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Annals of Oncology Conclusions: QOL in the studied patient population was negatively affected by fatigue and anorexia, and was improved by good response probably through decreased pain. Disclosure: Y. Ohashi: I have an advisory relationship and research funding to disclose. Name of Entity: Taiho Pharmaceutical Co. Ltd. T. Ioka: I have an advisory relationship and research funding to disclose. Name of Entity: Taiho Pharmaceutical Co. Ltd. T. Okusaka: I have an advisory relationship and research funding to disclose. Name of Entity: Taiho Pharmaceutical Co. Ltd 776TiP GAMMA (GEMCITABINE AND AMG 479 FOR METASTATIC ADENOCARCINOMA OF THE PANCREAS): A PHASE 3, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF GANITUMAB PLUS GEMCITABINE (G) OR PLACEBO PLUS G AS FIRST-LINE THERAPY FOR METASTATIC PANCREATIC CANCER Abstract withdrawn in exceptional circumstances. 777TiP SECOND INTERIM ANALYSIS OF THE GLOBAL INVESTIGATION OF THERAPEUTIC DECISIONS IN HEPATOCELLULAR CARCINOMA AND OF ITS TREATMENT WITH SORAFENIB (GIDEON) STUDY ACCORDING TO DISEASE STAGE B. Daniele 1 , J. Turnes 2 , G. Bodoky 3 , C. Papandreou 4 , A. Hubert 5 , P. Stål 6 , V.A. Gorbunova 7 , F. Serejo 8 , A. Croitoru 9 , P. Mathurin 10 1 Medical Oncology Unit, G. Rummo Hospital, Benevento, ITALY, 2 Gastroenterology Department, Hospital de Montecelo, Pontevedra, SPAIN, 3 Department of Oncology, St László Hospital, Budapest, HUNGARY, 4 Department of Medical Oncology, University Hospital of Larissa, Larissa, GREECE, 5 Gastrointestinal Cancer Center, Sharett Institute of Oncology, Jerusalem, ISRAEL, 6 Department of Gastroenterology and Hepatology, Karolinska University Hospital, Stockholm, SWEDEN, 7 Russian Scientific Research Oncology Centre, N. N. Blokhin Russian Cancer Research Center, Moscow, RUSSIAN FEDERATION, 8 Center of Gastroenterology, Liver Unit, Hospital de Santa Maria, Faculty of Medicine, Lisbon, PORTUGAL, 9 Hepatic Fundeni, FUNDENI Clinical Institute, Bucharest, ROMANIA, 10 Service Des Maladies De L’appareil Digestif, Hôpital Claude Huriez, Lille, FRANCE Background: GIDEON (NCT00812175) is an ongoing, global, prospective, non-interventional study of patients with unresectable hepatocellular carcinoma (HCC) receiving sorafenib (Nexavar®) in real-life practice. The aim is to evaluate sorafenib safety and efficacy in diverse settings and patient groups. The second interim analysis was triggered when ∼1500 patients had been treated for ≥ 4 months. We describe sorafenib use in Europe according to disease stage. Methods: Patient/disease characteristics (including Barcelona Clinic Liver Cancer [BCLC], tumour node metastases [TNM], Cancer for the Liver Italian Programme [CLIP]) and treatment history were recorded at enrolment; sorafenib dose, concomitant medications, performance status, liver function, adverse events (AEs) and efficacy are recorded at follow-up visits. Results: Of 1571 patients in the safety population, 588 are in Europe (see table). The majority of patients were BCLC-C (52.9%), TNM III (40.3%) or CLIP 1/2 (26.0%/ 25.9%), although sorafenib was also used in patients with early, intermediate and end-stage disease. Generally, AEs and serious AEs (SAEs) increased with advancing disease (AEs: 66.0%, 87.4%, 85.5%, 89.7%; SAEs: 22.6%, 37.8%, 38.3%, 58.6%; for BCLC-A, B, C and D; respectively), whereas sorafenib-related AEs and SAEs were comparable across BCLC groups (AEs: 60.4%, 74.1%, 68.5%, 41.4%; SAEs: 7.5%, 15.4%, 10.3%, 10.3%; for BCLC-A, B, C and D; respectively). Evaluation will continue