Concept Richtlijn Ovariumcarcinoom - Oncoline

Benedetti2006Jin Y2006Matsumoto2006Salani2007CCCCProspectivelycohortProspectivelynon randomisedcase controlRetrospect casecontrolRetrospectcohort47/81 EOCMedian age 52complete response primtreatment, DFI >6 mths,CA125 increasing orimaging proof ofrecurrenceExclusion: unresectablepre-op, bad clinicalstatus, contradict. forextensive surg.synchronous tumor54 Median age 52 EOC, pim. treatment insame hospital with(sub)optimal surgeryand platinum/taxolreceiving completeremission, ’90-‘0046 EOC, completion ofprim surgery andchemo, PF interval >6mths’88-‘0355 Median age 57,7Median interval32 mthsEOC≤ 5 sites pre-opComplete responseprimInterval >12 monthsSecondarysurgerySecondarysurgery andchemotherapy(n=23)Secondarysurgery (n=23)andchemotherapy(n=22)SecondarycytoreductiongeenChemotherapyn=28Nosurgeryn=23Succes of surgerySurvivalPredictors for survivalmultivariatelySurvival time(multivariately)Overall survivalDuration of stayDuration of time pts couldhave intake as per theirpreferenceIn surgery group:prognosis was influencedby :geen Complete surgery: 74.5%Predictors for survivalmultivariately: interval, nrimaging sites, residualdiseaseMacroscopic free: 78,8%< 1 cm 8,5%1-2 cm 8,5%>2 cm 4,9%median survival 49 mths≤ 1 cm : 61 mths>1 cm 19 mths (P= .02)Macroscopic free P=.02CA125 levelpre op P=.04Chemo free interval >6 mths:CI: 0.153-0.987 p=.047Surgery and chemo: CI: 1.611-10.914 p=.0003Surgery group: 41.7 mthsControls: 18.8 mthsP