68° Congresso Nazionale SCIVAC: Le domande più frequenti in ...

68° CONGRESSO NAZIONALE SCIVAC 11-13 Marzo 2011 - Milano
LE DOMANDE PIÙ FREQUENTI IN RIPRODUZIONE CANINA E FELINA
Tutto quello che i vostri clienti osano spesso chiedere e a cui voi non sapete rispondere
14 th EVSSAR Congress - Advances in Feline Reproduction - March 11 th 2011
Use of dopamine agonists
From our point of view, dopamine agonists should rather be used in late
pregnancy as complementary treatments only in case of failure with other
drugs.
TABLE 3 - EXAMPLES OF PROTOCOLS USING DOPAMINERGIC COMPOUNDS
ALONE TO INDUCE MID TO LATE-PREGNANCY TERMINATION (PREFERABLY
AFTER 40 DAYS) IN THE BITCH (WANKE ET AL. 2002, NÖTHLING ET AL. 2003)
Drug Protocol Duration of treatment
Cabergoline 5 μg/kg (0.1 ml/kg) > 7 to 9 days
orally once daily
Metergoline 0.6 mg/kg orally BID > 3 to 23 days
Note: bromocryptine alone has to be used at a high dose (100 μg/kg) which induces sideeffects,
mainly emesis.
TABLE 4 - EXAMPLES OF PROTOCOLS COMBINING PGF2α ANALOGUE CLOPROSTE-
NOL AND DOPAMINERGIC DRUGS TO INDUCE MID TO LATE-PREGNANCY TERMINA-
TION IN THE BITCH (ONCLIN ET AL. 1999, WANKE ET AL. 2002, CORRADA ET AL. 2006)
Cloprostenol Dopaminergic drug
1 μg/kg SC every other day (up to 9 days) Cabergoline 5 μg/kg (0.1 ml/kg) orally
once daily (9 days)
1 μg/kg SC Days 1 and 5 of treatment Cabergoline 5 μg/kg (0.1 ml/kg) orally
once daily (10 days)
2.5 μg/kg SC Day 1 of treatment Cabergoline 5 μg/kg (0.1 ml/kg) orally
once daily (10 days)
2.5 μg/kg SC Day 1 of treatment Bromocryptine 30 μg/kg orally TID
(10 days)
1 μg/kg SC Days 1 and 5 of treatment Bromocryptine 30 μg/kg orally TID
(10 days)
1 μg/kg SC Days 1 and 3 of treatment* Cabergoline 5 μg/kg (0.1 ml/kg) orally
once daily (7 days)*
*: this protocol is to begin minimum 35 to 45 days from the first mating.
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