with more mature data. Medical oncologist (n = 189) Hepatologist/ GI specialist (n = 332) EU total (n = 588) BCLC stage at study entry, % of n A 6.9 8.7 9.0 B 19.6 27.7 24.3 C 59.3 50.6 52.9 D 3.2 5.4 4.9 NE/missing 11.1 7.5 8.8 TNM stage at study entry, % of n I 3.2 10.5 8.8 II 8.5 12.3 10.2 III 39.2 41.9 40.3 IV 40.2 19.9 26.9 NE/missing 9.0 15.4 13.8 Child-Pugh score at start of sorafenib therapy, % of n A 68.3 64.8 66.3 B 13.8 26.8 21.6 C 1.1 1.8 1.5 NE/missing 16.9 6.6 10.5 CLIP score at start of sorafenib therapy, % of n 0 14.8 8.4 11.9 1 24.3 26.5 26.0 2 24.3 26.5 25.9 3 5.8 15.7 11.4 4–6 4.2 11.4 8.7 NE/missing 26.5 11.4 16.2 NE, not evaluable Conclusions: These data reflect real-world sorafenib given to a broad range of patients, indicating a similar safety profile across the different disease stages. Evaluation is ongoing, with more mature data expected from the final analysis. Disclosure: B. Daniele: Dr B. Daniele has participated in advisory boards and received lecture fees from Bayer. J. Turnes: Dr J Turnes has participated in advisory boards for Roche Pharma. C. Papandreou: Prof. C Papandreou has participated in advisory boards for Bayer, Sanofi Aventis, Novartis, Bristol Meyers Squibb and Janssen. P. Stål: Prof. Stål has advised and received a grant from Bayer. A. Croitoru: Dr A Croitoru has consulted for and received an investigator fee from Bayer. P: Mathurin: Dr. P . Mathurin was paid speaking at symposia for Roche, Schering-Plough, Gilead Sciences, Bristol-Myers Squibb, Janssen-Cilag and Bayer Healthcare pharmaceutical companies. He is an investigator for Roche, Schering-Plough, Bristol-Myers Squibb, Gilead Sciences, Vertex pharmaceuticals Janssen-Cilag, Boeringher, Novartis and Bayer Healthcare companies. He is a member of the French boards of experts in Hepatology for Roche Schering-Plough, Gilead Sciences, Bayer Healthcare and Bristol-Myers Squibb pharmaceutical companies. He is consulting for the Gilead Sciences, Bristol-Myers Squibb, Bayer Healthcare and Vertex pharmaceutical Companies. All other authors have declared no conflicts of interest. 778TiP INTERIM ANALYSIS OF OVERALL SURVIVAL PER SUBGROUPS IN THE PROSPECTIVE, NON-INTERVENTIONAL INSIGHT STUDY IN PATIENTS WITH HEPATOCELLULAR CARCINOMA TREATED WITH SORAFENIB T. Ganten 1 , E. Schott 2 , P. Galle 3 , T. Göhler 4 , P. Malfertheiner 5 , R. Stauber 6 , R. Buder 7 , K. Achilles 8 , G. Gerken 9 1 Medizinische Klinik, Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinik Heidelberg, Heidelberg, GERMANY, 2 Medizinische Klinik, Hepatologie und Gastroenterologie, Charité- Campus Virchow Klinikum, Berlin, GERMANY, 3 I. Medizinische Klinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, GERMANY, 4 Onkologische Praxis, Dresden, GERMANY, 5 Universitätsklinik für Gastroenterologie, Hepatologie und Infektiologie, Otto-von-Guericke Universität Magdeburg, Magdeburg, GERMANY, 6 Karl-Franzens-Universität Graz, Abteilung Innere Medizin, Gastroenterologie und Hepatologie, Graz, AUSTRIA, 7 Abteilung Innere Medizin, Konventspital Barmherzige Brüder, Linz, AUSTRIA, 8 Bayer HealthCare, Leverkusen, GERMANY, 9 Abteilung Gastroenterologie und Hepatologie, Universitätsklinik Essen, Essen, GERMANY Background: The efficacy of Sorafenib in patients (pts) with hepatocellular carcinoma (HCC) has been proven in randomized, controlled trials. INSIGHT is a Volume 23 | Supplement 9 | September 2012 doi:10.1093/annonc/mds398 | ix255
