. ix310 (9
Page 587 and 588:
subject index subject index A AAV-H
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subject index ix115 (316TiP), ix116
Page 591 and 592:
subject index diffuse large B-cell
Page 593 and 594:
subject index (1033P), ix340 (1036P
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subject index medical information,
Page 597 and 598:
subject index (612P), ix214 (633),
Page 599 and 600:
subject index RCC, ix274 (830P) re-
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subject index TR-FRET, ix84 (206P)
Page 603 and 604:
drug index drug index 1248P, 1250P,
Page 605 and 606:
translational research index transl
Page 607 and 608:
Page 609:
show all

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