APPENDICES. A systematic review and economic model of the ...

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Appendix 12
Core symptoms Educational performance Quality of life Adverse events
Total somatic complaints (parents)
MPH: 0.85 (1.08)
PLA: 0.49 (0.80); F(1,101) = 10.49,
p < 0.01
Abbreviated Conners’ Hyperactivity Questionnaire
(parents)
Means (SD) for NC/ADD/ADD-O populations at 3 weeks:
MPH: 0.84 (0.47)/0.99 (0.60)/1.13 (0.60)
PLA: 1.29 (0.63)/1.41 (0.60)/1.80 (0.57)
MPH > placebo, F(1,101) = 46,72, p < 0.01
Proportion of parents reporting:
Poor appetite:
MPH: 23.4%
PLA: 6.5%;
2 (1, N = 107) = 13.5, p < 0.01
Not reported Valence of weekly comments, parents
ratings:
Means (SD) for NC/ADD/ADD-O
populations at 3 weeks:
MPH:
0.24 (0.54)/0.19 (0.56)/0.15 (0.57)
PLA:
–0.04(0.53)/–0.39(0.38)/–0.29
(0.45)
MPH > placebo, F(1,38)=16,09, p < 0.01
Sleep difficulties:
MPH: 36.4%
PLA: 18.7%;
2 (1, N = 107) = 13.37, p < 0.01
Abbreviated Conners’ Hyperactivity Questionnaire
(teachers)
Means (SD) for NC/ADD/ADD-O populations at 3 weeks:
MPH: 0.43 (0.34)/0.56 (0.42)/0.77 (0.45)
PLA: 0.69 (0.43)/1.09 (0.52)/1.80 (0.67)
MPH > placebo, F(1,98) = 122.18, p < 0.01
Total counts of negative moods:
MPH: 0.64 (0.99)
PLA: 1.16 (1.19); F(1,101) = 15.60,
p < 0.01
Valence of weekly comments, teacher
ratings:
Means (SD) for NC/ADD/ADD-O
populations at 3 weeks:
MPH:
0.27 (0.46)/0.42(0.43)/0.45 (0.32)
PLA:
0.09(0.49)/–0.11(0.63)/–0.61 (0.33)
MPH > placebo, F(1,38)=52.61, p < 0.01
IOWA Conners’ Scales: inattention/overactivity (parents)
Means (SD) for NC/ADD/ADD-O populations at 3 weeks:
MPH: 0.90 (0.51)/1.02 (0.73)/1.14 (0.63)
PLA: 1.29 (0.55)/1.54 (0.68)/1.81 (0.59)
MPH > placebo, F(1,101) = 47.74, p < 0.01
Proportion of parents reporting:
Crying:
MPH: 19.6%
PLA: 37.4%;
2 (1, N = 107) = 9.26, p < 0.01
IOWA Conners’ Scales: inattention/overactivity (teachers)
Means (SD) for NC/ADD/ADD-O populations at 3 weeks:
MPH: 0.61 (0.48)/0.71 (0.51)/0.87 (0.48)
PLA: 0.94 (0.57)/1.44 (0.66)/2.02 (0.69)
MPH > placebo, F(1,98)=116.52, p < 0.01
Anger:
MPH: 28.0%
PLA: 50.5% ;
2 (1, N = 107) = 7.50, p < 0.01
Time on Task Scales (TOTS): hyperactivity (parents)
Means (SD) for NC/ADD/ADD-O populations at 3 weeks:
MPH: –0.46 (0.37)/–0.44 (0.51)/–0.39 (0.42)
PLA: –0.22 (0.41)/–0.11 (0.48)/0.04 (0.41)
MPH > placebo, F(1,93)=42.73, p < 0.01
Unhappiness:
MPH: 12.1%
PLA: 22.4% ;
2 (1, N = 107) = 5.26, p < 0.05
TOTS: hyperactivity (teachers)
Means (SD) for NC/ADD/ADD-O populations at 3 weeks:
MPH: –1.26 (0.37)/–1.04 (0.43)/–0.89 (0.47)
PLA: –0.97 (0.44)/–0.61 (0.45)/–0.14 (0.53)
MPH > placebo, F(1,92)=85.57, p < .01
Weight (kg):
Baseline: NC: 29.78 (7.75)/ADD: 28.87
(6.42)/ADD-O: 31.34 (9.39)
MPH: total group: –0.498 kg
PLA: total group: +0.567 kg
Total group: F(1,64) = 59.15, p < 0.01
TOTS: attention (parents)
Means (SD) for NC/ADD/ADD-O populations at 3 weeks:
MPH: 0.11 (0.38)/0.08 (0.49)/0.01 (0.40)
PLA: –0.12 (0.34)/–0.09 (0.38)/–0.25 (0.50)
MPH > placebo, F(1,93) = 25.73, p < 0.01
continued