prospective, non-interventional study, conducted in Germany and Austria in pts with HCC. The objectives of this study are the evaluation of safety and efficacy under practice conditions in both hospitals and private practices. Enrollment into INSIGHT is not restricted to a particular tumor stage. Recruitment into the study is ongoing. Methods: The second interim analysis (data cut-off 23 FEB 2012) evaluated overall survival and safety data in relevant subgroups. All patients with HCC were observed for the duration of their sorafenib therapy. In addition to baseline data the performance status, tumor status (clinical and/or radiological), time to progression and overall survival time are documented. Documentation of adverse events comprises relationship with drug, seriousness, grade (CTCAE version 3.0), and outcome. Results: Until the data cut-off 623 pts have been enrolled; 618 of which are evaluable for safety and efficacy analyses. The table summarises major baseline characteristics together with median overall survival (mOS) data for relevant subpopulations. Patients recruited n, Male n (%) 618, 528 (85) ECOG PS, n (%), 0, 1, 2 203 (33); 310 (50); 98 (16) BCLC-Stage n (%), A, B, C, D 80 (13); 149 (24); 319 (52); 12 (2) Child Pugh Stage, n (%), A(9), Missing 264 (43); 99 (16); 12 (2); 243 (39) Months mOS total population (Events n = 164) 17,1 mPFS total population (Events n = 408) 4,1 mOS according to BCLC A, B, C, D 29,2; 19,6; 14,5; 4,0 mOS according to Child Pugh A, B, C n.r.; 7,2; 4,0 mOS Child Pugh B: 7, 8, 9 points 11,5; 9,5; 2,5 mOS Duration of therapy > 24 weeks (n = 176); >40 weeks (n = 91) 19,8; 26,7 n.r.-not reached Conclusions: Results of mOS in pts with HCC treated under daily practice conditions in hospitals and private practices confirm the general efficacy of Sorafenib known from registration trials and gives further insight into pts with Child B/C cirrhosis and BCLC stage A/B. Further demographic data and efficacy and safety results will be presented. Disclosure: T. Ganten: Advisory Boards and Cooperate-sponsored research (Bayer HealthCare Germany). E. Schott: ES has received lecture fees and travel support from Bayer and has acted as an advisor to Bayer. P. Galle: Advisory Boards, Speaker for Bayer. P. Malfertheiner: - Anstellungsverhältnis, Führungsposition: Klinikdirektor - Beratungs- bzw. Gutachtertätigkeit: Aptalis, Novartis - Honorare: Aptalis, Falk Foundation, Abbott, AstraZeneca - Finanzierung wissenschaftlicher Untersuchungen: Bayer, Novartis. K. Achilles: I am employee of Bayer Vital. All other authors have declared no conflicts of interest. 779TiP A RANDOMIZED PHASE II TRIAL OF BIWEEKLY S-1 WITH PACLITAXEL (SPA) OR OXALIPLATIN (SOX) AS FIRST-LINE CHEMOTHERAPY IN ADVANCED GASTRIC CANCER PATIENTS: PRELIMINARY RESULTS M. Haibo, W. Fang, Y. Zheng, P. Zhao, C. Mao, X. Zhang, J. Qian, H. Jiang, Y. Zheng, N. Xu Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, CHINA Background: Gastric cancer patients are commonly treated with S-1-based chemotherapy for three weeks or more to ensure two weeks of exposure at therapeutic doses. Severe side effects of S-1 such as mucositis, diarrhea and neutropenia often occur in the second week of treatment. We evaluated the activity and safety of every other week S-1 regimens with paclitaxel or oxaliplatin combinations as first-line chemotherapy in advanced gastric cancer patients. Patients and methods: Eligible patients with pathologically confirmed advanced gastric cancer patients were randomized into two arms. S-1 was administered orally (80 mg/m 2 / day) for 7 consecutive days in combination with paclitaxel 120 mg/m 2 (SPA) or oxaliplatin 85 mg/m 2 (SOX) on day 1 followed by a 