27. Ellingrod VL, Schultz SK, Arndt S. Abnormal movements and tardive dyskinesiain smokers and nonsmokers with schizophrenia genotyped for cytochrome P450 2D6.Pharmacotherapy 2002 11;22(11):1416-1419.28. Fu Y, Fan CH, Deng HH, Hu SH, Lv DP, Li LH, et al. Association of <strong>CYP</strong>2D6and <strong>CYP</strong>1A2 gene polymorphism with tardive dyskinesia in Chinese schizophrenicpatients. Acta Pharmacol Sin 2006 03;27(3):328-332.29. Inada T, Senoo H, Iijima Y, Yamauchi T, Yagi G. Cytochrome P450 II D6 genepolymorphisms and the neuroleptic-induced extrapyramidal symptoms in Japaneseschizophrenic patients. Psychiatr Genet 2003 09;13(3):163-168.30. Jaanson P, Marandi T, Kiivet RA, Vasar V, Vaan S, Svensson JO, et al. Maintenancetherapy with zuclopenthixol decanoate: associations between plasma concentrations,neurological side effects and <strong>CYP</strong>2D6 genotype. Psychopharmacology (Berl) 200206;162(1):67-73.31. Kapitany T, Meszaros K, Lenzinger E, Schindler SD, Barnas C, Fuchs K, et al.Genetic polymorphisms for drug metabolism (<strong>CYP</strong>2D6) and tardive dyskinesia inschizophrenia. Schizophr Res 1998 07/27;32(2):101-106.32. Lam LC, Garcia-Barcelo MM, Ungvari GS, Tang WK, Lam VK, Kwong SL, et al.Cytochrome P450 2D6 genotyping and association with tardive dyskinesia in Chineseschizophrenic patients. Pharmacopsychiatry 2001 11;34(6):238-241.33. Liou YJ, Wang YC, Bai YM, Lin CC, Yu SC, Liao DL, et al. Cytochrome P-4502D6*10 C188T polymorphism is associated with antipsychotic-induced persistent tardi<strong>ved</strong>yskinesia in Chinese schizophrenic patients. Neuropsychobiology2004;49(4):167-173.34. Lohmann PL, Bagli M, Krauss H, Muller DJ, Schulze TG, Fangerau H, et al.<strong>CYP</strong>2D6 polymorphism and tardive dyskinesia in schizophrenic patients.Pharmacopsychiatry 2003 03;36(2):73-78.35. Nikoloff D, Shim JC, Fairchild M, Patten N, Fijal BA, Koch WH, et al.Association between <strong>CYP</strong>2D6 genotype and tardive dyskinesia in Korean schizophrenics.Pharmacogenomics J 2002;2(1470-269; 1470-269; 6):400-407.36. Ohmori O, Suzuki T, Kojima H, Shinkai T, Terao T, Mita T, et al. Tardive dyskinesiaand debrisoquine 4-hydroxylase (<strong>CYP</strong>2D6) genotype in Japanese schizophrenics.Schizophr Res 1998 07/27;32(2):107-113.37. Ohmori O, Kojima H, Shinkai T, Terao T, Suzuki T, Abe K. Genetic associationanalysis between <strong>CYP</strong>2D6*2 allele and tardive dyskinesia in schizophrenic patients.Psychiatry Res 1999 10/11;87(2-3):239-244.38. Plesnicar BK, Zalar B, Breskvar K, Dolzan V. The influence of the <strong>CYP</strong>2D6 polymorphismon psychopathological and extrapyramidal symptoms in the patients onlong-term antipsychotic treatment. J Psychopharmacol 2006 11;20(6):829-833.90 <strong>Rutinebrug</strong> <strong>af</strong> <strong>CYP</strong>-<strong>test</strong> <strong>ved</strong> <strong>antipsykotisk</strong> <strong>behandling</strong>
39. Scordo MG, Spina E, Romeo P, Dahl ML, Bertilsson L, Johansson I, et al.<strong>CYP</strong>2D6 genotype and antipsychotic-induced extrapyramidal side effects in schizophrenicpatients. Eur J Clin Pharmacol 2000 12;56(9-10):679-683.40. Topic E, Stefanovic M, Ivanisevic AM, Blazinic F, Culav J, Skocilic Z. <strong>CYP</strong>2D6genotyping in patients on psychoactive drug therapy. Clin Chem Lab Med 200009;38(9):921-927.41. Arthur H, Dahl ML, Siwers B, Sjoqvist F. Polymorphic drug metabolism in schizophrenicpatients with tardive dyskinesia. J Clin Psychopharmacol 1995 Jun;15(3):211-216.42. Ellingrod VL, Miller D, Schultz SK, Wehring H, Arndt S. <strong>CYP</strong>2D6 polymorphismsand atypical antipsychotic weight gain. Psychiatr Genet 2002 03;12(1):55-58.43. Kakihara S, Yoshimura R, Shinkai K, Matsumoto C, Goto M, Kaji K, et al.Prediction of response to risperidone treatment with respect to plasma concencentrationsof risperidone, catecholamine metabolites, and polymorphism of cytochrome P4502D6. Int Clin Psychopharmacol 2005 03;20(2):71-78.44. Kobylecki CJ, Jakobsen KD, Hansen T, Jakobsen IV, Rasmussen HB, Werge T.<strong>CYP</strong>2D6 genotype predicts antipsychotic side effects in schizophrenia inpatients: aretrospective matched case-control study. Neuropsychobiology 2009;59(4):222-226.45. Lane HY, Liu YC, Huang CL, Chang YC, Wu PL, Lu CT, et al. Risperidonerelatedweight gain: genetic and nongenetic predictors. J Clin Psychopharmacol 200604;26(2):128-134.46. Mihara K, Kondo T, Higuchi H, Takahashi H, Yoshida K, Shimizu T, et al. Tardi<strong>ved</strong>ystonia and genetic polymorphisms of cytochrome P4502D6 and dopamine D2 andD3 receptors: a preliminary finding. Am J Med Genet 2002 08/08;114(6):693-695.47. Panagiotidis G, Arthur HW, Lindh JD, Dahl ML, Sjoqvist F. Depot HaloperidolTreatment in Outpatients With Schizophrenia on Monotherapy: Impact of <strong>CYP</strong>2D6Polymorphism on Pharmacokinetics and Treatment Outcome. Ther Drug Monit 200708;29(4):417-422.48. Thanacoody RH, Daly AK, Reilly JG, Ferrier IN, Thomas SH. Factors <strong>af</strong>fectingdrug concentrations and QT interval during thioridazine therapy. Clin PharmacolTher 2007 11;82(5):555-565.49. Tiwari AK, Deshpande SN, Rao AR, Bhatia T, Lerer B, Nimgaonkar VL, et al.Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: III. Lackof association of <strong>CYP</strong>3A4 and <strong>CYP</strong>2D6 gene polymorphisms. Schizophr Res 200506/01;75(1):21-26.50. Patsopoulos NA, Ntzani EE, Zintzaras E, Ioannidis JP. <strong>CYP</strong>2D6 polymorphismsand the risk of tardive dyskinesia in schizophrenia: a meta-analysis. PharmacogenetGenomics 2005 Mar;15(3):151-158.91 <strong>Rutinebrug</strong> <strong>af</strong> <strong>CYP</strong>-<strong>test</strong> <strong>ved</strong> <strong>antipsykotisk</strong> <strong>behandling</strong>
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Rutinebrug af CYP-test vedantipsyko
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IndholdHvad er Medicinsk Teknologiv
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Hvad er Medicinsk Teknologivurderin
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TeknologiCYP-testen er en gentest.
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Samlet påviser dette studie, at en
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sættelse. Dette skyldes den store
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SummaryIntroductionA large part of
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• Are CYP2D6 and/or CYP2C19 geno
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The costs of pharmacy-dispensed dru
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Sundhedsstyrelsen vil gerne takke p
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1 Introduktion1.1 BaggrundDen medik
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faktor for testens anvendelighed. S
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lægens ordination af såvel antips
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NomenklaturCYP-enzymerne inddeles i
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I det følgende præsenteres egne s
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Figur 2 Studiepopulationerne i stud
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ner. Således er de hyppigste mutat
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- Page 41 and 42: 3.3 Diskussion af resultaterFra CYP
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- Page 47 and 48: Den begrænsede eksisterende viden
- Page 49 and 50: 4.2 ResultaterDet centrale spørgsm
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- Page 57 and 58: Lægerne i DPC udtrykker i spørges
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- Page 82 and 83: Tabel 9 Resultaterne fra to-trins-m
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- Page 88 and 89: 8 Referencer1. Lieberman JA, Stroup
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- Page 102 and 103: Statistiske analyserBehandlingspers
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- Page 106 and 107: Reference Design CYP2D6 alleles Pop
- Page 108 and 109: Reference Design CYP2D6 alleles Pop
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- Page 118 and 119: Symptom Spørgsmål Rating af svær
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- Page 126 and 127: York CRD-databasernePharmacogenetic
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- Page 132 and 133: Indtryk af CYP-testenI hvilket omfa
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Bilag 12 Resultaterne fra den blind
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Bilag 13 Variable i den økonomiske
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Bilag 15 Studiepopulation i den øk
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IndholdsfortegnelseSide 2:Side 3:Si
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Hvem anvender undersøgelsen:Rekvir
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Samtlige genotyper:CYP2D6Genotype A
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CYP 2D6 vejledninger:Tabel 1. Hurti
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Bilag 17 APPENDIKS til instruks ved
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(19-hydroxy-risperidon).Det må for
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CYP 2C19 analyseTabel 4. CYP 2C19-a
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Tabel 5. CYP 2C19-tilpasset doserin