APPENDICES. A systematic review and economic model of the ...
APPENDICES. A systematic review and economic model of the ...
APPENDICES. A systematic review and economic model of the ...
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Study Intervention Participants Outcomes<br />
Core symptoms<br />
Not reported<br />
Inclusion criteria<br />
A minimum <strong>of</strong> eight symptoms were required to confirm a<br />
diagnosis <strong>of</strong> ADHD<br />
Reference<br />
Fine <strong>and</strong> Johnston,<br />
1993 52<br />
Co-existent problems<br />
Not reported<br />
Diagnostic criteria<br />
DSM-III-R<br />
Arm 1<br />
MPH<br />
0.3 mg/kg; administered twice daily<br />
(Individual administering medication<br />
not reported)<br />
Educational performance<br />
Not reported<br />
Psychological function<br />
Not reported<br />
Number<br />
Total r<strong>and</strong>omised = 12 (male = not reported)<br />
Total withdrawals = 0<br />
Arm 2<br />
MPH<br />
0.6 mg/kg; administered twice daily<br />
(Individual administering medication<br />
not reported)<br />
Source<br />
AHRQ Report<br />
Setting<br />
Canada<br />
Design<br />
Crossover trial<br />
Depression or anxiety<br />
Not reported<br />
R<strong>and</strong>omisation procedure:<br />
Two doses <strong>of</strong> MPH <strong>and</strong> placebo were r<strong>and</strong>omly assigned across<br />
days<br />
Arm 3<br />
Placebo<br />
Administered twice daily<br />
(Individual administering medication<br />
not reported)<br />
Duration<br />
3 weeks<br />
Quality <strong>of</strong> life<br />
Not reported<br />
Age<br />
6–10 years (range)<br />
Adverse events<br />
Side Effects Questionnaire<br />
IQ<br />
Not reported<br />
Additional outcomes<br />
Not reported<br />
Co-morbid disorders<br />
Not reported<br />
Purpose<br />
To examine <strong>the</strong> nature<br />
<strong>and</strong> frequency <strong>of</strong> sideeffects<br />
<strong>of</strong> low- <strong>and</strong> highdose<br />
MPH compared<br />
with placebo. The<br />
authors also were<br />
interested in finding out<br />
whe<strong>the</strong>r <strong>the</strong> side-effects<br />
were similar to <strong>the</strong><br />
symptoms <strong>of</strong> ADHD<br />
reported by <strong>the</strong> parents<br />
© Queen’s Printer <strong>and</strong> Controller <strong>of</strong> HMSO 2006. All rights reserved.<br />
Diagnostic subtypes<br />
Not reported<br />
Health Technology Assessment 2006; Vol. 10: No. 23<br />
Additional information<br />
No relevant information reported<br />
247
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