7-day rest. Treatment continued in a biweekly manner until disease progressed, unacceptable toxicity was observed or the patient refused to continue. The primary endpoint was overall response rate (ORR). The secondary endpoints were progression-free survival (PFS), overall survival (OS) and safety. Results: Eighty-one gastric cancer patients were enrolled from June 2010 to March 2012. Patients were randomized to receive SPA (43) or SOX (38). Results are presented for 76 patients. The ORR for arm A was 43.6%, and that for arm B was 33.3% with no significant difference between the two arms (p = 0.35). The median PFS was 6.2 months for arm A vs. 5.1 months for arm B (p = 0.80); the median OS was 10.8 months for arm A and 10.0 months for arm B (p = 0.17). No treatment-related deaths occurred during the study. The most frequent toxicity was neutropenia (30.8% and 17.4% of grade 3/4 in arms A and B, respectively). The most common non-hematological toxicities were mucositis, diarrhea, and peripheral neuropathy, all in less than 5% of patients. Conclusions: These preliminary findings suggest that biweekly S-1-based regimens have an acceptable ORR with tolerable side effects in advanced gastric cancer patients. The study will continue until 100 patients have been enrolled. Disclosure: All authors have declared no conflicts of interest. 780TiP SAFETY AND EFFICACY OF ALBUMIN-BOUND PACLITAXEL AND OXALIPLATIN AND S-1 AS FIRST-LINE TREATMENT OF PATIENTS WITH ADVANCED GASTRIC CANCER H. Lou, H. Pan, Q. Pan, D. Li, W. Jin Medical Oncology, Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University, Hangzhou, CHINA Background: Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) is a novel formulation of paclitaxel that does not require solvents such as polyoxyethylated castor oil and ethanol. Use of these solvents has been associated with toxic response, including hypersensitivity reactions and prolonged sensory neuropathy. This study was conducted to evaluate the efficacy and safety of combination chemotherapy with nab-paclitaxel plus oxaliplatin and S-1 as first-line treatment for patients with advanced gastric cancer. Patients and methods: Eligible patients (pts) with histologically confirmed advanced gastric cancer,
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Annals of Oncology www.annonc.oxfor
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subscriptions A subscription to Ann
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Annals of Oncology Official Journal
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The European Society for Medical On
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Audit Committee Chair: Fortunato Ci
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Familial cancer Judith Balmaña, Ba
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ESMO 2012 Congress Travel Grants 47
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Exhibitors The following companies
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ESMO Fellowships, 1989-2011 The Eur
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Ondrej Gojis, Czech Republic 2008-2
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abstracts hpv biology and implicati
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abstracts the characterization of l
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abstracts description of intra-tumo
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prevent cell death. It is anticipat
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22IN TARGETING THE HOST IN TNBC G.
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abstracts a paradigm shift in early
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abstracts how can medical oncologis
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feasibility), but by how high the c
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abstracts re-inventing the medical
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abstracts emerging diagnostic and t
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abstracts biologically based treatm
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abstracts molecular targets in mali
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abstracts melanoma therapy: from fr
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diagnosis and can also be used for
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analysis at 11 months median follow
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mouse model of Kras mutant NSCLC. I
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abstracts subtyping soft tissue sar
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abstracts key topics in supportive
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ESMO-CSCO Joint Symposium: Building
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ESMO-EANM-ESR Joint Symposium: Imag
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ESMO-ESTRO Joint Symposium: Innovat
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ESMO-MASCC Joint Symposium: Integra
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ESO Society Symposium: Celebrating
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Results: TIMP-1 expression was incr
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will benefit from this targeted the
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cytomegalovirus (CMV). Analysis of
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functional consequences of Endoglin
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elationship between the ROR score,
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183P EPIDERMAL GROWTH FACTOR RECEPT
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Plasma adiponectin level on the pre
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Table: 198P PFS OS Median, mo HR Me
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204P EVALUATION OF PTEN AND PIK3CA
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Material and methods: We searched P
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Results: The median concentration o
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Table: 226P Methods: Pts were rando
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However, additional analysis sugges
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number of biomarkers have been trie
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Table: 248O 249PD PROTEOMIC PREDICT
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Conclusions: BW and serum Ctrough o
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261P BREAST CANCER SUBTYPES AND OUT
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90 mg/m2-cyclophophamide 600 mg/m2
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to 9 weeks after dosing. Trastuzuma
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Patients and methods: We reviewed d
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sector patients. The aim of this st
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Linear Logistic Model with Relaxed
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Results: The median CTC fold change
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312: Table: Chemotherapy uptake wit
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abstracts breast cancer, locally ad
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Results: 8 trials (2092 pts) with 1
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absolute difference of median value
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Novartis, Genentech, and sanofi-ave
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Results: Three RCTs with 1023 patie
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collected from all patients for det
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355P FIRST REPORT OF LONG-TERM RESP
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361P A RETROSPECTIVE ANALYSIS OF PL
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publications and aggregated in a me
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Thus the primary aim to target BCSC
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383 WHY DO WOMEN WITH BREAST CANCER
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Results: We evaluated 76 pts with M
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more than 6 cycles of capecitabine.
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406TiP PHASE II TRIAL OF PRIMARY SY
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abstracts CNS tumors 410O CONDITION
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Conclusions: Our data suggested tha
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Conclusions: As in other cancer typ
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432 GAMMA KNIFE RADIOSURGERY AS A M
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abstracts developmental therapeutic
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1PR), but no responses were seen in
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RO and Cd, as well as PD data for c
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and vulvar Ca), and 11 SDs were obs
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knowing HLA-A status double-blindly
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Acquired-resistance to EGFR inhibit
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474P PHASE 1 STUDY OF THE SELECTIVE
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TST is active in breast and gastric
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Treatment-induced shedding of circu
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Methods: Either co-cultures of peri
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501 PRECLINICAL DATA INVESTIGATING
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509TiP LUX-LUNG 8: A RANDOMIZED, OP
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(P = 0.64). Synchronous BBC was sig
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abstracts gastrointestinal tumors,
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Disclosure: M. Lee: I am an employe
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plus intravenous Bev(7.5mg/kg q 21d
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anti-EGFR treatment. The present st
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patients harboring a T/T genotype t
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551P ADJUVANT CHEMOTHERAPY (AC) USE
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experienced significantly more ≥
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functioning scales. Exploratory ana
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oxaliplatin (100 mg/m 2 )/raltitrex
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572P PANERB STUDY: WHICH CATEGORY O
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Results: 92/114 patients were preop
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585P CHANGES IN THE INTESTINAL ENVI
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592P PHASE II TRIAL OF COMBINED CHE
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Page 243 and 244: after Gem-based therapy. The additi
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Page 247 and 248: validate the revised AJCC 7th stagi
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928P LHRH AGONIST-INDUCED SUPPRESSI
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Disclosure: S. Oudard: Has acted as
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939P NEOADJUVANT SIPULEUCEL-T IN LO
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945 BONE TURNOVER MARKERS AND POTEN
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952 SEQUENTIAL ANDROGEN DEPRIVATION
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managed in a multidisciplinary (MD)
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or hypercalcemia at screening; prio
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meeting. The prevalence of LGSC is
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Table: 975PD Continued AMG 386 + pa
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physicians in the U.S. and Europe.
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989P PHASE II STUDY OF COMBINATION
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elated with stage, nodal involvemen
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1004P CASE CONTROL STUDY ON TWO DIF
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eight patients who had infertility
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abstracts head and neck cancer 1016
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same CT/RT; Arm B2: 3 cycles of ind
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induction chemotherapy in the treat
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patients. We have developed a rando
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evaluated by the screening instrume
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morbidities that radiation would le
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Conclusions: Through adequate selec
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abstracts hematological malignancie
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anthracyclines in vitro. A favorabl
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1076P RITUXIMAB PLUS SUBCUTANEOUS C
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than the standard target of ≥2.5
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Patients: From November 2002 to May
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lymphadenopathy and multiple cutane
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prospective non-interventional stud
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Funding: GSK Biologicals Disclosure
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survival rates of 13-25% (Prieto et
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high response rates and prolonged p
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GlaxoSmithKline, Merck Sharp & Dohm
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advisor for Merck Sharp & Dohme, an
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or cutaneous melanoma. A survival u
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systemic therapy or were intolerant
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abstracts neuroendocrine tumors and
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morbidity, with G3 tumors behaving
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pts. Poorly differentiated endocrin
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Adenocarcinoma was present in 25 pa
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Method: Endobronchial ultrasound gu
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widely used by single agent or plat
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disease after surgery were treated
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stage IIIA NSCLC, EML4-ALK fusion-p
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1200P CONCOMITANT CHEMORADIATION GI
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Patients and methods: The study was
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months (95% CI:13-25). The PFS and
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maintenance therapy had favourable
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abstracts non-small cell lung cance
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Ingelheim, GSK Biologicals (compens
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1234PD RANDOMIZED PHASE III TRIAL O
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GlaxoSmithKline (myself, compensate
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1243P IDENTIFICATION OF MICRORNA (M
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N-arm n=34 P-arm n=32 All n=66 Male
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1255P POPULATION BASED EVALUATION O
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1262P DISTINCT SPREAD OF EGFR MUTAT
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1268P VISUAL DISTURBANCES IN PATIEN
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MERCK SERONO: Advisor, speaker in s
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Conclusions: These data from SAiL a
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NSCLC diagnosis and time of BM diag
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1291P PHASE I/II DOSE-FINDING STUDY
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Network utilization of WBCGF in the
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1303P COST EFFECTIVENESS OF PEMETRE
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Results: The patients’ characteri
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EGFR mut at exons 18, 19, 21, and K
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Methods: EML4-ALK fusion was screen
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Results: The median survival time (
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enefit from sustained EGFR blockade
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epresented by 19 pts (32%) female,
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and at least one prior course of ch
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Methods: NSCLC patients with radiog
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1367TiP LONG-TERM ERLOTINIB THERAPY
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Austria, Czech Republic, Finland, G
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were every 6 weeks (wk) (S1), every
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Advantage enrollees (83% vs. 25%) [
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Results: Based on 10,000 simulation
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cancer tumors 12%, Germ cell tumor
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Material and methods: 50 lung cance
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1414TiP IMPLEMENTATION OF CANCER RE
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abstracts palliative care 1422O EFF
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Method and results: A total of 317
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1436P SURVEY ON MODELS OF INTEGRATI
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care unit (PCU) at the National Can
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Characteristic No. % Total 63 1 st
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hysterectomised-9.10% and cervix ca
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abstracts psycho-oncology 1462PD IN
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events, tumour response, and surviv
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abstracts sarcoma 1477O ADHESION TO
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1481PD A PHASE II STUDY OF DOVITINI
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1488P ORGANISATION OF SARCOMA PATIE
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Patients and methods: From August 2
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chemotherapy respectively. At a med
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of this group Those with relapsed d
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1515 PREDICTORS OF SURVIVAL IN ADOL
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abstracts small cell lung cancer an
Page 495 and 496:
emaining receiving either CAV or to
Page 497 and 498:
1533P EXPRESSION OF WILM⍰TUMOUR G
Page 499 and 500:
more than 3 months after first line
Page 501 and 502:
lower recurrence rate of NE. Pegfil
Page 503 and 504:
egimens (HR = 2.5, p < 0.001). Phys
Page 505 and 506:
1561P PREDICTIVE DIAGNOSTICS FOR RE
Page 507 and 508:
Methods: A prospective multicentre
Page 509 and 510:
Table: 1574P Pharmacokinetic parame
Page 511 and 512:
Novartis and unrestricted research
Page 513 and 514:
studies have shown that chemotherap
Page 515 and 516:
(Grade 1) and moderate to severe (G
Page 517 and 518:
declined to relatively lower level
Page 519 and 520:
1609P PHYSICAL ACTIVITY (PA) AND PH
Page 521 and 522:
patients were admitted to the oncol
Page 523 and 524:
Dicarbamin 100 mg/day on day 5 befo
Page 525 and 526:
Results: Anemia was detected in 83.
Page 527 and 528:
important to carry out randomized s
Page 529 and 530:
abstracts translational research 16
Page 531 and 532:
expression. Then, we analyzed PB sa
Page 533 and 534:
Table: 1657P TH BV + TH HR (95% CI)
Page 535 and 536:
BRAF mutations. Circulating free DN
Page 537 and 538:
1671P PHASE I CLINICAL TRIAL OF CAN
Page 539 and 540:
1678P PREDICTIVE VALUE OF TWO PHENO
Page 541 and 542:
theorized that the PI3K/AKT pathway
Page 543 and 544:
Material and methods: 101 patients
Page 545 and 546:
overexpressing and 232 had triple n
Page 547 and 548:
author index author index A Aamdal
Page 549 and 550:
author index Badran A. ix288 (874)
Page 551 and 552:
author index Bösmüller H. ix209 (
Page 553 and 554:
author index Chen A. ix319 (966O) C
Page 555 and 556:
author index De Droogh E. ix452 (13
Page 557 and 558:
author index Esposito G. ix209 (618
Page 559 and 560:
author index Geiges G. ix306 (930P)
Page 561 and 562:
author index Hartono S. ix70 (155P)
Page 563 and 564:
author index Iwasaki H. ix542 (1694
Page 565 and 566:
author index Kodaira M. ix90 (228P)
Page 567 and 568:
author index Lichtensztejn D. ix350
Page 569 and 570:
author index Martinez A. ix496 (153
Page 571 and 572:
author index Morishita N. ix432 (13
Page 573 and 574:
author index Okamoto N. ix432 (1320
Page 575 and 576:
author index Piau S. ix456 (1401P)
Page 577 and 578:
author index Rodríguez Rodríguez
Page 579 and 580:
author index Scoggins C.R. ix371 (1
Page 581 and 582:
author index Stern L. ix272 (823P)
Page 583 and 584:
author index Trypaki M. ix429 (1308
Page 585 and 586:
author index Whitmore J.B. ix310 (9
Page 587 and 588:
subject index subject index A AAV-H
Page 589 and 590:
subject index ix115 (316TiP), ix116
Page 591 and 592:
subject index diffuse large B-cell
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subject index (1033P), ix340 (1036P
Page 595 and 596:
subject index medical information,
Page 597 and 598:
subject index (612P), ix214 (633),
Page 599 and 600:
subject index RCC, ix274 (830P) re-
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subject index TR-FRET, ix84 (206P)
Page 603 and 604:
drug index drug index 1248P, 1250P,
Page 605 and 606:
translational research index transl
Page 607 and 608:
Page 609:
show all

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